Incidental Mutation 'R8515:Acss3'
ID 656090
Institutional Source Beutler Lab
Gene Symbol Acss3
Ensembl Gene ENSMUSG00000035948
Gene Name acyl-CoA synthetase short-chain family member 3
Synonyms LOC380660, 8430416H19Rik
MMRRC Submission 067847-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R8515 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 106769378-106959529 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106784524 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 566 (I566T)
Ref Sequence ENSEMBL: ENSMUSP00000128209 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165067]
AlphaFold Q14DH7
Predicted Effect possibly damaging
Transcript: ENSMUST00000165067
AA Change: I566T

PolyPhen 2 Score 0.514 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000128209
Gene: ENSMUSG00000035948
AA Change: I566T

DomainStartEndE-ValueType
Pfam:ACAS_N 57 111 8.8e-22 PFAM
Pfam:AMP-binding 113 557 3.2e-81 PFAM
Pfam:AMP-binding_C 565 644 2.2e-22 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aak1 A G 6: 86,902,112 (GRCm39) M94V possibly damaging Het
Adcy3 T C 12: 4,262,187 (GRCm39) V1080A probably damaging Het
Aldh1b1 C T 4: 45,803,818 (GRCm39) T452I probably damaging Het
Bptf A T 11: 106,946,064 (GRCm39) S2392T possibly damaging Het
Ccnb2 A G 9: 70,320,382 (GRCm39) probably null Het
Clec4a4 T A 6: 122,980,982 (GRCm39) Y72N probably benign Het
Clk4 G A 11: 51,166,088 (GRCm39) R198Q probably damaging Het
Coro2a ACCAGAAGAGCCATCCAG ACCAG 4: 46,544,117 (GRCm39) probably null Het
Ctbs T A 3: 146,164,568 (GRCm39) Y240* probably null Het
Cyp2d22 T C 15: 82,258,113 (GRCm39) D169G probably benign Het
Dnah11 C T 12: 117,939,533 (GRCm39) V3196I probably damaging Het
Fam110b T C 4: 5,799,380 (GRCm39) V266A probably benign Het
Fbxo40 A G 16: 36,791,015 (GRCm39) S32P probably damaging Het
Gm4787 T A 12: 81,424,043 (GRCm39) H705L probably benign Het
Grik1 A T 16: 87,720,170 (GRCm39) Y702* probably null Het
Hao2 A T 3: 98,790,963 (GRCm39) N70K probably benign Het
Heatr4 A G 12: 84,001,478 (GRCm39) I888T probably damaging Het
Herc4 T A 10: 63,151,565 (GRCm39) N935K probably benign Het
Kdm3b G T 18: 34,926,129 (GRCm39) A90S probably benign Het
Kif3b C T 2: 153,158,427 (GRCm39) T76M probably damaging Het
Kmo A T 1: 175,474,718 (GRCm39) H134L probably damaging Het
Lama3 C A 18: 12,544,688 (GRCm39) Q344K probably null Het
Man2a2 A T 7: 80,018,038 (GRCm39) F211I possibly damaging Het
Mmp19 T C 10: 128,631,471 (GRCm39) I189T probably benign Het
Muc4 G A 16: 32,575,629 (GRCm39) G1710S unknown Het
Myo15b G A 11: 115,749,610 (GRCm39) G127S Het
Naca T C 10: 127,880,112 (GRCm39) S1715P possibly damaging Het
Ndufs4 T C 13: 114,425,339 (GRCm39) N163S probably damaging Het
Nim1k G A 13: 120,173,986 (GRCm39) R303* probably null Het
Nkx6-3 A T 8: 23,643,707 (GRCm39) Y36F possibly damaging Het
Osbpl10 C A 9: 115,005,136 (GRCm39) Q188K probably benign Het
Pak6 G T 2: 118,520,478 (GRCm39) R156S probably benign Het
Pcf11 T A 7: 92,307,998 (GRCm39) K723N possibly damaging Het
Pcnx1 A G 12: 82,009,490 (GRCm39) Y546C possibly damaging Het
