Incidental Mutation 'R8470:Olfr1181'
ID 656979
Institutional Source Beutler Lab
Gene Symbol Olfr1181
Ensembl Gene ENSMUSG00000075125
Gene Name olfactory receptor 1181
Synonyms MOR225-9P, GA_x6K02T2Q125-49911636-49910701
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R8470 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88420321-88426171 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 88423884 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 47 (I47N)
Ref Sequence ENSEMBL: ENSMUSP00000150939 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099823] [ENSMUST00000102619] [ENSMUST00000213190] [ENSMUST00000216121] [ENSMUST00000217320]
AlphaFold Q7TR18
Predicted Effect probably damaging
Transcript: ENSMUST00000099823
AA Change: I47N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097411
Gene: ENSMUSG00000075125
AA Change: I47N

DomainStartEndE-ValueType
Pfam:7tm_4 28 303 1.5e-48 PFAM
Pfam:7tm_1 39 285 6.9e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000102619
AA Change: I47N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000099679
Gene: ENSMUSG00000075125
AA Change: I47N

DomainStartEndE-ValueType
low complexity region 24 34 N/A INTRINSIC
Pfam:7tm_1 39 285 7.2e-26 PFAM
Pfam:7tm_4 137 278 3.5e-39 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213190
AA Change: I47N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably benign
Transcript: ENSMUST00000216121
Predicted Effect probably benign
Transcript: ENSMUST00000217320
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932415D10Rik A C 10: 82,290,480 F2232C probably damaging Het
Abraxas2 A T 7: 132,874,956 I142F probably damaging Het
Adamts16 A G 13: 70,836,377 Y56H probably damaging Het
Alms1 A G 6: 85,641,375 D2801G probably damaging Het
Anpep A G 7: 79,839,521 I301T probably benign Het
Atxn7l2 G A 3: 108,206,969 T159M probably benign Het
B130006D01Rik C T 11: 95,726,349 probably benign Het
Ccdc175 T C 12: 72,155,618 K301R probably damaging Het
Cecr2 A T 6: 120,756,933 Q627L probably benign Het
Cerkl C A 2: 79,342,407 M307I probably benign Het
Eif2ak4 A G 2: 118,462,726 I1254M probably damaging Het
Epha3 T C 16: 63,844,147 T37A probably benign Het
Fancm T C 12: 65,125,157 V1857A probably damaging Het
Gm20075 C A 13: 96,080,924 D136Y possibly damaging Het
Gm3486 T C 14: 41,484,581 probably null Het
Il1r2 T C 1: 40,123,256 V353A probably damaging Het
Irgq A T 7: 24,534,290 R519W probably damaging Het
Map1b T A 13: 99,516,442 S16C probably damaging Het
Myo9a T G 9: 59,832,290 C762G probably damaging Het
Nup107 A T 10: 117,770,469 V454E probably damaging Het
Olfr1564 A G 17: 33,215,894 V150A probably benign Het
Olfr855 T G 9: 19,584,969 L144R probably damaging Het
Pcdha11 A G 18: 37,012,884 K676R probably benign Het
Pknox2 C T 9: 36,923,690 R161H probably damaging Het
Prr5l T C 2: 101,717,085 N365S probably benign Het
Prrg4 A G 2: 104,849,156 L8P probably damaging Het
Rasgrp2 T A 19: 6,403,565 probably null Het
Rtp4 A T 16: 23,610,077 H30L probably benign Het
Rxfp2 T G 5: 150,070,369 I632S possibly damaging Het
Sptbn1 C A 11: 30,120,758 E1533D possibly damaging Het
Ssbp1 A G 6: 40,478,007 I133M probably damaging Het
Stap1 A G 5: 86,094,743 I188V possibly damaging Het
Topaz1 T C 9: 122,774,108 M1040T probably benign Het
Trpm3 T C 19: 22,910,137 F877L possibly damaging Het
Ush1c A G 7: 46,209,250 L538P probably damaging Het
Zfp518a G A 19: 40,915,718 A1364T probably benign Het
Other mutations in Olfr1181
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00324:Olfr1181 APN 2 88423786 missense probably benign 0.30
IGL02224:Olfr1181 APN 2 88423708 splice site probably null
IGL03293:Olfr1181 APN 2 88423227 missense probably damaging 1.00
IGL02802:Olfr1181 UTSW 2 88423488 missense probably benign 0.23
R2214:Olfr1181 UTSW 2 88423117 missense probably benign 0.00
R2508:Olfr1181 UTSW 2 88423456 missense possibly damaging 0.95
R4050:Olfr1181 UTSW 2 88423623 missense probably damaging 0.99
R5404:Olfr1181 UTSW 2 88423801 missense probably damaging 0.98
R5727:Olfr1181 UTSW 2 88423447 missense probably benign 0.00
R6578:Olfr1181 UTSW 2 88423144 missense probably benign 0.12
R6663:Olfr1181 UTSW 2 88423350 missense probably benign 0.25
R6974:Olfr1181 UTSW 2 88423812 missense possibly damaging 0.93
R7042:Olfr1181 UTSW 2 88423402 missense possibly damaging 0.89
R7659:Olfr1181 UTSW 2 88423926 missense probably damaging 1.00
R8443:Olfr1181 UTSW 2 88423401 missense probably benign
R9479:Olfr1181 UTSW 2 88423333 missense probably damaging 0.99
R9546:Olfr1181 UTSW 2 88423705 missense probably benign
R9706:Olfr1181 UTSW 2 88423435 missense probably benign
R9735:Olfr1181 UTSW 2 88423157 missense probably damaging 1.00
X0018:Olfr1181 UTSW 2 88423662 missense probably benign
Z1177:Olfr1181 UTSW 2 88423815 missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- GAAGTGCATGGCAAAGACCTGTA -3'
(R):5'- TGCTTACATAGTTGTGATTACATTGA -3'

Sequencing Primer
(F):5'- CAAAGACCTGTAGCATGCAGTTTG -3'
(R):5'- GGCTATCTTCCAAGCAGA -3'
Posted On 2021-01-18