Mutagenetix > Incidental Mutation

Incidental Mutation 'R8506:Dnah8'

655605

Institutional Source

Beutler Lab

Gene Symbol

Dnah8

Ensembl Gene

ENSMUSG00000033826

Gene Name

dynein, axonemal, heavy chain 8

Synonyms

Dnahc8, P1-Loop, Hst6.7b

MMRRC Submission

067842-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.423) question?

Stock #

R8506 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

30624354-30875264 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 30721134 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 1685 (S1685P)

Ref Sequence

ENSEMBL: ENSMUSP00000127878 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170651]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000170651
AA Change: S1685P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000127878
Gene: ENSMUSG00000033826
AA Change: S1685P

Domain	Start	End	E-Value	Type
low complexity region	2	54	N/A	INTRINSIC
Pfam:DHC_N1	379	936	8.4e-159	PFAM
low complexity region	1069	1080	N/A	INTRINSIC
low complexity region	1224	1237	N/A	INTRINSIC
Pfam:DHC_N2	1509	1917	1.6e-134	PFAM
AAA	2082	2226	1.38e-1	SMART
AAA	2363	2516	2.04e-1	SMART
AAA	2689	2837	8.15e-2	SMART
Pfam:AAA_8	3022	3294	4e-72	PFAM
Pfam:MT	3306	3656	3.6e-48	PFAM
Pfam:AAA_9	3676	3901	6.7e-85	PFAM
Pfam:Dynein_heavy	4039	4728	8.4e-250	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9630041A04Rik	A	T	9: 101,942,972 (GRCm38)	E197V	possibly damaging	Het
Alkbh8	C	T	9: 3,335,616 (GRCm38)		probably benign	Het
Ank1	G	A	8: 23,096,835 (GRCm38)	A498T	probably damaging	Het
Antxr1	T	A	6: 87,188,173 (GRCm38)	E427D	possibly damaging	Het
App	A	C	16: 85,082,816 (GRCm38)	V143G	unknown	Het
Bod1l	C	A	5: 41,819,055 (GRCm38)	E1639*	probably null	Het
C2cd2	T	C	16: 97,875,421 (GRCm38)	D122G		Het
Ccdc88b	G	T	19: 6,847,322 (GRCm38)	P1357T	probably damaging	Het
Ccnyl1	A	G	1: 64,714,662 (GRCm38)	T211A	possibly damaging	Het
Cdc25a	T	C	9: 109,891,752 (GRCm38)	Y434H	probably damaging	Het
Ceacam16	C	A	7: 19,852,270 (GRCm38)	A106S	unknown	Het
Celsr1	G	T	15: 86,033,085 (GRCm38)	S229*	probably null	Het
Chpf2	T	C	5: 24,588,297 (GRCm38)	L87P	probably damaging	Het
Col5a2	A	T	1: 45,442,784 (GRCm38)	I60N	unknown	Het
Cux1	T	A	5: 136,308,504 (GRCm38)	E718V	probably damaging	Het
Dchs2	A	T	3: 83,301,174 (GRCm38)	I1845L	probably benign	Het
Disp3	C	T	4: 148,241,570 (GRCm38)	V1244I	possibly damaging	Het
Etnppl	G	A	3: 130,629,473 (GRCm38)	V274I	possibly damaging	Het
Evc2	T	C	5: 37,383,142 (GRCm38)	S561P	probably damaging	Het
Fga	A	G	3: 83,033,316 (GRCm38)	E759G	probably damaging	Het
Gdpd5	T	C	7: 99,453,950 (GRCm38)	F372S	probably benign	Het
Gpr155	T	C	2: 73,343,462 (GRCm38)	T868A	probably damaging	Het
Herc1	A	G	9: 66,473,581 (GRCm38)	D3580G	possibly damaging	Het
Hmbs	A	G	9: 44,341,624 (GRCm38)		probably null	Het
