Mutagenetix > Incidental Mutation

Incidental Mutation 'R8507:Vmn2r75'

655629

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r75

Ensembl Gene

ENSMUSG00000090436

Gene Name

vomeronasal 2, receptor 75

Synonyms

EG546981

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

R8507 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

86148042-86171724 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 86148477 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 709 (C709*)

Ref Sequence

ENSEMBL: ENSMUSP00000126973 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167830]

AlphaFold

G5E8Z7

Predicted Effect

probably null
Transcript: ENSMUST00000167830
AA Change: C709*

SMART Domains

Protein: ENSMUSP00000126973
Gene: ENSMUSG00000090436
AA Change: C709*

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	80	466	2.8e-31	PFAM
Pfam:NCD3G	510	562	4.6e-20	PFAM
Pfam:7tm_3	593	829	7.7e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam7	A	G	14: 68,526,324	C126R	probably damaging	Het
Agpat5	G	A	8: 18,878,027	V203I	possibly damaging	Het
Ankrd12	T	A	17: 65,986,909	R510*	probably null	Het
Anxa6	C	T	11: 55,013,870	A22T	probably benign	Het
Barx2	A	T	9: 31,859,013	L73Q	probably damaging	Het
BC024139	T	C	15: 76,120,133	K702R	possibly damaging	Het
Cc2d1a	T	C	8: 84,134,976	K739R	probably benign	Het
Cdk12	A	G	11: 98,250,285	T1451A	unknown	Het
Chd7	A	G	4: 8,858,675	E2367G	probably damaging	Het
Cp	A	G	3: 19,971,029	Y384C	probably damaging	Het
Dnah14	T	A	1: 181,641,414	W1270R	probably benign	Het
Dyrk2	G	T	10: 118,860,662	S230R	probably damaging	Het
Epn3	A	T	11: 94,493,776	S290R	probably damaging	Het
Fas	C	T	19: 34,327,226	R296C	probably benign	Het
Fmnl1	A	T	11: 103,194,033	N659I	unknown	Het
Gas8	T	C	8: 123,531,038		probably null	Het
Gpr156	A	G	16: 37,948,236	T40A	probably benign	Het
Hey1	G	C	3: 8,664,776	A207G	probably benign	Het
Htr3b	C	A	9: 48,964,877		probably benign	Het
Itgal	C	T	7: 127,329,435	T1044I	probably benign	Het
Kcnip4	T	G	5: 48,482,655	D38A	possibly damaging	Het
Kcnma1	G	T	14: 23,591,638	Q216K	probably benign	Het
Kdsr	T	A	1: 106,743,670	E203V	probably null	Het
Lrp1b	T	C	2: 41,408,375	E999G		Het
Malt1	T	A	18: 65,470,523	W577R	probably damaging	Het
Mroh2b	A	C	15: 4,949,090	T1373P	probably damaging	Het
Mymk	A	G	2: 27,062,700		probably null	Het
Myo1f	T	A	17: 33,598,018	H707Q	probably benign	Het
Ncam2	C	A	16: 81,512,979	H452Q	possibly damaging	Het
Ndrg4	A	G	8: 95,678,347	M1V	probably null	Het
Nps	C	T	7: 135,272,350	S83L	probably damaging	Het
Nup155	T	A	15: 8,147,560	Y1040*	probably null	Het
Olfr1303	T	C	2: 111,814,706	T7A	probably benign	Het
Olfr190	C	T	16: 59,074,880	V67M	possibly damaging	Het
Olfr316	C	T	11: 58,758,159	Q165*	probably null	Het
Olfr344	T	C	2: 36,569,431	Y278H	probably damaging	Het
Pak1ip1	G	A	13: 41,009,294	R191Q	probably benign	Het
Pcdh17	G	A	14: 84,445,944		probably benign	Het
Pcdhgc5	G	T	18: 37,819,892	R73L	probably benign	Het
Peg10	C	CTCA	6: 4,756,453		probably benign	Het
Plat	G	T	8: 22,772,232	G91W	probably damaging	Het
Plscr4	C	T	9: 92,490,790	R322*	probably null	Het
Plxnd1	A	T	6: 115,966,905	N1144K	probably damaging	Het
Ppp1r1b	G	T	11: 98,355,484	E133D	probably damaging	Het
Ptpn13	A	G	5: 103,557,949	E1396G	probably damaging	Het
Reps1	T	C	10: 18,094,470	S272P	probably damaging	Het
Ric8b	T	C	10: 84,980,175	V430A	probably damaging	Het
Sept10	A	T	10: 59,177,003	N264K	possibly damaging	Het
Sgms1	A	T	19: 32,159,709	F152L	probably benign	Het
Snapc1	C	A	12: 73,964,732	F57L	probably damaging	Het
Spidr	A	G	16: 15,968,676	L401P	probably damaging	Het
Spn	C	T	7: 127,136,556	V260M	probably damaging	Het
Sptan1	G	A	2: 30,026,584	A2095T	probably damaging	Het
Ssfa2	A	G	2: 79,644,864	Q389R	probably benign	Het
Tbc1d15	A	G	10: 115,202,502		probably null	Het
Thsd7b	T	A	1: 129,678,053	F510L	probably benign	Het
Trpm5	T	A	7: 143,078,313	I920F	probably damaging	Het
Tspear	C	A	10: 77,875,064	H507N	probably benign	Het
Vmn2r108	T	A	17: 20,462,933	K670*	probably null	Het
Wdfy3	G	T	5: 101,872,901	S2494R	probably benign	Het
Zfp456	A	T	13: 67,366,989	F199L	probably damaging	Het
Zfp830	A	G	11: 82,764,703	Q111R	probably benign	Het
Znrf1	G	A	8: 111,537,210	A24T	probably damaging	Het

