Incidental Mutation 'R8514:Or4a15'
ID 656014
Institutional Source Beutler Lab
Gene Symbol Or4a15
Ensembl Gene ENSMUSG00000075090
Gene Name olfactory receptor family 4 subfamily A member 15
Synonyms Olfr1234, MOR231-2, GA_x6K02T2Q125-50805620-50804676
MMRRC Submission 067945-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R8514 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 89190357-89195209 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 89193573 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 67 (I67V)
Ref Sequence ENSEMBL: ENSMUSP00000107168 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099783] [ENSMUST00000111543] [ENSMUST00000137692]
AlphaFold A2AVK5
Predicted Effect probably benign
Transcript: ENSMUST00000099783
AA Change: I67V

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000097371
Gene: ENSMUSG00000075090
AA Change: I67V

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 5.9e-32 PFAM
Pfam:7tm_4 137 278 1.5e-37 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111543
AA Change: I67V

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000107168
Gene: ENSMUSG00000075090
AA Change: I67V

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 3.2e-46 PFAM
Pfam:7tm_1 39 285 7.2e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000137692
AA Change: I67V

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency 96% (49/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcam A G 7: 19,492,466 (GRCm39) V543A probably damaging Het
Calhm6 G A 10: 34,002,399 (GRCm39) T228I possibly damaging Het
Capn1 T C 19: 6,047,854 (GRCm39) E403G probably damaging Het
Casp12 T C 9: 5,352,735 (GRCm39) F186L probably damaging Het
Ccdc40 A G 11: 119,121,459 (GRCm39) Q13R unknown Het
Cip2a T C 16: 48,817,810 (GRCm39) V60A possibly damaging Het
Ckap2l G T 2: 129,127,788 (GRCm39) A130E possibly damaging Het
Creld1 C T 6: 113,469,830 (GRCm39) R411C probably damaging Het
Dock9 A T 14: 121,896,199 (GRCm39) S167T probably benign Het
Emc10 G T 7: 44,142,646 (GRCm39) Q99K probably damaging Het
Fryl T A 5: 73,242,699 (GRCm39) I1287L probably benign Het
Gjc3 T A 5: 137,955,772 (GRCm39) Y171F probably damaging Het
Glrp1 GTGCTGCTGCTGCTGCTG GTGCTGCTGCTGCTG 1: 88,431,042 (GRCm39) probably benign Het
Golga4 T C 9: 118,384,864 (GRCm39) V662A possibly damaging Het
Gpr33 A G 12: 52,070,181 (GRCm39) V286A probably benign Het
Htr1d A G 4: 136,170,650 (GRCm39) E293G probably damaging Het
Ints6 A G 14: 62,933,166 (GRCm39) V847A possibly damaging Het
Iqsec3 A G 6: 121,390,521 (GRCm39) C317R unknown Het
Mdn1 T A 4: 32,739,857 (GRCm39) Y3704N probably damaging Het
Micall2 C A 5: 139,701,977 (GRCm39) R422L probably damaging Het
Mndal T C 1: 173,687,758 (GRCm39) D492G possibly damaging Het
Myom2 C T 8: 15,175,153 (GRCm39) P1244L possibly damaging Het
Notch1 A G 2: 26,362,181 (GRCm39) C1025R probably damaging Het
Nthl1 G A 17: 24,853,089 (GRCm39) V98M probably damaging Het
Or12e10 A T 2: 87,641,054 (GRCm39) I297F probably damaging Het
Pank3 A G 11: 35,667,186 (GRCm39) D101G probably null Het
Phtf2 T C 5: 21,007,030 (GRCm39) R178G possibly damaging Het
Pitrm1 T C 13: 6,618,822 (GRCm39) probably null Het
Platr25 T C 13: 62,848,586 (GRCm39) Y92C probably damaging Het
Plpp1 A T 13: 112,971,462 (GRCm39) D43V probably damaging Het
