Incidental Mutation 'R8490:Or8k33'
ID 657930
Institutional Source Beutler Lab
Gene Symbol Or8k33
Ensembl Gene ENSMUSG00000110912
Gene Name olfactory receptor family 8 subfamily K member 33
Synonyms GA_x6K02T2Q125-48039418-48038477, MOR192-1, Olfr1080
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R8490 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 86383525-86388482 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86384027 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 147 (M147K)
Ref Sequence ENSEMBL: ENSMUSP00000150502 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000213185]
AlphaFold Q7TR67
Predicted Effect probably benign
Transcript: ENSMUST00000213185
AA Change: M147K

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T G 1: 71,323,256 (GRCm39) K1609Q probably damaging Het
Arl5a A G 2: 52,314,614 (GRCm39) F12L probably benign Het
Armc9 C T 1: 86,202,125 (GRCm39) T761I probably benign Het
Bmp1 A G 14: 70,727,573 (GRCm39) F670S possibly damaging Het
Cd34 T C 1: 194,621,281 (GRCm39) V3A probably benign Het
Cdkn2a A T 4: 89,212,759 (GRCm39) M1K probably null Het
Cep135 C A 5: 76,786,054 (GRCm39) H1052Q probably benign Het
Cfap100 T C 6: 90,390,721 (GRCm39) probably benign Het
Cib4 A T 5: 30,703,075 (GRCm39) Y17N probably damaging Het
Col3a1 T G 1: 45,385,116 (GRCm39) S78A probably benign Het
Crebzf A G 7: 90,092,706 (GRCm39) M162V probably benign Het
Dbx2 T A 15: 95,552,454 (GRCm39) M64L possibly damaging Het
Epb41l2 A T 10: 25,380,128 (GRCm39) T884S probably damaging Het
Erich3 T A 3: 154,401,461 (GRCm39) S37T Het
Eya1 G T 1: 14,254,899 (GRCm39) Q383K possibly damaging Het
Gm15130 A T 2: 110,983,230 (GRCm39) probably null Het
Ido1 A T 8: 25,086,954 (GRCm39) M1K probably null Het
Loxhd1 C T 18: 77,529,162 (GRCm39) T1069M possibly damaging Het
Lrrtm2 T G 18: 35,346,451 (GRCm39) probably null Het
Map1a C T 2: 121,135,045 (GRCm39) H1716Y possibly damaging Het
Mycbp2 T A 14: 103,446,267 (GRCm39) T1854S probably benign Het
Myh13 T C 11: 67,255,351 (GRCm39) S1574P probably damaging Het
Neu1 G A 17: 35,150,982 (GRCm39) A78T probably benign Het
Nfam1 T C 15: 82,907,238 (GRCm39) probably benign Het
Or1e27-ps1 T A 11: 73,555,675 (GRCm39) L80Q probably damaging Het
Or4c10b A C 2: 89,711,511 (GRCm39) T114P probably damaging Het
Pdgfra T C 5: 75,331,329 (GRCm39) probably null Het
Ptgfrn A T 3: 100,963,686 (GRCm39) M642K probably damaging Het
R3hdm1 T A 1: 128,162,864 (GRCm39) H980Q probably benign Het
Rfc2 C A 5: 134,611,698 (GRCm39) S19* probably null Het
Rhbdf1 C A 11: 32,160,162 (GRCm39) S738I probably damaging Het
Rif1 T A 2: 52,001,011 (GRCm39) N1488K probably damaging Het
Rnf31 G A 14: 55,833,566 (GRCm39) V525I probably damaging Het
Rps27a T C 11: 29,496,719 (GRCm39) D58G probably benign Het
Serpinc1 T G 1: 160,817,028 (GRCm39) C41G probably damaging Het
Siglece A T 7: 43,309,486 (GRCm39) V24D probably benign Het
Sparcl1 T A 5: 104,233,574 (GRCm39) R592W probably null Het
Stard13 A G 5: 150,987,090 (GRCm39) S104P probably damaging Het
Ston2 A G 12: 91,614,905 (GRCm39) V501A possibly damaging Het
Sv2b C A 7: 74,855,833 (GRCm39) probably null Het
Tiam1 T C 16: 89,681,932 (GRCm39) R349G probably damaging Het
Tmprss11g A G 5: 86,639,976 (GRCm39) probably null Het
