Incidental Mutation 'R8465:Vmn2r17'
| ID |
656755 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r17
|
| Ensembl Gene |
ENSMUSG00000091879 |
| Gene Name |
vomeronasal 2, receptor 17 |
| Synonyms |
EG384221 |
| MMRRC Submission |
067909-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.112)
|
| Stock # |
R8465 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109567879-109601253 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 109600691 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 663
(I663N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131450
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171841]
|
| AlphaFold |
E9PYF5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171841
AA Change: I663N
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000131450
Gene: ENSMUSG00000091879
AA Change: I663N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
465 |
7e-26 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
3.5e-18 |
PFAM |
|
Pfam:7tm_3
|
593 |
830 |
4.8e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (80/80) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acot6 |
A |
T |
12: 84,153,215 (GRCm39) |
|
probably null |
Het |
| Adamtsl3 |
A |
T |
7: 82,247,330 (GRCm39) |
N1429Y |
probably benign |
Het |
| Adk |
T |
C |
14: 21,153,892 (GRCm39) |
S32P |
possibly damaging |
Het |
| Akap13 |
A |
T |
7: 75,376,786 (GRCm39) |
M2005L |
probably benign |
Het |
| Atp10a |
A |
T |
7: 58,478,058 (GRCm39) |
D1367V |
probably benign |
Het |
| Bckdhb |
A |
G |
9: 83,870,915 (GRCm39) |
I142V |
probably benign |
Het |
| Brap |
C |
T |
5: 121,817,358 (GRCm39) |
Q322* |
probably null |
Het |
| Carmil3 |
A |
T |
14: 55,734,305 (GRCm39) |
N401I |
probably damaging |
Het |
| Cdan1 |
A |
T |
2: 120,558,921 (GRCm39) |
S426T |
possibly damaging |
Het |
| Cdc27 |
C |
A |
11: 104,408,317 (GRCm39) |
S531I |
probably benign |
Het |
| Cela3a |
A |
T |
4: 137,131,185 (GRCm39) |
Y184* |
probably null |
Het |
| Cep63 |
T |
C |
9: 102,490,576 (GRCm39) |
K178R |
probably benign |
Het |
| Cfb |
G |
A |
17: 35,076,290 (GRCm39) |
Q152* |
probably null |
Het |
| Cnpy2 |
G |
A |
10: 128,162,044 (GRCm39) |
V106I |
probably benign |
Het |
| Cntn1 |
GCTGTCTTC |
GC |
15: 92,237,404 (GRCm39) |
|
probably null |
Het |
| Ctc1 |
G |
A |
11: 68,917,045 (GRCm39) |
G67D |
probably damaging |
Het |
| Cwc27 |
G |
T |
13: 104,940,772 (GRCm39) |
P196T |
probably benign |
Het |
| Cwc27 |
C |
A |
13: 104,940,776 (GRCm39) |
L194F |
possibly damaging |
Het |
| Cyp2d12 |
T |
G |
15: 82,439,378 (GRCm39) |
S11A |
possibly damaging |
Het |
| Ddx55 |
T |
A |
5: 124,697,184 (GRCm39) |
|
probably null |
Het |
| Dedd2 |
G |
T |
7: 24,918,331 (GRCm39) |
R75S |
probably damaging |
Het |
| Fat2 |
G |
A |
11: 55,147,530 (GRCm39) |
S3904F |
possibly damaging |
Het |
| Fibp |
G |
A |
19: 5,513,215 (GRCm39) |
V177I |
probably damaging |
Het |
| Fsip2 |
A |
T |
2: 82,810,284 (GRCm39) |
E2201V |
probably benign |
Het |
| Gbp11 |
C |
T |
5: 105,472,928 (GRCm39) |
D499N |
probably benign |
Het |
| Gfm1 |
A |
G |
3: 67,339,032 (GRCm39) |
E45G |
probably damaging |
Het |
| H2-D1 |
A |
G |
17: 35,482,487 (GRCm39) |
Y69C |
probably damaging |
Het |
| Hcar1 |
A |
G |
5: 124,017,109 (GRCm39) |
F194S |
probably damaging |
Het |
| Heatr4 |
A |
T |
12: 84,024,707 (GRCm39) |
|
probably null |
Het |
| Kcnd2 |
G |
A |
6: 21,216,695 (GRCm39) |
C133Y |
probably damaging |
Het |
| Kcnq1 |
A |
T |
7: 142,979,711 (GRCm39) |
Q619L |
probably benign |
Het |
| Kctd12 |
T |
A |
14: 103,218,901 (GRCm39) |
R326W |
probably damaging |
Het |
