Incidental Mutation 'R8017:Zfp873'
ID |
656306 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp873
|
Ensembl Gene |
ENSMUSG00000061371 |
Gene Name |
zinc finger protein 873 |
Synonyms |
|
MMRRC Submission |
067457-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.083)
|
Stock # |
R8017 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
10 |
Chromosomal Location |
81883957-81900579 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 81896193 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Glutamic Acid
at position 308
(V308E)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000100950
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105313]
[ENSMUST00000209622]
[ENSMUST00000210325]
|
AlphaFold |
A0A1B0GT64 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000105313
AA Change: V308E
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
SMART Domains |
Protein: ENSMUSP00000100950 Gene: ENSMUSG00000061371 AA Change: V308E
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
68 |
90 |
1.12e2 |
SMART |
ZnF_C2H2
|
96 |
117 |
4.69e0 |
SMART |
ZnF_C2H2
|
123 |
145 |
2.06e1 |
SMART |
ZnF_C2H2
|
151 |
173 |
5.5e-3 |
SMART |
ZnF_C2H2
|
179 |
201 |
3.69e-4 |
SMART |
ZnF_C2H2
|
207 |
229 |
3.89e-3 |
SMART |
ZnF_C2H2
|
235 |
257 |
9.88e-5 |
SMART |
ZnF_C2H2
|
263 |
285 |
5.59e-4 |
SMART |
ZnF_C2H2
|
291 |
313 |
2.99e-4 |
SMART |
ZnF_C2H2
|
319 |
341 |
1.95e-3 |
SMART |
ZnF_C2H2
|
347 |
369 |
2.75e-3 |
SMART |
ZnF_C2H2
|
375 |
397 |
7.37e-4 |
SMART |
ZnF_C2H2
|
403 |
425 |
2.53e-2 |
SMART |
ZnF_C2H2
|
431 |
453 |
9.08e-4 |
SMART |
ZnF_C2H2
|
459 |
481 |
5.99e-4 |
SMART |
ZnF_C2H2
|
487 |
509 |
1.22e-4 |
SMART |
ZnF_C2H2
|
515 |
537 |
1.82e-3 |
SMART |
ZnF_C2H2
|
543 |
565 |
2.53e-2 |
SMART |
ZnF_C2H2
|
571 |
593 |
9.73e-4 |
SMART |
ZnF_C2H2
|
599 |
619 |
3.13e1 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000209622
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000210325
AA Change: V345E
PolyPhen 2
Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
Validation Efficiency |
95% (36/38) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 41 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aar2 |
T |
G |
2: 156,397,876 (GRCm39) |
I296S |
probably benign |
Het |
Acsl5 |
A |
G |
19: 55,257,228 (GRCm39) |
I42V |
probably benign |
Het |
Adam25 |
T |
A |
8: 41,207,124 (GRCm39) |
M130K |
possibly damaging |
Het |
Atosb |
A |
T |
4: 43,034,413 (GRCm39) |
F394Y |
probably damaging |
Het |
Bcl2l2 |
T |
A |
14: 55,121,840 (GRCm39) |
M1K |
probably null |
Het |
Cdh16 |
T |
C |
8: 105,342,899 (GRCm39) |
N724S |
probably damaging |
Het |
Cfi |
T |
C |
3: 129,648,748 (GRCm39) |
S211P |
probably benign |
Het |
Clpsl2 |
G |
A |
17: 28,769,702 (GRCm39) |
G55R |
probably damaging |
Het |
Crybg2 |
T |
A |
4: 133,800,484 (GRCm39) |
V239E |