Tnik G T 3: 28,650,321 (GRCm39) R507L probably damaging Het
Trabd2b G T 4: 114,460,113 (GRCm39) S417I probably damaging Het
Ube2q1 T A 3: 89,681,308 (GRCm39) V97E probably benign Het
Vim A T 2: 13,584,265 (GRCm39) N306Y probably damaging Het
Vmn1r216 G T 13: 23,283,979 (GRCm39) A221S possibly damaging Het
Vmn2r113 G A 17: 23,177,372 (GRCm39) A719T probably benign Het
Vmn2r66 A G 7: 84,654,794 (GRCm39) probably null Het
Vps45 T C 3: 95,948,661 (GRCm39) S365G probably benign Het
Zzz3 T A 3: 152,134,290 (GRCm39) C449* probably null Het
Other mutations in Or8k33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01937:Or8k33 APN 2 86,383,793 (GRCm39) missense probably benign 0.34
IGL02169:Or8k33 APN 2 86,384,226 (GRCm39) missense probably benign 0.39
IGL02234:Or8k33 APN 2 86,383,610 (GRCm39) missense probably damaging 1.00
IGL02530:Or8k33 APN 2 86,384,224 (GRCm39) missense possibly damaging 0.60
R0046:Or8k33 UTSW 2 86,383,976 (GRCm39) missense probably damaging 1.00
R0360:Or8k33 UTSW 2 86,384,123 (GRCm39) missense probably damaging 1.00
R0364:Or8k33 UTSW 2 86,384,123 (GRCm39) missense probably damaging 1.00
R0377:Or8k33 UTSW 2 86,383,927 (GRCm39) missense probably damaging 1.00
R1496:Or8k33 UTSW 2 86,384,096 (GRCm39) missense probably damaging 1.00
R1609:Or8k33 UTSW 2 86,383,949 (GRCm39) missense probably damaging 1.00
R1674:Or8k33 UTSW 2 86,384,204 (GRCm39) missense probably damaging 0.96
R1816:Or8k33 UTSW 2 86,384,011 (GRCm39) nonsense probably null
R2870:Or8k33 UTSW 2 86,383,928 (GRCm39) missense possibly damaging 0.95
R2870:Or8k33 UTSW 2 86,383,928 (GRCm39) missense possibly damaging 0.95
R4387:Or8k33 UTSW 2 86,384,298 (GRCm39) missense probably damaging 1.00
R4915:Or8k33 UTSW 2 86,384,399 (GRCm39) missense probably damaging 1.00
R4924:Or8k33 UTSW 2 86,383,853 (GRCm39) missense probably damaging 1.00
R4987:Or8k33 UTSW 2 86,383,579 (GRCm39) splice site probably null 0.10
R5774:Or8k33 UTSW 2 86,384,351 (GRCm39) missense possibly damaging 0.68
R6305:Or8k33 UTSW 2 86,383,839 (GRCm39) missense possibly damaging 0.91
R6829:Or8k33 UTSW 2 86,383,613 (GRCm39) nonsense probably null
R7152:Or8k33 UTSW 2 86,383,673 (GRCm39) missense probably benign 0.14
R7561:Or8k33 UTSW 2 86,383,661 (GRCm39) missense probably benign 0.45
R7963:Or8k33 UTSW 2 86,383,639 (GRCm39) missense possibly damaging 0.86
R8031:Or8k33 UTSW 2 86,384,447 (GRCm39) missense probably damaging 1.00
R8177:Or8k33 UTSW 2 86,383,623 (GRCm39) missense noncoding transcript
R8349:Or8k33 UTSW 2 86,383,980 (GRCm39) missense probably benign 0.22
R8449:Or8k33 UTSW 2 86,383,980 (GRCm39) missense probably benign 0.22
R8787:Or8k33 UTSW 2 86,384,297 (GRCm39) missense probably damaging 1.00
R8801:Or8k33 UTSW 2 86,383,727 (GRCm39) missense probably benign 0.22
R8808:Or8k33 UTSW 2 86,384,297 (GRCm39) missense probably damaging 1.00
R9035:Or8k33 UTSW 2 86,384,021 (GRCm39) missense probably damaging 0.98
R9301:Or8k33 UTSW 2 86,383,818 (GRCm39) missense possibly damaging 0.91
Z1088:Or8k33 UTSW 2 86,384,310 (GRCm39) missense probably benign 0.40
Z1191:Or8k33 UTSW 2 86,384,471 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- AGAGAAAGCTTTGCGTCTGC -3'
(R):5'- TAGACGCCAAGCTACAGACG -3'

Sequencing Primer
(F):5'- CTCAGCAGAGTTCATCCTGAG -3'
(R):5'- GCTACAGACGCCAATGTATTTC -3'
Posted On 2021-01-18