Incidental Mutation 'R8465:Naip6'
ID 656795
Institutional Source Beutler Lab
Gene Symbol Naip6
Ensembl Gene ENSMUSG00000078942
Gene Name NLR family, apoptosis inhibitory protein 6
Synonyms Naip-rs4, Birc1f, Naip-rs4A
MMRRC Submission 067909-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.142) question?
Stock # R8465 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 100417629-100453124 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 100433423 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Asparagine at position 1138 (T1138N)
Ref Sequence ENSEMBL: ENSMUSP00000112867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042220] [ENSMUST00000118574]
AlphaFold Q9JIB6
Predicted Effect possibly damaging
Transcript: ENSMUST00000042220
AA Change: T1138N

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000041766
Gene: ENSMUSG00000078942
AA Change: T1138N

DomainStartEndE-ValueType
BIR 58 129 6.21e-20 SMART
BIR 157 229 8.04e-37 SMART
BIR 276 347 5.19e-31 SMART
Pfam:NACHT 464 618 7.6e-37 PFAM
low complexity region 851 862 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000118574
AA Change: T1138N

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000112867
Gene: ENSMUSG00000078942
AA Change: T1138N

DomainStartEndE-ValueType
BIR 58 129 6.21e-20 SMART
BIR 157 229 8.04e-37 SMART
BIR 276 347 5.19e-31 SMART
Pfam:NACHT 464 618 2.5e-35 PFAM
low complexity region 851 862 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (80/80)
MGI Phenotype FUNCTION: Closest sequence match is AF381772. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot6 A T 12: 84,153,215 (GRCm39) probably null Het
Adamtsl3 A T 7: 82,247,330 (GRCm39) N1429Y probably benign Het
Adk T C 14: 21,153,892 (GRCm39) S32P possibly damaging Het
Akap13 A T 7: 75,376,786 (GRCm39) M2005L probably benign Het
Atp10a A T 7: 58,478,058 (GRCm39) D1367V probably benign Het
Bckdhb A G 9: 83,870,915 (GRCm39) I142V probably benign Het
Brap C T 5: 121,817,358 (GRCm39) Q322* probably null Het
Carmil3 A T 14: 55,734,305 (GRCm39) N401I probably damaging Het
Cdan1 A T 2: 120,558,921 (GRCm39) S426T possibly damaging Het
Cdc27 C A 11: 104,408,317 (GRCm39) S531I probably benign Het
Cela3a A T 4: 137,131,185 (GRCm39) Y184* probably null Het
Cep63 T C 9: 102,490,576 (GRCm39) K178R probably benign Het
Cfb G A 17: 35,076,290 (GRCm39) Q152* probably null Het
Cnpy2 G A 10: 128,162,044 (GRCm39) V106I probably benign Het
Cntn1 GCTGTCTTC GC 15: 92,237,404 (GRCm39) probably null Het
Ctc1 G A 11: 68,917,045 (GRCm39) G67D probably damaging Het
Cwc27 G T 13: 104,940,772 (GRCm39) P196T probably benign Het
Cwc27 C A 13: 104,940,776 (GRCm39) L194F possibly damaging Het
Cyp2d12 T G 15: 82,439,378 (GRCm39) S11A possibly damaging Het
Ddx55 T A 5: 124,697,184 (GRCm39) probably null Het
Dedd2 G T 7: 24,918,331 (GRCm39) R75S probably damaging Het
Fat2 G A 11: 55,147,530 (GRCm39) S3904F possibly damaging Het
Fibp G A 19: 5,513,215 (GRCm39) V177I probably damaging Het
Fsip2 A T 2: 82,810,284 (GRCm39) E2201V probably benign Het
Gbp11 C T 5: 105,472,928 (GRCm39) D499N probably benign Het
Gfm1 A G 3: 67,339,032 (GRCm39) E45G probably damaging Het
H2-D1 A G 17: 35,482,487 (GRCm39) Y69C probably damaging Het
Hcar1 A G 5: 124,017,109 (GRCm39) F194S probably damaging Het
Heatr4 A T 12: 84,024,707 (GRCm39) probably null Het