possibly damaging |
Het |
Dcn |
G |
A |
10: 97,319,397 (GRCm39) |
R58Q |
probably damaging |
Het |
Dnah10 |
A |
G |
5: 124,877,949 (GRCm39) |
N2678S |
probably benign |
Het |
Dnai7 |
A |
G |
6: 145,140,283 (GRCm39) |
S173P |
probably damaging |
Het |
Fbxo24 |
C |
A |
5: 137,611,073 (GRCm39) |
M572I |
probably benign |
Het |
Hnrnpul1 |
T |
C |
7: 25,447,889 (GRCm39) |
E145G |
probably benign |
Het |
Ica1 |
A |
G |
6: 8,658,286 (GRCm39) |
V277A |
probably benign |
Het |
Idi1 |
G |
A |
13: 8,937,974 (GRCm39) |
S140N |
probably benign |
Het |
Kank1 |
TGCGA |
T |
19: 25,388,568 (GRCm39) |
|
probably null |
Het |
Kank1 |
GCGAACG |
GCG |
19: 25,388,569 (GRCm39) |
|
probably null |
Het |
Kif20b |
T |
C |
19: 34,917,279 (GRCm39) |
V603A |
probably damaging |
Het |
Klc2 |
T |
C |
19: 5,161,867 (GRCm39) |
K276R |
probably benign |
Het |
Lmbrd2 |
T |
A |
15: 9,172,317 (GRCm39) |
N370K |
probably benign |
Het |
Map2k5 |
G |
T |
9: 63,246,403 (GRCm39) |
A108D |
probably damaging |
Het |
Obox2 |
T |
C |
7: 15,130,974 (GRCm39) |
S69P |
possibly damaging |
Het |
Or2w2 |
G |
A |
13: 21,758,648 (GRCm39) |
|
probably benign |
Het |
Or4b1d |
A |
C |
2: 89,969,170 (GRCm39) |
F104L |
probably benign |
Het |
Or4f57 |
G |
A |
2: 111,790,918 (GRCm39) |
P167S |
probably damaging |
Het |
Pcdhga8 |
A |
G |
18: 37,860,783 (GRCm39) |
E613G |
probably damaging |
Het |
Pira2 |
A |
T |
7: 3,844,696 (GRCm39) |
F445Y |
probably benign |
Het |
Rab2a |
T |
C |
4: 8,604,444 (GRCm39) |
|
probably null |
Het |
Rsph4a |
A |
C |
10: 33,785,455 (GRCm39) |
R455S |
probably damaging |
Het |
Spata31f1a |
T |
C |
4: 42,850,840 (GRCm39) |
T439A |
probably damaging |
Het |
St6gal1 |
G |
A |
16: 23,176,585 (GRCm39) |
A393T |
probably benign |
Het |
Tmem151a |
T |
C |
19: 5,132,588 (GRCm39) |
E206G |
probably damaging |
Het |
Tmem156 |
C |
T |
5: 65,231,204 (GRCm39) |
C222Y |
probably damaging |
Het |
Tnfrsf11b |
C |
T |
15: 54,117,598 (GRCm39) |
W219* |
probably null |
Het |
Ttc36 |
T |
C |
9: 44,710,898 (GRCm39) |
E144G |
probably damaging |
Het |
Ttn |
C |
T |
2: 76,597,801 (GRCm39) |
R19704H |
probably damaging |
Het |
Wdr17 |
A |
C |
8: 55,091,403 (GRCm39) |
I1137S |
possibly damaging |
Het |
Xxylt1 |
A |
G |
16: 30,826,637 (GRCm39) |
L226P |
probably damaging |
Het |
Zbtb8b |
G |
A |
4: 129,322,238 (GRCm39) |
R408W |
probably damaging |
Het |
Zfp268 |
A |
G |
4: 145,349,138 (GRCm39) |
T192A |
probably benign |
Het |
|
Other mutations in Zfp873 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02250:Zfp873
|
APN |
10 |
81,894,252 (GRCm39) |
start codon destroyed |
probably null |
0.45 |
G1Funyon:Zfp873
|
UTSW |
10 |
81,896,713 (GRCm39) |
missense |
probably damaging |
1.00 |
R0666:Zfp873
|
UTSW |
10 |
81,896,595 (GRCm39) |
missense |
possibly damaging |
0.75 |
R1568:Zfp873
|
UTSW |
10 |
81,896,113 (GRCm39) |
