Mutagenetix > Incidental Mutation

Incidental Mutation 'R8481:Vmn1r19'

657522

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r19

Ensembl Gene

ENSMUSG00000115799

Gene Name

vomeronasal 1 receptor 19

Synonyms

V1rc27

MMRRC Submission

067925-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

R8481 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

57381449-57382375 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 57381932 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 162 (S162P)

Ref Sequence

ENSEMBL: ENSMUSP00000087264 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089830]

AlphaFold

Q8R2C7

Predicted Effect

probably damaging
Transcript: ENSMUST00000089830
AA Change: S162P

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000087264
Gene: ENSMUSG00000115799
AA Change: S162P

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	6.6e-58	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

98% (45/46)

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss2	T	A	2: 155,398,381 (GRCm39)	Y380*	probably null	Het
Apob	T	A	12: 8,044,807 (GRCm39)		probably null	Het
Aste1	G	A	9: 105,274,189 (GRCm39)	R143Q	possibly damaging	Het
BC024139	T	C	15: 76,004,882 (GRCm39)	D598G	probably damaging	Het
Bpifb9a	T	C	2: 154,111,399 (GRCm39)	V551A	probably benign	Het
Ccdc88b	A	T	19: 6,831,900 (GRCm39)	L427Q	probably damaging	Het
Cept1	A	G	3: 106,412,569 (GRCm39)	V301A	probably benign	Het
Chuk	G	T	19: 44,084,678 (GRCm39)	H306Q	probably benign	Het
Cryzl1	C	A	16: 91,504,161 (GRCm39)	E69*	probably null	Het
Cul5	A	T	9: 53,558,123 (GRCm39)	D160E	probably benign	Het
Dlec1	G	A	9: 118,972,335 (GRCm39)		probably null	Het
Dnah12	A	G	14: 26,575,753 (GRCm39)	M2954V	probably benign	Het
Dnah5	T	A	15: 28,419,941 (GRCm39)	D3746E	probably benign	Het
Dnm1	A	G	2: 32,230,490 (GRCm39)	V108A	probably benign	Het
Dpp9	C	A	17: 56,501,467 (GRCm39)	D582Y	possibly damaging	Het
Evi2	T	A	11: 79,406,288 (GRCm39)		probably benign	Het
Got2	T	A	8: 96,615,152 (GRCm39)		probably benign	Het
Gria2	A	T	3: 80,708,998 (GRCm39)	H61Q	possibly damaging	Het
Hnrnpa2b1	C	T	6: 51,444,391 (GRCm39)	V8I	probably benign	Het
Impg2	A	G	16: 56,072,629 (GRCm39)	I354V	possibly damaging	Het
Letm2	T	C	8: 26,070,375 (GRCm39)	K421R	possibly damaging	Het
Lrp1	T	C	10: 127,404,779 (GRCm39)	D1974G	probably damaging	Het
Magi2	A	T	5: 20,594,152 (GRCm39)	E5D	possibly damaging	Het
Mprip	T	A	11: 59,648,982 (GRCm39)	Y895*	probably null	Het
Myo5c	T	C	9: 75,208,726 (GRCm39)	F1679S	probably damaging	Het
Neb	T	C	2: 52,114,597 (GRCm39)	K4221E	probably damaging	Het
Nek4	A	G	14: 30,685,991 (GRCm39)	Y308C	probably damaging	Het
Nrsn1	T	C	13: 25,437,598 (GRCm39)	N110S	probably damaging	Het
Or11a4	T	A	17: 37,536,295 (GRCm39)	I93K	probably damaging	Het
Or4k40	T	A	2: 111,250,994 (GRCm39)	I101F	possibly damaging	Het
Padi2	A	G	4: 140,660,564 (GRCm39)	Q348R	probably benign	Het
Pdgfrb	C	T	18: 61,198,814 (GRCm39)	T324I	probably benign	Het
Pon3	C	T	6: 5,221,715 (GRCm39)	R305H	probably benign	Het
Prlhr	A	G	19: 60,456,125 (GRCm39)	V147A	possibly damaging	Het
Ptpn21	T	C	12: 98,655,153 (GRCm39)	T605A	probably benign	Het
Rabep1	T	C	11: 70,777,953 (GRCm39)	S162P	probably damaging	Het
Rgs7bp	A	G	13: 105,190,716 (GRCm39)	S3P	probably damaging	Het
Sec24d	T	A	3: 123,147,073 (GRCm39)	L677H	probably damaging	Het
Slc13a3	T	C	2: 165,275,958 (GRCm39)	R263G	probably damaging	Het
Slu7	C	A	11: 43,328,320 (GRCm39)	L45M	probably damaging	Het
Slu7	T	A	11: 43,328,321 (GRCm39)	L45Q	probably damaging	Het
Sp140	A	G	1: 85,569,512 (GRCm39)	D374G	probably damaging	Het
Sppl2b	TGTCACAGGT	TGT	10: 80,701,903 (GRCm39)		probably null	Het
Tex36	A	T	7: 133,189,189 (GRCm39)	S128T	probably damaging	Het
Tpbg	T	C	9: 85,726,138 (GRCm39)	S36P	unknown	Het
Tubgcp2	C	A	7: 139,613,588 (GRCm39)	D30Y	probably damaging	Het

