Incidental Mutation 'R7947:Arnt'
| ID |
656329 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arnt
|
| Ensembl Gene |
ENSMUSG00000015522 |
| Gene Name |
aryl hydrocarbon receptor nuclear translocator |
| Synonyms |
Hif1b, ESTM42, D3Ertd557e, bHLHe2 |
| MMRRC Submission |
045992-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7947 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
95341699-95404551 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to G
at 95381837 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102779
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015666]
[ENSMUST00000015666]
[ENSMUST00000015666]
[ENSMUST00000090804]
[ENSMUST00000090804]
[ENSMUST00000090804]
[ENSMUST00000102749]
[ENSMUST00000102749]
[ENSMUST00000102749]
[ENSMUST00000107161]
[ENSMUST00000107161]
[ENSMUST00000107161]
[ENSMUST00000136413]
|
| AlphaFold |
P53762 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000015666
|
| SMART Domains |
Protein: ENSMUSP00000015666
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
69 |
128 |
2.9e-11 |
SMART |
|
PAS
|
143 |
210 |
7.4e-13 |
SMART |
|
low complexity region
|
231 |
242 |
N/A |
INTRINSIC |
|
PAS
|
332 |
397 |
7.6e-10 |
SMART |
|
PAC
|
404 |
447 |
9.6e-7 |
SMART |
|
low complexity region
|
705 |
718 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000015666
|
| SMART Domains |
Protein: ENSMUSP00000015666
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
69 |
128 |
2.9e-11 |
SMART |
|
PAS
|
143 |
210 |
7.4e-13 |
SMART |
|
low complexity region
|
231 |
242 |
N/A |
INTRINSIC |
|
PAS
|
332 |
397 |
7.6e-10 |
SMART |
|
PAC
|
404 |
447 |
9.6e-7 |
SMART |
|
low complexity region
|
705 |
718 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000015666
|
| SMART Domains |
Protein: ENSMUSP00000015666
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
69 |
128 |
2.9e-11 |
SMART |
|
PAS
|
143 |
210 |
7.4e-13 |
SMART |
|
low complexity region
|
231 |
242 |
N/A |
INTRINSIC |
|
PAS
|
332 |
397 |
7.6e-10 |
SMART |
|
PAC
|
404 |
447 |
9.6e-7 |
SMART |
|
low complexity region
|
705 |
718 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000090804
|
| SMART Domains |
Protein: ENSMUSP00000088313
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
80 |
133 |
1e-14 |
SMART |
|
PAS
|
148 |
215 |
1.51e-10 |
SMART |
|
low complexity region
|
236 |
247 |
N/A |
INTRINSIC |
|
PAS
|
337 |
402 |
1.55e-7 |
SMART |
|
PAC
|
409 |
452 |
1.95e-4 |
SMART |
|
low complexity region
|
710 |
723 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000090804
|
| SMART Domains |
Protein: ENSMUSP00000088313
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
80 |
133 |
1e-14 |
SMART |
|
PAS
|
148 |
215 |
1.51e-10 |
SMART |
|
low complexity region
|
236 |
247 |
N/A |
INTRINSIC |
|
PAS
|
337 |
402 |
1.55e-7 |
SMART |
|
PAC
|
409 |
452 |
1.95e-4 |
SMART |
|
low complexity region
|
710 |
723 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000090804
|
| SMART Domains |
Protein: ENSMUSP00000088313
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
80 |
133 |
1e-14 |
SMART |
|
PAS
|
148 |
215 |
1.51e-10 |
SMART |
|
low complexity region
|
236 |
247 |
N/A |
INTRINSIC |
|
PAS
|
337 |
402 |
1.55e-7 |
SMART |
|
PAC
|
409 |
452 |
1.95e-4 |
SMART |
|
low complexity region
|
