|Institutional Source||Beutler Lab|
|Gene Name||leucine-rich repeat-containing G protein-coupled receptor 6|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8516 (G1)|
|Chromosomal Location||134983301-135105276 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to T at 135075283 bp (GRCm38)|
|Amino Acid Change||Asparagine to Lysine at position 76 (N76K)|
|Ref Sequence||ENSEMBL: ENSMUSP00000035444 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000044828]|
AA Change: N76K
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: N76K
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a reporter/null allele are viable and fertile with no apparent abnormal phenotype. Similarly, mice homozygous for a knock-in allele are healthy and fertile. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Lgr6||
(F):5'- TTTTCCCGAGTGAGCTCTGC -3'
(R):5'- TGTTGCCAGACATCCAGTG -3'
(F):5'- TCAAGTTCCAGAGAGCCCAGG -3'
(R):5'- ACATCCAGTGGGGTCCAGATG -3'