Incidental Mutation 'IGL00539:Sfpq'
ID |
6573 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Sfpq
|
Ensembl Gene |
ENSMUSG00000028820 |
Gene Name |
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) |
Synonyms |
1110004P21Rik, 5730453G22Rik, 9030402K04Rik, 2810416M14Rik, PSF, REP1, D4Ertd314e |
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
IGL00539
|
Quality Score |
|
Status
|
|
Chromosome |
4 |
Chromosomal Location |
126915117-126930806 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 126917481 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Alanine
at position 437
(V437A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000030623
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030623]
|
AlphaFold |
Q8VIJ6 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000030623
AA Change: V437A
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000030623 Gene: ENSMUSG00000028820 AA Change: V437A
Domain | Start | End | E-Value | Type |
low complexity region
|
2 |
33 |
N/A |
INTRINSIC |
low complexity region
|
48 |
101 |
N/A |
INTRINSIC |
low complexity region
|
105 |
236 |
N/A |
INTRINSIC |
low complexity region
|
238 |
258 |
N/A |
INTRINSIC |
RRM
|
290 |
357 |
3.97e-18 |
SMART |
RRM
|
364 |
440 |
3.83e-11 |
SMART |
low complexity region
|
526 |
544 |
N/A |
INTRINSIC |
low complexity region
|
554 |
587 |
N/A |
INTRINSIC |
low complexity region
|
595 |
614 |
N/A |
INTRINSIC |
low complexity region
|
617 |
639 |
N/A |
INTRINSIC |
low complexity region
|
660 |
680 |
N/A |
INTRINSIC |
low complexity region
|
682 |
692 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125453
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140682
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143168
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144630
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146285
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a gene trap allele die. Heterozygous mice show abnormality in entrainment of circadian rhythm. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 26 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ahnak |
C |
A |
19: 8,985,272 (GRCm39) |
D2185E |
possibly damaging |
Het |
Camk2b |
A |
G |
11: 5,922,310 (GRCm39) |
S560P |
probably damaging |
Het |
Cdh13 |
C |
A |
8: 120,039,245 (GRCm39) |
N562K |
possibly damaging |
Het |
Cdhr4 |
A |
G |
9: 107,876,744 (GRCm39) |
Y771C |
probably damaging |
Het |
Ermap |
A |
G |
4: 119,041,114 (GRCm39) |
S299P |
probably damaging |
Het |
Fgd3 |
A |
G |
13: 49,429,119 (GRCm39) |
|
probably benign |
Het |
Fpr-rs4 |
T |
A |
17: 18,242,188 (GRCm39) |
L65Q |
probably damaging |
Het |
Hsph1 |
C |
T |
5: 149,542,254 (GRCm39) |
R723H |
possibly damaging |
Het |
Iqcb1 |
A |
G |
16: 36,678,873 (GRCm39) |
K396E |
probably damaging |
Het |
Kif21a |
T |
C |
15: 90,821,504 (GRCm39) |
T1424A |
probably damaging |
Het |
Mpdz |
T |
C |
4: 81,279,588 (GRCm39) |
S700G |
possibly damaging |
Het |
Mta3 |
G |
A |
17: 84,070,412 (GRCm39) |
R39Q |
probably benign |
Het |
Muc4 |
A |
T |