Pik3r6 A G 11: 68,430,783 (GRCm39) Y528C probably damaging Het
Ppp3cb T A 14: 20,581,844 (GRCm39) N57I probably benign Het
Preb A G 5: 31,116,722 (GRCm39) L57P probably damaging Het
Prkdc A G 16: 15,482,232 (GRCm39) D425G probably damaging Het
Rab35 G A 5: 115,781,467 (GRCm39) V90I probably damaging Het
Rab3gap2 G C 1: 184,995,017 (GRCm39) S852T probably benign Het
Rcn1 C T 2: 105,219,464 (GRCm39) R243Q probably null Het
Rom1 A G 19: 8,906,465 (GRCm39) S25P probably damaging Het
Shank3 C A 15: 89,387,775 (GRCm39) Y286* probably null Het
Sis T A 3: 72,836,742 (GRCm39) I837L probably benign Het
Ski T C 4: 155,245,083 (GRCm39) S388G possibly damaging Het
Skint1 T C 4: 111,867,921 (GRCm39) F16S probably benign Het
Slc22a21 T G 11: 53,846,904 (GRCm39) D323A possibly damaging Het
Slc40a1 G A 1: 45,951,467 (GRCm39) T230I probably damaging Het
Snrpa1 G A 7: 65,720,381 (GRCm39) G195R probably benign Het
Spata31d1c G T 13: 65,180,991 (GRCm39) S30I probably damaging Het
Spata31h1 T A 10: 82,124,436 (GRCm39) D2858V probably benign Het
Spdl1 G A 11: 34,704,252 (GRCm39) T527I possibly damaging Het
Sptb A T 12: 76,658,815 (GRCm39) L1240Q probably benign Het
Tef T A 15: 81,687,037 (GRCm39) V18D possibly damaging Het
Uckl1 T C 2: 181,216,280 (GRCm39) D155G probably damaging Het
Vmn1r215 A G 13: 23,260,037 (GRCm39) I26V probably benign Het
Wac A G 18: 7,871,606 (GRCm39) M46V probably benign Het
Wbp1 C T 6: 83,096,866 (GRCm39) G146D probably damaging Het
Zfand2a A C 5: 139,459,546 (GRCm39) S147A probably benign Het
Zfhx4 A T 3: 5,464,534 (GRCm39) Y1589F probably benign Het
Zfp345 G C 2: 150,314,348 (GRCm39) D396E probably benign Het
Other mutations in Acss3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00781:Acss3 APN 10 106,801,887 (GRCm39) missense probably benign
IGL00941:Acss3 APN 10 106,889,187 (GRCm39) critical splice donor site probably null
IGL00983:Acss3 APN 10 106,802,825 (GRCm39) nonsense probably null
IGL01010:Acss3 APN 10 106,859,710 (GRCm39) splice site probably benign
IGL02227:Acss3 APN 10 106,881,196 (GRCm39) missense probably benign
IGL02296:Acss3 APN 10 106,889,312 (GRCm39) nonsense probably null
IGL02319:Acss3 APN 10 106,784,611 (GRCm39) missense probably damaging 0.99
IGL03181:Acss3 APN 10 106,889,249 (GRCm39) missense probably damaging 1.00
R0032:Acss3 UTSW 10 106,959,156 (GRCm39) missense probably benign 0.13
R0032:Acss3 UTSW 10 106,959,156 (GRCm39) missense probably benign 0.13
R0279:Acss3 UTSW 10 106,920,732 (GRCm39) missense possibly damaging 0.95
R0418:Acss3 UTSW 10 106,859,773 (GRCm39) missense probably damaging 0.99
R0550:Acss3 UTSW 10 106,889,332 (GRCm39) missense probably damaging 1.00
R1114:Acss3 UTSW 10 106,824,740 (GRCm39) missense possibly damaging 0.89
R1491:Acss3 UTSW 10 106,773,169 (GRCm39) missense probably benign
R1625:Acss3 UTSW 10 106,773,263 (GRCm39) critical splice donor site probably null
R1771:Acss3 UTSW 10 106,773,061 (GRCm39) missense probably damaging 1.00
R1956:Acss3 UTSW 10 106,772,029 (GRCm39) missense probably benign 0.00
