Incidental Mutation 'R8512:Olfr119'
ID 655959
Institutional Source Beutler Lab
Gene Symbol Olfr119
Ensembl Gene ENSMUSG00000059964
Gene Name olfactory receptor 119
Synonyms MOR263-7, GA_x6K02T2PSCP-2159633-2160598
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R8512 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 37696564-37702124 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 37701180 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 170 (F170Y)
Ref Sequence ENSEMBL: ENSMUSP00000092919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080483] [ENSMUST00000213732]
AlphaFold Q7TRJ5
Predicted Effect probably damaging
Transcript: ENSMUST00000080483
AA Change: F170Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000092919
Gene: ENSMUSG00000059964
AA Change: F170Y

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 5.6e-59 PFAM
Pfam:7TM_GPCR_Srsx 41 311 1.7e-5 PFAM
Pfam:7tm_1 47 296 3.1e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213732
AA Change: F170Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre4 T C 17: 55,818,760 probably null Het
Akap13 T C 7: 75,611,086 S350P probably damaging Het
Celsr2 A G 3: 108,413,838 F553L probably damaging Het
Ces3a A T 8: 105,058,029 T548S probably benign Het
Chtf8 G A 8: 106,885,434 T291I probably benign Het
Ckmt1 A T 2: 121,361,208 R286S probably damaging Het
Dnajb2 C T 1: 75,241,431 R191W Het
Dtnbp1 G T 13: 44,922,391 A292E probably benign Het
Esrrg T G 1: 188,043,580 Y101* probably null Het
Etaa1 G A 11: 17,947,442 S225L probably damaging Het
Evi5l A G 8: 4,193,121 Y335C probably benign Het
Fcho2 T C 13: 98,755,222 D344G possibly damaging Het
Ggnbp2 C T 11: 84,837,989 probably null Het
Gm12569 T A 11: 51,234,660 S137T probably benign Het
Gsdmc2 C T 15: 63,835,015 V101I probably null Het
Gsdmc4 A G 15: 63,891,959 C430R probably damaging Het
Irak4 A C 15: 94,566,778 I410L probably benign Het
Kirrel A G 3: 87,088,227 V436A probably benign Het
Lrrc30 T A 17: 67,631,952 Q211L probably damaging Het
Map4k1 C T 7: 28,996,158 H512Y possibly damaging Het
Matn3 T A 12: 8,961,183 S365T probably benign Het
Msantd2 T C 9: 37,522,935 I358T possibly damaging Het
Msx3 G T 7: 140,048,971 A10E probably benign Het
Muc16 T C 9: 18,638,192 T5602A probably benign Het
Myh2 T C 11: 67,190,361 S1268P probably benign Het
Mynn C T 3: 30,616,649 P557S probably damaging Het
Naglu T C 11: 101,070,342 V73A probably benign Het
Ncor1 AGCTGCTGCTGCTGCTGCTGCTGCTG AGCTGCTGCTGCTGCTGCTGCTG 11: 62,433,611 probably benign Het
Olfr790 T A 10: 129,501,627 S240T probably damaging Het
P2rx3 C T 2: 85,024,411 E100K probably damaging Het
Pnisr C T 4: 21,870,372 Q375* probably null Het
Psmb9 C T 17: 34,183,628 C126Y probably benign Het
Ptprt A G 2: 161,558,863 F1085L probably benign Het
Rev3l A G 10: 39,821,538 Y677C probably damaging Het
Rftn2 G A 1: 55,214,165 P93L probably damaging Het
Rtl1 T A 12: 109,594,617 M263L unknown Het
Sec24c T C 14: 20,690,852 V722A possibly damaging Het
Slc2a7 T C 4: 150,163,295 L384P probably benign Het
Slc6a11 T C 6: 114,238,441 L434P probably damaging Het
Sptb T C 12: 76,602,052 E1869G possibly damaging Het
Susd2 G A 10: 75,639,651 T473I probably benign Het
Synpo C T 18: 60,602,411 R821H probably damaging Het
Tdrd9 G A 12: 112,046,193 V1184I probably benign Het
Tle1 T G 4: 72,122,433 K630Q possibly damaging Het
Traf3 A T 12: 111,261,992 T546S probably benign Het
Ttc17 G A 2: 94,371,763 T398M probably damaging Het
Ttn G C 2: 76,868,348 N136K Het
Ttn T C 2: 76,916,767 E4646G probably benign Het
Xbp1 T C 11: 5,524,266 S156P probably damaging Het
Yipf7 C T 5: 69,517,044 V253I probably benign Het
Other mutations in Olfr119
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02209:Olfr119 APN 17 37700992 missense probably damaging 1.00
IGL03339:Olfr119 APN 17 37700791 missense probably damaging 0.99
R0092:Olfr119 UTSW 17 37700805 missense probably damaging 0.98
R0207:Olfr119 UTSW 17 37701058 nonsense probably null
R0378:Olfr119 UTSW 17 37701041 missense probably damaging 1.00
R0408:Olfr119 UTSW 17 37701299 missense probably benign
R0483:Olfr119 UTSW 17 37701297 missense probably benign 0.01
R1595:Olfr119 UTSW 17 37701113 missense probably benign 0.03
R1901:Olfr119 UTSW 17 37701421 missense probably damaging 1.00
R1902:Olfr119 UTSW 17 37701421 missense probably damaging 1.00
R2845:Olfr119 UTSW 17 37700823 missense probably damaging 1.00
R2846:Olfr119 UTSW 17 37700823 missense probably damaging 1.00
R4356:Olfr119 UTSW 17 37700899 missense probably damaging 0.97
R4381:Olfr119 UTSW 17 37700899 missense probably damaging 0.97
R6744:Olfr119 UTSW 17 37701445 nonsense probably null
R7674:Olfr119 UTSW 17 37700682 missense probably benign 0.03
R7677:Olfr119 UTSW 17 37701066 missense probably damaging 1.00
R7994:Olfr119 UTSW 17 37701435 missense probably damaging 0.99
R8305:Olfr119 UTSW 17 37701498 missense probably benign 0.10
R9300:Olfr119 UTSW 17 37700924 missense probably damaging 1.00
R9760:Olfr119 UTSW 17 37701543 missense probably damaging 1.00
Z1177:Olfr119 UTSW 17 37701053 missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- AGAAATCTCTCGGGAGGGTTG -3'
(R):5'- ACTGCAACCAAAATTCTGACATAGG -3'

Sequencing Primer
(F):5'- GGGTTGTGCCACACAGATG -3'
(R):5'- GGAATAAATGATCAACAAAAATGGGC -3'
Posted On 2020-10-20