Incidental Mutation 'R8518:Or51t4'
ID 656251
Institutional Source Beutler Lab
Gene Symbol Or51t4
Ensembl Gene ENSMUSG00000045824
Gene Name olfactory receptor family 51 subfamily T member 4
Synonyms GA_x6K02T2PBJ9-5659738-5660748, MOR14-9, Olfr574
MMRRC Submission 067850-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.175) question?
Stock # R8518 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 102597674-102598714 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 102597804 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 44 (V44A)
Ref Sequence ENSEMBL: ENSMUSP00000095815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052997] [ENSMUST00000211329] [ENSMUST00000213477] [ENSMUST00000216420]
AlphaFold F8VQ18
Predicted Effect probably damaging
Transcript: ENSMUST00000052997
AA Change: V44A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000095815
Gene: ENSMUSG00000045824
AA Change: V44A

DomainStartEndE-ValueType
low complexity region 14 31 N/A INTRINSIC
Pfam:7tm_4 44 323 3.8e-96 PFAM
Pfam:7TM_GPCR_Srsx 48 195 1.2e-8 PFAM
Pfam:7tm_1 54 305 2e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000211329
AA Change: V34A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably benign
Transcript: ENSMUST00000213477
Predicted Effect probably benign
Transcript: ENSMUST00000216420
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 A G 16: 20,223,398 (GRCm39) V170A possibly damaging Het
Adamts2 A G 11: 50,666,957 (GRCm39) E418G probably damaging Het
Adra2b T C 2: 127,206,056 (GRCm39) L191P probably damaging Het
Ampd2 C A 3: 107,987,432 (GRCm39) V134L probably benign Het
Bag2 T C 1: 33,787,358 (GRCm39) I55V probably benign Het
Bltp2 T C 11: 78,156,064 (GRCm39) L192P possibly damaging Het
Bmpr1b T C 3: 141,563,343 (GRCm39) I200M possibly damaging Het
Cacna1i C A 15: 80,243,095 (GRCm39) Y417* probably null Het
Cdc7 T A 5: 107,120,864 (GRCm39) I162N probably damaging Het
Chchd1 T C 14: 20,754,211 (GRCm39) I89T probably benign Het
Cxcl16 T C 11: 70,346,510 (GRCm39) N224S probably benign Het
Dync1i1 T G 6: 5,913,330 (GRCm39) L188V probably damaging Het
Dync2h1 A G 9: 7,051,452 (GRCm39) V3161A probably benign Het
E2f3 T A 13: 30,097,453 (GRCm39) K303N probably damaging Het
Fermt1 T C 2: 132,748,635 (GRCm39) T663A probably benign Het
Fhod3 A G 18: 25,189,390 (GRCm39) R611G probably damaging Het
Frem3 A T 8: 81,339,224 (GRCm39) S506C probably damaging Het
Gm10318 T A 10: 77,688,712 (GRCm39) M6K unknown Het
Gm6563 T A 19: 23,653,480 (GRCm39) V90E probably damaging Het
Gpc6 T C 14: 117,163,384 (GRCm39) S13P probably benign Het
Gpr107 C A 2: 31,066,939 (GRCm39) H196Q probably benign Het
Heatr1 T G 13: 12,425,415 (GRCm39) D618E probably benign Het
Lrrc27 T C 7: 138,808,690 (GRCm39) V391A probably benign Het
Mindy3 T G 2: 12,360,154 (GRCm39) K349N probably damaging Het
Mllt10 T C 2: 18,151,670 (GRCm39) V261A probably damaging Het
Mrpl48 G A 7: 100,232,269 (GRCm39) probably benign Het
Msantd5f5 T A 4: 73,542,641 (GRCm39) L47Q probably damaging Het
Muc16 T C 9: 18,430,927 (GRCm39) I8062V probably benign Het
Myo7a T C 7: 97,740,270 (GRCm39) N575D possibly damaging Het
Nfrkb T C 9: 31,311,261 (GRCm39) L370P probably damaging Het
Numbl T C 7: 26,964,361 (GRCm39) V57A probably benign Het
Or5b12 G A 19: 12,896,959 (GRCm39) T238I probably damaging Het
Or6y1 T A 1: 174,276,742 (GRCm39) C184* probably null Het
Pdia2 A T 17: 26,417,144 (GRCm39) L100* probably null Het
