Incidental Mutation 'R8489:Or5p60'
ID 657890
Institutional Source Beutler Lab
Gene Symbol Or5p60
Ensembl Gene ENSMUSG00000110171
Gene Name olfactory receptor family 5 subfamily P member 60
Synonyms GA_x6K02T2PBJ9-10454128-10453163, MOR204-16, Olfr484
MMRRC Submission 067932-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # R8489 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 107723503-107724468 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 107724372 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 33 (I33F)
Ref Sequence ENSEMBL: ENSMUSP00000150774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000210881] [ENSMUST00000214722]
AlphaFold Q8VFD3
Predicted Effect probably benign
Transcript: ENSMUST00000210881
AA Change: I33F

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000214722
AA Change: I33F

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AI661453 C A 17: 47,777,254 (GRCm39) probably benign Het
Apc2 T G 10: 80,143,298 (GRCm39) L466R probably damaging Het
Baz1b C A 5: 135,245,709 (GRCm39) P386H probably damaging Het
Ccdc149 T C 5: 52,533,999 (GRCm39) D389G probably benign Het
Cit T A 5: 116,083,962 (GRCm39) probably null Het
Cmas C A 6: 142,702,596 (GRCm39) A33E probably benign Het
Dcaf7 A G 11: 105,942,743 (GRCm39) N230S probably damaging Het
Dcun1d5 C A 9: 7,206,837 (GRCm39) probably benign Het
Dennd5b T A 6: 148,986,389 (GRCm39) D58V probably benign Het
Dmrt2 C A 19: 25,655,831 (GRCm39) Q477K probably damaging Het
Eva1c A G 16: 90,672,999 (GRCm39) N90S probably damaging Het
Fcgbp A T 7: 27,804,435 (GRCm39) I1848F possibly damaging Het
Fgfr2 T G 7: 129,769,534 (GRCm39) M522L probably benign Het
Fshr C A 17: 89,293,795 (GRCm39) K294N probably benign Het
Gja10 T C 4: 32,601,866 (GRCm39) I173V probably benign Het
Gmnn A G 13: 24,941,614 (GRCm39) S32P probably damaging Het
Hdac9 T C 12: 34,487,180 (GRCm39) N95D probably damaging Het
Ipo13 T C 4: 117,758,219 (GRCm39) T715A probably damaging Het
Klrc2 A G 6: 129,635,787 (GRCm39) S97P probably benign Het
Lrrn4 G A 2: 132,721,364 (GRCm39) S151L probably benign Het
Man2a1 G T 17: 64,908,765 (GRCm39) S12I possibly damaging Het
Mplkipl1 T C 19: 61,164,085 (GRCm39) T117A probably damaging Het
Mrgprb8 T A 7: 48,038,701 (GRCm39) V124E possibly damaging Het
Myo5c T C 9: 75,180,128 (GRCm39) W690R probably damaging Het
Ncapd2 T C 6: 125,150,745 (GRCm39) K817E probably damaging Het
Or51k2 T C 7: 103,596,328 (GRCm39) I185T probably damaging Het
Or5h27 A G 16: 59,006,400 (GRCm39) *149Q probably null Het
Or8b50 T C 9: 38,518,232 (GRCm39) M157T probably benign Het
Pcdh18 A T 3: 49,709,038 (GRCm39) I759N probably damaging Het
Pcdhac2 A T 18: 37,278,207 (GRCm39) N396Y probably damaging Het
Pcm1 T A 8: 41,766,437 (GRCm39) C1542S probably benign Het
Pcsk1 T A 13: 75,274,121 (GRCm39) V450E probably damaging Het
Pld2 A G 11: 70,445,121 (GRCm39) K574E probably damaging Het
Pramel52-ps T C 5: 94,531,551 (GRCm39) L145P probably damaging Het
Psmc1 C T 12: 100,089,356 (GRCm39) R410C probably benign Het
Rad51b C T 12: 79,374,024 (GRCm39) S201L probably benign Het
Rgs3 T A 4: 62,544,733 (GRCm39) L200Q probably damaging Het
Rims2 A G 15: 39,479,846 (GRCm39) M1293V probably damaging Het