16: 32,569,728 (GRCm39) |
T263S |
possibly damaging |
Het |
Ncan |
G |
A |
8: 70,567,921 (GRCm39) |
P64S |
probably benign |
Het |
Pisd |
T |
C |
5: 32,895,756 (GRCm39) |
I441V |
probably benign |
Het |
Pla2g4f |
T |
C |
2: 120,133,219 (GRCm39) |
H660R |
possibly damaging |
Het |
Polq |
A |
G |
16: 36,880,931 (GRCm39) |
T753A |
probably damaging |
Het |
Ptchd4 |
C |
T |
17: 42,627,817 (GRCm39) |
Q93* |
probably null |
Het |
Slc18b1 |
G |
A |
10: 23,700,659 (GRCm39) |
|
probably null |
Het |
Taf1c |
C |
T |
8: 120,328,067 (GRCm39) |
V277I |
possibly damaging |
Het |
Tcf20 |
T |
A |
15: 82,736,957 (GRCm39) |
Q1498L |
probably benign |
Het |
Tet1 |
C |
A |
10: 62,650,276 (GRCm39) |
C1644F |
probably damaging |
Het |
Trmt5 |
T |
C |
12: 73,331,693 (GRCm39) |
E121G |
possibly damaging |
Het |
Wapl |
A |
G |
14: 34,416,965 (GRCm39) |
D525G |
probably damaging |
Het |
Ylpm1 |
A |
G |
12: 85,075,728 (GRCm39) |
T360A |
possibly damaging |
Het |
Zfp292 |
G |
A |
4: 34,808,790 (GRCm39) |
P1418L |
probably damaging |
Het |
|
Other mutations in Sfpq |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00578:Sfpq
|
APN |
4 |
126,919,700 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01301:Sfpq
|
APN |
4 |
126,920,553 (GRCm39) |
splice site |
probably benign |
|
IGL02385:Sfpq
|
APN |
4 |
126,919,929 (GRCm39) |
splice site |
probably null |
|
IGL03373:Sfpq
|
APN |
4 |
126,920,578 (GRCm39) |
missense |
possibly damaging |
0.92 |
R0645:Sfpq
|
UTSW |
4 |
126,916,762 (GRCm39) |
missense |
possibly damaging |
0.75 |
R2038:Sfpq
|
UTSW |
4 |
126,915,295 (GRCm39) |
missense |
unknown |
|
R3120:Sfpq
|
UTSW |
4 |
126,915,926 (GRCm39) |
missense |
unknown |
|
R4609:Sfpq
|
UTSW |
4 |
126,915,404 (GRCm39) |
missense |
unknown |
|
R4788:Sfpq
|
UTSW |
4 |
126,919,791 (GRCm39) |
missense |
probably damaging |
1.00 |
R5034:Sfpq
|
UTSW |
4 |
126,917,462 (GRCm39) |
splice site |
probably benign |
|
R5411:Sfpq
|
UTSW |
4 |
126,915,516 (GRCm39) |
missense |
unknown |
|
R6115:Sfpq
|
UTSW |
4 |
126,915,141 (GRCm39) |
start gained |
probably null |
|
R6906:Sfpq
|
UTSW |
4 |
126,915,419 (GRCm39) |
small deletion |
probably benign |
|
R6907:Sfpq
|
UTSW |
4 |
126,915,419 (GRCm39) |
small deletion |
probably benign |
|
R6908:Sfpq
|
UTSW |
4 |
126,915,419 (GRCm39) |
small deletion |
probably benign |
|
R6929:Sfpq
|
UTSW |
4 |
126,915,419 (GRCm39) |
small deletion |
probably benign |
|
R6933:Sfpq
|
UTSW |
4 |
126,915,419 (GRCm39) |
small deletion |
probably benign |
|
R7029:Sfpq
|
UTSW |
4 |
126,923,675 (GRCm39) |
missense |
probably benign |
0.23 |
R7124:Sfpq
|
UTSW |
4 |
126,919,725 (GRCm39) |
missense |
possibly damaging |
0.50 |
R8752:Sfpq
|
UTSW |
4 |
126,919,969 (GRCm39) |
missense |
possibly damaging |
0.47 |
R9041:Sfpq
|
UTSW |
4 |
126,915,296 (GRCm39) |
missense |
unknown |
|
R9111:Sfpq
|
UTSW |
4 |
126,915,401 (GRCm39) |
small deletion |
probably benign |
|
R9125:Sfpq
|
UTSW |
4 |
126,915,633 (GRCm39) |
missense |
unknown |
|
R9288:Sfpq
|
UTSW |
4 |
126,916,627 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Posted On |
2012-04-20 |