Mutagenetix > Incidental Mutation

Incidental Mutation 'R8309:Zc3h7a'

656537

Institutional Source

Beutler Lab

Gene Symbol

Zc3h7a

Ensembl Gene

ENSMUSG00000037965

Gene Name

zinc finger CCCH type containing 7 A

Synonyms

A430104C18Rik, Zc3h7

MMRRC Submission

067794-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

R8309 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

10954458-10994257 bp(-) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to T at 10964417 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037633] [ENSMUST00000128083] [ENSMUST00000138185] [ENSMUST00000140755]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000037633

SMART Domains

Protein: ENSMUSP00000041308
Gene: ENSMUSG00000037965

Domain	Start	End	E-Value	Type
PDB:2DBA\|A	26	157	9e-7	PDB
Blast:TPR	43	76	1e-7	BLAST
SCOP:d1ihga1	46	169	1e-11	SMART
Blast:TPR	124	156	9e-9	BLAST
low complexity region	308	319	N/A	INTRINSIC
low complexity region	380	398	N/A	INTRINSIC
ZnF_C2H2	443	467	1.83e2	SMART
ZnF_C3H1	630	654	1.57e1	SMART
ZnF_C3H1	770	795	8.81e0	SMART
ZnF_C2H2	856	880	1.62e0	SMART
ZnF_C3H1	902	926	1.76e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000128083

SMART Domains

Protein: ENSMUSP00000114246
Gene: ENSMUSG00000037965

Domain	Start	End	E-Value	Type
Pfam:TPR_11	41	120	2.7e-8	PFAM
Blast:TPR	124	156	4e-9	BLAST
low complexity region	308	319	N/A	INTRINSIC
low complexity region	380	398	N/A	INTRINSIC
Blast:ZnF_C2H2	443	467	2e-10	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000138185

SMART Domains

Protein: ENSMUSP00000119480
Gene: ENSMUSG00000037965

Domain	Start	End	E-Value	Type
Pfam:TPR_11	41	120	3.9e-8	PFAM
Blast:TPR	124	156	6e-9	BLAST
low complexity region	308	319	N/A	INTRINSIC
low complexity region	380	398	N/A	INTRINSIC
Blast:ZnF_C2H2	443	467	4e-10	BLAST
Blast:ZnF_C3H1	628	654	5e-10	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000140755

SMART Domains

Protein: ENSMUSP00000120720
Gene: ENSMUSG00000037965

Domain	Start	End	E-Value	Type
Pfam:TPR_11	41	120	1e-7	PFAM
Blast:TPR	124	156	5e-9	BLAST
low complexity region	308	319	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000140898

SMART Domains

Protein: ENSMUSP00000118771
Gene: ENSMUSG00000037965

Domain	Start	End	E-Value	Type
Blast:ZnF_C3H1	45	71	3e-10	BLAST

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

100% (82/82)

