Incidental Mutation 'R8489:Ccdc149'
ID 657877
Institutional Source Beutler Lab
Gene Symbol Ccdc149
Ensembl Gene ENSMUSG00000045790
Gene Name coiled-coil domain containing 149
Synonyms Gm447, LOC242997
MMRRC Submission 067932-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R8489 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 52531993-52628863 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 52533999 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 389 (D389G)
Ref Sequence ENSEMBL: ENSMUSP00000062411 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059428] [ENSMUST00000198008]
AlphaFold F6V035
Predicted Effect probably benign
Transcript: ENSMUST00000059428
AA Change: D389G

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000062411
Gene: ENSMUSG00000045790
AA Change: D389G

DomainStartEndE-ValueType
Pfam:DUF2353 21 333 3.5e-117 PFAM
low complexity region 388 404 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000198008
AA Change: M127V
SMART Domains Protein: ENSMUSP00000143041
Gene: ENSMUSG00000045790
AA Change: M127V

DomainStartEndE-ValueType
Pfam:DUF2353 21 138 1.5e-28 PFAM
Predicted Effect
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AI661453 C A 17: 47,777,254 (GRCm39) probably benign Het
Apc2 T G 10: 80,143,298 (GRCm39) L466R probably damaging Het
Baz1b C A 5: 135,245,709 (GRCm39) P386H probably damaging Het
Cit T A 5: 116,083,962 (GRCm39) probably null Het
Cmas C A 6: 142,702,596 (GRCm39) A33E probably benign Het
Dcaf7 A G 11: 105,942,743 (GRCm39) N230S probably damaging Het
Dcun1d5 C A 9: 7,206,837 (GRCm39) probably benign Het
Dennd5b T A 6: 148,986,389 (GRCm39) D58V probably benign Het
Dmrt2 C A 19: 25,655,831 (GRCm39) Q477K probably damaging Het
Eva1c A G 16: 90,672,999 (GRCm39) N90S probably damaging Het
Fcgbp A T 7: 27,804,435 (GRCm39) I1848F possibly damaging Het
Fgfr2 T G 7: 129,769,534 (GRCm39) M522L probably benign Het
Fshr C A 17: 89,293,795 (GRCm39) K294N probably benign Het
Gja10 T C 4: 32,601,866 (GRCm39) I173V probably benign Het
Gmnn A G 13: 24,941,614 (GRCm39) S32P probably damaging Het
Hdac9 T C 12: 34,487,180 (GRCm39) N95D probably damaging Het
Ipo13 T C 4: 117,758,219 (GRCm39) T715A probably damaging Het
Klrc2 A G 6: 129,635,787 (GRCm39) S97P probably benign Het
Lrrn4 G A 2: 132,721,364 (GRCm39) S151L probably benign Het
Man2a1 G T 17: 64,908,765 (GRCm39) S12I possibly damaging Het
Mplkipl1 T C 19: 61,164,085 (GRCm39) T117A probably damaging Het
Mrgprb8 T A 7: 48,038,701 (GRCm39) V124E possibly damaging Het
Myo5c T C 9: 75,180,128 (GRCm39) W690R probably damaging Het
Ncapd2 T C 6: 125,150,745 (GRCm39) K817E probably damaging Het
Or51k2 T C 7: 103,596,328 (GRCm39) I185T probably damaging Het
Or5h27 A G 16: 59,006,400 (GRCm39) *149Q probably null Het
Or5p60 T A 7: 107,724,372 (GRCm39) I33F probably benign Het
Or8b50 T C 9: 38,518,232 (GRCm39) M157T probably benign Het
Pcdh18 A T 3: 49,709,038 (GRCm39) I759N probably damaging Het
Pcdhac2 A T 18: 37,278,207 (GRCm39) N396Y probably damaging Het
Pcm1 T A 8: 41,766,437 (GRCm39) C1542S probably benign Het
Pcsk1 T A 13: 75,274,121 (GRCm39) V450E probably damaging Het
Pld2 A G 11: 70,445,121 (GRCm39) K574E probably damaging Het
Pramel52-ps T C 5: 94,531,551 (GRCm39) L145P probably damaging Het
