Incidental Mutation 'R8511:Gpsm2'
ID 655854
Institutional Source Beutler Lab
Gene Symbol Gpsm2
Ensembl Gene ENSMUSG00000027883
Gene Name G-protein signalling modulator 2 (AGS3-like, C. elegans)
Synonyms 6230410J09Rik, LGN, Pins
MMRRC Submission 067888-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.915) question?
Stock # R8511 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 108585954-108629625 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108589399 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 580 (S580P)
Ref Sequence ENSEMBL: ENSMUSP00000029482 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029482] [ENSMUST00000029483] [ENSMUST00000106609] [ENSMUST00000106613]
AlphaFold Q8VDU0
PDB Structure Structures of the LGN/NuMA complex [X-RAY DIFFRACTION]
crystal structure of LGN/mInscuteable complex [X-RAY DIFFRACTION]
Structure complex of LGN binding with FRMPD1 [X-RAY DIFFRACTION]
Structure of LGN GL4/Galphai3(Q147L) complex [X-RAY DIFFRACTION]
Structure of LGN GL4/Galphai1 complex [X-RAY DIFFRACTION]
Structure of LGN GL4/Galphai3 complex [X-RAY DIFFRACTION]
Structure of LGN GL3/Galphai3 complex [X-RAY DIFFRACTION]
An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000029482
AA Change: S580P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000029482
Gene: ENSMUSG00000027883
AA Change: S580P

DomainStartEndE-ValueType
TPR 62 95 7.86e-3 SMART
TPR 102 135 4.34e-5 SMART
Blast:TPR 142 188 9e-22 BLAST
TPR 202 235 1.69e-2 SMART
TPR 242 275 3.99e-4 SMART
TPR 282 315 1.51e-4 SMART
TPR 322 355 1.04e-2 SMART
GoLoco 490 512 3.69e-9 SMART
low complexity region 518 527 N/A INTRINSIC
GoLoco 543 565 7.27e-8 SMART
GoLoco 594 616 2.31e-10 SMART
GoLoco 628 650 2.75e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000029483
SMART Domains Protein: ENSMUSP00000029483
Gene: ENSMUSG00000027884

DomainStartEndE-ValueType
Pfam:MCLC 3 539 2e-266 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106609
SMART Domains Protein: ENSMUSP00000102220
Gene: ENSMUSG00000027884

DomainStartEndE-ValueType
Pfam:MCLC 3 539 2e-266 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106613
SMART Domains Protein: ENSMUSP00000102224
Gene: ENSMUSG00000027884