Allele List at MGI

Other mutations in this stock

Total: 84 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402F06Rik	T	A	2: 35,279,599 (GRCm39)	Y34F	possibly damaging	Het
Abcb6	A	T	1: 75,149,588 (GRCm39)	S664T	probably benign	Het
Abcc4	C	T	14: 118,853,804 (GRCm39)	V443M	probably damaging	Het
Abhd2	G	A	7: 78,998,095 (GRCm39)	G209D	probably damaging	Het
Acte1	A	G	7: 143,437,680 (GRCm39)	N126S	possibly damaging	Het
Ampd2	C	A	3: 107,987,432 (GRCm39)	V134L	probably benign	Het
Apbb2	T	A	5: 66,520,179 (GRCm39)	M449L	probably benign	Het
Ccdc81	T	A	7: 89,526,786 (GRCm39)		probably null	Het
Cd209b	A	T	8: 3,976,559 (GRCm39)	C42*	probably null	Het
Cdhr18	G	A	14: 13,814,954 (GRCm38)	Q860*	probably null	Het
Clec18a	A	T	8: 111,808,689 (GRCm39)	M11K	probably benign	Het
Clock	A	T	5: 76,402,269 (GRCm39)	S130R	probably benign	Het
Col12a1	G	A	9: 79,512,465 (GRCm39)	A2910V	possibly damaging	Het
Col6a4	C	T	9: 105,952,414 (GRCm39)	A495T	probably benign	Het
Cyp4f37	A	T	17: 32,853,952 (GRCm39)	N467I	probably damaging	Het
Ddo	G	A	10: 40,513,375 (GRCm39)	V106M	possibly damaging	Het
Dennd5a	A	G	7: 109,500,332 (GRCm39)	L931P	probably damaging	Het
Dgcr6	A	G	16: 17,884,598 (GRCm39)	D82G	probably damaging	Het
Dnah7b	T	C	1: 46,179,032 (GRCm39)	S902P	probably damaging	Het
Dnal4	T	G	15: 79,646,711 (GRCm39)	I57L	probably benign	Het
Dst	T	A	1: 34,156,592 (GRCm39)	I174N	probably damaging	Het
Dync2i1	T	C	12: 116,219,705 (GRCm39)	E79G	probably damaging	Het
Dync2i2	A	G	2: 29,922,201 (GRCm39)	L420P	probably damaging	Het
Eeig2	G	A	3: 108,934,658 (GRCm39)		probably benign	Het
Efhb	T	C	17: 53,756,563 (GRCm39)	T363A	probably damaging	Het
Ehbp1l1	A	G	19: 5,767,103 (GRCm39)	F1245S	probably damaging	Het
Eif4g1	A	G	16: 20,507,578 (GRCm39)	D1453G	probably benign	Het
Fbp1	T	C	13: 63,016,831 (GRCm39)	I224V	probably benign	Het
Gm10782	T	G	13: 56,510,948 (GRCm39)	F79V	noncoding transcript	Het
Gpaa1	C	G	15: 76,216,160 (GRCm39)	R47G	possibly damaging	Het
Hs2st1	G	A	3: 144,143,365 (GRCm39)	S226L	possibly damaging	Het
Hydin	A	G	8: 111,334,534 (GRCm39)	Y4992C	probably benign	Het
Ikbke	A	T	1: 131,191,065 (GRCm39)	C549*	probably null	Het
Insrr	G	A	3: 87,717,749 (GRCm39)	G817S	probably benign	Het
Itgb5	G	A	16: 33,685,923 (GRCm39)	V88I	probably benign	Het
Krt78	A	G	15: 101,854,922 (GRCm39)	V963A	probably benign	Het
Lars1	T	C	18: 42,376,093 (GRCm39)	Y239C	possibly damaging	Het
Map2k5	A	G	9: 63,246,361 (GRCm39)		probably null	Het
Mfn2	A	T	4: 147,974,693 (GRCm39)	W118R	probably benign	Het
Mga	T	A	2: 119,791,411 (GRCm39)	I2550N	probably damaging	Het
Mgam	A	G	6: 40,722,111 (GRCm39)	I401V	possibly damaging	Het