Ibsp	A	T	5: 104,310,081 (GRCm38)	E161D	probably damaging	Het
Ighv8-4	A	G	12: 115,024,108 (GRCm38)	V90A	possibly damaging	Het
Itpr2	A	G	6: 146,418,416 (GRCm38)		probably null	Het
Kcnc2	T	A	10: 112,455,632 (GRCm38)	F242I	probably damaging	Het
Kcnj5	A	G	9: 32,322,332 (GRCm38)	I229T	probably damaging	Het
Lamb1	A	T	12: 31,329,361 (GRCm38)	L1791F	probably damaging	Het
Med6	A	T	12: 81,594,960 (GRCm38)	M1K	probably null	Het
Mei4	A	G	9: 81,979,238 (GRCm38)	D294G	probably benign	Het
Nat10	T	C	2: 103,732,237 (GRCm38)	I585V	probably benign	Het
Nid1	T	C	13: 13,476,174 (GRCm38)	V432A	probably damaging	Het
Nlrp4c	G	T	7: 6,100,776 (GRCm38)	G903V	possibly damaging	Het
Nrf1	G	A	6: 30,126,257 (GRCm38)	A416T	probably benign	Het
Nsl1	G	C	1: 191,076,635 (GRCm38)	C173S	unknown	Het
Obsl1	G	A	1: 75,505,656 (GRCm38)	A190V	probably benign	Het
Olfr1047	A	G	2: 86,228,578 (GRCm38)	L131P	possibly damaging	Het
Olfr1085	T	C	2: 86,658,401 (GRCm38)	D19G	probably benign	Het
Olfr1151	A	T	2: 87,857,837 (GRCm38)	I221F	probably damaging	Het
Olfr1469	A	G	19: 13,411,240 (GRCm38)	T224A	possibly damaging	Het
Olfr535	G	A	7: 140,493,423 (GRCm38)	V262I	probably benign	Het
Olfr583	T	A	7: 103,051,502 (GRCm38)	M68K	probably damaging	Het
Osbpl1a	G	A	18: 12,768,586 (GRCm38)	T621I	probably benign	Het
Pabpc4l	G	A	3: 46,446,397 (GRCm38)	R271*	probably null	Het
Paics	A	T	5: 76,964,590 (GRCm38)	D307V	possibly damaging	Het
Pcdhga9	A	G	18: 37,738,684 (GRCm38)	D522G	probably damaging	Het
Pclo	T	A	5: 14,540,745 (GRCm38)	C1020S	unknown	Het
Pfkfb4	T	G	9: 109,005,599 (GRCm38)	D113E	possibly damaging	Het
Plod3	A	G	5: 136,988,976 (GRCm38)	Y202C	probably damaging	Het
Pmp22	T	A	11: 63,158,264 (GRCm38)	M111K	probably damaging	Het
Pole2	A	C	12: 69,208,960 (GRCm38)	S344A	probably benign	Het
Pom121l2	A	G	13: 21,983,619 (GRCm38)	T687A	probably benign	Het
Psmd6	A	G	14: 14,114,181 (GRCm38)	S313P	probably damaging	Het
Rd3	T	G	1: 191,983,267 (GRCm38)	M1R	probably null	Het
Rtn4ip1	G	A	10: 43,928,356 (GRCm38)	V235I	probably benign	Het
Senp5	T	C	16: 31,968,901 (GRCm38)	I635V	probably damaging	Het
Stox2	T	C	8: 47,192,073 (GRCm38)	E784G	possibly damaging	Het
Syce2	A	T	8: 84,887,166 (GRCm38)	D168V	probably benign	Het
Taar6	A	G	10: 23,985,631 (GRCm38)	S6P	probably benign	Het
Tbc1d16	A	C	11: 119,148,958 (GRCm38)	H675Q	probably damaging	Het
Tmem151b	A	T	17: 45,545,401 (GRCm38)	I371N	probably damaging	Het
Trim31	A	T	17: 36,907,258 (GRCm38)		probably null	Het
Usp48	A	G	4: 137,610,718 (GRCm38)	Y268C	probably damaging	Het
Vmn2r11	A	G	5: 109,059,404 (GRCm38)	S17P	probably benign	Het
Vmn2r110	T	A	17: 20,584,365 (GRCm38)	N98Y	probably benign	Het
Vps13b	T	A	15: 35,446,745 (GRCm38)	D515E	probably benign	Het
Yeats2	T	G	16: 20,152,934 (GRCm38)	I42M	probably damaging	Het

