Mutagenetix > Incidental Mutation

Incidental Mutation 'R8274:Oog4'

656420

Institutional Source

Beutler Lab

Gene Symbol

Oog4

Ensembl Gene

ENSMUSG00000047799

Gene Name

oogenesin 4

Synonyms

MMRRC Submission

067697-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

R8274 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

143163734-143176894 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 143166459 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000073325 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061277] [ENSMUST00000073641]

AlphaFold

Q4G0C7

Predicted Effect

probably benign
Transcript: ENSMUST00000061277

SMART Domains

Protein: ENSMUSP00000052217
Gene: ENSMUSG00000047799

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	195	357	6e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000073641

SMART Domains

Protein: ENSMUSP00000073325
Gene: ENSMUSG00000047799

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	267	429	3e-7	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.5%

Validation Efficiency

100% (46/46)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921536K21Rik	T	C	11: 3,844,964 (GRCm39)	T42A	possibly damaging	Het
Adamts6	T	C	13: 104,450,181 (GRCm39)	V294A	probably benign	Het
Ahr	A	C	12: 35,560,068 (GRCm39)	V195G	probably benign	Het
Ankrd17	A	T	5: 90,430,718 (GRCm39)	I1022N	probably benign	Het
Arsk	A	T	13: 76,220,303 (GRCm39)	C264S	probably damaging	Het
Astn2	A	G	4: 65,570,098 (GRCm39)		probably null	Het
Atf7ip	C	A	6: 136,537,988 (GRCm39)	T407K	probably benign	Het
Axl	A	G	7: 25,463,438 (GRCm39)	I613T	probably damaging	Het
Baz2a	T	C	10: 127,957,716 (GRCm39)	M1021T	probably benign	Het
Cacna2d2	T	C	9: 107,401,861 (GRCm39)	V765A	possibly damaging	Het
Chd7	T	C	4: 8,839,432 (GRCm39)	Y1323H	probably damaging	Het
Col7a1	G	T	9: 108,799,029 (GRCm39)	G1794V	probably damaging	Het
Csmd1	T	C	8: 15,960,453 (GRCm39)	M3321V	possibly damaging	Het
Dcp1b	T	C	6: 119,160,612 (GRCm39)	S65P	probably damaging	Het
Depdc7	A	G	2: 104,558,551 (GRCm39)	S157P	probably benign	Het
Dnah1	T	A	14: 31,017,531 (GRCm39)	H1500L	probably benign	Het
Erbb2	C	T	11: 98,324,722 (GRCm39)	A772V	probably damaging	Het
Fan1	T	A	7: 64,022,234 (GRCm39)	N340Y	probably damaging	Het
Fat3	T	A	9: 16,288,786 (GRCm39)	K246*	probably null	Het
Fbxl9	T	A	8: 106,042,166 (GRCm39)	I221F	probably benign	Het
Gbp4	T	C	5: 105,267,338 (GRCm39)	N527S	probably benign	Het
Gpr157	C	T	4: 150,172,500 (GRCm39)	T97M	probably damaging	Het
Gpt2	T	C	8: 86,242,853 (GRCm39)	L295P	probably benign	Het
Grm8	T	A	6: 27,761,335 (GRCm39)	K296N	probably benign	Het
Gss	T	A	2: 155,429,424 (GRCm39)	I23L	probably benign	Het
Hk3	A	G	13: 55,159,230 (GRCm39)	V442A	possibly damaging	Het
Hoxa3	C	A	6: 52,147,524 (GRCm39)	R243L	unknown	Het
Junb	T	A	8: 85,705,058 (GRCm39)	M1L	possibly damaging	Het
Kcnh6	T	C	11: 105,910,987 (GRCm39)	I514T	probably damaging	Het
Kif11	C	A	19: 37,391,994 (GRCm39)	T463N	probably damaging	Het
Lmf2	C	T	15: 89,236,866 (GRCm39)	G459S	probably damaging	Het
Lpl	A	G	8: 69,345,250 (GRCm39)	T85A	possibly damaging	Het
Myo9b	G	A	8: 71,812,480 (GRCm39)	A2084T	probably benign	Het
Or7g18	T	A	9: 18,786,795 (GRCm39)	H57Q	probably benign	Het
Polr2a	G	A	11: 69,638,882 (GRCm39)	R51C	probably damaging	Het
Ppip5k2	A	G	1: 97,686,941 (GRCm39)	V94A	possibly damaging	Het
Ptprk	G	T	10: 28,456,408 (GRCm39)	R1056L	probably damaging	Het
Rfx2	C	T	17: 57,111,348 (GRCm39)	A75T	probably benign	Het
Scn11a	T	C	9: 119,632,548 (GRCm39)	T441A	probably benign	Het
Siglec1	A	G	2: 130,925,830 (GRCm39)	V292A	probably benign	Het
Smok2a	G	A	17: 13,445,781 (GRCm39)	A453T	probably benign	Het
Tmcc3	T	C	10: 94,422,738 (GRCm39)	V427A	probably damaging	Het
Tmem208	T	G	8: 106,055,257 (GRCm39)	I106S	probably damaging	Het
Tpr	A	G	1: 150,299,230 (GRCm39)		probably benign	Het
Trav9-2	G	T	14: 53,828,810 (GRCm39)	R60L	probably benign	Het
Vcan	T	C	13: 89,853,089 (GRCm39)	K624E	probably benign	Het
Zfp318	A	T	17: 46,723,915 (GRCm39)	M1973L	probably benign	Het

