Incidental Mutation 'R8514:Yeats4'
ID 656042
Institutional Source Beutler Lab
Gene Symbol Yeats4
Ensembl Gene ENSMUSG00000020171
Gene Name YEATS domain containing 4
Synonyms GAS41, B230215M10Rik, 4930573H17Rik, NuBI-1
MMRRC Submission 067945-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # R8514 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 117051126-117060412 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 117051660 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 199 (E199G)
Ref Sequence ENSEMBL: ENSMUSP00000020382 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020382] [ENSMUST00000218887]
AlphaFold Q9CR11
Predicted Effect possibly damaging
Transcript: ENSMUST00000020382
AA Change: E199G

PolyPhen 2 Score 0.495 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000020382
Gene: ENSMUSG00000020171
AA Change: E199G

DomainStartEndE-ValueType
Pfam:YEATS 44 124 4.6e-38 PFAM
low complexity region 152 163 N/A INTRINSIC
coiled coil region 178 226 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000218887
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency 96% (49/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcam A G 7: 19,492,466 (GRCm39) V543A probably damaging Het
Calhm6 G A 10: 34,002,399 (GRCm39) T228I possibly damaging Het
Capn1 T C 19: 6,047,854 (GRCm39) E403G probably damaging Het
Casp12 T C 9: 5,352,735 (GRCm39) F186L probably damaging Het
Ccdc40 A G 11: 119,121,459 (GRCm39) Q13R unknown Het
Cip2a T C 16: 48,817,810 (GRCm39) V60A possibly damaging Het
Ckap2l G T 2: 129,127,788 (GRCm39) A130E possibly damaging Het
Creld1 C T 6: 113,469,830 (GRCm39) R411C probably damaging Het
Dock9 A T 14: 121,896,199 (GRCm39) S167T probably benign Het
Emc10 G T 7: 44,142,646 (GRCm39) Q99K probably damaging Het
Fryl T A 5: 73,242,699 (GRCm39) I1287L probably benign Het
Gjc3 T A 5: 137,955,772 (GRCm39) Y171F probably damaging Het
Glrp1 GTGCTGCTGCTGCTGCTG GTGCTGCTGCTGCTG 1: 88,431,042 (GRCm39) probably benign Het
Golga4 T C 9: 118,384,864 (GRCm39) V662A possibly damaging Het
Gpr33 A G 12: 52,070,181 (GRCm39) V286A probably benign Het
Htr1d A G 4: 136,170,650 (GRCm39) E293G probably damaging Het
Ints6 A G 14: 62,933,166 (GRCm39) V847A possibly damaging Het
Iqsec3 A G 6: 121,390,521 (GRCm39) C317R unknown Het
Mdn1 T A 4: 32,739,857 (GRCm39) Y3704N probably damaging Het
Micall2 C A 5: 139,701,977 (GRCm39) R422L probably damaging Het
Mndal T C 1: 173,687,758 (GRCm39) D492G possibly damaging Het
Myom2 C T 8: 15,175,153 (GRCm39) P1244L possibly damaging Het
Notch1 A G 2: 26,362,181 (GRCm39) C1025R probably damaging Het
Nthl1 G A 17: 24,853,089 (GRCm39) V98M probably damaging Het
Or12e10 A T 2: 87,641,054 (GRCm39) I297F probably damaging Het
Or4a15 T C 2: 89,193,573 (GRCm39) I67V probably benign Het
Pank3 A G 11: 35,667,186 (GRCm39) D101G probably null Het
Phtf2 T C 5: 21,007,030 (GRCm39) R178G possibly damaging Het
Pitrm1 T C 13: 6,618,822 (GRCm39) probably null Het
Platr25 T C 13: 62,848,586 (GRCm39) Y92C probably damaging Het
Plpp1 A T 13: 112,971,462 (GRCm39) D43V probably damaging Het
Prg4 G A 1: 150,330,396 (GRCm39) T759I unknown Het
Pros1 A G 16: 62,730,472 (GRCm39) T321A probably benign Het
Rad50 G A 11: 53,569,766 (GRCm39) Q882* probably null Het
Rasa3 A C 8: 13,631,322 (GRCm39) F533V probably benign Het
Rgs18 T A 1: 144,629,765 (GRCm39) I165F probably damaging Het
Rtl1 C T 12: 109,560,307 (GRCm39) V511I possibly damaging Het
Sdc3 A G 4: 130,546,072 (GRCm39) T144A unknown Het
Slc9a9 T C 9: 94,818,418 (GRCm39) F271L probably benign Het
Snrpa1 G A 7: 65,720,381 (GRCm39) G195R probably benign Het
Spata31e5 C T 1: 28,817,586 (GRCm39) V149M probably damaging Het
Tcerg1 T A 18: 42,697,187 (GRCm39) D759E probably damaging Het
Tecta A G 9: 42,284,406 (GRCm39) L893P probably damaging Het
Tex101 T A 7: 24,367,957 (GRCm39) Q167L possibly damaging Het
Tnrc6a C T 7: 122,783,438 (GRCm39) R970* probably null Het
Trmt1l T C 1: 151,329,742 (GRCm39) S562P probably damaging Het
Tut4 T A 4: 108,414,554 (GRCm39) W44R possibly damaging Het
Ubn1 A G 16: 4,891,263 (GRCm39) E546G probably damaging Het
Usp38 T A 8: 81,712,346 (GRCm39) Q563L probably benign Het
Vmn1r1 C T 1: 181,985,138 (GRCm39) V176I probably benign Het
Vmn2r1 A G 3: 63,993,942 (GRCm39) K96R probably benign Het
Vmn2r62 A G 7: 42,413,992 (GRCm39) V817A probably benign Het
Wdfy3 A T 5: 101,999,219 (GRCm39) C3066S possibly damaging Het
Other mutations in Yeats4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02383:Yeats4 APN 10 117,051,716 (GRCm39) missense probably benign 0.01
R0305:Yeats4 UTSW 10 117,051,741 (GRCm39) missense probably damaging 0.99
R1606:Yeats4 UTSW 10 117,053,344 (GRCm39) missense probably damaging 1.00
R1703:Yeats4 UTSW 10 117,051,628 (GRCm39) missense probably benign
R1907:Yeats4 UTSW 10 117,051,636 (GRCm39) missense probably benign 0.17
R3156:Yeats4 UTSW 10 117,058,186 (GRCm39) missense probably benign 0.11
R3625:Yeats4 UTSW 10 117,056,273 (GRCm39) missense probably benign 0.08
R5687:Yeats4 UTSW 10 117,051,585 (GRCm39) missense probably benign
R7900:Yeats4 UTSW 10 117,056,464 (GRCm39) missense possibly damaging 0.95
R8347:Yeats4 UTSW 10 117,053,374 (GRCm39) missense probably benign 0.26
R9665:Yeats4 UTSW 10 117,053,343 (GRCm39) nonsense probably null
R9688:Yeats4 UTSW 10 117,051,586 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGTCCTCTCTGAGAAAGCCAC -3'
(R):5'- CTCCGTGGGAGTTTAGACTTC -3'

Sequencing Primer
(F):5'- TCTGAGAAAGCCACGGCCG -3'
(R):5'- AGTGCTCTGTCTCCATGCAGG -3'
Posted On 2020-10-20