R2006:Acss3 UTSW 10 106,798,871 (GRCm39) missense possibly damaging 0.81
R2018:Acss3 UTSW 10 106,772,068 (GRCm39) missense probably benign 0.00
R2019:Acss3 UTSW 10 106,772,068 (GRCm39) missense probably benign 0.00
R2078:Acss3 UTSW 10 106,802,902 (GRCm39) missense possibly damaging 0.94
R2253:Acss3 UTSW 10 106,840,609 (GRCm39) missense probably damaging 1.00
R2391:Acss3 UTSW 10 106,959,348 (GRCm39) missense probably benign 0.00
R3082:Acss3 UTSW 10 106,859,576 (GRCm39) missense possibly damaging 0.94
R3083:Acss3 UTSW 10 106,859,576 (GRCm39) missense possibly damaging 0.94
R4072:Acss3 UTSW 10 106,959,446 (GRCm39) unclassified probably benign
R4086:Acss3 UTSW 10 106,889,313 (GRCm39) missense probably damaging 1.00
R4087:Acss3 UTSW 10 106,889,313 (GRCm39) missense probably damaging 1.00
R4089:Acss3 UTSW 10 106,889,313 (GRCm39) missense probably damaging 1.00
R4090:Acss3 UTSW 10 106,889,313 (GRCm39) missense probably damaging 1.00
R4406:Acss3 UTSW 10 106,889,198 (GRCm39) missense probably damaging 1.00
R4607:Acss3 UTSW 10 106,802,890 (GRCm39) missense possibly damaging 0.88
R4608:Acss3 UTSW 10 106,802,890 (GRCm39) missense possibly damaging 0.88
R4790:Acss3 UTSW 10 106,859,563 (GRCm39) nonsense probably null
R4834:Acss3 UTSW 10 106,920,666 (GRCm39) critical splice donor site probably null
R5130:Acss3 UTSW 10 106,840,586 (GRCm39) missense possibly damaging 0.87
R5303:Acss3 UTSW 10 106,920,712 (GRCm39) missense possibly damaging 0.74
R5365:Acss3 UTSW 10 106,840,589 (GRCm39) missense probably damaging 1.00
R5439:Acss3 UTSW 10 106,773,008 (GRCm39) nonsense probably null
R5617:Acss3 UTSW 10 106,787,851 (GRCm39) missense probably damaging 1.00
R5698:Acss3 UTSW 10 106,784,605 (GRCm39) missense probably damaging 1.00
R5726:Acss3 UTSW 10 106,959,183 (GRCm39) missense possibly damaging 0.63
R6154:Acss3 UTSW 10 106,959,210 (GRCm39) missense probably benign 0.02
R6298:Acss3 UTSW 10 106,920,717 (GRCm39) missense probably damaging 1.00
R6592:Acss3 UTSW 10 106,859,579 (GRCm39) missense possibly damaging 0.94
R6707:Acss3 UTSW 10 106,920,783 (GRCm39) missense probably damaging 1.00
R6999:Acss3 UTSW 10 106,889,362 (GRCm39) missense probably damaging 1.00
R7567:Acss3 UTSW 10 106,959,174 (GRCm39) missense probably benign 0.00
R8351:Acss3 UTSW 10 106,885,265 (GRCm39) missense probably damaging 0.98
R8451:Acss3 UTSW 10 106,885,265 (GRCm39) missense probably damaging 0.98
R8917:Acss3 UTSW 10 106,773,124 (GRCm39) missense probably benign
R8972:Acss3 UTSW 10 106,920,783 (GRCm39) missense probably damaging 1.00
R9308:Acss3 UTSW 10 106,959,282 (GRCm39) missense possibly damaging 0.93
R9387:Acss3 UTSW 10 106,959,255 (GRCm39) missense probably damaging 0.99
R9801:Acss3 UTSW 10 106,881,091 (GRCm39) missense possibly damaging 0.85
X0027:Acss3 UTSW 10 106,959,205 (GRCm39) missense probably benign 0.05
Z1177:Acss3 UTSW 10 106,840,638 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCACAAAGAGCAAGTATGTGC -3'
(R):5'- CAGACCTTTACCTAGCACTGC -3'

Sequencing Primer
(F):5'- TGACTTGCCTAGCATGAAGG -3'
(R):5'- CTGCATGCTAGCTGCATA -3'
Posted On 2020-10-20