Other mutations in Oog4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01580:Oog4	APN	4	143,165,682 (GRCm39)	missense	probably benign	0.27
IGL02207:Oog4	APN	4	143,165,510 (GRCm39)	missense	probably benign	0.20
R0038:Oog4	UTSW	4	143,165,514 (GRCm39)	missense	probably benign	0.20
R0038:Oog4	UTSW	4	143,165,514 (GRCm39)	missense	probably benign	0.20
R0326:Oog4	UTSW	4	143,165,773 (GRCm39)	missense	probably benign	0.03
R0372:Oog4	UTSW	4	143,164,259 (GRCm39)	missense	probably damaging	1.00
R1056:Oog4	UTSW	4	143,164,581 (GRCm39)	missense	possibly damaging	0.72
R1598:Oog4	UTSW	4	143,164,571 (GRCm39)	missense	probably damaging	0.99
R1712:Oog4	UTSW	4	143,166,484 (GRCm39)	missense	probably damaging	1.00
R4028:Oog4	UTSW	4	143,166,770 (GRCm39)	missense	probably benign	0.02
R4029:Oog4	UTSW	4	143,166,770 (GRCm39)	missense	probably benign	0.02
R4030:Oog4	UTSW	4	143,166,770 (GRCm39)	missense	probably benign	0.02
R4705:Oog4	UTSW	4	143,165,445 (GRCm39)	missense	probably benign	0.00
R5260:Oog4	UTSW	4	143,164,424 (GRCm39)	missense	probably benign	0.00
R5945:Oog4	UTSW	4	143,164,293 (GRCm39)	missense	probably benign	0.01
R6499:Oog4	UTSW	4	143,164,548 (GRCm39)	missense	probably damaging	0.96
R6614:Oog4	UTSW	4	143,164,445 (GRCm39)	missense	possibly damaging	0.66
R6852:Oog4	UTSW	4	143,165,679 (GRCm39)	missense	possibly damaging	0.72
R7371:Oog4	UTSW	4	143,165,346 (GRCm39)	missense	possibly damaging	0.47
R7375:Oog4	UTSW	4	143,165,544 (GRCm39)	missense	possibly damaging	0.72
R7501:Oog4	UTSW	4	143,164,022 (GRCm39)	frame shift	probably null
R7564:Oog4	UTSW	4	143,164,022 (GRCm39)	frame shift	probably null
R7678:Oog4	UTSW	4	143,164,022 (GRCm39)	frame shift	probably null
R7688:Oog4	UTSW	4	143,164,022 (GRCm39)	frame shift	probably null
R7689:Oog4	UTSW	4	143,164,022 (GRCm39)	frame shift	probably null
R8219:Oog4	UTSW	4	143,166,508 (GRCm39)	missense	probably benign	0.00
R8352:Oog4	UTSW	4	143,164,047 (GRCm39)	missense	probably benign	0.22
R8452:Oog4	UTSW	4	143,164,047 (GRCm39)	missense	probably benign	0.22
Z1177:Oog4	UTSW	4	143,164,145 (GRCm39)	missense	probably benign	0.06
Z1177:Oog4	UTSW	4	143,164,144 (GRCm39)	missense	possibly damaging	0.91

Predicted Primers

PCR Primer
(F):5'- TACATTAGCCATTGTTTGCCCAG -3'
(R):5'- TGAGGCCTTGGCCATTTCTG -3'

Sequencing Primer
(F):5'- TTTGCCCAGATAGCTGAGAC -3'
(R):5'- GTTCCCAGCAATTTTTGAAGCAGC -3'

Posted On

2020-11-09