Incidental Mutation 'R8486:Dpp7'
ID 657716
Institutional Source Beutler Lab
Gene Symbol Dpp7
Ensembl Gene ENSMUSG00000026958
Gene Name dipeptidylpeptidase 7
Synonyms QPP
MMRRC Submission 067929-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R8486 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 25242302-25246365 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 25242561 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 464 (D464G)
Ref Sequence ENSEMBL: ENSMUSP00000028332 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028332] [ENSMUST00000042390]
AlphaFold Q9ET22
Predicted Effect probably damaging
Transcript: ENSMUST00000028332
AA Change: D464G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000028332
Gene: ENSMUSG00000026958
AA Change: D464G

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:Peptidase_S28 48 475 2.3e-90 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000042390
SMART Domains Protein: ENSMUSP00000036996
Gene: ENSMUSG00000036646

DomainStartEndE-ValueType
low complexity region 3 11 N/A INTRINSIC
low complexity region 29 42 N/A INTRINSIC
transmembrane domain 49 71 N/A INTRINSIC
Pfam:Glyco_hydro_47 215 654 9.5e-167 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(4) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(1)

Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,225,092 (GRCm39) S524G probably benign Het
Abca8b A T 11: 109,857,937 (GRCm39) I546N possibly damaging Het
Abcd4 C T 12: 84,650,752 (GRCm39) R532H probably damaging Het
Acsf2 A T 11: 94,460,786 (GRCm39) D373E probably damaging Het
Acsm1 A G 7: 119,259,880 (GRCm39) T510A probably damaging Het
Adam21 C T 12: 81,607,550 (GRCm39) V71I probably benign Het
Adgra3 T C 5: 50,147,621 (GRCm39) D473G probably damaging Het
Agbl2 G A 2: 90,631,499 (GRCm39) V286I possibly damaging Het
Alkbh8 A G 9: 3,344,642 (GRCm39) E141G probably null Het
Arhgap21 T C 2: 20,865,236 (GRCm39) D952G probably damaging Het
Asb4 A T 6: 5,390,653 (GRCm39) K15N possibly damaging Het
Cert1 T C 13: 96,770,690 (GRCm39) V533A probably damaging Het
Clip1 G T 5: 123,752,770 (GRCm39) probably benign Het
Clip4 T C 17: 72,170,839 (GRCm39) probably benign Het
Cyp2b10 T C 7: 25,614,306 (GRCm39) V260A probably benign Het
Dnm1 C T 2: 32,224,739 (GRCm39) M430I probably benign Het
Dspp A G 5: 104,321,883 (GRCm39) probably benign Het
Ephb1 A C 9: 101,841,164 (GRCm39) D730E probably benign Het
Fancf A G 7: 51,511,632 (GRCm39) V124A probably benign Het
Fgfr2 G A 7: 129,765,745 (GRCm39) P692S possibly damaging Het
Fkbp15 G A 4: 62,230,521 (GRCm39) R731* probably null Het
Fos T C 12: 85,522,805 (GRCm39) F239S probably benign Het
Fuz T C 7: 44,548,092 (GRCm39) Y107H probably damaging Het
Gm3159 A C 14: 4,400,520 (GRCm38) N193T probably damaging Het
Helz2 T A 2: 180,871,124 (GRCm39) D2771V probably damaging Het
Ighv1-18 T A 12: 114,646,325 (GRCm39) K92M probably damaging Het
Kcnh3 A G 15: 99,136,091 (GRCm39) Y696C probably damaging Het
Klf15 T A 6: 90,444,160 (GRCm39) V245D probably damaging Het
L1td1 C T 4: 98,625,911 (GRCm39) A702V probably damaging Het
Lamc2 A G 1: 153,034,637 (GRCm39) M122T probably benign Het
Lrp1b A G 2: 41,618,702 (GRCm39) L124P probably damaging Het
