Incidental Mutation 'R8473:Vmn1r59'
| ID |
657119 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r59
|
| Ensembl Gene |
ENSMUSG00000074401 |
| Gene Name |
vomeronasal 1 receptor 59 |
| Synonyms |
V1rd10 |
| MMRRC Submission |
067917-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.056)
|
| Stock # |
R8473 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
5456826-5457758 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 5457064 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 232
(M232K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073768
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074132]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000074132
AA Change: M232K
PolyPhen 2
Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000073768
Gene: ENSMUSG00000074401
AA Change: M232K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
289 |
2e-14 |
PFAM |
|
Pfam:7tm_1
|
20 |
279 |
1.9e-6 |
PFAM |
|
Pfam:V1R
|
31 |
287 |
3e-16 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
100% (33/33) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930583I09Rik |
T |
C |
17: 65,141,513 (GRCm39) |
D30G |
unknown |
Het |
| Acad12 |
T |
C |
5: 121,745,538 (GRCm39) |
D251G |
probably damaging |
Het |
| Adamts15 |
T |
A |
9: 30,816,085 (GRCm39) |
T625S |
probably damaging |
Het |
| Atg13 |
A |
T |
2: 91,518,993 (GRCm39) |
L151M |
probably damaging |
Het |
| Atp5f1a |
T |
C |
18: 77,867,625 (GRCm39) |
F250L |
probably damaging |
Het |
| Blnk |
T |
C |
19: 40,940,854 (GRCm39) |
E183G |
possibly damaging |
Het |
| Csf3 |
T |
C |
11: 98,592,928 (GRCm39) |
L97P |
probably damaging |
Het |
| Derl2 |
A |
G |
11: 70,910,035 (GRCm39) |
Y10H |
probably damaging |
Het |
| Dgkb |
A |
G |
12: 38,234,939 (GRCm39) |
N435D |
probably damaging |
Het |
| Dpy19l2 |
C |
A |
9: 24,492,526 (GRCm39) |
V691L |
probably benign |
Het |
| Exoc5 |
T |
C |
14: 49,256,860 (GRCm39) |
S509G |
probably null |
Het |
| Fancg |
A |
G |
4: 43,004,963 (GRCm39) |
I410T |
probably damaging |
Het |
| Fsip2 |
G |
A |
2: 82,777,336 (GRCm39) |
G121D |
probably damaging |
Het |
| Gfm1 |
T |
C |
3: 67,361,051 (GRCm39) |
S458P |
possibly damaging |
Het |
| Gm6882 |
A |
T |
7: 21,161,440 (GRCm39) |
Y143N |
probably damaging |
Het |
| Grm5 |
T |
A |
7: 87,252,278 (GRCm39) |
M176K |
probably damaging |
Het |
| Herc6 |
T |
A |
6: 57,624,099 (GRCm39) |
V623D |
probably damaging |
Het |
| Hmcn1 |
G |
T |
1: 150,479,551 (GRCm39) |
P4638T |
possibly damaging |
Het |
| Il27ra |
A |
G |
8: 84,768,735 (GRCm39) |
Y62H |
probably benign |
Het |
| Kcnh8 |
A |
T |
17: 53,285,320 (GRCm39) |
S1097C |
probably benign |
Het |
| Kif19a |
T |
G |
11: 114,678,377 (GRCm39) |
S677A |
probably damaging |
Het |
| Lrrc37 |
T |
C |
11: 103,434,266 (GRCm39) |
T792A |
unknown |
Het |
| Or8d4 |
T |
C |
9: 40,038,506 (GRCm39) |
I250M |
probably benign |
Het |
| Pcdhgb7 |
T |
A |
18: 37,886,852 (GRCm39) |
V674D |
probably benign |
Het |
| Pik3r6 |
A |
G |
11: 68,417,207 (GRCm39) |
S50G |
probably benign |
Het |
| Ptpn12 |
T |
C |
5: 21,203,357 (GRCm39) |
T474A |
probably benign |
Het |
| Rbbp6 |
T |
C |
7: 122,600,421 (GRCm39) |
|
probably benign |
Het |
| Scaper |
T |
C |
9: 55,458,131 (GRCm39) |
Y880C |
probably damaging |
Het |
| Smc5 |
A |
T |
19: 23,221,446 (GRCm39) |
V361D |
probably benign |
Het |
| Stag1 |
T |
A |
9: 100,762,840 (GRCm39) |
H480Q |
probably damaging |
Het |
| Tdpoz2 |
T |
C |
3: 93,559,153 (GRCm39) |
E273G |
probably damaging |
Het |