Kcnd2 G A 6: 21,216,695 (GRCm39) C133Y probably damaging Het
Kcnq1 A T 7: 142,979,711 (GRCm39) Q619L probably benign Het
Kctd12 T A 14: 103,218,901 (GRCm39) R326W probably damaging Het
Kel A G 6: 41,666,472 (GRCm39) probably null Het
Lipk A T 19: 34,024,197 (GRCm39) I332F probably benign Het
Lrrc37 T A 11: 103,506,947 (GRCm39) probably benign Het
Masp2 A G 4: 148,696,516 (GRCm39) D371G possibly damaging Het
Met A G 6: 17,571,809 (GRCm39) E1376G probably benign Het
Mup5 A T 4: 61,752,015 (GRCm39) I78K probably benign Het
Mynn A T 3: 30,670,790 (GRCm39) D526V probably damaging Het
Neurod1 G T 2: 79,284,696 (GRCm39) P229Q probably damaging Het
Npepps T G 11: 97,139,085 (GRCm39) R162S probably damaging Het
Ntrk3 T A 7: 78,112,631 (GRCm39) Q175L probably damaging Het
Obsl1 T C 1: 75,480,032 (GRCm39) T310A probably damaging Het
Or4g7 A T 2: 111,309,425 (GRCm39) T99S probably benign Het
Or8c9 A T 9: 38,241,410 (GRCm39) I176F possibly damaging Het
Or8j3c A T 2: 86,253,975 (GRCm39) M15K probably benign Het
Or8k32 A G 2: 86,368,731 (GRCm39) I176T probably damaging Het
Pigf G A 17: 87,304,964 (GRCm39) T193I possibly damaging Het
Pkp4 T C 2: 59,172,525 (GRCm39) V904A possibly damaging Het
Plekha6 C T 1: 133,197,778 (GRCm39) T141M probably damaging Het
Rapgef6 G A 11: 54,582,308 (GRCm39) D1407N probably benign Het
Rhobtb3 T C 13: 76,087,741 (GRCm39) D82G probably damaging Het
Rims1 T C 1: 22,498,731 (GRCm39) N767S possibly damaging Het
Ripor2 T A 13: 24,849,451 (GRCm39) probably benign Het
Sec14l4 T A 11: 3,993,948 (GRCm39) I296N probably damaging Het
Serpinb12 G T 1: 106,884,342 (GRCm39) V363F probably damaging Het
Serpinb9c A G 13: 33,334,016 (GRCm39) I342T probably damaging Het
Shmt2 A G 10: 127,355,945 (GRCm39) V133A probably damaging Het
Slc30a6 A G 17: 74,722,661 (GRCm39) M243V probably benign Het
Slfn2 T A 11: 82,960,487 (GRCm39) N155K probably damaging Het
Spata31h1 A T 10: 82,152,298 (GRCm39) L23M possibly damaging Het
Syne2 A T 12: 75,900,898 (GRCm39) D19V possibly damaging Het
Tcl1b3 A T 12: 105,160,736 (GRCm39) I116L probably benign Het
Tcp11 A G 17: 28,286,766 (GRCm39) I411T probably damaging Het
Tctn1 C T 5: 122,379,859 (GRCm39) A560T probably benign Het
Tenm3 C A 8: 48,682,216 (GRCm39) Q2471H probably damaging Het
Tnr A G 1: 159,713,645 (GRCm39) D691G probably benign Het
Ube3b C T 5: 114,528,451 (GRCm39) P150S probably damaging Het
Ugt2b5 T C 5: 87,287,518 (GRCm39) I216M possibly damaging Het
Unc5d T A 8: 29,156,877 (GRCm39) R789S probably damaging Het
Ush2a G A 1: 188,147,875 (GRCm39) G934D probably damaging Het
Usp6nl A T 2: 6,399,352 (GRCm39) R70S probably damaging Het
Vmn1r181 T C 7: 23,684,309 (GRCm39) I258T possibly damaging Het
Vmn2r15 C A 5: 109,445,302 (GRCm39) D41Y probably damaging Het
Vmn2r17 T A 5: 109,600,691 (GRCm39) I663N probably damaging Het
Vnn3 C A 10: 23,741,780 (GRCm39) Q362K possibly damaging Het
Wdr72 A G 9: 74,059,730 (GRCm39) D380G possibly damaging Het
Wfdc10 G A 2: 164,499,180 (GRCm39) E97K possibly damaging Het
Xdh A T 17: 74,206,007 (GRCm39) C1002* probably null Het
Zscan4e A C 7: 11,041,578 (GRCm39) V126G probably damaging Het
Other mutations in Naip6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00677:Naip6 APN 13 100,452,525 (GRCm39) missense probably benign 0.03