| Kel |
A |
G |
6: 41,666,472 (GRCm39) |
|
probably null |
Het |
| Lipk |
A |
T |
19: 34,024,197 (GRCm39) |
I332F |
probably benign |
Het |
| Lrrc37 |
T |
A |
11: 103,506,947 (GRCm39) |
|
probably benign |
Het |
| Masp2 |
A |
G |
4: 148,696,516 (GRCm39) |
D371G |
possibly damaging |
Het |
| Met |
A |
G |
6: 17,571,809 (GRCm39) |
E1376G |
probably benign |
Het |
| Mup5 |
A |
T |
4: 61,752,015 (GRCm39) |
I78K |
probably benign |
Het |
| Mynn |
A |
T |
3: 30,670,790 (GRCm39) |
D526V |
probably damaging |
Het |
| Naip6 |
G |
T |
13: 100,433,423 (GRCm39) |
T1138N |
possibly damaging |
Het |
| Neurod1 |
G |
T |
2: 79,284,696 (GRCm39) |
P229Q |
probably damaging |
Het |
| Npepps |
T |
G |
11: 97,139,085 (GRCm39) |
R162S |
probably damaging |
Het |
| Ntrk3 |
T |
A |
7: 78,112,631 (GRCm39) |
Q175L |
probably damaging |
Het |
| Obsl1 |
T |
C |
1: 75,480,032 (GRCm39) |
T310A |
probably damaging |
Het |
| Or4g7 |
A |
T |
2: 111,309,425 (GRCm39) |
T99S |
probably benign |
Het |
| Or8c9 |
A |
T |
9: 38,241,410 (GRCm39) |
I176F |
possibly damaging |
Het |
| Or8j3c |
A |
T |
2: 86,253,975 (GRCm39) |
M15K |
probably benign |
Het |
| Or8k32 |
A |
G |
2: 86,368,731 (GRCm39) |
I176T |
probably damaging |
Het |
| Pigf |
G |
A |
17: 87,304,964 (GRCm39) |
T193I |
possibly damaging |
Het |
| Pkp4 |
T |
C |
2: 59,172,525 (GRCm39) |
V904A |
possibly damaging |
Het |
| Plekha6 |
C |
T |
1: 133,197,778 (GRCm39) |
T141M |
probably damaging |
Het |
| Rapgef6 |
G |
A |
11: 54,582,308 (GRCm39) |
D1407N |
probably benign |
Het |
| Rhobtb3 |
T |
C |
13: 76,087,741 (GRCm39) |
D82G |
probably damaging |
Het |
| Rims1 |
T |
C |
1: 22,498,731 (GRCm39) |
N767S |
possibly damaging |
Het |
| Ripor2 |
T |
A |
13: 24,849,451 (GRCm39) |
|
probably benign |
Het |
| Sec14l4 |
T |
A |
11: 3,993,948 (GRCm39) |
I296N |
probably damaging |
Het |
| Serpinb12 |
G |
T |
1: 106,884,342 (GRCm39) |
V363F |
probably damaging |
Het |
| Serpinb9c |
A |
G |
13: 33,334,016 (GRCm39) |
I342T |
probably damaging |
Het |
| Shmt2 |
A |
G |
10: 127,355,945 (GRCm39) |
V133A |
probably damaging |
Het |
| Slc30a6 |
A |
G |
17: 74,722,661 (GRCm39) |
M243V |
probably benign |
Het |
| Slfn2 |
T |
A |
11: 82,960,487 (GRCm39) |
N155K |
probably damaging |
Het |
| Spata31h1 |
A |
T |
10: 82,152,298 (GRCm39) |
L23M |
possibly damaging |
Het |
| Syne2 |
A |
T |
12: 75,900,898 (GRCm39) |
D19V |
possibly damaging |
Het |
| Tcl1b3 |
A |
T |
12: 105,160,736 (GRCm39) |
I116L |
probably benign |
Het |
| Tcp11 |
A |
G |
17: 28,286,766 (GRCm39) |
I411T |
probably damaging |
Het |
| Tctn1 |
C |
T |
5: 122,379,859 (GRCm39) |
A560T |
probably benign |
Het |
| Tenm3 |
C |
A |
8: 48,682,216 (GRCm39) |
Q2471H |
probably damaging |
Het |
| Tnr |
A |
G |
1: 159,713,645 (GRCm39) |
D691G |
probably benign |
Het |
| Ube3b |
C |
T |
5: 114,528,451 (GRCm39) |
P150S |
probably damaging |
Het |
| Ugt2b5 |
T |
C |
5: 87,287,518 (GRCm39) |
I216M |
possibly damaging |
Het |
| Unc5d |
T |
A |
8: 29,156,877 (GRCm39) |
R789S |
probably damaging |
Het |
| Ush2a |
G |
A |
1: 188,147,875 (GRCm39) |
G934D |
probably damaging |
Het |
| Usp6nl |
A |
T |
2: 6,399,352 (GRCm39) |
R70S |
probably damaging |
Het |
| Vmn1r181 |
T |
C |
7: 23,684,309 (GRCm39) |
I258T |
possibly damaging |
Het |
| Vmn2r15 |
C |
A |
5: 109,445,302 (GRCm39) |
D41Y |
probably damaging |
Het |
| Vnn3 |
C |
A |
10: 23,741,780 (GRCm39) |
Q362K |
possibly damaging |
Het |
| Wdr72 |
A |
G |
9: 74,059,730 (GRCm39) |
D380G |
possibly damaging |
Het |
| Wfdc10 |
G |
A |
2: 164,499,180 (GRCm39) |
E97K |
possibly damaging |
Het |
| Xdh |
