Incidental Mutation 'R8481:Nrsn1'
ID 657538
Institutional Source Beutler Lab
Gene Symbol Nrsn1
Ensembl Gene ENSMUSG00000048978
Gene Name neurensin 1
Synonyms Vmp, Neuro-p24, Neurensin-1
MMRRC Submission 067925-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8481 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 25436022-25453979 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 25437598 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 110 (N110S)
Ref Sequence ENSEMBL: ENSMUSP00000128979 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057866] [ENSMUST00000167305]
AlphaFold P97799
Predicted Effect probably damaging
Transcript: ENSMUST00000057866
AA Change: N110S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000055048
Gene: ENSMUSG00000048978
AA Change: N110S

DomainStartEndE-ValueType
Pfam:Neurensin 24 154 2.3e-54 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000167305
AA Change: N110S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000128979
Gene: ENSMUSG00000048978
AA Change: N110S

DomainStartEndE-ValueType
Pfam:Neurensin 24 159 3.6e-57 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (45/46)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss2 T A 2: 155,398,381 (GRCm39) Y380* probably null Het
Apob T A 12: 8,044,807 (GRCm39) probably null Het
Aste1 G A 9: 105,274,189 (GRCm39) R143Q possibly damaging Het
BC024139 T C 15: 76,004,882 (GRCm39) D598G probably damaging Het
Bpifb9a T C 2: 154,111,399 (GRCm39) V551A probably benign Het
Ccdc88b A T 19: 6,831,900 (GRCm39) L427Q probably damaging Het
Cept1 A G 3: 106,412,569 (GRCm39) V301A probably benign Het
Chuk G T 19: 44,084,678 (GRCm39) H306Q probably benign Het
Cryzl1 C A 16: 91,504,161 (GRCm39) E69* probably null Het
Cul5 A T 9: 53,558,123 (GRCm39) D160E probably benign Het
Dlec1 G A 9: 118,972,335 (GRCm39) probably null Het
Dnah12 A G 14: 26,575,753 (GRCm39) M2954V probably benign Het
Dnah5 T A 15: 28,419,941 (GRCm39) D3746E probably benign Het
Dnm1 A G 2: 32,230,490 (GRCm39) V108A probably benign Het
Dpp9 C A 17: 56,501,467 (GRCm39) D582Y possibly damaging Het
Evi2 T A 11: 79,406,288 (GRCm39) probably benign Het
Got2 T A 8: 96,615,152 (GRCm39) probably benign Het
Gria2 A T 3: 80,708,998 (GRCm39) H61Q possibly damaging Het
Hnrnpa2b1 C T 6: 51,444,391 (GRCm39) V8I probably benign Het
Impg2 A G 16: 56,072,629 (GRCm39) I354V possibly damaging Het
Letm2 T C 8: 26,070,375 (GRCm39) K421R possibly damaging Het
Lrp1 T C 10: 127,404,779 (GRCm39) D1974G probably damaging Het
Magi2 A T 5: 20,594,152 (GRCm39) E5D possibly damaging Het
Mprip T A 11: 59,648,982 (GRCm39) Y895* probably null Het
Myo5c T C 9: 75,208,726 (GRCm39) F1679S probably damaging Het
Neb T C 2: 52,114,597 (GRCm39) K4221E probably damaging Het
Nek4 A G 14: 30,685,991 (GRCm39) Y308C probably damaging Het
Or11a4 T A 17: 37,536,295 (GRCm39) I93K probably damaging Het
Or4k40 T A 2: 111,250,994 (GRCm39) I101F possibly damaging Het
Padi2 A G 4: 140,660,564 (GRCm39) Q348R probably benign Het
Pdgfrb C T 18: 61,198,814 (GRCm39) T324I probably benign Het
Pon3 C T 6: 5,221,715 (GRCm39) R305H probably benign Het
Prlhr A G 19: 60,456,125 (GRCm39) V147A possibly damaging Het
Ptpn21 T C 12: 98,655,153 (GRCm39) T605A probably benign Het
Rabep1 T C 11: 70,777,953 (GRCm39) S162P probably damaging Het
Rgs7bp A G 13: 105,190,716 (GRCm39) S3P probably damaging Het
Sec24d T A 3: 123,147,073 (GRCm39) L677H probably damaging Het
Slc13a3 T C 2: 165,275,958 (GRCm39) R263G probably damaging Het
Slu7 C A 11: 43,328,320 (GRCm39) L45M probably damaging Het
Slu7 T A 11: 43,328,321 (GRCm39) L45Q probably damaging Het
Sp140 A G 1: 85,569,512 (GRCm39) D374G probably damaging Het
Sppl2b TGTCACAGGT TGT 10: 80,701,903 (GRCm39) probably null Het
Tex36 A T 7: 133,189,189 (GRCm39) S128T probably damaging Het
Tpbg T C 9: 85,726,138 (GRCm39) S36P unknown Het
Tubgcp2 C A 7: 139,613,588 (GRCm39) D30Y probably damaging Het
Vmn1r19 T C 6: 57,381,932 (GRCm39) S162P probably damaging Het
Other mutations in Nrsn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02839:Nrsn1 APN 13 25,437,527 (GRCm39) missense probably damaging 0.97
IGL03127:Nrsn1 APN 13 25,437,700 (GRCm39) missense probably damaging 0.97
R0549:Nrsn1 UTSW 13 25,446,241 (GRCm39) missense probably benign 0.01
R3076:Nrsn1 UTSW 13 25,437,542 (GRCm39) missense probably benign 0.12
R4804:Nrsn1 UTSW 13 25,437,580 (GRCm39) missense probably benign 0.40
R6020:Nrsn1 UTSW 13 25,437,355 (GRCm39) missense probably damaging 1.00
R7094:Nrsn1 UTSW 13 25,437,724 (GRCm39) missense possibly damaging 0.85
R7116:Nrsn1 UTSW 13 25,437,388 (GRCm39) missense probably damaging 0.99
R7226:Nrsn1 UTSW 13 25,437,451 (GRCm39) missense probably damaging 0.99
R7859:Nrsn1 UTSW 13 25,446,254 (GRCm39) missense probably damaging 1.00
R9102:Nrsn1 UTSW 13 25,437,517 (GRCm39) missense probably benign
R9753:Nrsn1 UTSW 13 25,437,563 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- TGACAGGGATCTTGGTGTCC -3'
(R):5'- GAAGGGTTCCACTGTTCACTTTC -3'

Sequencing Primer
(F):5'- CCTGGGCCTGGAGCTTTAG -3'
(R):5'- GGTTCCACTGTTCACTTTCTCCTG -3'
Posted On 2021-01-18