Incidental Mutation 'R7941:Rab24'
ID 656368
Institutional Source Beutler Lab
Gene Symbol Rab24
Ensembl Gene ENSMUSG00000034789
Gene Name RAB24, member RAS oncogene family
Synonyms 6530406O07Rik
MMRRC Submission 045987-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7941 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 55467556-55469759 bp(-) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) C to T at 55468120 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153246 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021941] [ENSMUST00000021942] [ENSMUST00000035242] [ENSMUST00000099490] [ENSMUST00000224685] [ENSMUST00000224973]
AlphaFold P35290
Predicted Effect probably benign
Transcript: ENSMUST00000021941
SMART Domains Protein: ENSMUSP00000021941
Gene: ENSMUSG00000021485

DomainStartEndE-ValueType
low complexity region 11 26 N/A INTRINSIC
HLH 63 115 5.8e-11 SMART
low complexity region 119 138 N/A INTRINSIC
low complexity region 148 167 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000021942
SMART Domains Protein: ENSMUSP00000021942
Gene: ENSMUSG00000021486

DomainStartEndE-ValueType
Pfam:PRELI 16 172 1.9e-61 PFAM
coiled coil region 178 215 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000035242
SMART Domains Protein: ENSMUSP00000046188
Gene: ENSMUSG00000034789

DomainStartEndE-ValueType
RAB 8 175 2.39e-44 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000099490
SMART Domains Protein: ENSMUSP00000097089
Gene: ENSMUSG00000021488

