Incidental Mutation 'R8518:Mllt10'
ID 656236
Institutional Source Beutler Lab
Gene Symbol Mllt10
Ensembl Gene ENSMUSG00000026743
Gene Name myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms B130021D15Rik, D630001B22Rik, Af10
MMRRC Submission 067850-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.704) question?
Stock # R8518 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 18060048-18217199 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 18151670 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 261 (V261A)
Ref Sequence ENSEMBL: ENSMUSP00000028076 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028076] [ENSMUST00000114669] [ENSMUST00000114671] [ENSMUST00000114680]
AlphaFold O54826
Predicted Effect probably damaging
Transcript: ENSMUST00000028076
AA Change: V261A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000028076
Gene: ENSMUSG00000026743
AA Change: V261A

DomainStartEndE-ValueType
PHD 24 72 8.51e-8 SMART
PHD 136 195 2.92e-6 SMART
low complexity region 217 248 N/A INTRINSIC
low complexity region 258 274 N/A INTRINSIC
low complexity region 308 326 N/A INTRINSIC
low complexity region 352 372 N/A INTRINSIC
low complexity region 490 515 N/A INTRINSIC
low complexity region 581 594 N/A INTRINSIC
low complexity region 609 627 N/A INTRINSIC
low complexity region 674 692 N/A INTRINSIC
coiled coil region 741 782 N/A INTRINSIC
low complexity region 836 879 N/A INTRINSIC
low complexity region 941 952 N/A INTRINSIC
low complexity region 966 986 N/A INTRINSIC
low complexity region 997 1018 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000114669
SMART Domains Protein: ENSMUSP00000110317
Gene: ENSMUSG00000026743

DomainStartEndE-ValueType
low complexity region 38 51 N/A INTRINSIC
low complexity region 66 84 N/A INTRINSIC
low complexity region 131 149 N/A INTRINSIC
coiled coil region 198 239 N/A INTRINSIC
low complexity region 293 336 N/A INTRINSIC
low complexity region 398 409 N/A INTRINSIC
low complexity region 423 443 N/A INTRINSIC
low complexity region 454 475 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000114671
AA Change: V183A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000110319
Gene: ENSMUSG00000026743
AA Change: V183A

DomainStartEndE-ValueType
PHD 58 117 2.92e-6 SMART
low complexity region 139 170 N/A INTRINSIC
low complexity region 180 196 N/A INTRINSIC
low complexity region 230 248 N/A INTRINSIC
low complexity region 274 294 N/A INTRINSIC
low complexity region 412 437 N/A INTRINSIC
low complexity region 503 516 N/A INTRINSIC
low complexity region 531 549 N/A INTRINSIC
low complexity region 596 614 N/A INTRINSIC
coiled coil region 663 704 N/A INTRINSIC
low complexity region 758 801 N/A INTRINSIC
low complexity region 863 874 N/A INTRINSIC
low complexity region 888 908 N/A INTRINSIC
low complexity region 919 940 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000114680
AA Change: V261A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000110328
Gene: ENSMUSG00000026743
AA Change: V261A

