Incidental Mutation 'R8504:Gm21190'
ID 655459
Institutional Source Beutler Lab
Gene Symbol Gm21190
Ensembl Gene ENSMUSG00000106445
Gene Name predicted gene, 21190
Synonyms
MMRRC Submission 067840-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R8504 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 15729454-15734220 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 15730862 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 165 (S165P)
Ref Sequence ENSEMBL: ENSMUSP00000143589 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000196384]
AlphaFold A0A0G2JGJ6
Predicted Effect probably benign
Transcript: ENSMUST00000196384
AA Change: S165P

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000143589
Gene: ENSMUSG00000106445
AA Change: S165P

DomainStartEndE-ValueType
Pfam:Takusan 50 134 7.3e-32 PFAM
low complexity region 234 258 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T C 3: 121,922,983 (GRCm39) S1181P probably benign Het
Acvr1c C T 2: 58,173,491 (GRCm39) C337Y probably damaging Het
Adgrf5 A G 17: 43,757,840 (GRCm39) E758G probably benign Het
Akap3 T A 6: 126,841,493 (GRCm39) D37E probably damaging Het
Ano5 A T 7: 51,222,776 (GRCm39) H445L probably benign Het
Ap4b1 T A 3: 103,720,116 (GRCm39) I121N probably damaging Het
Arhgdia T C 11: 120,470,354 (GRCm39) K135E probably benign Het
Ass1 T C 2: 31,391,544 (GRCm39) F273S possibly damaging Het
Atp8a2 A C 14: 59,885,366 (GRCm39) Y1119* probably null Het
Birc6 T A 17: 74,959,000 (GRCm39) M3839K probably damaging Het
Cacna1a A G 8: 85,365,370 (GRCm39) H2171R probably benign Het
Ccdc90b T A 7: 92,224,545 (GRCm39) D183E probably benign Het
Ccng2 C G 5: 93,421,202 (GRCm39) S237R probably benign Het
Cdh23 T A 10: 60,274,618 (GRCm39) T491S probably benign Het
Cercam T C 2: 29,771,829 (GRCm39) S550P possibly damaging Het
Chd9 A G 8: 91,723,472 (GRCm39) H1019R unknown Het
Coil A T 11: 88,871,980 (GRCm39) K114* probably null Het
Csmd2 A C 4: 128,440,483 (GRCm39) T3183P Het
Cul9 T C 17: 46,814,506 (GRCm39) Y2219C probably damaging Het
Efhd2 G A 4: 141,587,186 (GRCm39) Q199* probably null Het
Elp3 A T 14: 65,785,360 (GRCm39) S499R probably benign Het
Exoc8 T G 8: 125,622,709 (GRCm39) I553L probably benign Het
Fyco1 C A 9: 123,659,142 (GRCm39) V345L probably benign Het
Galr3 T A 15: 78,927,279 (GRCm39) V240E probably damaging Het
Gnal T A 18: 67,350,255 (GRCm39) Y372* probably null Het
H2-DMa A G 17: 34,357,416 (GRCm39) N230D probably damaging Het
Hk2 T C 6: 82,721,847 (GRCm39) D164G possibly damaging Het
Ighv3-4 T A 12: 114,217,544 (GRCm39) I16F possibly damaging Het
Ivl T C 3: 92,480,078 (GRCm39) probably benign Het
Klhl8 G A 5: 104,015,814 (GRCm39) T434M probably benign Het
Lct A T 1: 128,215,306 (GRCm39) S1757T probably damaging Het
Lmbr1l T A 15: 98,810,065 (GRCm39) Y132F probably damaging Het
M6pr T C 6: 122,293,029 (GRCm39) V203A possibly damaging Het
Map9 T C 3: 82,284,476 (GRCm39) probably null Het
Muc5ac A T 7: 141,360,892 (GRCm39) D1401V probably damaging Het
Myh7 A G 14: 55,227,786 (GRCm39) S291P probably damaging Het