A |
T |
17: 74,206,007 (GRCm39) |
C1002* |
probably null |
Het |
| Zscan4e |
A |
C |
7: 11,041,578 (GRCm39) |
V126G |
probably damaging |
Het |
|
| Other mutations in Vmn2r17 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00325:Vmn2r17
|
APN |
5 |
109,575,858 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL01457:Vmn2r17
|
APN |
5 |
109,600,898 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01527:Vmn2r17
|
APN |
5 |
109,601,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01693:Vmn2r17
|
APN |
5 |
109,600,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01738:Vmn2r17
|
APN |
5 |
109,577,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01767:Vmn2r17
|
APN |
5 |
109,567,903 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01932:Vmn2r17
|
APN |
5 |
109,574,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01970:Vmn2r17
|
APN |
5 |
109,575,813 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02009:Vmn2r17
|
APN |
5 |
109,600,714 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02365:Vmn2r17
|
APN |
5 |
109,601,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02385:Vmn2r17
|
APN |
5 |
109,582,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02457:Vmn2r17
|
APN |
5 |
109,601,012 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02646:Vmn2r17
|
APN |
5 |
109,600,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02741:Vmn2r17
|
APN |
5 |
109,568,077 (GRCm39) |
missense |
probably benign |
|
|
IGL03213:Vmn2r17
|
APN |
5 |
109,582,256 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03216:Vmn2r17
|
APN |
5 |
109,600,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03342:Vmn2r17
|
APN |
5 |
109,575,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03408:Vmn2r17
|
APN |
5 |
109,577,238 (GRCm39) |
splice site |
probably benign |
|
|
R0349:Vmn2r17
|
UTSW |
5 |
109,576,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0418:Vmn2r17
|
UTSW |
5 |
109,600,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Vmn2r17
|
UTSW |
5 |
109,575,192 (GRCm39) |
splice site |
probably benign |
|
|
R0836:Vmn2r17
|
UTSW |
5 |
109,575,822 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1715:Vmn2r17
|
UTSW |
5 |
109,576,110 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1738:Vmn2r17
|
UTSW |
5 |
109,576,377 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1801:Vmn2r17
|
UTSW |
5 |
109,576,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2054:Vmn2r17
|
UTSW |
5 |
109,600,352 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2060:Vmn2r17
|
UTSW |
5 |
109,575,075 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2192:Vmn2r17
|
UTSW |
5 |
109,582,144 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2315:Vmn2r17
|
UTSW |
5 |
109,575,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2374:Vmn2r17
|
UTSW |
5 |
109,575,104 (GRCm39) |
missense |
probably benign |
|
|
R3612:Vmn2r17
|
UTSW |
5 |
109,577,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3832:Vmn2r17
|
UTSW |
5 |
109,576,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4273:Vmn2r17
|
UTSW |
5 |
109,600,832 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4494:Vmn2r17
|
UTSW |
5 |
109,576,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4597:Vmn2r17
|
UTSW |
5 |
109,577,428 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4675:Vmn2r17
|
UTSW |
5 |
109,575,049 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4701:Vmn2r17
|
UTSW |
5 |
109,575,849 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4754:Vmn2r17
|
UTSW |
5 |