710 |
723 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000102749
|
| SMART Domains |
Protein: ENSMUSP00000099810
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
95 |
148 |
1e-14 |
SMART |
|
PAS
|
163 |
230 |
1.51e-10 |
SMART |
|
low complexity region
|
251 |
262 |
N/A |
INTRINSIC |
|
PAS
|
352 |
417 |
1.55e-7 |
SMART |
|
PAC
|
424 |
467 |
1.95e-4 |
SMART |
|
low complexity region
|
725 |
738 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000102749
|
| SMART Domains |
Protein: ENSMUSP00000099810
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
95 |
148 |
1e-14 |
SMART |
|
PAS
|
163 |
230 |
1.51e-10 |
SMART |
|
low complexity region
|
251 |
262 |
N/A |
INTRINSIC |
|
PAS
|
352 |
417 |
1.55e-7 |
SMART |
|
PAC
|
424 |
467 |
1.95e-4 |
SMART |
|
low complexity region
|
725 |
738 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000102749
|
| SMART Domains |
Protein: ENSMUSP00000099810
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
95 |
148 |
1e-14 |
SMART |
|
PAS
|
163 |
230 |
1.51e-10 |
SMART |
|
low complexity region
|
251 |
262 |
N/A |
INTRINSIC |
|
PAS
|
352 |
417 |
1.55e-7 |
SMART |
|
PAC
|
424 |
467 |
1.95e-4 |
SMART |
|
low complexity region
|
725 |
738 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000107161
|
| SMART Domains |
Protein: ENSMUSP00000102779
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
80 |
133 |
1e-14 |
SMART |
|
PAS
|
148 |
215 |
1.51e-10 |
SMART |
|
low complexity region
|
236 |
247 |
N/A |
INTRINSIC |
|
PAS
|
337 |
402 |
1.55e-7 |
SMART |
|
PAC
|
409 |
452 |
1.95e-4 |
SMART |
|
low complexity region
|
694 |
707 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000107161
|
| SMART Domains |
Protein: ENSMUSP00000102779
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
80 |
133 |
1e-14 |
SMART |
|
PAS
|
148 |
215 |
1.51e-10 |
SMART |
|
low complexity region
|
236 |
247 |
N/A |
INTRINSIC |
|
PAS
|
337 |
402 |
1.55e-7 |
SMART |
|
PAC
|
409 |
452 |
1.95e-4 |
SMART |
|
low complexity region
|
694 |
707 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000107161
|
| SMART Domains |
Protein: ENSMUSP00000102779
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
HLH
|
80 |
133 |
1e-14 |
SMART |
|
PAS
|
148 |
215 |
1.51e-10 |
SMART |
|
low complexity region
|
236 |
247 |
N/A |
INTRINSIC |
|
PAS
|
337 |
402 |
1.55e-7 |
SMART |
|
PAC
|
409 |
452 |
1.95e-4 |
SMART |
|
low complexity region
|
694 |
707 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136413
|
| SMART Domains |
Protein: ENSMUSP00000116688
Gene: ENSMUSG00000015522
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
12 |
23 |
N/A |
INTRINSIC |
|
Blast:PAS
|
97 |
126 |
7e-8 |
BLAST |
|
PDB:2B02|A
|
97 |
126 |
5e-9 |
PDB |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
98% (60/61) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
PHENOTYPE: Homozygotes for targeted null mutations exhibit loss of aryl hydrocarbon receptor and hypoxia-inducible factor 1 alpha gene induction, defective angiogenesis of the yolk sac and branchial arches, placental defects, and lethality by embryonic day 10.5. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310034C09Rik |
A |
G |
16: 88,555,938 (GRCm39) |
T51A |
probably benign |
Het |
| Abcc8 |
A |
G |
7: 45,754,886 (GRCm39) |
|