Psmc1 C T 12: 100,089,356 (GRCm39) R410C probably benign Het
Rad51b C T 12: 79,374,024 (GRCm39) S201L probably benign Het
Rgs3 T A 4: 62,544,733 (GRCm39) L200Q probably damaging Het
Rims2 A G 15: 39,479,846 (GRCm39) M1293V probably damaging Het
Scin C T 12: 40,131,019 (GRCm39) G298D probably damaging Het
Scn8a C A 15: 100,867,014 (GRCm39) F123L probably damaging Het
Snapc3 G A 4: 83,369,531 (GRCm39) C353Y probably damaging Het
Sned1 C A 1: 93,210,978 (GRCm39) S231* probably null Het
Tex15 A G 8: 34,067,574 (GRCm39) T2335A probably benign Het
Tigd4 G A 3: 84,502,526 (GRCm39) G481D probably benign Het
Trank1 T G 9: 111,219,343 (GRCm39) F2027V probably benign Het
Ubr1 C T 2: 120,711,548 (GRCm39) A1449T probably benign Het
Ulk1 G T 5: 110,947,002 (GRCm39) Y89* probably null Het
Usp54 A G 14: 20,611,604 (GRCm39) F1071L probably benign Het
Utrn C T 10: 12,587,190 (GRCm39) E949K probably benign Het
Vmn2r65 T A 7: 84,589,964 (GRCm39) T651S possibly damaging Het
Wdfy1 A G 1: 79,739,368 (GRCm39) L17P probably damaging Het
Zfp672 G A 11: 58,220,681 (GRCm39) probably benign Het
Other mutations in Ccdc149
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00549:Ccdc149 APN 5 52,533,664 (GRCm39) missense probably benign 0.15
IGL02002:Ccdc149 APN 5 52,563,421 (GRCm39) missense probably damaging 1.00
pequeno UTSW 5 52,562,475 (GRCm39) nonsense probably null
R0226:Ccdc149 UTSW 5 52,557,559 (GRCm39) missense probably damaging 1.00
R0420:Ccdc149 UTSW 5 52,557,581 (GRCm39) splice site probably benign
R0959:Ccdc149 UTSW 5 52,542,497 (GRCm39) missense probably damaging 1.00
R2075:Ccdc149 UTSW 5 52,596,510 (GRCm39) missense probably damaging 1.00
R2355:Ccdc149 UTSW 5 52,578,114 (GRCm39) missense probably damaging 0.99
R4755:Ccdc149 UTSW 5 52,561,493 (GRCm39) missense probably damaging 0.96
R5596:Ccdc149 UTSW 5 52,561,493 (GRCm39) missense probably damaging 0.96
R5955:Ccdc149 UTSW 5 52,533,877 (GRCm39) missense probably benign 0.00
R5993:Ccdc149 UTSW 5 52,560,117 (GRCm39) missense probably damaging 1.00
R6351:Ccdc149 UTSW 5 52,542,477 (GRCm39) missense probably benign
R6742:Ccdc149 UTSW 5 52,562,475 (GRCm39) nonsense probably null
R6939:Ccdc149 UTSW 5 52,533,607 (GRCm39) missense probably benign 0.00
R6963:Ccdc149 UTSW 5 52,596,439 (GRCm39) missense probably damaging 1.00
R7379:Ccdc149 UTSW 5 52,562,408 (GRCm39) missense probably damaging 0.99
R7715:Ccdc149 UTSW 5 52,561,533 (GRCm39) critical splice acceptor site probably null
R7920:Ccdc149 UTSW 5 52,562,436 (GRCm39) missense probably damaging 0.98
R8154:Ccdc149 UTSW 5 52,542,446 (GRCm39) critical splice donor site probably null
R8791:Ccdc149 UTSW 5 52,596,552 (GRCm39) missense probably damaging 1.00
R9091:Ccdc149 UTSW 5 52,563,352 (GRCm39) missense possibly damaging 0.81
R9270:Ccdc149 UTSW 5 52,563,352 (GRCm39) missense possibly damaging 0.81
R9332:Ccdc149 UTSW 5 52,562,399 (GRCm39) missense probably damaging 1.00
R9334:Ccdc149 UTSW 5 52,578,171 (GRCm39) missense possibly damaging 0.49
R9501:Ccdc149 UTSW 5 52,542,477 (GRCm39) missense probably benign
Z1176:Ccdc149 UTSW 5 52,578,155 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TGCCCATCAGTCAGTTGAATAC -3'
(R):5'- CATAAAGGCCCTCAGCTTCC -3'

Sequencing Primer
(F):5'- ATCAGTCAGTTGAATACTCTCCC -3'
(R):5'- GGATAACCTTGGTCCTCAGATTTAG -3'
Posted On 2021-01-18