Incidental Mutation 'R8468:Zfp937'
ID 656904
Institutional Source Beutler Lab
Gene Symbol Zfp937
Ensembl Gene ENSMUSG00000060336
Gene Name zinc finger protein 937
Synonyms Gm4979
MMRRC Submission 067912-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R8468 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 150059993-150082645 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 150080634 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 221 (D221E)
Ref Sequence ENSEMBL: ENSMUSP00000073454 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073782]
AlphaFold A2ANU7
Predicted Effect probably benign
Transcript: ENSMUST00000073782
AA Change: D221E

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000073454
Gene: ENSMUSG00000060336
AA Change: D221E

DomainStartEndE-ValueType
KRAB 4 66 8.19e-20 SMART
ZnF_C2H2 103 125 1.28e-3 SMART
ZnF_C2H2 131 153 2.53e-2 SMART
ZnF_C2H2 159 181 9.58e-3 SMART
ZnF_C2H2 187 209 2.09e-3 SMART
ZnF_C2H2 215 237 2.2e-2 SMART
ZnF_C2H2 243 265 2.2e-2 SMART
ZnF_C2H2 271 293 2.2e-2 SMART
ZnF_C2H2 299 321 1.82e-3 SMART
ZnF_C2H2 327 349 3.69e-4 SMART
ZnF_C2H2 355 377 4.47e-3 SMART
ZnF_C2H2 383 405 3.89e-3 SMART
ZnF_C2H2 411 433 4.79e-3 SMART
ZnF_C2H2 439 461 8.47e-4 SMART
ZnF_C2H2 467 490 7.26e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (36/36)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts1 A G 16: 85,592,444 (GRCm39) W655R possibly damaging Het
Adamts3 C T 5: 89,842,627 (GRCm39) A748T probably benign Het
Ano1 A C 7: 144,209,357 (GRCm39) F248C probably damaging Het
Ap2b1 T A 11: 83,241,891 (GRCm39) L628Q probably damaging Het
BC035947 C A 1: 78,474,967 (GRCm39) A522S probably damaging Het
Bdp1 A G 13: 100,197,076 (GRCm39) V1103A probably benign Het
Cd248 T A 19: 5,119,910 (GRCm39) I586N possibly damaging Het
Dnah9 C A 11: 65,722,556 (GRCm39) M4428I probably benign Het
Epha5 T C 5: 84,290,275 (GRCm39) probably null Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fastkd2 T A 1: 63,770,923 (GRCm39) L93Q probably benign Het
Gm6665 T C 18: 31,953,453 (GRCm39) D5G possibly damaging Het
Gphn T C 12: 78,273,601 (GRCm39) V17A probably benign Het
Gpr85 A T 6: 13,836,295 (GRCm39) L203H probably damaging Het
Grk6 A G 13: 55,599,198 (GRCm39) Y166C probably damaging Het
Ints3 A G 3: 90,313,560 (GRCm39) V356A probably damaging Het
Krt33b G A 11: 99,920,615 (GRCm39) R13C probably damaging Het
Lgals3 A G 14: 47,619,104 (GRCm39) I146V possibly damaging Het
Lrp1 G A 10: 127,394,519 (GRCm39) R2565C probably damaging Het
Miip G T 4: 147,945,928 (GRCm39) D325E probably damaging Het
Naaladl1 T A 19: 6,158,615 (GRCm39) V249E probably damaging Het
Nfxl1 C T 5: 72,675,548 (GRCm39) R811K possibly damaging Het
Or12e10 T C 2: 87,641,082 (GRCm39) I306T possibly damaging Het
Or2ag2b A G 7: 106,418,046 (GRCm39) Y252C possibly damaging Het
Or52e7 A T 7: 104,684,953 (GRCm39) I183F probably damaging Het
