Mutagenetix > Incidental Mutations

Incidental Mutation 'R8501:Gm40460'

655327

Institutional Source

Beutler Lab

Gene Symbol

Gm40460

Ensembl Gene

ENSMUSG00000110324

Gene Name

predicted gene, 40460

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Not available question?

Stock #

R8501 (G1)

Quality Score

106.461

Status

Not validated

Chromosome

Chromosomal Location

142240344-142241078 bp(-) (GRCm38)

Type of Mutation

small deletion (10 aa in frame mutation)

DNA Base Change (assembly)

ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG to ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG at 142240713 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000147331 (fasta)

Predicted Effect

probably benign
Transcript: ENSMUST00000211591

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921501E09Rik	C	A	17: 33,067,064	A255S	probably benign	Het
5031439G07Rik	C	T	15: 84,960,523	V98M	probably damaging	Het
Agbl2	G	A	2: 90,797,564	G238R	probably damaging	Het
Atg2a	T	C	19: 6,254,390	S1146P	probably damaging	Het
Atg3	C	A	16: 45,182,931	D207E	probably damaging	Het
Atp8b3	A	G	10: 80,520,146	V1244A	probably benign	Het
Cacna1i	T	C	15: 80,382,046		probably null	Het
Ccdc171	G	T	4: 83,663,658	E675*	probably null	Het
Cep68	A	T	11: 20,239,132	S627T	unknown	Het
Chrnd	T	C	1: 87,192,616	W165R	probably damaging	Het
Col6a2	G	T	10: 76,603,557	A791D	probably damaging	Het
Dlg2	C	A	7: 92,375,722	S598R	probably damaging	Het
Elfn2	G	T	15: 78,674,300	Q16K	probably benign	Het
Gpr165	C	A	X: 96,714,017	D7E	probably benign	Het
Grm8	A	T	6: 27,618,541	M434K	probably damaging	Het
Idh2	TCCCAGG	T	7: 80,098,331		probably benign	Het
Igf2	G	C	7: 142,654,042	P106R	probably damaging	Het
Klf7	T	C	1: 64,079,163	S92G	probably benign	Het
Mme	T	A	3: 63,326,735	M73K	probably damaging	Het
Musk	G	C	4: 58,367,502	K588N	probably damaging	Het
Naa30	C	A	14: 49,172,896	H94N	possibly damaging	Het
Naip6	C	T	13: 100,300,276	A580T	possibly damaging	Het
Nfya	A	G	17: 48,398,989	L52P	unknown	Het
Olfr126	A	G	17: 37,850,865	Y91C	probably damaging	Het
Olfr346	A	G	2: 36,688,797	N265S	probably benign	Het
Olfr65	T	A	7: 103,906,611	H54Q		Het
Otogl	A	T	10: 107,790,560	M1481K	probably benign	Het
P4ha3	A	G	7: 100,313,355	D440G	probably damaging	Het
Pcdhb13	A	T	18: 37,444,440	T624S	probably damaging	Het
Piezo2	A	G	18: 63,045,540	Y1769H	probably damaging	Het
Plekha6	T	A	1: 133,287,837	V913E	probably benign	Het
Rapgefl1	A	G	11: 98,842,227	E211G	possibly damaging	Het
Rcc2	T	C	4: 140,715,926	L305P	probably damaging	Het
Rgs3	G	T	4: 62,602,956	V47F	possibly damaging	Het
Scly	A	G	1: 91,319,076	S370G	probably damaging	Het
Setmar	T	A	6: 108,075,861	D105E	probably benign	Het
Slc9a9	A	G	9: 94,855,739	Y233C	probably damaging	Het
Sp140	A	T	1: 85,641,740	N357I	probably damaging	Het
Trim30c	G	C	7: 104,387,470	T227R	probably benign	Het
Unc79	G	A	12: 103,092,638	V1014I	probably damaging	Het
Vmn1r151	A	T	7: 22,499,609	F24I	probably damaging	Het
Vmn2r78	T	C	7: 86,920,886	V204A	probably damaging	Het
Vps13a	T	C	19: 16,682,120	D1681G	probably benign	Het
Vwa2	T	C	19: 56,908,982	V573A	probably benign	Het
Wfdc2	A	G	2: 164,563,359	D44G	probably damaging	Het
Zfp40	T	A	17: 23,178,298	N75I	probably damaging	Het

Other mutations in Gm40460

Allele	Source	Chr	Coord	Type	Predicted Effect
R6822:Gm40460	UTSW	7	142240713	small deletion	probably benign
R7016:Gm40460	UTSW	7	142240817	small deletion	probably benign
R7053:Gm40460	UTSW	7	142240817	small deletion	probably benign
R7083:Gm40460	UTSW	7	142240713	small deletion	probably benign
R7087:Gm40460	UTSW	7	142240434	small deletion	probably benign
R7110:Gm40460	UTSW	7	142240817	small deletion	probably benign
R7184:Gm40460	UTSW	7	142240713	small deletion	probably benign
R7224:Gm40460	UTSW	7	142240434	small deletion	probably benign
R7367:Gm40460	UTSW	7	142240434	small deletion	probably benign
R7411:Gm40460	UTSW	7	142240817	small deletion	probably benign
R7481:Gm40460	UTSW	7	142240817	small deletion	probably benign
R7491:Gm40460	UTSW	7	142240713	small deletion	probably benign
R7553:Gm40460	UTSW	7	142240713	small deletion	probably benign
R7637:Gm40460	UTSW	7	142240713	small deletion	probably benign
R7643:Gm40460	UTSW	7	142240713	small deletion	probably benign
R7663:Gm40460	UTSW	7	142240713	small deletion	probably benign
R7785:Gm40460	UTSW	7	142240434	small deletion	probably benign
R7871:Gm40460	UTSW	7	142240817	small deletion	probably benign
R7895:Gm40460	UTSW	7	142240713	small deletion	probably benign
R8054:Gm40460	UTSW	7	142240817	small deletion	probably benign
R8355:Gm40460	UTSW	7	142240817	small deletion	probably benign
R8389:Gm40460	UTSW	7	142240434	small deletion	probably benign
R8509:Gm40460	UTSW	7	142240817	small deletion	probably benign
RF040:Gm40460	UTSW	7	142240817	small deletion	probably benign
Z1177:Gm40460	UTSW	7	142240772	missense	unknown
Z1177:Gm40460	UTSW	7	142240906	missense	unknown

Predicted Primers

PCR Primer
(F):5'- GAACCTCAGATCTTGCACTGG -3'
(R):5'- AAGGGAGGCTGTAGTTCCTG -3'

Sequencing Primer
(F):5'- AGCAGCAGGGCTTACAGC -3'
(R):5'- TCCTGTGGGGGCTGCAAG -3'

Posted On

2020-10-20