DomainStartEndE-ValueType
low complexity region 177 187 N/A INTRINSIC
low complexity region 281 289 N/A INTRINSIC
PWWP 322 388 1.97e-3 SMART
low complexity region 635 644 N/A INTRINSIC
low complexity region 980 1000 N/A INTRINSIC
low complexity region 1296 1309 N/A INTRINSIC
PHD 1546 1588 4.25e-8 SMART
PHD 1593 1640 3.79e-5 SMART
RING 1594 1639 1.08e-1 SMART
PHD 1641 1694 1.09e1 SMART
PHD 1710 1750 1.02e-10 SMART
PWWP 1755 1817 8.87e-29 SMART
AWS 1891 1942 3.02e-22 SMART
SET 1943 2066 1e-45 SMART
PostSET 2067 2083 3.99e-3 SMART
PHD 2121 2164 1.08e-9 SMART
low complexity region 2224 2237 N/A INTRINSIC
low complexity region 2276 2286 N/A INTRINSIC
low complexity region 2335 2356 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000224685
Predicted Effect probably benign
Transcript: ENSMUST00000224973
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (43/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 T C 2: 31,579,691 (GRCm39) probably benign Het
AI467606 A G 7: 126,691,593 (GRCm39) E56G probably damaging Het
Ak9 C T 10: 41,285,133 (GRCm39) P1403S unknown Het
Akr1c14 A G 13: 4,109,713 (GRCm39) K28E probably benign Het
Ampd2 C A 3: 107,987,432 (GRCm39) V134L probably benign Het
Anks1b A T 10: 90,413,017 (GRCm39) N55I probably damaging Het
Cabyr T C 18: 12,877,825 (GRCm39) L54P probably damaging Het
Cachd1 A T 4: 100,845,370 (GRCm39) N954I probably damaging Het
Cenpf A G 1: 189,389,483 (GRCm39) S1450P probably damaging Het
Chst10 T A 1: 38,910,772 (GRCm39) I131L probably damaging Het
Cluh A T 11: 74,550,583 (GRCm39) M270L probably benign Het
Dagla T C 19: 10,248,867 (GRCm39) H29R probably damaging Het
Dusp5 A G 19: 53,525,964 (GRCm39) N202S probably benign Het
Elavl3 A G 9: 21,947,612 (GRCm39) I110T possibly damaging Het
Fam222b G T 11: 78,045,885 (GRCm39) G482V possibly damaging Het
Fbxl7 A G 15: 26,543,699 (GRCm39) L316P probably damaging Het
Gad1 T A 2: 70,424,929 (GRCm39) probably null Het
H2-K2 T C 17: 34,218,305 (GRCm39) T204A probably benign Het
Hmcn1 A G 1: 150,525,835 (GRCm39) V3296A possibly damaging Het
Hyal1 T C 9: 107,455,299 (GRCm39) F203S probably damaging Het
Il16 T A 7: 83,332,037 (GRCm39) D181V probably damaging Het
Ip6k1 T C 9: 107,901,631 (GRCm39) F69L probably damaging Het
Klf4 G A 4: 55,531,755 (GRCm39) probably benign Het
Lsr T G 7: 30,672,520 (GRCm39) I27L probably benign Het
Mettl4 A T 17: 95,040,622 (GRCm39) probably null Het
Mpdz A G 4: 81,200,987 (GRCm39) V1902A probably benign Het
Nfkbiz C T 16: 55,642,307 (GRCm39) G37D probably damaging Het
Or5w11 T C 2: 87,459,248 (GRCm39) V31A probably benign Het
Otogl A T 10: 107,642,663 (GRCm39) probably null Het
Pcdh1 T C 18: 38,332,133 (GRCm39) D429G probably damaging Het
Pramel34 A T 5: 93,785,887 (GRCm39) V131D probably benign Het
Prelid2 A T 18: 42,065,816 (GRCm39) L73* probably null Het
Psg20 T A 7: 18,415,102 (GRCm39) probably null Het
Ptprb GAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT GAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT 10: 116,119,582 (GRCm39) probably benign Het
Rag1 T G 2: 101,472,691 (GRCm39) K817T probably benign Het
Rgl2 T C 17: 34,150,713 (GRCm39) V57A probably benign Het
Ric1 T C 19: 29,510,659 (GRCm39) M80T probably damaging Het
Sh3rf3 T C 10: 58,842,883 (GRCm39) I283T probably damaging Het
Skint2 C A 4: 112,483,187 (GRCm39) N197K probably damaging Het
Snapc4 A G 2: 26,266,730 (GRCm39) I126T probably damaging Het
Srcap GTCCTCCTCCTCCTCCTCCTGCTCCTCCTCCTCCTCCT GTCCTCCTCCTCCTCCTGCTCCTCCTCCTCCTCCT 7: 127,157,462 (GRCm39) probably benign Het
Svip T C 7: 51,653,161 (GRCm39) K51R probably benign Het
Syndig1 T A 2: 149,741,708 (GRCm39) V98E probably benign Het
Tshz1 A T 18: 84,033,517 (GRCm39) M297K possibly damaging Het
Ttn A G 2: 76,749,694 (GRCm39) V3785A probably benign Het
Usf3 T C 16: 44,035,924 (GRCm39) S135P probably damaging Het
Vmn2r10 A T 5: 109,144,306 (GRCm39) M548K probably damaging Het
Vmn2r92 T C 17: 18,405,099 (GRCm39) S748P possibly damaging Het
Zbtb39 A G 10: 127,579,409 (GRCm39) Y661C probably damaging Het
Zfp804b A G 5: 6,820,042 (GRCm39) I1007T probably benign Het
Zscan4-ps2 A G 7: 11,251,599 (GRCm39) I212V probably benign Het
Other mutations in Rab24
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0518:Rab24 UTSW 13 55,468,738 (GRCm39) critical splice donor site probably null
R0521:Rab24 UTSW 13 55,468,738 (GRCm39) critical splice donor site probably null
R3871:Rab24 UTSW 13 55,468,992 (GRCm39) missense probably damaging 1.00
R5935:Rab24 UTSW 13 55,468,343 (GRCm39) missense probably damaging 1.00
R5964:Rab24 UTSW 13 55,469,389 (GRCm39) missense probably damaging 1.00
R7528:Rab24 UTSW 13 55,468,921 (GRCm39) missense probably damaging 1.00
R8044:Rab24 UTSW 13 55,469,345 (GRCm39) unclassified probably benign
R9416:Rab24 UTSW 13 55,468,049 (GRCm39) missense unknown
V1024:Rab24 UTSW 13 55,468,561 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- AATTCCACTGGGCCAGATGAG -3'
(R):5'- TTGAAACATCCAGCAAGACAGG -3'

Sequencing Primer
(F):5'- GTGGTGACTCAGTGATGACAAC -3'
(R):5'- CTTGGGTCCTGTCAGCAG -3'
Posted On 2020-10-29