|Institutional Source||Beutler Lab|
|Gene Name||cyclin T1|
|Essential gene?||Probably essential (E-score: 0.918)|
|Stock #||R7988 (G1)|
|Chromosomal Location||98538689-98570923 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 98565143 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000126874 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000012104] [ENSMUST00000168928] [ENSMUST00000169707]|
|Coding Region Coverage||
|Validation Efficiency||100% (59/59)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ccnt1||
(F):5'- ACATTTGTCTTCTTACTCGGAAAGC -3'
(R):5'- GGATCGTCTTTGCAGAAGGC -3'
(F):5'- TCATAGTTCAATAACAACGACCAATC -3'
(R):5'- AAGCCTGAGGTCGTATGCAGC -3'