Other mutations in Dnah8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Dnah8	APN	17	30,677,176 (GRCm38)	missense	probably benign	0.06
IGL00508:Dnah8	APN	17	30,855,930 (GRCm38)	missense	probably damaging	1.00
IGL00547:Dnah8	APN	17	30,815,703 (GRCm38)	nonsense	probably null
IGL00551:Dnah8	APN	17	30,663,478 (GRCm38)	nonsense	probably null
IGL00732:Dnah8	APN	17	30,656,641 (GRCm38)	missense	probably damaging	1.00
IGL00775:Dnah8	APN	17	30,767,906 (GRCm38)	nonsense	probably null
IGL00840:Dnah8	APN	17	30,790,941 (GRCm38)	missense	probably damaging	1.00
IGL00845:Dnah8	APN	17	30,819,276 (GRCm38)	critical splice donor site	probably null
IGL00953:Dnah8	APN	17	30,706,457 (GRCm38)	nonsense	probably null
IGL00976:Dnah8	APN	17	30,851,710 (GRCm38)	missense	probably damaging	0.98
IGL01395:Dnah8	APN	17	30,636,005 (GRCm38)	missense	probably benign	0.06
IGL01467:Dnah8	APN	17	30,779,916 (GRCm38)	missense	probably damaging	1.00
IGL01469:Dnah8	APN	17	30,683,714 (GRCm38)	splice site	probably benign
IGL01515:Dnah8	APN	17	30,648,485 (GRCm38)	missense	probably benign
IGL01723:Dnah8	APN	17	30,708,471 (GRCm38)	missense	probably damaging	1.00
IGL01837:Dnah8	APN	17	30,751,591 (GRCm38)	critical splice donor site	probably null
IGL01921:Dnah8	APN	17	30,736,141 (GRCm38)	missense	probably benign
IGL01958:Dnah8	APN	17	30,855,895 (GRCm38)	splice site	probably benign
IGL01968:Dnah8	APN	17	30,656,598 (GRCm38)	nonsense	probably null
IGL02093:Dnah8	APN	17	30,717,880 (GRCm38)	missense	probably damaging	0.99
IGL02151:Dnah8	APN	17	30,648,417 (GRCm38)	missense	possibly damaging	0.50
IGL02182:Dnah8	APN	17	30,794,763 (GRCm38)	missense	possibly damaging	0.45
IGL02233:Dnah8	APN	17	30,706,513 (GRCm38)	critical splice donor site	probably null
IGL02236:Dnah8	APN	17	30,649,773 (GRCm38)	nonsense	probably null
IGL02259:Dnah8	APN	17	30,759,614 (GRCm38)	missense	probably benign
IGL02263:Dnah8	APN	17	30,729,165 (GRCm38)	missense	probably benign	0.00
IGL02303:Dnah8	APN	17	30,713,047 (GRCm38)	missense	probably benign	0.03
IGL02341:Dnah8	APN	17	30,747,257 (GRCm38)	missense	probably damaging	1.00
IGL02351:Dnah8	APN	17	30,767,811 (GRCm38)	missense	probably damaging	1.00
IGL02358:Dnah8	APN	17	30,767,811 (GRCm38)	missense	probably damaging	1.00
IGL02377:Dnah8	APN	17	30,794,796 (GRCm38)	missense	probably damaging	0.98
IGL02390:Dnah8	APN	17	30,830,845 (GRCm38)	missense	probably benign	0.01
IGL02392:Dnah8	APN	17	30,818,051 (GRCm38)	splice site	probably benign
IGL02414:Dnah8	APN	17	30,700,413 (GRCm38)	missense	probably benign
IGL02455:Dnah8	APN	17	30,672,334 (GRCm38)	missense	probably damaging	0.99
IGL02817:Dnah8	APN	17	30,668,295 (GRCm38)	missense	probably benign
IGL02831:Dnah8	APN	17	30,712,276 (GRCm38)	missense	probably benign	0.23
IGL02863:Dnah8	APN	17	30,769,697 (GRCm38)	missense	probably damaging	1.00
IGL02894:Dnah8	APN	17	30,721,110 (GRCm38)	nonsense	probably null
IGL02954:Dnah8	APN	17	30,704,835 (GRCm38)	missense	probably benign	0.30
IGL02964:Dnah8	APN	17	30,746,761 (GRCm38)	missense	probably damaging	1.00
IGL03080:Dnah8	APN	17	30,719,006 (GRCm38)	missense	probably benign	0.01
IGL03081:Dnah8	APN	17	30,686,373 (GRCm38)	splice site	probably benign
IGL03086:Dnah8	APN	17	30,742,780 (GRCm38)	missense	probably damaging	1.00
IGL03087:Dnah8	APN	17	30,784,144 (GRCm38)	missense	probably benign
IGL03176:Dnah8	APN	17	30,694,037 (GRCm38)	missense	probably benign
IGL03191:Dnah8	APN	17	30,726,830 (GRCm38)	missense	probably damaging	0.99
IGL03210:Dnah8	APN	17	30,815,665 (GRCm38)	missense	probably damaging	0.96
IGL03252:Dnah8	APN	17	30,673,920 (GRCm38)	splice site	probably null
IGL03255:Dnah8	APN	17	30,741,381 (GRCm38)	missense	probably damaging	1.00
IGL03288:Dnah8	APN	17	30,672,349 (GRCm38)	missense	probably benign
IGL03348:Dnah8	APN	17	30,746,986 (GRCm38)	missense	probably damaging	0.99
Alternator	UTSW	17	30,765,635 (GRCm38)	missense	probably benign
armature	UTSW	17	30,708,390 (GRCm38)	missense	probably benign	0.02
Brush	UTSW	17	30,746,990 (GRCm38)	missense	probably damaging	1.00