probably null |
Het |
| Accs |
A |
T |
2: 93,674,602 (GRCm39) |
M123K |
probably damaging |
Het |
| Ace |
G |
A |
11: 105,863,880 (GRCm39) |
G443S |
possibly damaging |
Het |
| Adprhl1 |
C |
T |
8: 13,298,682 (GRCm39) |
V83I |
probably damaging |
Het |
| Arhgap25 |
T |
C |
6: 87,440,069 (GRCm39) |
D526G |
probably benign |
Het |
| Arhgef18 |
T |
C |
8: 3,482,775 (GRCm39) |
L160P |
probably damaging |
Het |
| Art3 |
A |
G |
5: 92,540,359 (GRCm39) |
N34S |
possibly damaging |
Het |
| Avl9 |
A |
T |
6: 56,700,526 (GRCm39) |
E53D |
possibly damaging |
Het |
| AW209491 |
A |
T |
13: 14,811,447 (GRCm39) |
E100V |
probably benign |
Het |
| Axin2 |
T |
C |
11: 108,814,529 (GRCm39) |
I139T |
probably damaging |
Het |
| Birc7 |
G |
T |
2: 180,575,103 (GRCm39) |
V280L |
probably damaging |
Het |
| Bmal1 |
T |
C |
7: 112,886,353 (GRCm39) |
Y137H |
probably damaging |
Het |
| C1ra |
A |
G |
6: 124,494,338 (GRCm39) |
N262D |
probably benign |
Het |
| Cacna1g |
A |
G |
11: 94,348,001 (GRCm39) |
F696L |
probably benign |
Het |
| Casp14 |
T |
A |
10: 78,550,079 (GRCm39) |
|
probably null |
Het |
| Ciao2a |
A |
G |
9: 66,045,684 (GRCm39) |
I151V |
probably benign |
Het |
| Crlf1 |
T |
C |
8: 70,951,862 (GRCm39) |
Y176H |
probably damaging |
Het |
| Dnajb4 |
A |
T |
3: 151,892,468 (GRCm39) |
S122T |
probably benign |
Het |
| Dthd1 |
G |
A |
5: 62,971,653 (GRCm39) |
D159N |
possibly damaging |
Het |
| Erich6 |
A |
T |
3: 58,528,699 (GRCm39) |
I517N |
possibly damaging |
Het |
| Fam118b |
T |
A |
9: 35,129,239 (GRCm39) |
H343L |
probably benign |
Het |
| Fat2 |
T |
A |
11: 55,178,560 (GRCm39) |
D1500V |
probably damaging |
Het |
| Fcgbp |
T |
C |
7: 27,803,595 (GRCm39) |
|
probably null |
Het |
| Fgfrl1 |
A |
G |
5: 108,853,142 (GRCm39) |
D255G |
probably damaging |
Het |
| Gm9611 |
G |
A |
14: 42,118,087 (GRCm39) |
Q82* |
probably null |
Het |
| Ifit3 |
G |
T |
19: 34,565,359 (GRCm39) |
E302* |
probably null |
Het |
| Igkv3-9 |
G |
A |
6: 70,565,737 (GRCm39) |
C112Y |
probably damaging |
Het |
| Ints4 |
A |
G |
7: 97,148,792 (GRCm39) |
T233A |
probably benign |
Het |
| Khnyn |
A |
T |
14: 56,125,059 (GRCm39) |
S438C |
probably damaging |
Het |
| Kifc1 |
T |
C |
17: 34,102,849 (GRCm39) |
R192G |
probably benign |
Het |
| Kntc1 |
T |
C |
5: 123,919,951 (GRCm39) |
S98P |
unknown |
Het |
| Krt1c |
A |
T |
15: 101,724,769 (GRCm39) |
D280E |
probably damaging |
Het |
| Krt9 |
TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC |
TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC |
11: 100,079,903 (GRCm39) |
|
probably benign |
Het |
| Macf1 |
T |
C |
4: 123,295,200 (GRCm39) |
I5344V |
probably damaging |
Het |
| Mcf2l |
A |
T |
8: 13,053,529 (GRCm39) |
|
probably null |
Het |
| Mms22l |
A |
C |
4: 24,505,373 (GRCm39) |
H211P |
probably damaging |
Het |
| Nipsnap1 |
A |
G |
11: 4,839,145 (GRCm39) |
R163G |
possibly damaging |
Het |
| Nusap1 |
A |
G |
2: 119,477,616 (GRCm39) |
N375S |
possibly damaging |
Het |
| Or51t4 |
A |
G |
7: 102,598,278 (GRCm39) |
Y202C |
probably damaging |
Het |
| Or52e19b |
A |
T |
7: 103,032,735 (GRCm39) |
V158D |
possibly damaging |
Het |
| Or8g17 |
A |
G |
9: 38,930,747 (GRCm39) |
L30P |
probably damaging |
Het |
| Phf14 |
G |
A |
6: 11,933,306 (GRCm39) |
G56D |
unknown |
Het |
| Phykpl |
G |
A |