Scin C T 12: 40,131,019 (GRCm39) G298D probably damaging Het
Scn8a C A 15: 100,867,014 (GRCm39) F123L probably damaging Het
Snapc3 G A 4: 83,369,531 (GRCm39) C353Y probably damaging Het
Sned1 C A 1: 93,210,978 (GRCm39) S231* probably null Het
Tex15 A G 8: 34,067,574 (GRCm39) T2335A probably benign Het
Tigd4 G A 3: 84,502,526 (GRCm39) G481D probably benign Het
Trank1 T G 9: 111,219,343 (GRCm39) F2027V probably benign Het
Ubr1 C T 2: 120,711,548 (GRCm39) A1449T probably benign Het
Ulk1 G T 5: 110,947,002 (GRCm39) Y89* probably null Het
Usp54 A G 14: 20,611,604 (GRCm39) F1071L probably benign Het
Utrn C T 10: 12,587,190 (GRCm39) E949K probably benign Het
Vmn2r65 T A 7: 84,589,964 (GRCm39) T651S possibly damaging Het
Wdfy1 A G 1: 79,739,368 (GRCm39) L17P probably damaging Het
Zfp672 G A 11: 58,220,681 (GRCm39) probably benign Het
Other mutations in Or5p60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01879:Or5p60 APN 7 107,724,371 (GRCm39) missense possibly damaging 0.88
IGL01899:Or5p60 APN 7 107,724,048 (GRCm39) missense probably benign 0.01
IGL02124:Or5p60 APN 7 107,724,249 (GRCm39) missense probably benign 0.01
IGL02622:Or5p60 APN 7 107,723,595 (GRCm39) missense probably damaging 1.00
IGL03188:Or5p60 APN 7 107,723,841 (GRCm39) missense probably benign 0.00
R0389:Or5p60 UTSW 7 107,724,023 (GRCm39) missense probably benign 0.00
R0443:Or5p60 UTSW 7 107,724,023 (GRCm39) missense probably benign 0.00
R0731:Or5p60 UTSW 7 107,723,941 (GRCm39) missense probably benign 0.12
R1061:Or5p60 UTSW 7 107,723,663 (GRCm39) missense probably damaging 1.00
R1505:Or5p60 UTSW 7 107,724,200 (GRCm39) missense probably benign 0.00
R1591:Or5p60 UTSW 7 107,723,571 (GRCm39) missense possibly damaging 0.56
R1789:Or5p60 UTSW 7 107,724,122 (GRCm39) missense probably benign 0.44
R2988:Or5p60 UTSW 7 107,724,045 (GRCm39) nonsense probably null
R4778:Or5p60 UTSW 7 107,723,687 (GRCm39) missense possibly damaging 0.95
R5288:Or5p60 UTSW 7 107,724,375 (GRCm39) missense probably benign 0.00
R5644:Or5p60 UTSW 7 107,723,858 (GRCm39) missense probably benign 0.04
R6112:Or5p60 UTSW 7 107,724,369 (GRCm39) missense probably benign 0.01
R6351:Or5p60 UTSW 7 107,723,637 (GRCm39) missense probably damaging 1.00
R6934:Or5p60 UTSW 7 107,724,026 (GRCm39) missense probably benign 0.14
R7094:Or5p60 UTSW 7 107,723,840 (GRCm39) missense probably benign 0.35
R7135:Or5p60 UTSW 7 107,723,781 (GRCm39) missense probably damaging 0.99
R7422:Or5p60 UTSW 7 107,724,068 (GRCm39) missense probably damaging 1.00
R7660:Or5p60 UTSW 7 107,724,041 (GRCm39) missense probably benign 0.04
R7916:Or5p60 UTSW 7 107,724,329 (GRCm39) missense possibly damaging 0.59
R9204:Or5p60 UTSW 7 107,723,935 (GRCm39) missense possibly damaging 0.75
R9526:Or5p60 UTSW 7 107,723,801 (GRCm39) missense probably benign 0.06
X0021:Or5p60 UTSW 7 107,724,314 (GRCm39) missense probably damaging 1.00
X0025:Or5p60 UTSW 7 107,723,606 (GRCm39) nonsense probably null
Z1176:Or5p60 UTSW 7 107,724,086 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTTACAAGGAAGTTGACAAGCA -3'
(R):5'- TGAATATAACATTGATGATTGCTCCA -3'

Sequencing Primer
(F):5'- TGACAAGCATATTGGGTGTGAC -3'
(R):5'- ACATTGATGATTGCTCCAATTTTTG -3'
Posted On 2021-01-18