Incidental Mutation 'R8470:Or10h5'
ID 657009
Institutional Source Beutler Lab
Gene Symbol Or10h5
Ensembl Gene ENSMUSG00000096169
Gene Name olfactory receptor family 10 subfamily H member 5
Synonyms Olfr1564, Gm4461
MMRRC Submission 067914-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.156) question?
Stock # R8470 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 33434235-33435325 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 33434868 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 150 (V150A)
Ref Sequence ENSEMBL: ENSMUSP00000150573 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112162] [ENSMUST00000208645] [ENSMUST00000213642] [ENSMUST00000213751] [ENSMUST00000215450]
AlphaFold K7N6V7
Predicted Effect probably benign
Transcript: ENSMUST00000112162
AA Change: V153A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000127247
Gene: ENSMUSG00000096169
AA Change: V153A

DomainStartEndE-ValueType
Pfam:7tm_4 34 312 3.3e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 263 1.5e-5 PFAM
Pfam:7tm_1 44 297 5e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208645
AA Change: V150A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000213642
AA Change: V150A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000213751
AA Change: V150A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000215450
AA Change: V150A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abraxas2 A T 7: 132,476,685 (GRCm39) I142F probably damaging Het
Adamts16 A G 13: 70,984,496 (GRCm39) Y56H probably damaging Het
Alms1 A G 6: 85,618,357 (GRCm39) D2801G probably damaging Het
Anpep A G 7: 79,489,269 (GRCm39) I301T probably benign Het
Atxn7l2 G A 3: 108,114,285 (GRCm39) T159M probably benign Het
B130006D01Rik C T 11: 95,617,175 (GRCm39) probably benign Het
Btf3l4b C A 13: 96,217,432 (GRCm39) D136Y possibly damaging Het
Ccdc175 T C 12: 72,202,392 (GRCm39) K301R probably damaging Het
Cecr2 A T 6: 120,733,894 (GRCm39) Q627L probably benign Het
Cerkl C A 2: 79,172,751 (GRCm39) M307I probably benign Het
Eif2ak4 A G 2: 118,293,207 (GRCm39) I1254M probably damaging Het
Epha3 T C 16: 63,664,510 (GRCm39) T37A probably benign Het
Fancm T C 12: 65,171,931 (GRCm39) V1857A probably damaging Het
Gm3486 T C 14: 41,206,538 (GRCm39) probably null Het
Il1r2 T C 1: 40,162,416 (GRCm39) V353A probably damaging Het
Irgq A T 7: 24,233,715 (GRCm39) R519W probably damaging Het
Map1b T A 13: 99,652,950 (GRCm39) S16C probably damaging Het
Myo9a T G 9: 59,739,573 (GRCm39) C762G probably damaging Het
Nup107 A T 10: 117,606,374 (GRCm39) V454E probably damaging Het
Or4p20 A T 2: 88,254,228 (GRCm39) I47N probably damaging Het
Or7g35 T G 9: 19,496,265 (GRCm39) L144R probably damaging Het
Pcdha11 A G 18: 37,145,937 (GRCm39) K676R probably benign Het
Pknox2 C T 9: 36,834,986 (GRCm39) R161H probably damaging Het
Prr5l T C 2: 101,547,430 (GRCm39) N365S probably benign Het
Prrg4 A G 2: 104,679,501 (GRCm39) L8P probably damaging Het
Rasgrp2 T A 19: 6,453,595 (GRCm39) probably null Het
Rtp4 A T 16: 23,428,827 (GRCm39) H30L probably benign Het
Rxfp2 T G 5: 149,993,834 (GRCm39) I632S possibly damaging Het
Spata31h1 A C 10: 82,126,314 (GRCm39) F2232C probably damaging Het
Sptbn1 C A 11: 30,070,758 (GRCm39) E1533D possibly damaging Het
Ssbp1 A G 6: 40,454,941 (GRCm39) I133M probably damaging Het
Stap1 A G 5: 86,242,602 (GRCm39) I188V possibly damaging Het
Topaz1 T C 9: 122,603,173 (GRCm39) M1040T probably benign Het
Trpm3 T C 19: 22,887,501 (GRCm39) F877L possibly damaging Het
Ush1c A G 7: 45,858,674 (GRCm39) L538P probably damaging Het
Zfp518a G A 19: 40,904,162 (GRCm39) A1364T probably benign Het
Other mutations in Or10h5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00965:Or10h5 APN 17 33,434,947 (GRCm39) missense probably benign 0.41
R0079:Or10h5 UTSW 17 33,435,079 (GRCm39) missense probably benign 0.14
R0939:Or10h5 UTSW 17 33,434,635 (GRCm39) missense possibly damaging 0.72
R1279:Or10h5 UTSW 17 33,435,300 (GRCm39) missense possibly damaging 0.59
R2167:Or10h5 UTSW 17 33,434,542 (GRCm39) missense probably damaging 0.97
R2866:Or10h5 UTSW 17 33,435,252 (GRCm39) missense probably benign 0.22
R4738:Or10h5 UTSW 17 33,434,784 (GRCm39) missense probably benign 0.03
R4976:Or10h5 UTSW 17 33,434,728 (GRCm39) missense probably benign 0.35
R6452:Or10h5 UTSW 17 33,434,919 (GRCm39) missense probably benign 0.03
R6721:Or10h5 UTSW 17 33,434,508 (GRCm39) missense probably benign
R7322:Or10h5 UTSW 17 33,434,673 (GRCm39) missense probably damaging 1.00
R8032:Or10h5 UTSW 17 33,434,924 (GRCm39) missense possibly damaging 0.85
R9560:Or10h5 UTSW 17 33,434,986 (GRCm39) missense probably damaging 1.00
R9562:Or10h5 UTSW 17 33,434,415 (GRCm39) missense probably benign 0.06
R9753:Or10h5 UTSW 17 33,434,688 (GRCm39) missense possibly damaging 0.60
Predicted Primers PCR Primer
(F):5'- GACCCTCAGCTGATGGTATCTTC -3'
(R):5'- ATGTTGGCTGACCTGCTCTC -3'

Sequencing Primer
(F):5'- CCTCAGCTGATGGTATCTTCAAGATG -3'
(R):5'- GGCTGACCTGCTCTCCACAC -3'
Posted On 2021-01-18