11: 51,477,408 (GRCm39) |
V67M |
probably damaging |
Het |
| Pigk |
A |
G |
3: 152,453,404 (GRCm39) |
D374G |
probably benign |
Het |
| Pirb |
A |
G |
7: 3,722,857 (GRCm39) |
V45A |
probably damaging |
Het |
| Prm3 |
CTCTTCTTCTTCTTC |
CTCTTCTTCTTC |
16: 10,608,565 (GRCm39) |
|
probably benign |
Het |
| Rb1cc1 |
T |
C |
1: 6,318,786 (GRCm39) |
V735A |
probably damaging |
Het |
| Rcor2 |
A |
G |
19: 7,251,225 (GRCm39) |
T333A |
possibly damaging |
Het |
| Ret |
A |
G |
6: 118,151,305 (GRCm39) |
V593A |
probably benign |
Het |
| Scgb1b10 |
A |
T |
7: 31,800,570 (GRCm39) |
D53V |
probably damaging |
Het |
| Sec61a2 |
G |
A |
2: 5,881,794 (GRCm39) |
A212V |
probably damaging |
Het |
| Sgpl1 |
A |
T |
10: 60,942,121 (GRCm39) |
F245I |
probably damaging |
Het |
| Sh2d4b |
A |
C |
14: 40,542,723 (GRCm39) |
V351G |
probably damaging |
Het |
| Shld2 |
C |
T |
14: 33,990,436 (GRCm39) |
V157I |
probably benign |
Het |
| Slc22a1 |
T |
A |
17: 12,871,310 (GRCm39) |
M484L |
probably benign |
Het |
| Slit1 |
C |
G |
19: 41,599,247 (GRCm39) |
G1066R |
probably damaging |
Het |
| Slit1 |
A |
T |
19: 41,599,248 (GRCm39) |
D1065E |
probably benign |
Het |
| Spg11 |
G |
A |
2: 121,922,803 (GRCm39) |
A882V |
probably damaging |
Het |
| Stab2 |
A |
C |
10: 86,681,897 (GRCm39) |
F2501L |
probably benign |
Het |
| Stim2 |
A |
T |
5: 54,275,671 (GRCm39) |
K607N |
probably damaging |
Het |
| Syde1 |
C |
T |
10: 78,425,916 (GRCm39) |
V84M |
probably damaging |
Het |
| Tepsin |
A |
T |
11: 119,985,061 (GRCm39) |
N202K |
probably benign |
Het |
| Tmem207 |
T |
A |
16: 26,335,495 (GRCm39) |
I81F |
possibly damaging |
Het |
| Tnc |
C |
A |
4: 63,935,580 (GRCm39) |
G452V |
probably damaging |
Het |
| Tshz1 |
G |
T |
18: 84,033,782 (GRCm39) |
Q209K |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,773,696 (GRCm39) |
N2308K |
unknown |
Het |
| Zfp266 |
A |
G |
9: 20,410,548 (GRCm39) |
I543T |
probably benign |
Het |
| Zfp777 |
G |
T |
6: 48,001,645 (GRCm39) |
P815Q |
probably damaging |
Het |
| Zhx3 |
A |
G |
2: 160,623,015 (GRCm39) |
I384T |
probably damaging |
Het |
|
| Other mutations in Arnt |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00835:Arnt
|
APN |
3 |
95,397,651 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00949:Arnt
|
APN |
3 |
95,394,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01304:Arnt
|
APN |
3 |
95,355,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01634:Arnt
|
APN |
3 |
95,377,709 (GRCm39) |
splice site |
probably benign |
|
|
IGL01685:Arnt
|
APN |
3 |
95,381,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01768:Arnt
|
APN |
3 |
95,398,327 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02738:Arnt
|
APN |
3 |
95,402,631 (GRCm39) |
splice site |
probably null |
|
|
IGL02941:Arnt
|
APN |
3 |
95,367,681 (GRCm39) |
splice site |
probably benign |
|
|
R0211:Arnt
|
UTSW |
3 |
95,383,460 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Arnt
|
UTSW |
3 |
95,383,460 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0420:Arnt
|
UTSW |
3 |
95,377,705 (GRCm39) |
splice site |
probably benign |
|
|
R0801:Arnt
|
UTSW |
3 |
95,401,157 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1418:Arnt
|
UTSW |
3 |
95,377,710 (GRCm39) |
splice site |
probably benign |
|
|
R1523:Arnt
|
UTSW |