IGL01123:Naip6 APN 13 100,440,946 (GRCm39) missense probably benign 0.02
IGL01151:Naip6 APN 13 100,435,601 (GRCm39) missense probably benign 0.00
IGL01382:Naip6 APN 13 100,436,364 (GRCm39) missense possibly damaging 0.95
IGL01415:Naip6 APN 13 100,439,798 (GRCm39) missense probably benign 0.17
IGL01654:Naip6 APN 13 100,435,853 (GRCm39) missense probably benign 0.00
IGL01662:Naip6 APN 13 100,436,862 (GRCm39) missense probably damaging 1.00
IGL01726:Naip6 APN 13 100,439,760 (GRCm39) missense probably benign 0.02
IGL01810:Naip6 APN 13 100,424,603 (GRCm39) splice site probably benign
IGL01867:Naip6 APN 13 100,436,820 (GRCm39) missense probably benign 0.40
IGL01926:Naip6 APN 13 100,436,704 (GRCm39) missense probably damaging 1.00
IGL01964:Naip6 APN 13 100,435,238 (GRCm39) splice site probably benign
IGL02145:Naip6 APN 13 100,433,486 (GRCm39) missense possibly damaging 0.77
IGL02160:Naip6 APN 13 100,435,933 (GRCm39) missense probably benign 0.01
IGL02214:Naip6 APN 13 100,452,567 (GRCm39) missense probably damaging 1.00
IGL02342:Naip6 APN 13 100,439,748 (GRCm39) missense possibly damaging 0.69
IGL02568:Naip6 APN 13 100,452,780 (GRCm39) missense probably damaging 1.00
IGL02573:Naip6 APN 13 100,435,979 (GRCm39) nonsense probably null
IGL02680:Naip6 APN 13 100,420,256 (GRCm39) missense probably benign
IGL02829:Naip6 APN 13 100,437,273 (GRCm39) missense probably benign 0.11
IGL02833:Naip6 APN 13 100,436,121 (GRCm39) missense probably damaging 1.00
IGL02851:Naip6 APN 13 100,437,168 (GRCm39) missense probably benign 0.01
IGL02860:Naip6 APN 13 100,436,984 (GRCm39) missense possibly damaging 0.95
IGL02886:Naip6 APN 13 100,436,984 (GRCm39) missense possibly damaging 0.95
IGL03155:Naip6 APN 13 100,452,932 (GRCm39) missense possibly damaging 0.62
R0032:Naip6 UTSW 13 100,439,745 (GRCm39) missense probably benign 0.00
R0310:Naip6 UTSW 13 100,444,721 (GRCm39) missense possibly damaging 0.72
R0437:Naip6 UTSW 13 100,433,432 (GRCm39) missense possibly damaging 0.75
R0472:Naip6 UTSW 13 100,438,768 (GRCm39) missense probably benign 0.02
R0560:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R0638:Naip6 UTSW 13 100,437,036 (GRCm39) missense probably benign 0.00
R0792:Naip6 UTSW 13 100,420,274 (GRCm39) missense possibly damaging 0.78
R0963:Naip6 UTSW 13 100,452,983 (GRCm39) missense probably benign 0.11
R1102:Naip6 UTSW 13 100,440,923 (GRCm39) missense possibly damaging 0.62
R1278:Naip6 UTSW 13 100,436,870 (GRCm39) missense probably damaging 1.00
R1462:Naip6 UTSW 13 100,436,748 (GRCm39) missense possibly damaging 0.64
R1462:Naip6 UTSW 13 100,436,748 (GRCm39) missense possibly damaging 0.64
R1544:Naip6 UTSW 13 100,452,983 (GRCm39) missense probably benign
R1595:Naip6 UTSW 13 100,435,602 (GRCm39) missense probably damaging 0.96
R1749:Naip6 UTSW 13 100,444,763 (GRCm39) missense probably benign 0.03
R1838:Naip6 UTSW 13 100,452,644 (GRCm39) missense probably damaging 0.99
R1863:Naip6 UTSW 13 100,437,067 (GRCm39) missense probably benign 0.03
R1914:Naip6 UTSW 13 100,435,936 (GRCm39) missense probably benign 0.13
R2001:Naip6 UTSW 13 100,437,237 (GRCm39) missense probably benign 0.44
R2082:Naip6 UTSW 13 100,440,852 (GRCm39) splice site probably null
R2143:Naip6 UTSW 13 100,436,367 (GRCm39) missense probably damaging 1.00
R2174:Naip6 UTSW 13 100,435,495 (GRCm39) missense probably benign