Prpf31 A T 7: 3,635,742 (GRCm39) N105I probably damaging Het
Rbm20 A G 19: 53,839,923 (GRCm39) N971D probably benign Het
Rnf213 T A 11: 119,353,043 (GRCm39) M3980K Het
Skint6 A G 4: 113,095,465 (GRCm39) F65L possibly damaging Het
Smpd4 T A 16: 17,458,884 (GRCm39) C536S possibly damaging Het
Tcof1 G C 18: 60,962,123 (GRCm39) A702G possibly damaging Het
Tfpt A G 7: 3,632,065 (GRCm39) F15S possibly damaging Het
Tnp2 A G 16: 10,606,372 (GRCm39) C32R possibly damaging Het
Tns3 A T 11: 8,442,971 (GRCm39) V464E probably damaging Het
Tpp2 T A 1: 44,019,545 (GRCm39) L824H probably damaging Het
Trav15-1-dv6-1 A G 14: 53,797,666 (GRCm39) D105G probably benign Het
Ttc3 T C 16: 94,258,238 (GRCm39) S1679P probably benign Het
Xpo7 A G 14: 70,944,837 (GRCm39) Y19H probably damaging Het
Zswim4 G A 8: 84,938,586 (GRCm39) R1099W probably damaging Het
Other mutations in Or51t4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01154:Or51t4 APN 7 102,598,046 (GRCm39) missense probably damaging 1.00
IGL01732:Or51t4 APN 7 102,598,446 (GRCm39) missense probably damaging 1.00
IGL02185:Or51t4 APN 7 102,597,721 (GRCm39) missense probably damaging 0.96
PIT4382001:Or51t4 UTSW 7 102,598,656 (GRCm39) missense probably benign
PIT4520001:Or51t4 UTSW 7 102,597,921 (GRCm39) missense probably damaging 1.00
R0765:Or51t4 UTSW 7 102,597,939 (GRCm39) missense probably damaging 1.00
R1616:Or51t4 UTSW 7 102,597,721 (GRCm39) missense probably damaging 0.96
R2041:Or51t4 UTSW 7 102,598,170 (GRCm39) missense probably damaging 0.98
R2079:Or51t4 UTSW 7 102,598,702 (GRCm39) missense probably benign 0.00
R2261:Or51t4 UTSW 7 102,598,464 (GRCm39) missense probably damaging 1.00
R2263:Or51t4 UTSW 7 102,598,464 (GRCm39) missense probably damaging 1.00
R2513:Or51t4 UTSW 7 102,598,700 (GRCm39) missense probably benign
R2903:Or51t4 UTSW 7 102,598,661 (GRCm39) missense probably benign 0.05
R4445:Or51t4 UTSW 7 102,598,005 (GRCm39) missense possibly damaging 0.93
R4512:Or51t4 UTSW 7 102,597,945 (GRCm39) missense probably damaging 1.00
R4513:Or51t4 UTSW 7 102,597,945 (GRCm39) missense probably damaging 1.00
R4528:Or51t4 UTSW 7 102,598,013 (GRCm39) missense probably damaging 1.00
R4904:Or51t4 UTSW 7 102,598,272 (GRCm39) missense probably damaging 1.00
R5935:Or51t4 UTSW 7 102,598,017 (GRCm39) missense probably benign 0.01
R6784:Or51t4 UTSW 7 102,597,722 (GRCm39) missense possibly damaging 0.91
R6889:Or51t4 UTSW 7 102,597,975 (GRCm39) missense possibly damaging 0.94
R7082:Or51t4 UTSW 7 102,598,455 (GRCm39) missense probably damaging 1.00
R7125:Or51t4 UTSW 7 102,598,386 (GRCm39) missense probably damaging 0.99
R7549:Or51t4 UTSW 7 102,597,798 (GRCm39) missense possibly damaging 0.92
R7564:Or51t4 UTSW 7 102,598,473 (GRCm39) missense probably damaging 1.00
R7947:Or51t4 UTSW 7 102,598,278 (GRCm39) missense probably damaging 1.00
R8460:Or51t4 UTSW 7 102,598,531 (GRCm39) nonsense probably null
R8859:Or51t4 UTSW 7 102,598,373 (GRCm39) missense probably damaging 1.00
R9116:Or51t4 UTSW 7 102,598,527 (GRCm39) missense possibly damaging 0.87
R9327:Or51t4 UTSW 7 102,597,687 (GRCm39) missense probably benign 0.00
R9408:Or51t4 UTSW 7 102,598,443 (GRCm39) missense probably damaging 1.00
Z1177:Or51t4 UTSW 7 102,597,959 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCCTGGGGTTTGCAAGAAAG -3'
(R):5'- CCAGGAATGAGAAGCCATGCAC -3'

Sequencing Primer
(F):5'- CCCTGGGGTTTGCAAGAAAGATTTG -3'
(R):5'- TAATGCTGATCTCCCGGGCATG -3'
Posted On 2020-10-20