Incidental Mutation 'R8516:Lgr6'
ID 656122
Institutional Source Beutler Lab
Gene Symbol Lgr6
Ensembl Gene ENSMUSG00000042793
Gene Name leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms A530037C04Rik
MMRRC Submission 067848-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8516 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 134911039-135033014 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 135003021 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 76 (N76K)
Ref Sequence ENSEMBL: ENSMUSP00000035444 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044828]
AlphaFold Q3UVD5
Predicted Effect probably damaging
Transcript: ENSMUST00000044828
AA Change: N76K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035444
Gene: ENSMUSG00000042793
AA Change: N76K

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
LRRNT 34 70 5.19e-3 SMART
LRR 64 88 1.03e1 SMART
LRR_TYP 89 112 6.52e-5 SMART
LRR_TYP 113 136 2.71e-2 SMART
LRR_TYP 137 160 4.79e-3 SMART
LRR_TYP 161 184 1.58e-3 SMART
LRR_TYP 185 208 2.36e-2 SMART
LRR_TYP 209 232 3.39e-3 SMART
LRR 233 255 8.97e0 SMART
LRR_TYP 256 279 1.36e-2 SMART
Blast:LRR 281 303 6e-7 BLAST
LRR 327 350 9.24e1 SMART
LRR 351 373 1.41e0 SMART
LRR 374 396 4.84e1 SMART
LRR_TYP 397 420 4.54e-4 SMART
LRR_TYP 421 444 7.15e-2 SMART
transmembrane domain 568 590 N/A INTRINSIC
transmembrane domain 599 621 N/A INTRINSIC
transmembrane domain 643 665 N/A INTRINSIC
transmembrane domain 686 708 N/A INTRINSIC
transmembrane domain 728 750 N/A INTRINSIC
transmembrane domain 776 798 N/A INTRINSIC
transmembrane domain 808 830 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a reporter/null allele are viable and fertile with no apparent abnormal phenotype. Similarly, mice homozygous for a knock-in allele are healthy and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdhppt A T 9: 4,309,373 (GRCm39) S22T probably benign Het
Acte1 T A 7: 143,451,011 (GRCm39) I342N probably damaging Het
Actr8 G T 14: 29,712,856 (GRCm39) A500S probably benign Het
Adamtsl1 A G 4: 86,260,780 (GRCm39) Y1005C probably damaging Het
Ank3 T A 10: 69,763,559 (GRCm39) Y884* probably null Het
Arhgap28 T C 17: 68,180,068 (GRCm39) R306G probably benign Het
Atp8a2 A C 14: 59,928,921 (GRCm39) I1044M probably benign Het
Bahd1 A G 2: 118,747,452 (GRCm39) Y357C probably benign Het
Btd A T 14: 31,388,824 (GRCm39) T182S probably damaging Het
Casc3 C T 11: 98,713,607 (GRCm39) R280C probably damaging Het
Cisd2 T C 3: 135,116,774 (GRCm39) T106A probably damaging Het
Cldn15 G T 5: 137,003,550 (GRCm39) C184F probably damaging Het
Clk4 G A 11: 51,166,088 (GRCm39) R198Q probably damaging Het
Coprs G T 8: 13,935,065 (GRCm39) F163L probably damaging Het
Csmd3 G A 15: 47,492,761 (GRCm39) R2216* probably null Het
Defb7 A T 8: 19,547,623 (GRCm39) I43F possibly damaging Het
Dpp8 C A 9: 64,985,291 (GRCm39) T783K probably damaging Het
Eif2s1 G A 12: 78,927,936 (GRCm39) G204D probably damaging Het
Elavl4 T C 4: 110,108,576 (GRCm39) N56S probably damaging Het
Emilin1 G A 5: 31,074,515 (GRCm39) R252H probably damaging Het
Exd1 A T 2: 119,350,554 (GRCm39) L569Q probably damaging Het
Gpn2 C T 4: 133,312,142 (GRCm39) R125C probably damaging Het
Gria2 T C 3: 80,614,294 (GRCm39) E582G probably benign Het
Hadha A T 5: 30,331,582 (GRCm39) V458E probably damaging Het
Hap1 T C 11: 100,246,893 (GRCm39) K4R possibly damaging Het
Hectd4 A T 5: 121,487,073 (GRCm39) H3356L possibly damaging Het
Herc2 G A 7: 55,856,318 (GRCm39) V3919I probably benign Het
Or52w1 A G 7: 105,017,976 (GRCm39) I148V probably benign Het
P4ha3 A G 7: 99,963,869 (GRCm39) M462V probably damaging Het
Pde3b A T 7: 114,126,084 (GRCm39) M773L probably benign Het
Peak1 T C 9: 56,167,284 (GRCm39) S215G probably damaging Het
Pgm5 T A 19: 24,793,074 (GRCm39) M331L probably benign Het
Piwil2 A G 14: 70,658,188 (GRCm39) V213A probably benign Het
Plch2 T C 4: 155,070,764 (GRCm39) H1205R probably benign Het
Pop4 A T 7: 37,966,826 (GRCm39) M85K probably benign Het
Ppp3ca T A 3: 136,583,529 (GRCm39) I212N probably damaging Het
Prom1 T C 5: 44,164,441 (GRCm39) K714R probably benign Het
Psip1 C T 4: 83,384,952 (GRCm39) G207S probably benign Het
Rgs22 A G 15: 36,010,481 (GRCm39) *1259Q probably null Het