Dynos	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
joule	UTSW	17	30,713,098 (GRCm38)	critical splice donor site	probably null
solenoid	UTSW	17	30,741,178 (GRCm38)	missense	probably damaging	1.00
FR4340:Dnah8	UTSW	17	30,635,463 (GRCm38)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,635,477 (GRCm38)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,635,465 (GRCm38)	small deletion	probably benign
I2288:Dnah8	UTSW	17	30,663,454 (GRCm38)	missense	probably benign
P0029:Dnah8	UTSW	17	30,765,720 (GRCm38)	missense	probably damaging	1.00
PIT4812001:Dnah8	UTSW	17	30,708,445 (GRCm38)	missense	probably benign	0.04
R0016:Dnah8	UTSW	17	30,663,316 (GRCm38)	missense	probably benign
R0035:Dnah8	UTSW	17	30,683,621 (GRCm38)	splice site	probably benign
R0035:Dnah8	UTSW	17	30,683,621 (GRCm38)	splice site	probably benign
R0062:Dnah8	UTSW	17	30,765,711 (GRCm38)	missense	probably damaging	1.00
R0062:Dnah8	UTSW	17	30,765,711 (GRCm38)	missense	probably damaging	1.00
R0087:Dnah8	UTSW	17	30,755,119 (GRCm38)	missense	probably damaging	1.00
R0090:Dnah8	UTSW	17	30,784,090 (GRCm38)	missense	probably benign	0.20
R0119:Dnah8	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
R0164:Dnah8	UTSW	17	30,748,665 (GRCm38)	missense	probably benign
R0164:Dnah8	UTSW	17	30,748,665 (GRCm38)	missense	probably benign
R0184:Dnah8	UTSW	17	30,683,683 (GRCm38)	missense	probably benign	0.04
R0240:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0240:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0265:Dnah8	UTSW	17	30,690,271 (GRCm38)	missense	probably benign
R0268:Dnah8	UTSW	17	30,769,707 (GRCm38)	missense	probably damaging	1.00
R0282:Dnah8	UTSW	17	30,736,156 (GRCm38)	missense	probably damaging	1.00
R0299:Dnah8	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
R0334:Dnah8	UTSW	17	30,871,351 (GRCm38)	missense	probably damaging	0.99
R0393:Dnah8	UTSW	17	30,708,390 (GRCm38)	missense	probably benign	0.02
R0423:Dnah8	UTSW	17	30,701,981 (GRCm38)	missense	probably benign
R0470:Dnah8	UTSW	17	30,708,540 (GRCm38)	splice site	probably benign
R0477:Dnah8	UTSW	17	30,755,080 (GRCm38)	missense	probably damaging	1.00
R0490:Dnah8	UTSW	17	30,700,419 (GRCm38)	missense	probably benign
R0499:Dnah8	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
R0582:Dnah8	UTSW	17	30,718,961 (GRCm38)	missense	probably benign	0.01
R0601:Dnah8	UTSW	17	30,708,358 (GRCm38)	missense	probably benign	0.06
R0646:Dnah8	UTSW	17	30,684,173 (GRCm38)	missense	probably damaging	0.97
R0665:Dnah8	UTSW	17	30,736,155 (GRCm38)	missense	probably damaging	0.99
R0800:Dnah8	UTSW	17	30,704,662 (GRCm38)	missense	probably benign
R0843:Dnah8	UTSW	17	30,813,095 (GRCm38)	missense	probably damaging	1.00
R0940:Dnah8	UTSW	17	30,803,243 (GRCm38)	missense	probably damaging	1.00
R0964:Dnah8	UTSW	17	30,673,920 (GRCm38)	splice site	probably null
R1102:Dnah8	UTSW	17	30,854,764 (GRCm38)	splice site	probably null
R1137:Dnah8	UTSW	17	30,855,936 (GRCm38)	missense	probably damaging	1.00
R1342:Dnah8	UTSW	17	30,721,000 (GRCm38)	missense	probably damaging	0.99
R1375:Dnah8	UTSW	17	30,737,295 (GRCm38)	missense	probably damaging	1.00
R1377:Dnah8	UTSW	17	30,840,622 (GRCm38)	nonsense	probably null
R1464:Dnah8	UTSW	17	30,695,173 (GRCm38)	missense	possibly damaging	0.81
R1464:Dnah8	UTSW	17	30,695,173 (GRCm38)	missense	possibly damaging	0.81
R1470:Dnah8	UTSW	17	30,747,277 (GRCm38)	nonsense	probably null
R1470:Dnah8	UTSW	17	30,747,277 (GRCm38)	nonsense	probably null
R1497:Dnah8	UTSW	17	30,752,075 (GRCm38)	missense	probably damaging	1.00
R1513:Dnah8	UTSW	17	30,673,888 (GRCm38)	missense	probably benign
R1541:Dnah8	UTSW	17	30,747,247 (GRCm38)	missense	probably damaging	1.00
R1563:Dnah8	UTSW	17	30,635,664 (GRCm38)	missense	probably benign	0.07
R1634:Dnah8	UTSW	17	30,713,098 (GRCm38)	critical splice donor site	probably null
R1670:Dnah8	UTSW	17	30,725,124 (GRCm38)	missense	probably damaging	1.00
R1710:Dnah8	UTSW	17	30,854,940 (GRCm38)	missense	probably damaging	1.00