Mrps18c	A	G	5: 100,952,264 (GRCm39)	Y141C	probably damaging	Het
Myo1e	A	T	9: 70,254,045 (GRCm39)	I565L	possibly damaging	Het
Nfatc4	G	A	14: 56,063,848 (GRCm39)	E112K	probably damaging	Het
Nubp1	A	G	16: 10,239,486 (GRCm39)	M255V	probably benign	Het
Or13n4	A	C	7: 106,423,620 (GRCm39)	S38A	probably benign	Het
Or52a33	A	G	7: 103,288,658 (GRCm39)	S230P	probably damaging	Het
Or8g33	C	T	9: 39,337,966 (GRCm39)	V134I	probably benign	Het
Pask	A	T	1: 93,240,573 (GRCm39)	C1264*	probably null	Het
Pcgf2	T	C	11: 97,582,569 (GRCm39)	T173A	probably benign	Het
Plcg1	T	C	2: 160,595,853 (GRCm39)	I574T	probably benign	Het
Plin4	T	C	17: 56,411,437 (GRCm39)	T865A	probably damaging	Het
Pnpt1	T	C	11: 29,103,277 (GRCm39)	V514A	probably benign	Het
Ppp1r3a	T	A	6: 14,719,700 (GRCm39)	I405F	probably benign	Het
Qpctl	A	G	7: 18,882,398 (GRCm39)	V86A	probably benign	Het
Rab3gap1	G	T	1: 127,837,655 (GRCm39)	W239L	possibly damaging	Het
Ralgapa2	T	A	2: 146,246,786 (GRCm39)	T939S	possibly damaging	Het
Rapgef2	G	T	3: 78,990,509 (GRCm39)	T923N	possibly damaging	Het
Rit2	T	A	18: 31,286,898 (GRCm39)	I96F	probably damaging	Het
Rnase13	A	T	14: 52,159,893 (GRCm39)	I82N	probably damaging	Het
Rp1	C	A	1: 4,417,312 (GRCm39)	V1267L	probably benign	Het
Serpinb9b	G	A	13: 33,223,554 (GRCm39)	E249K	probably damaging	Het
Serpinb9c	G	T	13: 33,334,094 (GRCm39)	T344K	possibly damaging	Het
Serpinh1	T	C	7: 98,998,151 (GRCm39)	I160V	possibly damaging	Het
Sipa1	A	G	19: 5,704,964 (GRCm39)	S544P	probably damaging	Het
Slc17a5	A	T	9: 78,478,311 (GRCm39)	Y231*	probably null	Het
Srcap	T	C	7: 127,148,529 (GRCm39)	V1959A	probably damaging	Het
Srrm4	G	A	5: 116,729,626 (GRCm39)		probably benign	Het
Stat1	T	C	1: 52,190,404 (GRCm39)	I553T	possibly damaging	Het
Stpg1	A	G	4: 135,256,903 (GRCm39)	I231M	probably benign	Het
Szt2	G	GC	4: 118,232,679 (GRCm39)		probably null	Het
Trpv3	C	T	11: 73,170,747 (GRCm39)	T209M	probably damaging	Het
Tsc22d2	G	T	3: 58,324,544 (GRCm39)	G479C	unknown	Het
Ttc3	A	G	16: 94,267,838 (GRCm39)	H1950R	probably damaging	Het
Tusc3	A	G	8: 39,617,882 (GRCm39)	*348W	probably null	Het
Utp4	A	T	8: 107,642,853 (GRCm39)	T504S	probably benign	Het
Vmn1r15	A	G	6: 57,235,635 (GRCm39)	M168V	probably benign	Het
Wdsub1	C	T	2: 59,704,578 (GRCm39)		probably benign	Het
Xrcc5	T	A	1: 72,358,286 (GRCm39)	M207K	possibly damaging	Het
Zdbf2	T	A	1: 63,345,750 (GRCm39)	N1376K	possibly damaging	Het
Zfp558	A	C	9: 18,368,213 (GRCm39)	S192A	probably benign	Het
Zfp764l1	C	T	7: 126,992,496 (GRCm39)	C38Y	probably null	Het
Zfp964	A	G	8: 70,115,924 (GRCm39)	T175A	possibly damaging	Het
Zfp988	A	G	4: 147,416,765 (GRCm39)	R400G	probably damaging	Het