Scn1a C T 2: 66,156,478 (GRCm39) G477D possibly damaging Het
Sf3b1 T C 1: 55,051,262 (GRCm39) E222G probably null Het
Snrpa1 G A 7: 65,720,381 (GRCm39) G195R probably benign Het
Spem2 T C 11: 69,707,721 (GRCm39) R415G possibly damaging Het
Tmem167 T A 13: 90,246,515 (GRCm39) V13E probably damaging Het
Trim2 C T 3: 84,115,627 (GRCm39) A102T probably damaging Het
Trim30b A G 7: 104,006,611 (GRCm39) S82P probably benign Het
Uba6 A C 5: 86,275,607 (GRCm39) S760R possibly damaging Het
Upf2 T C 2: 6,023,782 (GRCm39) F711L unknown Het
Utrn T A 10: 12,362,254 (GRCm39) D2693V probably damaging Het
Vmn1r30 T G 6: 58,412,109 (GRCm39) Y241S probably damaging Het
Vmn2r110 A G 17: 20,794,875 (GRCm39) L598P probably damaging Het
Wfdc18 T A 11: 83,599,984 (GRCm39) F14Y probably benign Het
Wnt10b A T 15: 98,670,761 (GRCm39) C256S probably damaging Het
Xrn1 T A 9: 95,930,444 (GRCm39) Y1554* probably null Het
Zc3h12a T A 4: 125,013,632 (GRCm39) S411C probably damaging Het
Zfp112 G A 7: 23,823,389 (GRCm39) G63E probably benign Het
Zfp786 A T 6: 47,797,477 (GRCm39) L487Q probably damaging Het
Zfp953 T A 13: 67,493,419 (GRCm39) Y75F possibly damaging Het
Other mutations in Lgr6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02481:Lgr6 APN 1 134,929,429 (GRCm39) splice site probably benign
IGL02483:Lgr6 APN 1 134,929,429 (GRCm39) splice site probably benign
IGL03270:Lgr6 APN 1 134,925,442 (GRCm39) missense probably damaging 1.00
R0002:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0294:Lgr6 UTSW 1 135,032,799 (GRCm39) missense unknown
R0294:Lgr6 UTSW 1 134,915,629 (GRCm39) missense probably damaging 0.99
R0361:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0390:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0731:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0734:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0741:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0742:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0765:Lgr6 UTSW 1 134,921,624 (GRCm39) missense probably benign 0.04
R0903:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0904:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0905:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0906:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0907:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0908:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R0967:Lgr6 UTSW 1 134,921,750 (GRCm39) missense probably damaging 1.00
R1078:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R1079:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R1131:Lgr6 UTSW 1 134,915,042 (GRCm39) missense probably damaging 0.98
R1440:Lgr6 UTSW 1 134,915,210 (GRCm39) missense probably damaging 1.00
R1533:Lgr6 UTSW 1 135,032,670 (GRCm39) missense possibly damaging 0.66
R1728:Lgr6 UTSW 1 134,931,214 (GRCm39) missense probably benign
R1728:Lgr6 UTSW 1 134,918,373 (GRCm39) missense probably benign 0.18
R1728:Lgr6 UTSW 1 134,914,826 (GRCm39) missense probably benign 0.00
R1729:Lgr6 UTSW 1 134,918,373 (GRCm39) missense probably benign 0.18
R1729:Lgr6 UTSW 1 134,915,747 (GRCm39) missense probably benign
R1729:Lgr6 UTSW 1 134,914,826 (GRCm39) missense probably benign 0.00
R1729:Lgr6 UTSW 1 134,931,214 (GRCm39) missense probably benign
R1730:Lgr6 UTSW 1 134,915,747 (GRCm39) missense probably benign
R1730:Lgr6 UTSW 1 134,914,826 (GRCm39) missense probably benign 0.00
R1730:Lgr6 UTSW 1 134,931,214 (GRCm39) missense probably benign
R1730:Lgr6 UTSW 1 134,918,373 (GRCm39) missense probably benign 0.18
R1739:Lgr6 UTSW 1 134,931,214 (GRCm39) missense probably benign
R1739:Lgr6 UTSW 1 134,914,826 (GRCm39) missense probably benign 0.00
R1739:Lgr6 UTSW 1 134,915,747 (GRCm39) missense probably benign
R1739:Lgr6 UTSW 1 134,918,373 (GRCm39) missense probably benign 0.18
R1762:Lgr6 UTSW 1 134,931,214 (GRCm39) missense probably benign
R1762:Lgr6 UTSW 1 134,914,826 (GRCm39) missense probably benign 0.00
R1762:Lgr6 UTSW 1 134,915,747 (GRCm39) missense probably benign
R1762:Lgr6 UTSW 1 134,918,373 (GRCm39) missense probably benign 0.18
R1782:Lgr6 UTSW 1 134,915,717 (GRCm39) missense probably damaging 0.98
R1783:Lgr6 UTSW 1 134,915,747 (GRCm39) missense probably benign