R1743:Dnah8	UTSW	17	30,769,651 (GRCm38)	missense	probably benign	0.28
R1761:Dnah8	UTSW	17	30,779,916 (GRCm38)	missense	probably damaging	1.00
R1785:Dnah8	UTSW	17	30,722,937 (GRCm38)	missense	probably damaging	0.98
R1804:Dnah8	UTSW	17	30,708,407 (GRCm38)	missense	probably benign	0.00
R1808:Dnah8	UTSW	17	30,684,186 (GRCm38)	missense	probably damaging	1.00
R1824:Dnah8	UTSW	17	30,731,180 (GRCm38)	missense	possibly damaging	0.67
R1836:Dnah8	UTSW	17	30,874,927 (GRCm38)	missense	possibly damaging	0.94
R1935:Dnah8	UTSW	17	30,635,505 (GRCm38)	missense	unknown
R1935:Dnah8	UTSW	17	30,726,896 (GRCm38)	splice site	probably benign
R1940:Dnah8	UTSW	17	30,731,207 (GRCm38)	missense	probably damaging	1.00
R1946:Dnah8	UTSW	17	30,712,385 (GRCm38)	missense	probably benign	0.00
R2025:Dnah8	UTSW	17	30,731,159 (GRCm38)	missense	probably damaging	0.99
R2038:Dnah8	UTSW	17	30,758,281 (GRCm38)	missense	probably damaging	1.00
R2042:Dnah8	UTSW	17	30,635,658 (GRCm38)	missense	probably benign	0.01
R2148:Dnah8	UTSW	17	30,737,258 (GRCm38)	missense	probably damaging	1.00
R2177:Dnah8	UTSW	17	30,653,393 (GRCm38)	missense	probably benign
R2180:Dnah8	UTSW	17	30,840,647 (GRCm38)	missense	probably benign	0.00
R2262:Dnah8	UTSW	17	30,673,835 (GRCm38)	missense	probably damaging	1.00
R2263:Dnah8	UTSW	17	30,673,835 (GRCm38)	missense	probably damaging	1.00
R2328:Dnah8	UTSW	17	30,794,744 (GRCm38)	missense	probably damaging	1.00
R2357:Dnah8	UTSW	17	30,771,872 (GRCm38)	missense	probably benign
R2357:Dnah8	UTSW	17	30,874,935 (GRCm38)	missense	probably benign	0.00
R2360:Dnah8	UTSW	17	30,677,204 (GRCm38)	missense	probably benign	0.22
R2496:Dnah8	UTSW	17	30,851,731 (GRCm38)	missense	probably damaging	1.00
R2497:Dnah8	UTSW	17	30,741,365 (GRCm38)	nonsense	probably null
R2509:Dnah8	UTSW	17	30,775,045 (GRCm38)	missense	probably benign	0.02
R3114:Dnah8	UTSW	17	30,833,568 (GRCm38)	missense	probably benign	0.04
R3708:Dnah8	UTSW	17	30,739,657 (GRCm38)	missense	probably damaging	0.98
R3720:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3722:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3727:Dnah8	UTSW	17	30,739,648 (GRCm38)	nonsense	probably null
R3747:Dnah8	UTSW	17	30,784,174 (GRCm38)	nonsense	probably null
R3748:Dnah8	UTSW	17	30,784,174 (GRCm38)	nonsense	probably null
R3749:Dnah8	UTSW	17	30,784,174 (GRCm38)	nonsense	probably null
R3787:Dnah8	UTSW	17	30,755,041 (GRCm38)	missense	probably damaging	1.00
R3790:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3804:Dnah8	UTSW	17	30,670,647 (GRCm38)	missense	probably benign	0.00
R3857:Dnah8	UTSW	17	30,663,422 (GRCm38)	missense	probably damaging	0.96
R3898:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3899:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3938:Dnah8	UTSW	17	30,854,937 (GRCm38)	missense	probably damaging	1.00
R3943:Dnah8	UTSW	17	30,694,065 (GRCm38)	splice site	probably benign
R4091:Dnah8	UTSW	17	30,769,839 (GRCm38)	missense	probably damaging	1.00
R4291:Dnah8	UTSW	17	30,748,559 (GRCm38)	missense	probably benign
R4326:Dnah8	UTSW	17	30,752,092 (GRCm38)	missense	probably benign	0.04
R4346:Dnah8	UTSW	17	30,725,098 (GRCm38)	missense	possibly damaging	0.92
R4429:Dnah8	UTSW	17	30,752,146 (GRCm38)	missense	probably damaging	1.00
R4457:Dnah8	UTSW	17	30,813,151 (GRCm38)	missense	probably benign
R4475:Dnah8	UTSW	17	30,656,985 (GRCm38)	missense	probably benign	0.12
R4565:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4566:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4568:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4573:Dnah8	UTSW	17	30,700,406 (GRCm38)	missense	probably benign	0.00
R4580:Dnah8	UTSW	17	30,662,052 (GRCm38)	missense	probably benign	0.00
R4585:Dnah8	UTSW	17	30,751,567 (GRCm38)	missense	probably benign	0.01
R4611:Dnah8	UTSW	17	30,684,237 (GRCm38)	missense	probably damaging	1.00
R4720:Dnah8	UTSW	17	30,683,634 (GRCm38)	missense	probably benign	0.08
R4721:Dnah8	UTSW	17	30,725,166 (GRCm38)	missense	probably damaging	1.00
R4727:Dnah8	UTSW	17	30,851,747 (GRCm38)	missense	probably damaging	1.00