R2266:Naip6 UTSW 13 100,420,067 (GRCm39) missense possibly damaging 0.46
R2284:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2285:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2286:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2351:Naip6 UTSW 13 100,420,169 (GRCm39) missense probably damaging 1.00
R2363:Naip6 UTSW 13 100,452,928 (GRCm39) missense possibly damaging 0.90
R2445:Naip6 UTSW 13 100,437,176 (GRCm39) missense probably damaging 0.99
R2971:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2975:Naip6 UTSW 13 100,424,695 (GRCm39) missense probably damaging 1.00
R3081:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
R3082:Naip6 UTSW 13 100,452,925 (GRCm39) missense probably benign 0.00
R3122:Naip6 UTSW 13 100,453,031 (GRCm39) missense probably benign 0.00
R3417:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R3943:Naip6 UTSW 13 100,431,247 (GRCm39) missense probably benign 0.01
R3944:Naip6 UTSW 13 100,431,247 (GRCm39) missense probably benign 0.01
R4080:Naip6 UTSW 13 100,435,815 (GRCm39) missense probably damaging 1.00
R4166:Naip6 UTSW 13 100,452,657 (GRCm39) missense probably benign 0.23
R4396:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4397:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4418:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4512:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4670:Naip6 UTSW 13 100,431,239 (GRCm39) critical splice donor site probably null
R4671:Naip6 UTSW 13 100,431,239 (GRCm39) critical splice donor site probably null
R4722:Naip6 UTSW 13 100,443,580 (GRCm39) missense possibly damaging 0.72
R4811:Naip6 UTSW 13 100,422,299 (GRCm39) missense probably damaging 1.00
R4900:Naip6 UTSW 13 100,433,477 (GRCm39) missense probably damaging 0.99
R5162:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R5316:Naip6 UTSW 13 100,420,290 (GRCm39) missense probably benign 0.00
R5403:Naip6 UTSW 13 100,436,585 (GRCm39) missense probably benign 0.12
R5437:Naip6 UTSW 13 100,439,812 (GRCm39) nonsense probably null
R5507:Naip6 UTSW 13 100,435,423 (GRCm39) missense probably benign 0.01
R5631:Naip6 UTSW 13 100,436,646 (GRCm39) missense probably benign 0.02
R5657:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R5684:Naip6 UTSW 13 100,436,888 (GRCm39) missense probably damaging 1.00
R5786:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5787:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5788:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5878:Naip6 UTSW 13 100,436,181 (GRCm39) missense probably damaging 1.00
R5895:Naip6 UTSW 13 100,452,500 (GRCm39) missense possibly damaging 0.90
R5898:Naip6 UTSW 13 100,435,829 (GRCm39) missense possibly damaging 0.93
R6113:Naip6 UTSW 13 100,435,794 (GRCm39) missense possibly damaging 0.96
R6141:Naip6 UTSW 13 100,444,741 (GRCm39) missense possibly damaging 0.91
R6199:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R6321:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6402:Naip6 UTSW 13 100,437,226 (GRCm39) missense probably benign 0.30
R6435:Naip6 UTSW 13 100,431,249 (GRCm39) missense probably benign 0.04
R6477:Naip6 UTSW 13 100,452,516 (GRCm39) missense probably damaging 1.00
R6601:Naip6 UTSW 13 100,420,266 (GRCm39) missense probably benign