R1783:Lgr6 UTSW 1 134,918,373 (GRCm39) missense probably benign 0.18
R1783:Lgr6 UTSW 1 134,931,214 (GRCm39) missense probably benign
R1783:Lgr6 UTSW 1 134,914,826 (GRCm39) missense probably benign 0.00
R1784:Lgr6 UTSW 1 134,931,214 (GRCm39) missense probably benign
R1784:Lgr6 UTSW 1 134,914,826 (GRCm39) missense probably benign 0.00
R1784:Lgr6 UTSW 1 134,915,747 (GRCm39) missense probably benign
R1784:Lgr6 UTSW 1 134,918,373 (GRCm39) missense probably benign 0.18
R1785:Lgr6 UTSW 1 134,915,747 (GRCm39) missense probably benign
R1785:Lgr6 UTSW 1 134,914,826 (GRCm39) missense probably benign 0.00
R1785:Lgr6 UTSW 1 134,931,214 (GRCm39) missense probably benign
R1785:Lgr6 UTSW 1 134,918,373 (GRCm39) missense probably benign 0.18
R2020:Lgr6 UTSW 1 135,003,013 (GRCm39) missense probably damaging 1.00
R3104:Lgr6 UTSW 1 134,928,210 (GRCm39) splice site probably null
R4629:Lgr6 UTSW 1 135,032,670 (GRCm39) missense probably damaging 0.99
R4792:Lgr6 UTSW 1 134,949,544 (GRCm39) missense probably benign 0.03
R5001:Lgr6 UTSW 1 134,918,370 (GRCm39) missense probably benign 0.01
R5191:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5194:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5195:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5196:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5197:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5228:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5230:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5243:Lgr6 UTSW 1 135,037,010 (GRCm39) unclassified probably benign
R5299:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5300:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5417:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5419:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5601:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5603:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5636:Lgr6 UTSW 1 134,914,816 (GRCm39) missense probably benign 0.28
R5699:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5748:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5767:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5825:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R5971:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R6078:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R6079:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R6138:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R6258:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R6259:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R6260:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R6740:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R6871:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
R6984:Lgr6 UTSW 1 134,915,740 (GRCm39) missense possibly damaging 0.54
R6986:Lgr6 UTSW 1 134,921,694 (GRCm39) missense possibly damaging 0.80
R7233:Lgr6 UTSW 1 134,928,214 (GRCm39) critical splice donor site probably null
R7699:Lgr6 UTSW 1 134,923,770 (GRCm39) missense probably damaging 1.00
R7700:Lgr6 UTSW 1 134,923,770 (GRCm39) missense probably damaging 1.00
R7734:Lgr6 UTSW 1 134,930,981 (GRCm39) missense probably damaging 1.00
R7849:Lgr6 UTSW 1 134,915,419 (GRCm39) missense probably damaging 1.00
R7970:Lgr6 UTSW 1 134,921,723 (GRCm39) missense probably benign
R8068:Lgr6 UTSW 1 134,991,402 (GRCm39) missense probably benign 0.00
R8252:Lgr6 UTSW 1 134,931,215 (GRCm39) missense probably null 0.78
R8771:Lgr6 UTSW 1 134,933,429 (GRCm39) nonsense probably null
R8858:Lgr6 UTSW 1 134,923,849 (GRCm39) critical splice acceptor site probably null
R8885:Lgr6 UTSW 1 134,915,342 (GRCm39) missense probably benign 0.00
R9014:Lgr6 UTSW 1 134,931,248 (GRCm39) missense probably damaging 1.00
R9277:Lgr6 UTSW 1 134,915,217 (GRCm39) nonsense probably null
R9660:Lgr6 UTSW 1 134,915,245 (GRCm39) missense probably damaging 1.00
R9728:Lgr6 UTSW 1 134,915,245 (GRCm39) missense probably damaging 1.00
Z1088:Lgr6 UTSW 1 134,915,809 (GRCm39) missense possibly damaging 0.89
Z1191:Lgr6 UTSW 1 134,921,748 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTTCCCGAGTGAGCTCTGC -3'
(R):5'- TGTTGCCAGACATCCAGTG -3'

Sequencing Primer
(F):5'- TCAAGTTCCAGAGAGCCCAGG -3'
(R):5'- ACATCCAGTGGGGTCCAGATG -3'
Posted On 2020-10-20