R4731:Dnah8	UTSW	17	30,775,061 (GRCm38)	missense	probably null	0.02
R4732:Dnah8	UTSW	17	30,775,061 (GRCm38)	missense	probably null	0.02
R4733:Dnah8	UTSW	17	30,775,061 (GRCm38)	missense	probably null	0.02
R4798:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4814:Dnah8	UTSW	17	30,767,924 (GRCm38)	missense	probably damaging	1.00
R4892:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4894:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4900:Dnah8	UTSW	17	30,746,975 (GRCm38)	missense	probably damaging	1.00
R4901:Dnah8	UTSW	17	30,840,714 (GRCm38)	critical splice donor site	probably null
R4913:Dnah8	UTSW	17	30,819,139 (GRCm38)	missense	probably damaging	0.99
R4931:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4932:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4933:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4942:Dnah8	UTSW	17	30,729,142 (GRCm38)	missense	probably benign
R4969:Dnah8	UTSW	17	30,723,014 (GRCm38)	missense	probably damaging	1.00
R4975:Dnah8	UTSW	17	30,656,985 (GRCm38)	missense	probably benign	0.12
R4977:Dnah8	UTSW	17	30,663,301 (GRCm38)	missense	probably benign	0.00
R5001:Dnah8	UTSW	17	30,787,185 (GRCm38)	missense	probably damaging	1.00
R5011:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5013:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5014:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5024:Dnah8	UTSW	17	30,736,096 (GRCm38)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5075:Dnah8	UTSW	17	30,800,531 (GRCm38)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,739,757 (GRCm38)	critical splice donor site	probably null
R5112:Dnah8	UTSW	17	30,731,038 (GRCm38)	missense	probably benign	0.02
R5121:Dnah8	UTSW	17	30,810,353 (GRCm38)	missense	probably benign	0.14
R5138:Dnah8	UTSW	17	30,765,597 (GRCm38)	missense	probably damaging	0.99
R5151:Dnah8	UTSW	17	30,712,295 (GRCm38)	missense	probably benign	0.06
R5191:Dnah8	UTSW	17	30,746,765 (GRCm38)	missense	probably damaging	1.00
R5238:Dnah8	UTSW	17	30,790,917 (GRCm38)	missense	probably damaging	1.00
R5260:Dnah8	UTSW	17	30,700,419 (GRCm38)	missense	probably benign
R5358:Dnah8	UTSW	17	30,746,954 (GRCm38)	missense	probably damaging	1.00
R5403:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5404:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5482:Dnah8	UTSW	17	30,800,547 (GRCm38)	missense	probably damaging	0.96
R5489:Dnah8	UTSW	17	30,790,956 (GRCm38)	missense	probably damaging	1.00
R5513:Dnah8	UTSW	17	30,752,916 (GRCm38)	missense	probably damaging	0.99
R5635:Dnah8	UTSW	17	30,706,386 (GRCm38)	missense	probably benign	0.00
R5640:Dnah8	UTSW	17	30,803,108 (GRCm38)	missense	probably damaging	1.00
R5649:Dnah8	UTSW	17	30,800,587 (GRCm38)	missense	probably benign	0.13
R5662:Dnah8	UTSW	17	30,737,333 (GRCm38)	missense	probably damaging	1.00
R5673:Dnah8	UTSW	17	30,803,261 (GRCm38)	missense	probably damaging	1.00
R5677:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5699:Dnah8	UTSW	17	30,810,324 (GRCm38)	missense	probably benign	0.22
R5737:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5738:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5739:Dnah8	UTSW	17	30,719,007 (GRCm38)	missense	probably benign	0.00
R5766:Dnah8	UTSW	17	30,690,261 (GRCm38)	missense	probably benign	0.01
R5790:Dnah8	UTSW	17	30,875,004 (GRCm38)	missense	probably damaging	0.98
R5848:Dnah8	UTSW	17	30,728,191 (GRCm38)	missense	possibly damaging	0.69
R5854:Dnah8	UTSW	17	30,794,763 (GRCm38)	missense	possibly damaging	0.45
R5885:Dnah8	UTSW	17	30,794,717 (GRCm38)	missense	probably damaging	1.00
R5886:Dnah8	UTSW	17	30,794,717 (GRCm38)	missense	probably damaging	1.00
R5887:Dnah8	UTSW	17	30,794,717 (GRCm38)	missense	probably damaging	1.00
R5899:Dnah8	UTSW	17	30,656,685 (GRCm38)	missense	probably benign	0.32
R5979:Dnah8	UTSW	17	30,815,664 (GRCm38)	nonsense	probably null
R5986:Dnah8	UTSW	17	30,851,630 (GRCm38)	missense	possibly damaging	0.83
R5999:Dnah8	UTSW	17	30,663,305 (GRCm38)	missense	probably benign	0.32