109,600,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4841:Vmn2r17
|
UTSW |
5 |
109,582,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4842:Vmn2r17
|
UTSW |
5 |
109,582,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4865:Vmn2r17
|
UTSW |
5 |
109,574,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4902:Vmn2r17
|
UTSW |
5 |
109,601,220 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4989:Vmn2r17
|
UTSW |
5 |
109,575,739 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5101:Vmn2r17
|
UTSW |
5 |
109,576,217 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5109:Vmn2r17
|
UTSW |
5 |
109,577,342 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5123:Vmn2r17
|
UTSW |
5 |
109,575,774 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5474:Vmn2r17
|
UTSW |
5 |
109,582,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5485:Vmn2r17
|
UTSW |
5 |
109,567,972 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5611:Vmn2r17
|
UTSW |
5 |
109,576,030 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5652:Vmn2r17
|
UTSW |
5 |
109,577,430 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5717:Vmn2r17
|
UTSW |
5 |
109,575,140 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5735:Vmn2r17
|
UTSW |
5 |
109,600,716 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5766:Vmn2r17
|
UTSW |
5 |
109,575,139 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6645:Vmn2r17
|
UTSW |
5 |
109,576,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6786:Vmn2r17
|
UTSW |
5 |
109,575,695 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6821:Vmn2r17
|
UTSW |
5 |
109,577,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6979:Vmn2r17
|
UTSW |
5 |
109,576,265 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6984:Vmn2r17
|
UTSW |
5 |
109,600,533 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7269:Vmn2r17
|
UTSW |
5 |
109,576,337 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7509:Vmn2r17
|
UTSW |
5 |
109,575,695 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7736:Vmn2r17
|
UTSW |
5 |
109,600,757 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7789:Vmn2r17
|
UTSW |
5 |
109,600,831 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7814:Vmn2r17
|
UTSW |
5 |
109,575,739 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7847:Vmn2r17
|
UTSW |
5 |
109,568,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7863:Vmn2r17
|
UTSW |
5 |
109,568,035 (GRCm39) |
missense |
probably benign |
|
|
R7893:Vmn2r17
|
UTSW |
5 |
109,575,944 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8234:Vmn2r17
|
UTSW |
5 |
109,601,235 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8382:Vmn2r17
|
UTSW |
5 |
109,576,387 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8435:Vmn2r17
|
UTSW |
5 |
109,576,172 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8555:Vmn2r17
|
UTSW |
5 |
109,600,810 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8900:Vmn2r17
|
UTSW |
5 |
109,575,863 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9293:Vmn2r17
|
UTSW |
5 |
109,600,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9308:Vmn2r17
|
UTSW |
5 |
109,600,505 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9378:Vmn2r17
|
UTSW |
5 |
109,575,732 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9597:Vmn2r17
|
UTSW |
5 |
109,575,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTTATGAAGATCCACTGGGG -3'
(R):5'- TGCAAATAAGGATGGTCTTCCC -3'
Sequencing Primer
(F):5'- TCCACTGGGGATGGCTCTAG -3'
(R):5'- TGTATCTCTACCAATAAAAGGAGGAG -3'
|
| Posted On |
2021-01-18 |
Incidental Mutation