DomainStartEndE-ValueType
PHD 24 72 8.51e-8 SMART
PHD 136 195 2.92e-6 SMART
low complexity region 217 248 N/A INTRINSIC
low complexity region 258 274 N/A INTRINSIC
low complexity region 308 326 N/A INTRINSIC
low complexity region 352 372 N/A INTRINSIC
low complexity region 490 515 N/A INTRINSIC
low complexity region 581 594 N/A INTRINSIC
low complexity region 609 627 N/A INTRINSIC
low complexity region 674 692 N/A INTRINSIC
coiled coil region 741 782 N/A INTRINSIC
low complexity region 836 879 N/A INTRINSIC
low complexity region 941 952 N/A INTRINSIC
low complexity region 966 986 N/A INTRINSIC
low complexity region 997 1018 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 A G 16: 20,223,398 (GRCm39) V170A possibly damaging Het
Adamts2 A G 11: 50,666,957 (GRCm39) E418G probably damaging Het
Adra2b T C 2: 127,206,056 (GRCm39) L191P probably damaging Het
Ampd2 C A 3: 107,987,432 (GRCm39) V134L probably benign Het
Bag2 T C 1: 33,787,358 (GRCm39) I55V probably benign Het
Bltp2 T C 11: 78,156,064 (GRCm39) L192P possibly damaging Het
Bmpr1b T C 3: 141,563,343 (GRCm39) I200M possibly damaging Het
Cacna1i C A 15: 80,243,095 (GRCm39) Y417* probably null Het
Cdc7 T A 5: 107,120,864 (GRCm39) I162N probably damaging Het
Chchd1 T C 14: 20,754,211 (GRCm39) I89T probably benign Het
Cxcl16 T C 11: 70,346,510 (GRCm39) N224S probably benign Het
Dync1i1 T G 6: 5,913,330 (GRCm39) L188V probably damaging Het
Dync2h1 A G 9: 7,051,452 (GRCm39) V3161A probably benign Het
E2f3 T A 13: 30,097,453 (GRCm39) K303N probably damaging Het
Fermt1 T C 2: 132,748,635 (GRCm39) T663A probably benign Het
Fhod3 A G 18: 25,189,390 (GRCm39) R611G probably damaging Het
Frem3 A T 8: 81,339,224 (GRCm39) S506C probably damaging Het
Gm10318 T A 10: 77,688,712 (GRCm39) M6K unknown Het
Gm6563 T A 19: 23,653,480 (GRCm39) V90E probably damaging Het
Gpc6 T C 14: 117,163,384 (GRCm39) S13P probably benign Het
Gpr107 C A 2: 31,066,939 (GRCm39) H196Q probably benign Het
Heatr1 T G 13: 12,425,415 (GRCm39) D618E probably benign Het
Lrrc27 T C 7: 138,808,690 (GRCm39) V391A probably benign Het
Mindy3 T G 2: 12,360,154 (GRCm39) K349N probably damaging Het
Mrpl48 G A 7: 100,232,269 (GRCm39) probably benign Het
Msantd5f5 T A 4: 73,542,641 (GRCm39) L47Q probably damaging Het
Muc16 T C 9: 18,430,927 (GRCm39) I8062V probably benign Het
Myo7a T C 7: 97,740,270 (GRCm39) N575D possibly damaging Het
Nfrkb T C 9: 31,311,261 (GRCm39) L370P probably damaging Het
Numbl T C 7: 26,964,361 (GRCm39) V57A probably benign Het
Or51t4 T C 7: 102,597,804 (GRCm39) V44A probably damaging Het
Or5b12 G A 19: 12,896,959 (GRCm39) T238I probably damaging Het
Or6y1 T A 1: 174,276,742 (GRCm39) C184* probably null Het
Pdia2 A T 17: 26,417,144 (GRCm39) L100* probably null Het
Prpf31 A T 7: 3,635,742 (GRCm39) N105I probably damaging Het
Rbm20 A G 19: 53,839,923 (GRCm39) N971D probably benign Het
Rnf213 T A 11: 119,353,043 (GRCm39) M3980K Het
Skint6 A G 4: 113,095,465 (GRCm39) F65L possibly damaging Het
Smpd4 T A 16: 17,458,884 (GRCm39) C536S possibly damaging Het
Tcof1 G C 18: 60,962,123 (GRCm39) A702G possibly damaging Het
Tfpt A G 7: 3,632,065 (GRCm39) F15S possibly damaging Het
Tnp2 A G 16: 10,606,372 (GRCm39) C32R possibly damaging Het
Tns3 A T 11: 8,442,971 (GRCm39) V464E probably damaging Het
Tpp2 T A 1: 44,019,545 (GRCm39) L824H probably damaging Het
Trav15-1-dv6-1 A G 14: 53,797,666 (GRCm39) D105G probably benign Het
Ttc3 T C 16: 94,258,238 (GRCm39) S1679P probably benign Het
Xpo7 A G 14: 70,944,837 (GRCm39) Y19H probably damaging Het
Zswim4 G A 8: 84,938,586 (GRCm39) R1099W probably damaging Het