3 |
95,396,965 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1956:Arnt
|
UTSW |
3 |
95,355,704 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1957:Arnt
|
UTSW |
3 |
95,355,704 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1958:Arnt
|
UTSW |
3 |
95,355,704 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1969:Arnt
|
UTSW |
3 |
95,355,704 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1970:Arnt
|
UTSW |
3 |
95,355,704 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1971:Arnt
|
UTSW |
3 |
95,355,704 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3743:Arnt
|
UTSW |
3 |
95,382,016 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4561:Arnt
|
UTSW |
3 |
95,359,924 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4780:Arnt
|
UTSW |
3 |
95,395,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4827:Arnt
|
UTSW |
3 |
95,397,224 (GRCm39) |
splice site |
probably null |
|
|
R4913:Arnt
|
UTSW |
3 |
95,397,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5051:Arnt
|
UTSW |
3 |
95,377,648 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5572:Arnt
|
UTSW |
3 |
95,382,015 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5866:Arnt
|
UTSW |
3 |
95,398,037 (GRCm39) |
unclassified |
probably benign |
|
|
R6376:Arnt
|
UTSW |
3 |
95,397,936 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6491:Arnt
|
UTSW |
3 |
95,383,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6873:Arnt
|
UTSW |
3 |
95,381,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6920:Arnt
|
UTSW |
3 |
95,397,932 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7485:Arnt
|
UTSW |
3 |
95,402,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7731:Arnt
|
UTSW |
3 |
95,391,086 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7786:Arnt
|
UTSW |
3 |
95,392,267 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7797:Arnt
|
UTSW |
3 |
95,387,572 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8143:Arnt
|
UTSW |
3 |
95,377,294 (GRCm39) |
splice site |
probably null |
|
|
R8446:Arnt
|
UTSW |
3 |
95,382,014 (GRCm39) |
frame shift |
probably null |
|
|
R8701:Arnt
|
UTSW |
3 |
95,401,076 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8859:Arnt
|
UTSW |
3 |
95,397,691 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9096:Arnt
|
UTSW |
3 |
95,397,588 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9097:Arnt
|
UTSW |
3 |
95,397,588 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9244:Arnt
|
UTSW |
3 |
95,397,879 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9322:Arnt
|
UTSW |
3 |
95,397,929 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9386:Arnt
|
UTSW |
3 |
95,395,687 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9481:Arnt
|
UTSW |
3 |
95,391,092 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9542:Arnt
|
UTSW |
3 |
95,397,954 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0020:Arnt
|
UTSW |
3 |
95,401,876 (GRCm39) |
missense |
probably benign |
0.10 |
|
X0026:Arnt
|
UTSW |
3 |
95,381,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTTGAGTGCTAAGAGGCAAATAGC -3'
(R):5'- TATCCACATCATCTGGGTGCAC -3'
Sequencing Primer
(F):5'- GCAAATAGCAACTTAGAGAAATTGC -3'
(R):5'- TCTGGGTGCACCTGATCATACAG -3'
|
| Posted On |
2020-10-22 |
Incidental Mutation