|Institutional Source||Beutler Lab|
|Gene Name||stathmin-like 2|
|Is this an essential gene?||Probably essential (E-score: 0.770)|
|Stock #||R8511 (G1)|
|Chromosomal Location||8509360-8561606 bp(+) (GRCm38)|
|Type of Mutation||start gained|
|DNA Base Change (assembly)||A to G at 8509555 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000029002 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000029002]|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Stmn2||
(F):5'- TTGTACTCCAGCACCATTGGC -3'
(R):5'- CCCGGTTCCTGTCATGAATG -3'
(F):5'- GGCCGATCAATATTTAATGCTTGGAG -3'
(R):5'- GGTTCCTGTCATGAATGTCTTTC -3'