R6042:Dnah8	UTSW	17	30,747,265 (GRCm38)	missense	probably damaging	1.00
R6175:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6181:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6237:Dnah8	UTSW	17	30,747,854 (GRCm38)	nonsense	probably null
R6239:Dnah8	UTSW	17	30,810,359 (GRCm38)	missense	probably damaging	0.99
R6337:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6365:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6416:Dnah8	UTSW	17	30,765,635 (GRCm38)	missense	probably benign
R6443:Dnah8	UTSW	17	30,771,885 (GRCm38)	missense	probably benign	0.10
R6478:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6479:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6480:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6481:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6533:Dnah8	UTSW	17	30,746,990 (GRCm38)	missense	probably damaging	1.00
R6606:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6608:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6610:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6675:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6723:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6724:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6754:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6755:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6759:Dnah8	UTSW	17	30,663,292 (GRCm38)	splice site	probably null
R6765:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6766:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6778:Dnah8	UTSW	17	30,635,666 (GRCm38)	missense	probably benign	0.00
R6781:Dnah8	UTSW	17	30,765,724 (GRCm38)	frame shift	probably null
R6788:Dnah8	UTSW	17	30,648,465 (GRCm38)	missense	probably benign	0.14
R6814:Dnah8	UTSW	17	30,762,679 (GRCm38)	missense	probably damaging	1.00
R6825:Dnah8	UTSW	17	30,741,173 (GRCm38)	missense	probably damaging	1.00
R6838:Dnah8	UTSW	17	30,710,551 (GRCm38)	missense	probably damaging	1.00
R6872:Dnah8	UTSW	17	30,762,679 (GRCm38)	missense	probably damaging	1.00
R6877:Dnah8	UTSW	17	30,746,959 (GRCm38)	missense	probably damaging	1.00
R6944:Dnah8	UTSW	17	30,794,659 (GRCm38)	missense	probably benign	0.09
R6982:Dnah8	UTSW	17	30,767,925 (GRCm38)	missense	probably benign	0.03
R6984:Dnah8	UTSW	17	30,739,738 (GRCm38)	missense	probably damaging	1.00
R6987:Dnah8	UTSW	17	30,662,091 (GRCm38)	missense	possibly damaging	0.95
R6988:Dnah8	UTSW	17	30,643,275 (GRCm38)	missense	probably damaging	1.00
R7099:Dnah8	UTSW	17	30,704,724 (GRCm38)	missense	possibly damaging	0.93
R7106:Dnah8	UTSW	17	30,741,178 (GRCm38)	missense	probably damaging	1.00
R7112:Dnah8	UTSW	17	30,871,392 (GRCm38)	missense	possibly damaging	0.79
R7146:Dnah8	UTSW	17	30,769,644 (GRCm38)	missense	possibly damaging	0.90
R7146:Dnah8	UTSW	17	30,644,617 (GRCm38)	missense	probably benign	0.01
R7309:Dnah8	UTSW	17	30,875,014 (GRCm38)	missense	probably damaging	1.00
R7324:Dnah8	UTSW	17	30,784,125 (GRCm38)	missense	probably benign	0.01
R7373:Dnah8	UTSW	17	30,767,965 (GRCm38)	critical splice donor site	probably null
R7423:Dnah8	UTSW	17	30,704,769 (GRCm38)	missense	possibly damaging	0.86
R7430:Dnah8	UTSW	17	30,706,389 (GRCm38)	missense	probably damaging	0.98
R7450:Dnah8	UTSW	17	30,787,191 (GRCm38)	missense	probably damaging	0.99
R7580:Dnah8	UTSW	17	30,775,103 (GRCm38)	missense	probably damaging	0.98
R7604:Dnah8	UTSW	17	30,813,095 (GRCm38)	missense	probably damaging	1.00
R7635:Dnah8	UTSW	17	30,785,107 (GRCm38)	missense	probably damaging	1.00
R7646:Dnah8	UTSW	17	30,649,677 (GRCm38)	missense	probably benign	0.00
R7685:Dnah8	UTSW	17	30,657,973 (GRCm38)	missense	probably damaging	1.00
R7793:Dnah8	UTSW	17	30,855,944 (GRCm38)	missense	probably benign	0.20
R7827:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R7866:Dnah8	UTSW	17	30,874,927 (GRCm38)	missense	possibly damaging	0.94
R7877:Dnah8	UTSW	17	30,663,374 (GRCm38)	missense	probably benign
R7891:Dnah8	UTSW	17	30,712,289 (GRCm38)	missense	probably benign	0.09
