Incidental Mutation 'R8496:Or1ad8'
ID 658281
Institutional Source Beutler Lab
Gene Symbol Or1ad8
Ensembl Gene ENSMUSG00000060918
Gene Name olfactory receptor family 1 subfamily AD member 8
Synonyms Olfr51, ID7, GA_x6K02T2QP88-4431129-4430206, MOR129-3
MMRRC Submission 067938-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R8496 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 50897801-50898724 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 50897877 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 26 (V26A)
Ref Sequence ENSEMBL: ENSMUSP00000151005 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076514] [ENSMUST00000213415]
AlphaFold Q8VGG9
Predicted Effect probably benign
Transcript: ENSMUST00000076514
AA Change: V26A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000075832
Gene: ENSMUSG00000060918
AA Change: V26A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.4e-50 PFAM
Pfam:7tm_1 41 289 8.7e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213415
AA Change: V26A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik A G 5: 138,645,120 (GRCm39) E335G probably benign Het
Afp C T 5: 90,639,572 (GRCm39) S34F probably damaging Het
Ano6 T A 15: 95,847,807 (GRCm39) I639N probably damaging Het
Atp13a1 T G 8: 70,250,618 (GRCm39) V411G probably damaging Het
Cadm2 A T 16: 66,461,309 (GRCm39) C383S probably damaging Het
Capn2 T C 1: 182,304,840 (GRCm39) I556V probably benign Het
Cd34 A G 1: 194,642,089 (GRCm39) E322G probably benign Het
Cel T C 2: 28,446,200 (GRCm39) D557G probably benign Het
Cemip T C 7: 83,600,634 (GRCm39) I996V probably benign Het
Clca3a1 A T 3: 144,453,182 (GRCm39) *514R probably null Het
Cry2 C G 2: 92,257,284 (GRCm39) R95P probably damaging Het
Ctse T A 1: 131,592,118 (GRCm39) I148N probably damaging Het
Cyp4f13 G C 17: 33,143,833 (GRCm39) P497R probably damaging Het
Dsn1 C T 2: 156,839,640 (GRCm39) V254M probably benign Het
Fcgbpl1 A G 7: 27,843,377 (GRCm39) D755G possibly damaging Het
Gm4847 T A 1: 166,469,761 (GRCm39) H104L possibly damaging Het
Gpr88 T C 3: 116,046,117 (GRCm39) T65A possibly damaging Het
Gtse1 A G 15: 85,746,283 (GRCm39) D33G probably damaging Het
Ints6 A G 14: 62,943,325 (GRCm39) Y455H probably benign Het
Kctd1 A T 18: 15,107,228 (GRCm39) C150S probably damaging Het
Kctd11 T G 11: 69,770,877 (GRCm39) T54P probably damaging Het
Kif1b C A 4: 149,277,068 (GRCm39) G56* probably null Het
Kifap3 T A 1: 163,656,866 (GRCm39) probably null Het
Naip5 G T 13: 100,349,247 (GRCm39) H1360Q probably benign Het
Ncapd2 T C 6: 125,147,127 (GRCm39) E1198G probably damaging Het
Nova1 T A 12: 46,760,325 (GRCm39) K90* probably null Het
Odc1 T A 12: 17,598,396 (GRCm39) L179H probably damaging Het
Or10w1 T A 19: 13,632,388 (GRCm39) H193Q probably damaging Het
Or1s2 A G 19: 13,758,384 (GRCm39) N136S probably benign Het
Palm C T 10: 79,642,485 (GRCm39) T6I probably benign Het
Parp10 T A 15: 76,117,749 (GRCm39) D879V probably damaging Het
Phf2 A G 13: 48,971,181 (GRCm39) V497A unknown Het
Pparg A G 6: 115,440,112 (GRCm39) I199V probably benign Het
Ppm1b T A 17: 85,301,660 (GRCm39) I180N probably damaging Het
Prdx5 A T 19: 6,885,542 (GRCm39) C37* probably null Het
Ptprz1 A T 6: 22,972,797 (GRCm39) T236S probably damaging Het
Rab5b G A 10: 128,518,776 (GRCm39) Q119* probably null Het
Rdh19 T A 10: 127,695,469 (GRCm39) W228R probably damaging Het
Schip1 G T 3: 68,401,946 (GRCm39) G36C probably damaging Het
Secisbp2 T C 13: 51,819,383 (GRCm39) V321A probably damaging Het
Slc6a5 T A 7: 49,585,960 (GRCm39) V426D probably damaging Het
Syne1 T A 10: 5,178,896 (GRCm39) E4526V probably damaging Het
Syne1 T C 10: 5,268,441 (GRCm39) K2083E probably damaging Het
Tecta T A 9: 42,241,547 (GRCm39) I2143F probably benign Het
Tfap4 T C 16: 4,369,170 (GRCm39) D90G probably damaging Het
Ttll12 T C 15: 83,462,010 (GRCm39) Y569C probably damaging Het
Zfp326 T G 5: 106,036,451 (GRCm39) S121A probably damaging Het
Other mutations in Or1ad8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01771:Or1ad8 APN 11 50,898,593 (GRCm39) missense probably benign 0.15
IGL02729:Or1ad8 APN 11 50,897,892 (GRCm39) missense probably damaging 1.00
R0367:Or1ad8 UTSW 11 50,897,904 (GRCm39) missense probably damaging 1.00
R1675:Or1ad8 UTSW 11 50,898,464 (GRCm39) missense probably benign 0.01
R1716:Or1ad8 UTSW 11 50,898,679 (GRCm39) missense probably damaging 1.00
R1943:Or1ad8 UTSW 11 50,898,502 (GRCm39) missense probably benign 0.42
R3027:Or1ad8 UTSW 11 50,897,879 (GRCm39) missense possibly damaging 0.77
R4569:Or1ad8 UTSW 11 50,898,381 (GRCm39) missense possibly damaging 0.94
R5190:Or1ad8 UTSW 11 50,898,381 (GRCm39) missense probably damaging 0.98
R5447:Or1ad8 UTSW 11 50,898,170 (GRCm39) missense possibly damaging 0.66
R5560:Or1ad8 UTSW 11 50,898,350 (GRCm39) missense possibly damaging 0.61
R6396:Or1ad8 UTSW 11 50,898,312 (GRCm39) missense possibly damaging 0.46
R6943:Or1ad8 UTSW 11 50,898,153 (GRCm39) missense probably damaging 1.00
R7199:Or1ad8 UTSW 11 50,898,223 (GRCm39) nonsense probably null
R7991:Or1ad8 UTSW 11 50,898,071 (GRCm39) missense possibly damaging 0.48
R8118:Or1ad8 UTSW 11 50,898,327 (GRCm39) missense probably damaging 1.00
R8178:Or1ad8 UTSW 11 50,898,437 (GRCm39) missense probably damaging 1.00
R9006:Or1ad8 UTSW 11 50,897,975 (GRCm39) missense probably damaging 0.98
R9246:Or1ad8 UTSW 11 50,897,891 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACAAGCCAGCAGAAGTAGTTTAC -3'
(R):5'- CAACATATGATTCACCAATGCCTTG -3'

Sequencing Primer
(F):5'- GCCAGCAGAAGTAGTTTACAAAAC -3'
(R):5'- TGGGGACAATGACAGATGGAGC -3'
Posted On 2021-01-18