Other mutations in Mllt10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01646:Mllt10 APN 2 18,127,128 (GRCm39) missense probably damaging 1.00
IGL02366:Mllt10 APN 2 18,069,898 (GRCm39) missense probably damaging 0.99
IGL02990:Mllt10 APN 2 18,128,522 (GRCm39) splice site probably benign
IGL03034:Mllt10 APN 2 18,069,847 (GRCm39) start codon destroyed probably null 0.55
R0348:Mllt10 UTSW 2 18,167,424 (GRCm39) missense probably damaging 1.00
R0487:Mllt10 UTSW 2 18,211,948 (GRCm39) missense probably damaging 0.98
R0492:Mllt10 UTSW 2 18,151,698 (GRCm39) splice site probably benign
R0518:Mllt10 UTSW 2 18,076,017 (GRCm39) critical splice donor site probably null
R0720:Mllt10 UTSW 2 18,201,406 (GRCm39) missense probably benign
R0733:Mllt10 UTSW 2 18,208,577 (GRCm39) intron probably benign
R1532:Mllt10 UTSW 2 18,097,646 (GRCm39) critical splice donor site probably null
R1665:Mllt10 UTSW 2 18,213,601 (GRCm39) missense possibly damaging 0.93
R1768:Mllt10 UTSW 2 18,167,657 (GRCm39) missense probably damaging 1.00
R2098:Mllt10 UTSW 2 18,167,464 (GRCm39) missense possibly damaging 0.50
R2114:Mllt10 UTSW 2 18,167,380 (GRCm39) missense probably benign
R2116:Mllt10 UTSW 2 18,167,380 (GRCm39) missense probably benign
R2117:Mllt10 UTSW 2 18,167,380 (GRCm39) missense probably benign
R2179:Mllt10 UTSW 2 18,215,604 (GRCm39) missense probably damaging 1.00
R2192:Mllt10 UTSW 2 18,211,871 (GRCm39) missense probably benign 0.11
R2510:Mllt10 UTSW 2 18,069,935 (GRCm39) missense possibly damaging 0.94
R2511:Mllt10 UTSW 2 18,069,935 (GRCm39) missense possibly damaging 0.94
R4669:Mllt10 UTSW 2 18,208,444 (GRCm39) missense probably damaging 1.00
R5004:Mllt10 UTSW 2 18,175,079 (GRCm39) missense probably damaging 1.00
R5072:Mllt10 UTSW 2 18,114,685 (GRCm39) missense possibly damaging 0.72
R5187:Mllt10 UTSW 2 18,213,585 (GRCm39) nonsense probably null
R5561:Mllt10 UTSW 2 18,114,656 (GRCm39) missense probably damaging 0.98
R6141:Mllt10 UTSW 2 18,215,604 (GRCm39) missense probably damaging 1.00
R6352:Mllt10 UTSW 2 18,128,604 (GRCm39) missense probably damaging 1.00
R6844:Mllt10 UTSW 2 18,164,294 (GRCm39) missense probably benign 0.02
R7060:Mllt10 UTSW 2 18,164,371 (GRCm39) missense possibly damaging 0.64
R7464:Mllt10 UTSW 2 18,175,090 (GRCm39) missense probably benign
R7691:Mllt10 UTSW 2 18,208,423 (GRCm39) missense probably null 0.94
R7691:Mllt10 UTSW 2 18,208,422 (GRCm39) missense possibly damaging 0.94
R7937:Mllt10 UTSW 2 18,210,895 (GRCm39) missense probably damaging 1.00
R7956:Mllt10 UTSW 2 18,175,068 (GRCm39) missense probably benign 0.01
R7976:Mllt10 UTSW 2 18,167,214 (GRCm39) missense possibly damaging 0.94
R8079:Mllt10 UTSW 2 18,128,567 (GRCm39) missense probably damaging 0.99
R8084:Mllt10 UTSW 2 18,114,637 (GRCm39) missense probably damaging 0.99
R8768:Mllt10 UTSW 2 18,167,583 (GRCm39) missense probably damaging 1.00
R8826:Mllt10 UTSW 2 18,167,353 (GRCm39) missense probably benign 0.10
R8850:Mllt10 UTSW 2 18,201,469 (GRCm39) missense probably benign 0.33
R8932:Mllt10 UTSW 2 18,128,617 (GRCm39) missense probably benign 0.31
R9009:Mllt10 UTSW 2 18,167,163 (GRCm39) missense probably damaging 0.96
R9129:Mllt10 UTSW 2 18,167,404 (GRCm39) missense probably benign 0.41
R9514:Mllt10 UTSW 2 18,164,322 (GRCm39) missense probably damaging 1.00
R9602:Mllt10 UTSW 2 18,211,850 (GRCm39) missense probably damaging 1.00
R9706:Mllt10 UTSW 2 18,151,655 (GRCm39) missense possibly damaging 0.50
Z1177:Mllt10 UTSW 2 18,175,887 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- ATCTATGACAACTGTTACAAGGGG -3'
(R):5'- GTGAGCCTTACACAGTCCTTAGAG -3'

Sequencing Primer
(F):5'- TATGACAACTGTTACAAGGGGGTGAC -3'
(R):5'- TTACACAGTCCTTAGAGACAAGTAC -3'
Posted On 2020-10-20