Prg4 G A 1: 150,330,396 (GRCm39) T759I unknown Het
Pros1 A G 16: 62,730,472 (GRCm39) T321A probably benign Het
Rad50 G A 11: 53,569,766 (GRCm39) Q882* probably null Het
Rasa3 A C 8: 13,631,322 (GRCm39) F533V probably benign Het
Rgs18 T A 1: 144,629,765 (GRCm39) I165F probably damaging Het
Rtl1 C T 12: 109,560,307 (GRCm39) V511I possibly damaging Het
Sdc3 A G 4: 130,546,072 (GRCm39) T144A unknown Het
Slc9a9 T C 9: 94,818,418 (GRCm39) F271L probably benign Het
Snrpa1 G A 7: 65,720,381 (GRCm39) G195R probably benign Het
Spata31e5 C T 1: 28,817,586 (GRCm39) V149M probably damaging Het
Tcerg1 T A 18: 42,697,187 (GRCm39) D759E probably damaging Het
Tecta A G 9: 42,284,406 (GRCm39) L893P probably damaging Het
Tex101 T A 7: 24,367,957 (GRCm39) Q167L possibly damaging Het
Tnrc6a C T 7: 122,783,438 (GRCm39) R970* probably null Het
Trmt1l T C 1: 151,329,742 (GRCm39) S562P probably damaging Het
Tut4 T A 4: 108,414,554 (GRCm39) W44R possibly damaging Het
Ubn1 A G 16: 4,891,263 (GRCm39) E546G probably damaging Het
Usp38 T A 8: 81,712,346 (GRCm39) Q563L probably benign Het
Vmn1r1 C T 1: 181,985,138 (GRCm39) V176I probably benign Het
Vmn2r1 A G 3: 63,993,942 (GRCm39) K96R probably benign Het
Vmn2r62 A G 7: 42,413,992 (GRCm39) V817A probably benign Het
Wdfy3 A T 5: 101,999,219 (GRCm39) C3066S possibly damaging Het
Yeats4 T C 10: 117,051,660 (GRCm39) E199G possibly damaging Het
Other mutations in Or4a15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02134:Or4a15 APN 2 89,193,172 (GRCm39) missense probably damaging 0.97
R0945:Or4a15 UTSW 2 89,193,599 (GRCm39) missense probably damaging 0.98
R1018:Or4a15 UTSW 2 89,193,523 (GRCm39) missense possibly damaging 0.95
R1419:Or4a15 UTSW 2 89,193,666 (GRCm39) missense probably damaging 1.00
R1872:Or4a15 UTSW 2 89,192,933 (GRCm39) missense probably damaging 1.00
R1929:Or4a15 UTSW 2 89,193,353 (GRCm39) missense probably benign 0.01
R2143:Or4a15 UTSW 2 89,193,447 (GRCm39) missense probably damaging 1.00
R3499:Or4a15 UTSW 2 89,193,294 (GRCm39) missense probably benign 0.07
R3776:Or4a15 UTSW 2 89,193,108 (GRCm39) missense possibly damaging 0.69
R4595:Or4a15 UTSW 2 89,193,669 (GRCm39) missense probably damaging 0.98
R6287:Or4a15 UTSW 2 89,193,363 (GRCm39) nonsense probably null
R7256:Or4a15 UTSW 2 89,192,838 (GRCm39) missense probably benign 0.21
R7516:Or4a15 UTSW 2 89,193,719 (GRCm39) missense probably benign 0.01
R7636:Or4a15 UTSW 2 89,193,583 (GRCm39) nonsense probably null
R7975:Or4a15 UTSW 2 89,193,413 (GRCm39) missense probably benign 0.23
R8240:Or4a15 UTSW 2 89,192,896 (GRCm39) missense probably benign 0.01
R8680:Or4a15 UTSW 2 89,193,065 (GRCm39) missense probably benign 0.00
R8780:Or4a15 UTSW 2 89,193,652 (GRCm39) missense probably damaging 1.00
R8898:Or4a15 UTSW 2 89,192,957 (GRCm39) missense possibly damaging 0.56
R9402:Or4a15 UTSW 2 89,193,123 (GRCm39) nonsense probably null
R9434:Or4a15 UTSW 2 89,193,692 (GRCm39) missense probably benign 0.02
R9451:Or4a15 UTSW 2 89,193,243 (GRCm39) missense probably damaging 1.00
R9632:Or4a15 UTSW 2 89,193,065 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GCCACATAACGGTCATAGGC -3'
(R):5'- ATCTAAGTGAGTTCAGCACACTC -3'

Sequencing Primer
(F):5'- TAACGGTCATAGGCCATCAC -3'
(R):5'- TGAGTTCAGCACACTCAGAAG -3'
Posted On 2020-10-20