Other mutations in Vmn2r75

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01133:Vmn2r75	APN	7	86148032	unclassified	probably benign
IGL01287:Vmn2r75	APN	7	86148593	missense	probably damaging	0.97
IGL01318:Vmn2r75	APN	7	86165566	missense	probably benign	0.06
IGL01331:Vmn2r75	APN	7	86171662	nonsense	probably null
IGL01406:Vmn2r75	APN	7	86163292	splice site	probably benign
IGL01615:Vmn2r75	APN	7	86148473	missense	probably benign	0.03
IGL01657:Vmn2r75	APN	7	86164247	missense	probably damaging	1.00
IGL02237:Vmn2r75	APN	7	86165578	missense	possibly damaging	0.88
IGL02275:Vmn2r75	APN	7	86165140	missense	probably benign	0.04
IGL02307:Vmn2r75	APN	7	86165766	missense	probably benign	0.00
IGL03136:Vmn2r75	APN	7	86148703	missense	possibly damaging	0.89
IGL03160:Vmn2r75	APN	7	86148436	missense	probably damaging	1.00
IGL03244:Vmn2r75	APN	7	86171725	unclassified	probably benign
PIT4449001:Vmn2r75	UTSW	7	86165583	missense	probably damaging	1.00
R0049:Vmn2r75	UTSW	7	86148101	nonsense	probably null
R0049:Vmn2r75	UTSW	7	86148101	nonsense	probably null
R0083:Vmn2r75	UTSW	7	86165658	missense	probably benign	0.00
R0108:Vmn2r75	UTSW	7	86165658	missense	probably benign	0.00
R0276:Vmn2r75	UTSW	7	86148307	missense	probably benign	0.01
R0320:Vmn2r75	UTSW	7	86165080	missense	probably benign	0.36
R0471:Vmn2r75	UTSW	7	86165513	missense	probably benign	0.01
R0562:Vmn2r75	UTSW	7	86148241	nonsense	probably null
R0631:Vmn2r75	UTSW	7	86163270	missense	probably null	1.00
R0661:Vmn2r75	UTSW	7	86165658	missense	probably benign	0.00
R0811:Vmn2r75	UTSW	7	86165367	missense	probably benign	0.38
R0812:Vmn2r75	UTSW	7	86165367	missense	probably benign	0.38
R0891:Vmn2r75	UTSW	7	86164268	missense	possibly damaging	0.81
R1340:Vmn2r75	UTSW	7	86148590	missense	probably damaging	0.98
R1501:Vmn2r75	UTSW	7	86165642	missense	possibly damaging	0.85
R1760:Vmn2r75	UTSW	7	86148811	missense	probably damaging	1.00
R1970:Vmn2r75	UTSW	7	86148262	missense	probably damaging	1.00
R2060:Vmn2r75	UTSW	7	86165164	missense	probably benign	0.00
R2292:Vmn2r75	UTSW	7	86148936	missense	probably damaging	1.00
R3688:Vmn2r75	UTSW	7	86148421	missense	probably damaging	0.99
R3892:Vmn2r75	UTSW	7	86164286	missense	probably null	1.00
R4532:Vmn2r75	UTSW	7	86148141	nonsense	probably null
R4583:Vmn2r75	UTSW	7	86164082	missense	possibly damaging	0.81