DomainStartEndE-ValueType
Pfam:MCLC 8 544 N/A PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
PHENOTYPE: Targeted disruption of this gene randomizes the spindle orientation of normally planar neuroepithelial divisions. The ensuing loss of the apical membrane from daughter cells frequently converts them into abnormally localized progenitors with no apparent effect on neuronal production. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930512M02Rik T C 11: 11,540,056 (GRCm39) H186R unknown Het
6430548M08Rik A G 8: 120,879,301 (GRCm39) N233S probably benign Het
Acan A G 7: 78,747,683 (GRCm39) D818G possibly damaging Het
Adam22 G A 5: 8,184,558 (GRCm39) T478I probably damaging Het
Afg2a A G 3: 37,490,897 (GRCm39) M481V probably damaging Het
Agmo T A 12: 37,294,396 (GRCm39) *115R probably null Het
Ahnak A G 19: 8,989,719 (GRCm39) K3668E unknown Het
Aldh6a1 G A 12: 84,480,745 (GRCm39) T430I possibly damaging Het
Ankrd11 T C 8: 123,626,468 (GRCm39) D17G Het
Apol10b T C 15: 77,469,211 (GRCm39) E322G probably benign Het
Apol10b C G 15: 77,469,210 (GRCm39) E322D probably benign Het
Apol8 C T 15: 77,634,273 (GRCm39) G101E probably benign Het
Arhgef26 A T 3: 62,336,350 (GRCm39) M630L probably damaging Het
Aspm T C 1: 139,385,046 (GRCm39) L230P probably damaging Het
Atg101 T C 15: 101,188,503 (GRCm39) S203P probably damaging Het
Baz2b T A 2: 59,732,158 (GRCm39) T1996S probably benign Het
Brwd1 A T 16: 95,859,938 (GRCm39) M350K probably damaging Het
Cad A G 5: 31,233,165 (GRCm39) K1869R probably benign Het
Caskin1 A T 17: 24,724,910 (GRCm39) I1233F probably benign Het
Ckap5 T A 2: 91,445,492 (GRCm39) L1770I possibly damaging Het
Clip1 T C 5: 123,791,969 (GRCm39) N67S possibly damaging Het
Csmd2 A G 4: 128,262,692 (GRCm39) N626S Het
Cuedc2 C A 19: 46,319,358 (GRCm39) probably null Het
Dmbt1 A T 7: 130,703,742 (GRCm39) N1275Y unknown Het
Dnm3 A G 1: 162,113,611 (GRCm39) V483A possibly damaging Het
Dock9 A T 14: 121,864,801 (GRCm39) H718Q probably benign Het
Dock9 T C 14: 121,918,847 (GRCm39) D50G probably damaging Het
Egfr T G 11: 16,846,949 (GRCm39) I782S probably damaging Het
Elmod1 A T 9: 53,820,095 (GRCm39) F298I probably damaging Het
Enthd1 T C 15: 80,358,428 (GRCm39) Q364R probably damaging Het
Fat2 T A 11: 55,200,063 (GRCm39) S1004C probably damaging Het
Fga A T 3: 82,939,064 (GRCm39) K480* probably null Het
Fhod3 A G 18: 25,265,994 (GRCm39) T1561A probably damaging Het
Foxg1 T A 12: 49,431,868 (GRCm39) Y200* probably null Het
Foxj2 C T 6: 122,808,404 (GRCm39) R115* probably null Het
Ggnbp2 C T 11: 84,728,815 (GRCm39) probably null Het
Hectd1 A G 12: 51,834,654 (GRCm39) S870P probably benign Het
Hic2 T A 16: 17,075,874 (GRCm39) N234K possibly damaging Het
Ica1 A G 6: 8,754,726 (GRCm39) F15L probably benign Het
Immp1l G A 2: 105,761,100 (GRCm39) R3H probably benign Het
Iqca1l T A 5: 24,750,906 (GRCm39) H559L possibly damaging Het
Jak3 T A 8: 72,138,194 (GRCm39) Y882N probably damaging Het
Klk1b1 C T 7: 43,619,767 (GRCm39) R109C possibly damaging Het
Luzp1 A G 4: 136,268,650 (GRCm39) D291G probably damaging Het
Map3k19 C T 1: 127,775,155 (GRCm39) E61K possibly damaging Het
Mical3 A G 6: 121,015,513 (GRCm39) I175T possibly damaging Het
Nectin3 G A 16: 46,284,363 (GRCm39) P107L probably damaging Het
Or10d5 A G 9: 39,861,455 (GRCm39) V204A probably benign Het
Pira1 A G 7: 3,742,347 (GRCm39) L60P probably damaging Het
Polr1a C A 6: 71,897,504 (GRCm39) H207N probably benign Het
Prokr2 A G 2: 132,223,422 (GRCm39) V40A probably benign Het
Prtg T C 9: 72,798,156 (GRCm39) probably null Het
Ptprs G A 17: 56,754,440 (GRCm39) T200I probably damaging Het
Ramp3 C T 11: 6,626,709 (GRCm39) R139C probably benign Het
Scfd2 A G 5: 74,372,949 (GRCm39) V642A possibly damaging Het
Scn11a T C 9: 119,618,981 (GRCm39) K787R probably damaging Het
Slco3a1 A G 7: 73,952,990 (GRCm39) V523A probably benign Het
Smo A G 6: 29,755,531 (GRCm39) Y401C probably damaging Het
Stmn2 A G 3: 8,574,615 (GRCm39) probably benign Het
Stra6l G T 4: 45,885,347 (GRCm39) G605V probably benign Het
Syne2 A G 12: 76,055,647 (GRCm39) I4170V probably benign Het
Tgm7 T A 2: 120,924,141 (GRCm39) I594F probably damaging Het
Tle2 T C 10: 81,423,830 (GRCm39) L648P probably damaging Het
Tmprss2 G T 16: 97,369,662 (GRCm39) L371I possibly damaging Het
Ttn T C 2: 76,579,866 (GRCm39) R23676G probably damaging Het
Tvp23b T C 11: 62,774,563 (GRCm39) I69T possibly damaging Het
Vmn2r66 A T 7: 84,656,026 (GRCm39) I330N probably damaging Het
Vmn2r99 A T 17: 19,614,443 (GRCm39) D721V probably damaging Het
Zan A T 5: 137,445,108 (GRCm39) V1717E unknown Het
Zmiz2 C T 11: 6,353,190 (GRCm39) H658Y probably damaging Het
Other mutations in Gpsm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01597:Gpsm2 APN 3 108,604,303 (GRCm39) missense probably benign 0.00
IGL01754:Gpsm2 APN 3 108,610,361 (GRCm39) missense probably damaging 1.00
IGL02624:Gpsm2 APN 3 108,589,349 (GRCm39) missense probably benign 0.01
IGL03005:Gpsm2 APN 3 108,594,322 (GRCm39) splice site probably benign
R0482:Gpsm2 UTSW 3 108,609,710 (GRCm39) splice site probably benign
R1793:Gpsm2 UTSW 3 108,608,225 (GRCm39) missense probably benign 0.14
R1796:Gpsm2 UTSW 3 108,609,166 (GRCm39) missense probably damaging 0.99
R4174:Gpsm2 UTSW 3 108,609,825 (GRCm39) missense probably damaging 1.00
R7048:Gpsm2 UTSW 3 108,610,361 (GRCm39) missense probably damaging 1.00
R7325:Gpsm2 UTSW 3 108,610,244 (GRCm39) missense probably damaging 1.00
R7400:Gpsm2 UTSW 3 108,587,004 (GRCm39) missense probably damaging 1.00
R7574:Gpsm2 UTSW 3 108,608,061 (GRCm39) missense probably damaging 0.98
R7657:Gpsm2 UTSW 3 108,608,061 (GRCm39) missense probably damaging 0.98
R7709:Gpsm2 UTSW 3 108,609,097 (GRCm39) missense probably benign 0.08
R8181:Gpsm2 UTSW 3 108,597,080 (GRCm39) critical splice donor site probably null
R8880:Gpsm2 UTSW 3 108,610,335 (GRCm39) missense possibly damaging 0.81
R9399:Gpsm2 UTSW 3 108,590,090 (GRCm39) nonsense probably null
R9439:Gpsm2 UTSW 3 108,610,397 (GRCm39) missense probably damaging 1.00
Z1088:Gpsm2 UTSW 3 108,608,076 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCTTGGCACCTCCCTAAAG -3'
(R):5'- TCAACACGTTTGTAACATTTCGGTG -3'

Sequencing Primer
(F):5'- GGCACCTCCCTAAAGGCCAG -3'
(R):5'- ACGTTTGTAACATTTCGGTGTTATTC -3'
Posted On 2020-10-20