Other mutations in Vmn1r19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00948:Vmn1r19	APN	6	57,382,247 (GRCm39)	missense	probably benign	0.03
IGL01287:Vmn1r19	APN	6	57,382,179 (GRCm39)	missense	probably damaging	1.00
IGL01516:Vmn1r19	APN	6	57,381,857 (GRCm39)	missense	probably benign	0.03
IGL01895:Vmn1r19	APN	6	57,382,245 (GRCm39)	missense	probably benign	0.02
IGL02676:Vmn1r19	APN	6	57,382,025 (GRCm39)	missense	possibly damaging	0.94
IGL03040:Vmn1r19	APN	6	57,382,347 (GRCm39)	missense	unknown
IGL03087:Vmn1r19	APN	6	57,381,476 (GRCm39)	missense	probably benign	0.01
PIT4802001:Vmn1r19	UTSW	6	57,382,037 (GRCm39)	missense	probably damaging	1.00
R0319:Vmn1r19	UTSW	6	57,381,600 (GRCm39)	missense	possibly damaging	0.93
R1368:Vmn1r19	UTSW	6	57,381,656 (GRCm39)	missense	probably benign	0.01
R1997:Vmn1r19	UTSW	6	57,382,033 (GRCm39)	missense	probably damaging	1.00
R2920:Vmn1r19	UTSW	6	57,381,909 (GRCm39)	missense	probably benign	0.03
R3857:Vmn1r19	UTSW	6	57,382,098 (GRCm39)	missense	possibly damaging	0.68
R4090:Vmn1r19	UTSW	6	57,381,720 (GRCm39)	missense	probably damaging	1.00
R4547:Vmn1r19	UTSW	6	57,381,774 (GRCm39)	missense	possibly damaging	0.56
R4823:Vmn1r19	UTSW	6	57,382,219 (GRCm39)	nonsense	probably null
R4951:Vmn1r19	UTSW	6	57,381,927 (GRCm39)	missense	probably benign	0.36
R5077:Vmn1r19	UTSW	6	57,382,026 (GRCm39)	missense	probably benign	0.00
R5459:Vmn1r19	UTSW	6	57,381,475 (GRCm39)	nonsense	probably null
R5625:Vmn1r19	UTSW	6	57,382,281 (GRCm39)	missense	probably damaging	1.00
R5690:Vmn1r19	UTSW	6	57,381,780 (GRCm39)	missense	probably benign	0.10
R5761:Vmn1r19	UTSW	6	57,382,338 (GRCm39)	missense	unknown
R6124:Vmn1r19	UTSW	6	57,381,602 (GRCm39)	missense	probably benign	0.02
R6373:Vmn1r19	UTSW	6	57,382,317 (GRCm39)	missense	unknown
R6476:Vmn1r19	UTSW	6	57,381,578 (GRCm39)	missense	probably damaging	0.99
R6938:Vmn1r19	UTSW	6	57,381,992 (GRCm39)	missense	possibly damaging	0.94
R7027:Vmn1r19	UTSW	6	57,381,475 (GRCm39)	nonsense	probably null
R7359:Vmn1r19	UTSW	6	57,382,080 (GRCm39)	missense	probably damaging	0.99
R7568:Vmn1r19	UTSW	6	57,381,813 (GRCm39)	missense	possibly damaging	0.69
R7893:Vmn1r19	UTSW	6	57,381,664 (GRCm39)	missense	probably damaging	1.00
R8487:Vmn1r19	UTSW	6	57,382,166 (GRCm39)	missense	probably benign	0.03
R8812:Vmn1r19	UTSW	6	57,381,436 (GRCm39)	start gained	probably benign
R8907:Vmn1r19	UTSW	6	57,381,991 (GRCm39)	missense	probably benign
R8976:Vmn1r19	UTSW	6	57,381,719 (GRCm39)	missense	probably benign	0.01
R9277:Vmn1r19	UTSW	6	57,382,322 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- GTGTATCCCAGGCTATCACAATC -3'
(R):5'- CAAGATGTTTTGGGTGGCCC -3'

Sequencing Primer
(F):5'- AATCAGTCCCAGTACCTCTTTGTTGG -3'
(R):5'- TCTCAGGGGATGCTCTCAG -3'

Posted On

2021-01-18