R6638:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6639:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6804:Naip6 UTSW 13 100,435,675 (GRCm39) missense probably benign
R6922:Naip6 UTSW 13 100,438,706 (GRCm39) missense possibly damaging 0.88
R6975:Naip6 UTSW 13 100,452,773 (GRCm39) missense probably damaging 1.00
R7050:Naip6 UTSW 13 100,452,007 (GRCm39) missense probably damaging 1.00
R7135:Naip6 UTSW 13 100,436,927 (GRCm39) missense probably damaging 1.00
R7140:Naip6 UTSW 13 100,436,708 (GRCm39) missense possibly damaging 0.95
R7182:Naip6 UTSW 13 100,452,657 (GRCm39) missense probably benign 0.23
R7196:Naip6 UTSW 13 100,436,666 (GRCm39) missense probably benign 0.10
R7234:Naip6 UTSW 13 100,452,011 (GRCm39) nonsense probably null
R7259:Naip6 UTSW 13 100,440,863 (GRCm39) missense probably damaging 1.00
R7322:Naip6 UTSW 13 100,435,896 (GRCm39) missense possibly damaging 0.94
R7332:Naip6 UTSW 13 100,437,209 (GRCm39) missense possibly damaging 0.62
R7339:Naip6 UTSW 13 100,452,527 (GRCm39) missense probably damaging 1.00
R7353:Naip6 UTSW 13 100,436,259 (GRCm39) missense probably benign 0.00
R7485:Naip6 UTSW 13 100,420,359 (GRCm39) missense probably benign 0.07
R7597:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R7835:Naip6 UTSW 13 100,452,512 (GRCm39) missense probably benign 0.19
R7840:Naip6 UTSW 13 100,451,979 (GRCm39) missense probably damaging 1.00
R8082:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
R8082:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R8103:Naip6 UTSW 13 100,437,851 (GRCm39) missense probably benign 0.00
R8164:Naip6 UTSW 13 100,452,797 (GRCm39) missense probably benign 0.00
R8206:Naip6 UTSW 13 100,431,344 (GRCm39) nonsense probably null
R8258:Naip6 UTSW 13 100,452,920 (GRCm39) missense probably benign 0.02
R8259:Naip6 UTSW 13 100,452,920 (GRCm39) missense probably benign 0.02
R8348:Naip6 UTSW 13 100,436,894 (GRCm39) missense possibly damaging 0.61
R8405:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8406:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8441:Naip6 UTSW 13 100,422,265 (GRCm39) missense possibly damaging 0.77
R8448:Naip6 UTSW 13 100,436,894 (GRCm39) missense possibly damaging 0.61
R8501:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8502:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8687:Naip6 UTSW 13 100,435,636 (GRCm39) missense probably benign 0.10
R8806:Naip6 UTSW 13 100,437,161 (GRCm39) missense possibly damaging 0.93
R9186:Naip6 UTSW 13 100,436,390 (GRCm39) missense possibly damaging 0.89
R9340:Naip6 UTSW 13 100,452,494 (GRCm39) missense probably damaging 1.00
R9352:Naip6 UTSW 13 100,437,893 (GRCm39) missense possibly damaging 0.85
R9585:Naip6 UTSW 13 100,436,577 (GRCm39) missense probably damaging 0.96
R9597:Naip6 UTSW 13 100,436,646 (GRCm39) missense probably benign 0.02
R9601:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
X0066:Naip6 UTSW 13 100,451,970 (GRCm39) nonsense probably null
Z1177:Naip6 UTSW 13 100,437,308 (GRCm39) missense probably damaging 1.00
Z1177:Naip6 UTSW 13 100,435,925 (GRCm39) missense probably benign 0.20
Z1177:Naip6 UTSW 13 100,452,638 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCAAGAAAGGGTGATGTTCCC -3'
(R):5'- AGGATGTCTGAGGAGTTTCATC -3'

Sequencing Primer
(F):5'- AAAGGGTGATGTTCCCACAGTTC -3'
(R):5'- AGCACCTTGAGAACTTGCACTTG -3'
Posted On 2021-01-18