Incidental Mutation 'R8496:Gpr88'
ID 658262
Institutional Source Beutler Lab
Gene Symbol Gpr88
Ensembl Gene ENSMUSG00000068696
Gene Name G-protein coupled receptor 88
Synonyms Strg
MMRRC Submission 067938-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R8496 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 116043304-116047123 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 116046117 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 65 (T65A)
Ref Sequence ENSEMBL: ENSMUSP00000087959 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090473] [ENSMUST00000197759]
AlphaFold Q9EPB7
Predicted Effect possibly damaging
Transcript: ENSMUST00000090473
AA Change: T65A

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000087959
Gene: ENSMUSG00000068696
AA Change: T65A

DomainStartEndE-ValueType
low complexity region 4 26 N/A INTRINSIC
Pfam:7tm_1 48 336 5.2e-16 PFAM
low complexity region 357 373 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000197759
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik A G 5: 138,645,120 (GRCm39) E335G probably benign Het
Afp C T 5: 90,639,572 (GRCm39) S34F probably damaging Het
Ano6 T A 15: 95,847,807 (GRCm39) I639N probably damaging Het
Atp13a1 T G 8: 70,250,618 (GRCm39) V411G probably damaging Het
Cadm2 A T 16: 66,461,309 (GRCm39) C383S probably damaging Het
Capn2 T C 1: 182,304,840 (GRCm39) I556V probably benign Het
Cd34 A G 1: 194,642,089 (GRCm39) E322G probably benign Het
Cel T C 2: 28,446,200 (GRCm39) D557G probably benign Het
Cemip T C 7: 83,600,634 (GRCm39) I996V probably benign Het
Clca3a1 A T 3: 144,453,182 (GRCm39) *514R probably null Het
Cry2 C G 2: 92,257,284 (GRCm39) R95P probably damaging Het
Ctse T A 1: 131,592,118 (GRCm39) I148N probably damaging Het
Cyp4f13 G C 17: 33,143,833 (GRCm39) P497R probably damaging Het
Dsn1 C T 2: 156,839,640 (GRCm39) V254M probably benign Het
Fcgbpl1 A G 7: 27,843,377 (GRCm39) D755G possibly damaging Het
Gm4847 T A 1: 166,469,761 (GRCm39) H104L possibly damaging Het
Gtse1 A G 15: 85,746,283 (GRCm39) D33G probably damaging Het
Ints6 A G 14: 62,943,325 (GRCm39) Y455H probably benign Het
Kctd1 A T 18: 15,107,228 (GRCm39) C150S probably damaging Het
Kctd11 T G 11: 69,770,877 (GRCm39) T54P probably damaging Het
Kif1b C A 4: 149,277,068 (GRCm39) G56* probably null Het
Kifap3 T A 1: 163,656,866 (GRCm39) probably null Het
Naip5 G T 13: 100,349,247 (GRCm39) H1360Q probably benign Het
Ncapd2 T C 6: 125,147,127 (GRCm39) E1198G probably damaging Het
Nova1 T A 12: 46,760,325 (GRCm39) K90* probably null Het
Odc1 T A 12: 17,598,396 (GRCm39) L179H probably damaging Het
Or10w1 T A 19: 13,632,388 (GRCm39) H193Q probably damaging Het
Or1ad8 T C 11: 50,897,877 (GRCm39) V26A probably benign Het
Or1s2 A G 19: 13,758,384 (GRCm39) N136S probably benign Het
Palm C T 10: 79,642,485 (GRCm39) T6I probably benign Het
Parp10 T A 15: 76,117,749 (GRCm39) D879V probably damaging Het
Phf2 A G 13: 48,971,181 (GRCm39) V497A unknown Het
Pparg A G 6: 115,440,112 (GRCm39) I199V probably benign Het
Ppm1b T A 17: 85,301,660 (GRCm39) I180N probably damaging Het
Prdx5 A T 19: 6,885,542 (GRCm39) C37* probably null Het
Ptprz1 A T 6: 22,972,797 (GRCm39) T236S probably damaging Het
Rab5b G A 10: 128,518,776 (GRCm39) Q119* probably null Het
Rdh19 T A 10: 127,695,469 (GRCm39) W228R probably damaging Het
Schip1 G T 3: 68,401,946 (GRCm39) G36C probably damaging Het
Secisbp2 T C 13: 51,819,383 (GRCm39) V321A probably damaging Het
Slc6a5 T A 7: 49,585,960 (GRCm39) V426D probably damaging Het
Syne1 T A 10: 5,178,896 (GRCm39) E4526V probably damaging Het
Syne1 T C 10: 5,268,441 (GRCm39) K2083E probably damaging Het
Tecta T A 9: 42,241,547 (GRCm39) I2143F probably benign Het
Tfap4 T C 16: 4,369,170 (GRCm39) D90G probably damaging Het
Ttll12 T C 15: 83,462,010 (GRCm39) Y569C probably damaging Het
Zfp326 T G 5: 106,036,451 (GRCm39) S121A probably damaging Het
Other mutations in Gpr88
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4498001:Gpr88 UTSW 3 116,046,264 (GRCm39) missense unknown
R1914:Gpr88 UTSW 3 116,046,073 (GRCm39) missense possibly damaging 0.86
R1915:Gpr88 UTSW 3 116,046,073 (GRCm39) missense possibly damaging 0.86
R5934:Gpr88 UTSW 3 116,045,958 (GRCm39) missense probably damaging 1.00
R6593:Gpr88 UTSW 3 116,046,273 (GRCm39) missense unknown
R7184:Gpr88 UTSW 3 116,045,643 (GRCm39) missense possibly damaging 0.51
R9055:Gpr88 UTSW 3 116,046,300 (GRCm39) missense unknown
RF007:Gpr88 UTSW 3 116,046,018 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTGGTGATGAGCAGGTAGC -3'
(R):5'- CGAGGTGTGAAGAGTTGGCC -3'

Sequencing Primer
(F):5'- AGGTAGCGGTTCAGCGC -3'
(R):5'- GTTGGCCAGAATGACCAACTC -3'
Posted On 2021-01-18