Other mutations in Zc3h7a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00515:Zc3h7a	APN	16	10,955,202 (GRCm39)	missense	probably damaging	0.98
IGL00908:Zc3h7a	APN	16	10,963,106 (GRCm39)	missense	probably damaging	0.99
IGL01087:Zc3h7a	APN	16	10,971,046 (GRCm39)	missense	probably benign	0.28
IGL01285:Zc3h7a	APN	16	10,956,979 (GRCm39)	missense	probably damaging	1.00
IGL01453:Zc3h7a	APN	16	10,967,242 (GRCm39)	missense	probably benign	0.00
IGL01639:Zc3h7a	APN	16	10,959,572 (GRCm39)	missense	possibly damaging	0.75
IGL01716:Zc3h7a	APN	16	10,963,580 (GRCm39)	missense	probably damaging	1.00
IGL02059:Zc3h7a	APN	16	10,978,862 (GRCm39)	unclassified	probably benign
IGL02170:Zc3h7a	APN	16	10,964,259 (GRCm39)	missense	probably benign
IGL02256:Zc3h7a	APN	16	10,965,140 (GRCm39)	missense	probably benign	0.04
IGL02904:Zc3h7a	APN	16	10,968,530 (GRCm39)	missense	probably damaging	1.00
IGL02941:Zc3h7a	APN	16	10,976,458 (GRCm39)	critical splice acceptor site	probably null
IGL03198:Zc3h7a	APN	16	10,980,528 (GRCm39)	nonsense	probably null
IGL03201:Zc3h7a	APN	16	10,974,166 (GRCm39)	critical splice acceptor site	probably null
IGL03302:Zc3h7a	APN	16	10,959,574 (GRCm39)	missense	probably damaging	1.00
agreement	UTSW	16	10,971,025 (GRCm39)	missense	probably benign	0.02
Clement	UTSW	16	10,982,466 (GRCm39)	nonsense	probably null
consensus	UTSW	16	10,978,890 (GRCm39)	missense	probably damaging	1.00
R0062:Zc3h7a	UTSW	16	10,957,011 (GRCm39)	missense	probably damaging	1.00
R0255:Zc3h7a	UTSW	16	10,958,601 (GRCm39)	missense	probably damaging	1.00
R0376:Zc3h7a	UTSW	16	10,974,066 (GRCm39)	missense	probably benign	0.00
R0545:Zc3h7a	UTSW	16	10,970,197 (GRCm39)	unclassified	probably benign
R0666:Zc3h7a	UTSW	16	10,974,167 (GRCm39)	unclassified	probably benign
R0831:Zc3h7a	UTSW	16	10,969,744 (GRCm39)	missense	probably damaging	0.99
R1127:Zc3h7a	UTSW	16	10,956,939 (GRCm39)	missense	probably damaging	1.00
R1296:Zc3h7a	UTSW	16	10,978,890 (GRCm39)	missense	probably damaging	1.00
R1472:Zc3h7a	UTSW	16	10,978,890 (GRCm39)	missense	probably damaging	1.00
R1499:Zc3h7a	UTSW	16	10,980,520 (GRCm39)	missense	probably damaging	1.00
R1747:Zc3h7a	UTSW	16	10,963,117 (GRCm39)	missense	possibly damaging	0.67
R1786:Zc3h7a	UTSW	16	10,968,469 (GRCm39)	nonsense	probably null
R1840:Zc3h7a	UTSW	16	10,978,890 (GRCm39)	missense	probably damaging	1.00
R1866:Zc3h7a	UTSW	16	10,965,168 (GRCm39)	missense	possibly damaging	0.81
R2055:Zc3h7a	UTSW	16	10,955,340 (GRCm39)	missense	probably benign	0.00
R2131:Zc3h7a	UTSW	16	10,968,469 (GRCm39)	nonsense	probably null
R2281:Zc3h7a	UTSW	16	10,976,458 (GRCm39)	unclassified	probably benign
R2399:Zc3h7a	UTSW	16	10,965,265 (GRCm39)	missense	probably damaging	1.00
R2979:Zc3h7a	UTSW	16	10,976,837 (GRCm39)	missense	probably damaging	1.00
R3915:Zc3h7a	UTSW	16	10,974,074 (GRCm39)	missense	possibly damaging	0.92
R4078:Zc3h7a	UTSW	16	10,969,011 (GRCm39)	missense	probably benign	0.05
R4095:Zc3h7a	UTSW	16	10,963,099 (GRCm39)	missense	probably damaging	1.00
R4208:Zc3h7a	UTSW	16	10,982,508 (GRCm39)	missense	possibly damaging	0.60
R4444:Zc3h7a	UTSW	16	10,968,457 (GRCm39)	critical splice donor site	probably null
R4739:Zc3h7a	UTSW	16	10,959,573 (GRCm39)	missense	probably damaging	1.00
R5059:Zc3h7a	UTSW	16	10,978,985 (GRCm39)	frame shift	probably null
R5545:Zc3h7a	UTSW	16	10,966,315 (GRCm39)	missense	possibly damaging	0.89
R5815:Zc3h7a	UTSW	16	10,974,050 (GRCm39)	missense	probably damaging	0.98
R5915:Zc3h7a	UTSW	16	10,982,466 (GRCm39)	nonsense	probably null
R5993:Zc3h7a	UTSW	16	10,968,526 (GRCm39)	missense	probably damaging	1.00
R6183:Zc3h7a	UTSW	16	10,965,234 (GRCm39)	missense	possibly damaging	0.81
R6459:Zc3h7a	UTSW	16	10,971,025 (GRCm39)	missense	probably damaging	1.00
R6513:Zc3h7a	UTSW	16	10,976,629 (GRCm39)	critical splice acceptor site	probably null
R6700:Zc3h7a	UTSW	16	10,976,831 (GRCm39)	missense	possibly damaging	0.59
R6904:Zc3h7a	UTSW	16	10,963,535 (GRCm39)	missense	probably damaging	1.00
R6964:Zc3h7a	UTSW	16	10,967,088 (GRCm39)	missense	probably benign	0.00
R7354:Zc3h7a	UTSW	16	10,966,378 (GRCm39)	missense	probably damaging	1.00
R7667:Zc3h7a	UTSW	16	10,956,890 (GRCm39)	nonsense	probably null
R7742:Zc3h7a	UTSW	16	10,971,025 (GRCm39)	missense	probably benign	0.02
R7780:Zc3h7a	UTSW	16	10,967,115 (GRCm39)	missense	probably benign	0.26
R8228:Zc3h7a	UTSW	16	10,956,954 (GRCm39)	missense	probably damaging	1.00
R8302:Zc3h7a	UTSW	16	10,955,249 (GRCm39)	missense	probably damaging	1.00
R8795:Zc3h7a	UTSW	16	10,965,147 (GRCm39)	missense	possibly damaging	0.65
R9060:Zc3h7a	UTSW	16	10,969,047 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCATGCTTGCTTGCAAACTTC -3'
(R):5'- AACCAGTAAGCTTTATCTCCTACC -3'

Sequencing Primer
(F):5'- TGCTTGCAAACTTCTCCAATATTG -3'
(R):5'- GCAGACCTGATTTGGAATCCTAC -3'

Posted On

2020-12-16