Mcrs1 G T 15: 99,146,349 (GRCm39) Y85* probably null Het
Mgst1 A T 6: 138,120,026 (GRCm39) I29L probably benign Het
Miga1 C T 3: 151,982,390 (GRCm39) R562H probably damaging Het
Mybpc3 T C 2: 90,959,117 (GRCm39) W687R probably damaging Het
Myh11 G T 16: 14,022,532 (GRCm39) A1682D possibly damaging Het
Nes T C 3: 87,887,320 (GRCm39) S1816P probably damaging Het
Or52p1 T C 7: 104,267,069 (GRCm39) V69A possibly damaging Het
Or5c1 T G 2: 37,222,662 (GRCm39) V301G probably damaging Het
Pkhd1l1 T G 15: 44,410,812 (GRCm39) F2773C probably damaging Het
Pkp1 C G 1: 135,846,714 (GRCm39) E13Q probably damaging Het
Ppp2r2b T C 18: 43,031,869 (GRCm39) D4G probably benign Het
Ppp6r3 G A 19: 3,537,072 (GRCm39) H455Y probably benign Het
R3hdm1 A G 1: 128,106,657 (GRCm39) R202G probably benign Het
Sgcz T G 8: 38,190,207 (GRCm39) K106N probably benign Het
Slc13a4 T C 6: 35,247,304 (GRCm39) Y572C probably damaging Het
Syne2 C T 12: 76,088,881 (GRCm39) Q5080* probably null Het
Tpst2 C T 5: 112,456,171 (GRCm39) Q5* probably null Het
Ttn T A 2: 76,561,877 (GRCm39) T28908S possibly damaging Het
Vmn1r120 C T 7: 20,787,027 (GRCm39) R228H probably benign Het
Vmn2r3 T C 3: 64,186,370 (GRCm39) N105S probably damaging Het
Zfp521 T C 18: 13,979,829 (GRCm39) T195A probably damaging Het
Zfp616 T A 11: 73,974,909 (GRCm39) S484T probably benign Het
Other mutations in Dpp7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01637:Dpp7 APN 2 25,244,625 (GRCm39) missense probably benign 0.01
IGL02897:Dpp7 APN 2 25,243,684 (GRCm39) missense probably damaging 1.00
IGL02992:Dpp7 APN 2 25,244,589 (GRCm39) missense possibly damaging 0.65
IGL03069:Dpp7 APN 2 25,245,735 (GRCm39) critical splice acceptor site probably null
1mM(1):Dpp7 UTSW 2 25,246,152 (GRCm39) missense probably benign 0.05
PIT4519001:Dpp7 UTSW 2 25,242,460 (GRCm39) missense probably damaging 0.97
R0051:Dpp7 UTSW 2 25,246,107 (GRCm39) missense possibly damaging 0.80
R0051:Dpp7 UTSW 2 25,246,107 (GRCm39) missense possibly damaging 0.80
R0900:Dpp7 UTSW 2 25,246,311 (GRCm39) missense probably damaging 0.99
R1889:Dpp7 UTSW 2 25,243,691 (GRCm39) splice site probably null
R1895:Dpp7 UTSW 2 25,243,691 (GRCm39) splice site probably null
R2055:Dpp7 UTSW 2 25,244,490 (GRCm39) missense possibly damaging 0.84
R4697:Dpp7 UTSW 2 25,244,931 (GRCm39) missense probably benign 0.00
R4832:Dpp7 UTSW 2 25,242,398 (GRCm39) unclassified probably benign
R4887:Dpp7 UTSW 2 25,242,770 (GRCm39) critical splice acceptor site probably null
R5114:Dpp7 UTSW 2 25,242,749 (GRCm39) missense possibly damaging 0.51
R6976:Dpp7 UTSW 2 25,244,836 (GRCm39) critical splice acceptor site probably null
R7577:Dpp7 UTSW 2 25,245,603 (GRCm39) missense probably benign
R8459:Dpp7 UTSW 2 25,242,550 (GRCm39) missense probably damaging 1.00
R8672:Dpp7 UTSW 2 25,246,133 (GRCm39) missense probably benign 0.00
R8690:Dpp7 UTSW 2 25,245,645 (GRCm39) missense probably damaging 1.00
X0058:Dpp7 UTSW 2 25,244,764 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- GGCAAGTTGTCACACCACTG -3'
(R):5'- GATCCAGAGCAACCTGAGTAC -3'

Sequencing Primer
(F):5'- AGTTGTCACACCACTGTAGATC -3'
(R):5'- GAGTACATCAGTCATTGCTGTCAC -3'
Posted On 2021-01-18