missense |
probably damaging |
1.00 |
R1739:Zfp873
|
UTSW |
10 |
81,896,541 (GRCm39) |
missense |
probably damaging |
1.00 |
R1848:Zfp873
|
UTSW |
10 |
81,896,406 (GRCm39) |
missense |
probably benign |
0.33 |
R1892:Zfp873
|
UTSW |
10 |
81,897,080 (GRCm39) |
missense |
probably damaging |
1.00 |
R2061:Zfp873
|
UTSW |
10 |
81,895,991 (GRCm39) |
missense |
probably benign |
0.01 |
R3735:Zfp873
|
UTSW |
10 |
81,897,015 (GRCm39) |
missense |
probably benign |
0.15 |
R4422:Zfp873
|
UTSW |
10 |
81,896,708 (GRCm39) |
missense |
probably benign |
0.13 |
R4674:Zfp873
|
UTSW |
10 |
81,895,814 (GRCm39) |
missense |
possibly damaging |
0.53 |
R4839:Zfp873
|
UTSW |
10 |
81,896,353 (GRCm39) |
missense |
probably damaging |
0.98 |
R5146:Zfp873
|
UTSW |
10 |
81,896,058 (GRCm39) |
missense |
probably damaging |
1.00 |
R5154:Zfp873
|
UTSW |
10 |
81,896,025 (GRCm39) |
missense |
possibly damaging |
0.54 |
R5160:Zfp873
|
UTSW |
10 |
81,896,876 (GRCm39) |
missense |
possibly damaging |
0.54 |
R5811:Zfp873
|
UTSW |
10 |
81,896,567 (GRCm39) |
missense |
probably damaging |
1.00 |
R6625:Zfp873
|
UTSW |
10 |
81,896,138 (GRCm39) |
missense |
probably damaging |
1.00 |
R6667:Zfp873
|
UTSW |
10 |
81,896,423 (GRCm39) |
missense |
probably benign |
0.22 |
R6742:Zfp873
|
UTSW |
10 |
81,894,256 (GRCm39) |
missense |
probably damaging |
1.00 |
R6878:Zfp873
|
UTSW |
10 |
81,896,529 (GRCm39) |
missense |
probably benign |
0.33 |
R7055:Zfp873
|
UTSW |
10 |
81,895,832 (GRCm39) |
missense |
probably damaging |
1.00 |
R7296:Zfp873
|
UTSW |
10 |
81,897,071 (GRCm39) |
missense |
probably damaging |
1.00 |
R7381:Zfp873
|
UTSW |
10 |
81,896,805 (GRCm39) |
missense |
probably damaging |
1.00 |
R7448:Zfp873
|
UTSW |
10 |
81,896,461 (GRCm39) |
missense |
probably damaging |
1.00 |
R7464:Zfp873
|
UTSW |
10 |
81,896,210 (GRCm39) |
missense |
possibly damaging |
0.51 |
R7470:Zfp873
|
UTSW |
10 |
81,895,773 (GRCm39) |
missense |
probably benign |
0.19 |
R7640:Zfp873
|
UTSW |
10 |
81,896,109 (GRCm39) |
missense |
possibly damaging |
0.72 |
R7862:Zfp873
|
UTSW |
10 |
81,896,109 (GRCm39) |
missense |
probably benign |
0.03 |
R8301:Zfp873
|
UTSW |
10 |
81,896,713 (GRCm39) |
missense |
probably damaging |
1.00 |
R8765:Zfp873
|
UTSW |
10 |
81,896,072 (GRCm39) |
missense |
probably damaging |
1.00 |
R8997:Zfp873
|
UTSW |
10 |
81,896,990 (GRCm39) |
missense |
probably benign |
0.03 |
R9305:Zfp873
|
UTSW |
10 |
81,896,514 (GRCm39) |
missense |
probably benign |
0.00 |
R9462:Zfp873
|
UTSW |
10 |
81,897,131 (GRCm39) |
missense |
probably benign |
0.31 |
Z1177:Zfp873
|
UTSW |
10 |
81,896,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CATACTGGAGAGAAACCGTATGA -3'
(R):5'- CTGTCCCGTGTGAGTTCTT -3'
Sequencing Primer
(F):5'- TGTAGTAAAGCCTTTCCAAGTCCCAG -3'
(R):5'- GTGTACCTGCAGATTACTGAGCC -3'
|
Posted On |
2020-10-20 |