| Tdpoz3 |
T |
A |
3: 93,733,870 (GRCm39) |
W182R |
possibly damaging |
Het |
| Tmx4 |
T |
C |
2: 134,451,444 (GRCm39) |
T170A |
probably benign |
Het |
| Wdr20rt |
A |
G |
12: 65,273,380 (GRCm39) |
D180G |
probably damaging |
Het |
|
| Other mutations in Vmn1r59 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01684:Vmn1r59
|
APN |
7 |
5,457,299 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02035:Vmn1r59
|
APN |
7 |
5,457,208 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02039:Vmn1r59
|
APN |
7 |
5,457,380 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL02812:Vmn1r59
|
APN |
7 |
5,457,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0033:Vmn1r59
|
UTSW |
7 |
5,457,433 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0115:Vmn1r59
|
UTSW |
7 |
5,457,115 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1164:Vmn1r59
|
UTSW |
7 |
5,457,410 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1629:Vmn1r59
|
UTSW |
7 |
5,457,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1845:Vmn1r59
|
UTSW |
7 |
5,457,553 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1969:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1970:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1971:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2011:Vmn1r59
|
UTSW |
7 |
5,457,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3712:Vmn1r59
|
UTSW |
7 |
5,457,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4580:Vmn1r59
|
UTSW |
7 |
5,457,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4593:Vmn1r59
|
UTSW |
7 |
5,457,686 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4697:Vmn1r59
|
UTSW |
7 |
5,457,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4856:Vmn1r59
|
UTSW |
7 |
5,457,532 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4873:Vmn1r59
|
UTSW |
7 |
5,457,108 (GRCm39) |
missense |
probably benign |
|
|
R4875:Vmn1r59
|
UTSW |
7 |
5,457,108 (GRCm39) |
missense |
probably benign |
|
|
R4925:Vmn1r59
|
UTSW |
7 |
5,457,115 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5319:Vmn1r59
|
UTSW |
7 |
5,457,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6239:Vmn1r59
|
UTSW |
7 |
5,457,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6533:Vmn1r59
|
UTSW |
7 |
5,457,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6912:Vmn1r59
|
UTSW |
7 |
5,457,599 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7023:Vmn1r59
|
UTSW |
7 |
5,457,477 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7205:Vmn1r59
|
UTSW |
7 |
5,457,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7374:Vmn1r59
|
UTSW |
7 |
5,457,160 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7390:Vmn1r59
|
UTSW |
7 |
5,456,986 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7776:Vmn1r59
|
UTSW |
7 |
5,457,634 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8306:Vmn1r59
|
UTSW |
7 |
5,456,966 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8499:Vmn1r59
|
UTSW |
7 |
5,457,750 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8523:Vmn1r59
|
UTSW |
7 |
5,457,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8706:Vmn1r59
|
UTSW |
7 |
5,457,715 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9104:Vmn1r59
|
UTSW |
7 |
5,457,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGAGAACAATGACCCCTAGG -3'
(R):5'- GTCAGTGGTCCACAGAAAACAC -3'
Sequencing Primer
(F):5'- TGACCCCTAGGATCCCTAAATATC -3'
(R):5'- CCATCTCTGGGGTCAATGTAGAC -3'
|
| Posted On |
2021-01-18 |
Incidental Mutation