Or56a3b A G 7: 104,770,685 (GRCm39) D7G probably benign Het
Or5ak24 T A 2: 85,260,522 (GRCm39) Y217F probably damaging Het
Or6c69c C T 10: 129,910,303 (GRCm39) T8I probably benign Het
Pkd2l2 A G 18: 34,560,464 (GRCm39) D357G possibly damaging Het
Ppp1r36 A G 12: 76,482,979 (GRCm39) Y189C probably damaging Het
Rev3l A G 10: 39,703,987 (GRCm39) E2011G probably damaging Het
Sestd1 T A 2: 77,022,090 (GRCm39) T534S probably benign Het
Sfmbt1 G A 14: 30,495,941 (GRCm39) A75T probably benign Het
Smarcc2 G A 10: 128,320,262 (GRCm39) R882H probably benign Het
Son CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC 16: 91,453,579 (GRCm39) probably benign Het
Speg C T 1: 75,407,953 (GRCm39) A3216V probably damaging Het
Vmn1r12 A G 6: 57,136,370 (GRCm39) T112A probably benign Het
Other mutations in Zfp937
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0350:Zfp937 UTSW 2 150,081,222 (GRCm39) missense possibly damaging 0.91
R0449:Zfp937 UTSW 2 150,081,466 (GRCm39) missense probably benign 0.13
R1403:Zfp937 UTSW 2 150,080,868 (GRCm39) nonsense probably null
R1403:Zfp937 UTSW 2 150,080,868 (GRCm39) nonsense probably null
R1465:Zfp937 UTSW 2 150,080,967 (GRCm39) nonsense probably null
R1465:Zfp937 UTSW 2 150,080,967 (GRCm39) nonsense probably null
R4510:Zfp937 UTSW 2 150,080,431 (GRCm39) missense probably damaging 0.98
R4511:Zfp937 UTSW 2 150,080,431 (GRCm39) missense probably damaging 0.98
R4689:Zfp937 UTSW 2 150,078,706 (GRCm39) missense probably damaging 1.00
R5290:Zfp937 UTSW 2 150,080,229 (GRCm39) nonsense probably null
R6287:Zfp937 UTSW 2 150,080,261 (GRCm39) missense possibly damaging 0.89
R6701:Zfp937 UTSW 2 150,081,136 (GRCm39) missense probably damaging 1.00
R6746:Zfp937 UTSW 2 150,081,343 (GRCm39) nonsense probably null
R6838:Zfp937 UTSW 2 150,081,266 (GRCm39) missense probably benign 0.01
R7162:Zfp937 UTSW 2 150,081,439 (GRCm39) missense probably benign 0.35
R7213:Zfp937 UTSW 2 150,081,385 (GRCm39) missense probably damaging 1.00
R7441:Zfp937 UTSW 2 150,080,630 (GRCm39) frame shift probably null
R7481:Zfp937 UTSW 2 150,081,266 (GRCm39) missense probably benign 0.01
R7694:Zfp937 UTSW 2 150,081,268 (GRCm39) missense probably damaging 1.00
R7856:Zfp937 UTSW 2 150,081,467 (GRCm39) missense probably benign 0.23
R7902:Zfp937 UTSW 2 150,080,681 (GRCm39) missense probably damaging 1.00
R7956:Zfp937 UTSW 2 150,081,076 (GRCm39) missense probably benign 0.03
R8058:Zfp937 UTSW 2 150,081,421 (GRCm39) missense probably benign 0.00
R9514:Zfp937 UTSW 2 150,080,890 (GRCm39) missense possibly damaging 0.95
R9617:Zfp937 UTSW 2 150,080,452 (GRCm39) missense probably damaging 1.00
X0017:Zfp937 UTSW 2 150,060,081 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- GAGTGGTCTCCAACAGCATAAAAG -3'
(R):5'- TGCAGACCACTTTGAAACCCAA -3'

Sequencing Primer
(F):5'- CTGTCATCTTCGAGGGCATCAAAG -3'
(R):5'- GTGCAAATGCCTTATCACACTGG -3'
Posted On 2021-01-18