R4592:Vmn2r75	UTSW	7	86166286	missense	probably benign	0.00
R4792:Vmn2r75	UTSW	7	86163170	missense	possibly damaging	0.46
R4859:Vmn2r75	UTSW	7	86148403	missense	probably benign	0.35
R4896:Vmn2r75	UTSW	7	86171579	missense	probably benign	0.01
R4943:Vmn2r75	UTSW	7	86165497	missense	probably damaging	1.00
R4992:Vmn2r75	UTSW	7	86166167	critical splice donor site	probably null
R5048:Vmn2r75	UTSW	7	86165527	missense	possibly damaging	0.66
R5063:Vmn2r75	UTSW	7	86164164	missense	probably benign
R5156:Vmn2r75	UTSW	7	86164228	missense	possibly damaging	0.51
R5243:Vmn2r75	UTSW	7	86164239	missense	probably damaging	1.00
R5277:Vmn2r75	UTSW	7	86166292	missense	probably benign
R5574:Vmn2r75	UTSW	7	86166302	missense	probably benign	0.22
R5622:Vmn2r75	UTSW	7	86148494	missense	probably benign	0.15
R5680:Vmn2r75	UTSW	7	86171571	missense	probably benign	0.10
R5884:Vmn2r75	UTSW	7	86165370	missense	probably benign
R6021:Vmn2r75	UTSW	7	86171612	missense	probably benign	0.01
R6217:Vmn2r75	UTSW	7	86166167	critical splice donor site	probably benign
R6242:Vmn2r75	UTSW	7	86165384	missense	probably damaging	1.00
R6299:Vmn2r75	UTSW	7	86165274	missense	probably benign	0.12
R6441:Vmn2r75	UTSW	7	86171576	missense	probably damaging	0.99
R6495:Vmn2r75	UTSW	7	86164079	missense	probably benign	0.00
R6553:Vmn2r75	UTSW	7	86164245	missense	probably benign	0.28
R6670:Vmn2r75	UTSW	7	86148436	missense	probably damaging	1.00
R7078:Vmn2r75	UTSW	7	86166360	missense	probably damaging	1.00
R7164:Vmn2r75	UTSW	7	86165384	missense	probably damaging	1.00
R8411:Vmn2r75	UTSW	7	86148514	missense	probably damaging	1.00
R8559:Vmn2r75	UTSW	7	86166272	missense	possibly damaging	0.65
R8677:Vmn2r75	UTSW	7	86165202	missense	possibly damaging	0.86
R8708:Vmn2r75	UTSW	7	86163268	missense	probably damaging	0.99
R8778:Vmn2r75	UTSW	7	86164289	missense	probably benign	0.40
R8968:Vmn2r75	UTSW	7	86171557	nonsense	probably null
R9145:Vmn2r75	UTSW	7	86164239	missense	probably damaging	1.00
R9316:Vmn2r75	UTSW	7	86148105	missense	possibly damaging	0.63
R9363:Vmn2r75	UTSW	7	86166215	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- GAACACCAGCATGCTAAATGTC -3'
(R):5'- AACAGACTGCATTTGCCATTGC -3'

Sequencing Primer
(F):5'- GTATCAGGCAGTTTCCTCGACAAG -3'
(R):5'- GCCATTGCATTCACTGTGG -3'

Posted On

2020-10-20