R7977:Dnah8	UTSW	17	30,744,524 (GRCm38)	missense	probably damaging	1.00
R7987:Dnah8	UTSW	17	30,744,524 (GRCm38)	missense	probably damaging	1.00
R8025:Dnah8	UTSW	17	30,741,337 (GRCm38)	nonsense	probably null
R8076:Dnah8	UTSW	17	30,784,153 (GRCm38)	missense	possibly damaging	0.94
R8170:Dnah8	UTSW	17	30,673,823 (GRCm38)	missense	probably damaging	1.00
R8199:Dnah8	UTSW	17	30,871,419 (GRCm38)	missense	probably benign	0.06
R8253:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R8270:Dnah8	UTSW	17	30,840,713 (GRCm38)	missense	probably damaging	1.00
R8291:Dnah8	UTSW	17	30,765,727 (GRCm38)	missense	probably damaging	1.00
R8334:Dnah8	UTSW	17	30,769,831 (GRCm38)	missense	probably benign	0.12
R8348:Dnah8	UTSW	17	30,673,840 (GRCm38)	missense	probably benign
R8348:Dnah8	UTSW	17	30,736,147 (GRCm38)	missense	probably damaging	0.96
R8354:Dnah8	UTSW	17	30,643,260 (GRCm38)	missense	probably benign	0.17
R8355:Dnah8	UTSW	17	30,695,178 (GRCm38)	missense	possibly damaging	0.89
R8439:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R8448:Dnah8	UTSW	17	30,673,840 (GRCm38)	missense	probably benign
R8459:Dnah8	UTSW	17	30,725,247 (GRCm38)	critical splice donor site	probably null
R8462:Dnah8	UTSW	17	30,656,629 (GRCm38)	missense	probably damaging	1.00
R8524:Dnah8	UTSW	17	30,715,498 (GRCm38)	missense	possibly damaging	0.95
R8555:Dnah8	UTSW	17	30,721,110 (GRCm38)	nonsense	probably null
R8698:Dnah8	UTSW	17	30,875,035 (GRCm38)	missense	probably damaging	1.00
R8719:Dnah8	UTSW	17	30,741,315 (GRCm38)	missense	probably damaging	0.97
R8778:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R8781:Dnah8	UTSW	17	30,725,104 (GRCm38)	missense	probably damaging	1.00
R8821:Dnah8	UTSW	17	30,794,738 (GRCm38)	missense	probably damaging	1.00
R8864:Dnah8	UTSW	17	30,762,642 (GRCm38)	missense	possibly damaging	0.95
R8885:Dnah8	UTSW	17	30,708,312 (GRCm38)	missense	possibly damaging	0.83
R8983:Dnah8	UTSW	17	30,851,654 (GRCm38)	missense	probably damaging	0.98
R8994:Dnah8	UTSW	17	30,790,833 (GRCm38)	missense	probably benign	0.05
R9031:Dnah8	UTSW	17	30,737,427 (GRCm38)	missense	probably damaging	1.00
R9068:Dnah8	UTSW	17	30,756,755 (GRCm38)	missense	possibly damaging	0.63
R9225:Dnah8	UTSW	17	30,635,673 (GRCm38)	missense	probably benign	0.01
R9280:Dnah8	UTSW	17	30,785,097 (GRCm38)	missense	possibly damaging	0.52
R9291:Dnah8	UTSW	17	30,725,125 (GRCm38)	missense	probably damaging	1.00
R9314:Dnah8	UTSW	17	30,771,883 (GRCm38)	missense	probably benign
R9347:Dnah8	UTSW	17	30,708,359 (GRCm38)	missense	probably benign	0.00
R9393:Dnah8	UTSW	17	30,653,387 (GRCm38)	missense	possibly damaging	0.53
R9415:Dnah8	UTSW	17	30,810,323 (GRCm38)	missense	probably benign	0.02
R9458:Dnah8	UTSW	17	30,830,803 (GRCm38)	missense	probably damaging	1.00
R9465:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9518:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9524:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9564:Dnah8	UTSW	17	30,713,047 (GRCm38)	missense	probably benign	0.07
R9587:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9599:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9641:Dnah8	UTSW	17	30,713,055 (GRCm38)	missense	probably benign	0.13
R9674:Dnah8	UTSW	17	30,779,138 (GRCm38)	missense	possibly damaging	0.84
R9679:Dnah8	UTSW	17	30,818,141 (GRCm38)	missense	probably benign
R9789:Dnah8	UTSW	17	30,761,130 (GRCm38)	critical splice donor site	probably null
RF027:Dnah8	UTSW	17	30,635,476 (GRCm38)	frame shift	probably null
X0001:Dnah8	UTSW	17	30,748,680 (GRCm38)	missense	probably damaging	1.00
X0013:Dnah8	UTSW	17	30,819,186 (GRCm38)	missense	possibly damaging	0.71
Z1176:Dnah8	UTSW	17	30,648,540 (GRCm38)	missense	probably benign
Z1177:Dnah8	UTSW	17	30,713,095 (GRCm38)	missense	probably null	1.00
Z1177:Dnah8	UTSW	17	30,694,033 (GRCm38)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- GTGCGATTGAGATTCCATGACC -3'
(R):5'- CTCAGGAAGAATACACACTGGG -3'

Sequencing Primer
(F):5'- GATTGAGATTCCATGACCCGTTC -3'
(R):5'- TACAGGTATGCACAAAAGCTTG -3'

Posted On

2020-10-20