Nynrin G C 14: 56,107,703 (GRCm39) V937L probably benign Het
Or5d44 C T 2: 88,141,825 (GRCm39) G105D probably benign Het
Or5m3 T G 2: 85,838,149 (GRCm39) F10V probably damaging Het
Pank2 A G 2: 131,135,320 (GRCm39) N386S probably benign Het
Phkg2 G T 7: 127,181,528 (GRCm39) R237L possibly damaging Het
Pkhd1 C T 1: 20,590,432 (GRCm39) V1772I probably benign Het
Plch2 G T 4: 155,068,852 (GRCm39) P1258Q probably benign Het
Plekhm2 A T 4: 141,369,764 (GRCm39) I77N probably damaging Het
Ptprb A G 10: 116,176,936 (GRCm39) T954A probably benign Het
Ranbp3 T C 17: 57,015,273 (GRCm39) V325A probably damaging Het
Rgs10 A T 7: 128,019,793 (GRCm39) S16T probably benign Het
Scaper A T 9: 55,771,722 (GRCm39) V398E probably benign Het
Selenot A G 3: 58,492,698 (GRCm39) I62V probably benign Het
Serpinb9e T A 13: 33,439,092 (GRCm39) C173S probably benign Het
Slc13a3 G T 2: 165,275,999 (GRCm39) T249K probably damaging Het
Slc4a8 T A 15: 100,701,171 (GRCm39) V741D possibly damaging Het
Slco4a1 T C 2: 180,106,592 (GRCm39) V258A probably damaging Het
Sycp2l T G 13: 41,291,390 (GRCm39) L256R probably damaging Het
Tektl1 T C 10: 78,585,038 (GRCm39) D266G probably benign Het
Tektl1 T C 10: 78,586,463 (GRCm39) D196G probably damaging Het
Top2a C T 11: 98,905,567 (GRCm39) V337I probably benign Het
Tut4 T C 4: 108,388,139 (GRCm39) L1160P probably damaging Het
Unc13a A C 8: 72,098,405 (GRCm39) F1127V possibly damaging Het
Wdr25 C T 12: 108,992,393 (GRCm39) Q435* probably null Het
Zc3h7b T G 15: 81,664,719 (GRCm39) L526R probably damaging Het
Zeb1 C A 18: 5,705,127 (GRCm39) T48K possibly damaging Het
Zfhx2 A C 14: 55,303,243 (GRCm39) S1580R probably benign Het
Zfhx3 A G 8: 109,583,549 (GRCm39) I1139V possibly damaging Het
Zfp536 C A 7: 37,179,492 (GRCm39) V1038L probably benign Het
Zfp759 T A 13: 67,286,947 (GRCm39) V166E probably benign Het
Zfp985 A T 4: 147,667,883 (GRCm39) K250N possibly damaging Het
Other mutations in Gm21190
AlleleSourceChrCoordTypePredicted EffectPPH Score
R5992:Gm21190 UTSW 5 15,729,849 (GRCm39) missense probably damaging 0.97
R6656:Gm21190 UTSW 5 15,730,849 (GRCm39) missense possibly damaging 0.79
R7345:Gm21190 UTSW 5 15,732,902 (GRCm39) splice site probably null
R7658:Gm21190 UTSW 5 15,732,923 (GRCm39) missense possibly damaging 0.48
R8093:Gm21190 UTSW 5 15,730,814 (GRCm39) missense possibly damaging 0.48
R8368:Gm21190 UTSW 5 15,729,848 (GRCm39) missense possibly damaging 0.94
Z1176:Gm21190 UTSW 5 15,731,578 (GRCm39) missense probably benign
Z1176:Gm21190 UTSW 5 15,729,972 (GRCm39) missense not run
Z1176:Gm21190 UTSW 5 15,729,892 (GRCm39) missense probably benign 0.06
Z1177:Gm21190 UTSW 5 15,730,805 (GRCm39) missense probably benign 0.00
Z1177:Gm21190 UTSW 5 15,729,972 (GRCm39) missense not run
Z1177:Gm21190 UTSW 5 15,729,892 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- GGTATCAGACAGTCATAGCCTG -3'
(R):5'- TGGACTGCAGCCAAAATTTCTTC -3'

Sequencing Primer
(F):5'- ATAGCCTGACCGAATTGTCC -3'
(R):5'- ACAGCTGTCATGGATGTATTGAG -3'
Posted On 2020-10-20