Incidental Mutation 'R8500:Or5t16'
ID 658455
Institutional Source Beutler Lab
Gene Symbol Or5t16
Ensembl Gene ENSMUSG00000075167
Gene Name olfactory receptor family 5 subfamily T member 16
Synonyms GA_x6K02T2Q125-48475870-48474938, MOR179-3, Olfr1101
MMRRC Submission 067942-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # R8500 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 86818586-86819518 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 86818822 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 233 (K233E)
Ref Sequence ENSEMBL: ENSMUSP00000151171 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099870] [ENSMUST00000214411]
AlphaFold Q7TR59
Predicted Effect probably damaging
Transcript: ENSMUST00000099870
AA Change: K233E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097455
Gene: ENSMUSG00000075167
AA Change: K233E

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.7e-51 PFAM
Pfam:7tm_1 38 287 5.1e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214411
AA Change: K233E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031439G07Rik C T 15: 84,871,836 (GRCm39) S56N probably benign Het
Atg16l2 T G 7: 100,939,473 (GRCm39) D542A probably damaging Het
Blm A G 7: 80,105,032 (GRCm39) L1412P probably damaging Het
Cdc37 T C 9: 21,052,097 (GRCm39) D314G probably damaging Het
Cela1 T A 15: 100,573,213 (GRCm39) M39L probably benign Het
Col12a1 T A 9: 79,517,133 (GRCm39) D2849V probably damaging Het
Fam53c A G 18: 34,901,854 (GRCm39) E257G probably damaging Het
Fmo9 A T 1: 166,502,039 (GRCm39) N144K probably damaging Het
Gabrd T A 4: 155,470,148 (GRCm39) M354L probably benign Het
Gm5773 A T 3: 93,680,835 (GRCm39) D169V probably benign Het
Gria2 A T 3: 80,599,774 (GRCm39) F703L probably damaging Het
Grm3 A T 5: 9,561,726 (GRCm39) I708N probably benign Het
Hlcs G A 16: 94,063,617 (GRCm39) P481L possibly damaging Het
Ifi206 T C 1: 173,314,311 (GRCm39) Y43C Het
Igf2r A G 17: 12,928,328 (GRCm39) L1005P probably damaging Het
Ighv2-6-8 T C 12: 113,759,834 (GRCm39) N92D possibly damaging Het
Invs A G 4: 48,422,109 (GRCm39) K914E probably damaging Het
Iqsec3 T C 6: 121,389,813 (GRCm39) probably benign Het
Klra6 T C 6: 129,999,660 (GRCm39) T103A probably benign Het
Lipo5 C T 19: 33,441,849 (GRCm39) probably null Het
Llgl1 T C 11: 60,595,809 (GRCm39) probably null Het
Lonrf1 T C 8: 36,698,292 (GRCm39) E402G probably benign Het
Lrp1b T A 2: 41,396,791 (GRCm39) Y311F probably benign Het
Lrrc8a T A 2: 30,146,208 (GRCm39) W341R possibly damaging Het
Lrriq1 A G 10: 102,882,016 (GRCm39) I117T Het
Mmp9 T C 2: 164,795,486 (GRCm39) V668A possibly damaging Het
Naip5 A C 13: 100,359,220 (GRCm39) M672R probably damaging Het
Ncam1 A T 9: 49,431,445 (GRCm39) L664Q probably damaging Het
Nol4l T C 2: 153,278,266 (GRCm39) D234G probably damaging Het
Oscp1 T A 4: 125,971,203 (GRCm39) H170Q possibly damaging Het
Pard3 T A 8: 128,186,784 (GRCm39) M1021K probably damaging Het
Pkd1l2 T A 8: 117,774,302 (GRCm39) probably null Het
Plcxd2 T C 16: 45,800,949 (GRCm39) K92E probably damaging Het
Ptpdc1 A T 13: 48,739,759 (GRCm39) C557* probably null Het
Robo2 G A 16: 73,745,228 (GRCm39) T849I probably damaging Het
Rp1 A T 1: 4,416,813 (GRCm39) I1433N possibly damaging Het
Scarb1 A G 5: 125,371,227 (GRCm39) S282P probably damaging Het
Schip1 G T 3: 68,401,946 (GRCm39) G36C probably damaging Het
Sf3a1 T A 11: 4,125,039 (GRCm39) S357T probably benign Het
Sh3glb2 A T 2: 30,249,216 (GRCm39) M1K probably null Het
Slc1a3 T C 15: 8,671,853 (GRCm39) T368A probably damaging Het
Slc66a1 A G 4: 139,027,440 (GRCm39) probably benign Het
Taf11 A T 17: 28,121,594 (GRCm39) I138N probably damaging Het
Tnfaip8l1 C T 17: 56,478,749 (GRCm39) A13V probably damaging Het
Trav6-2 T G 14: 52,905,092 (GRCm39) F38V probably benign Het
Vmn2r73 A G 7: 85,519,638 (GRCm39) V440A probably benign Het
Zfp292 A G 4: 34,826,691 (GRCm39) probably null Het
Zfp429 A T 13: 67,538,828 (GRCm39) C205* probably null Het
Zfp735 C G 11: 73,601,811 (GRCm39) L252V possibly damaging Het
Zfyve26 A T 12: 79,334,454 (GRCm39) L188Q probably damaging Het
Other mutations in Or5t16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01288:Or5t16 APN 2 86,818,598 (GRCm39) missense probably benign
IGL03018:Or5t16 APN 2 86,819,349 (GRCm39) missense probably damaging 1.00
IGL03265:Or5t16 APN 2 86,819,424 (GRCm39) missense probably damaging 1.00
R0627:Or5t16 UTSW 2 86,819,358 (GRCm39) missense probably benign 0.21
R2871:Or5t16 UTSW 2 86,819,192 (GRCm39) nonsense probably null
R2871:Or5t16 UTSW 2 86,819,192 (GRCm39) nonsense probably null
R7012:Or5t16 UTSW 2 86,819,051 (GRCm39) missense possibly damaging 0.50
R7144:Or5t16 UTSW 2 86,819,164 (GRCm39) missense probably damaging 1.00
R7151:Or5t16 UTSW 2 86,819,385 (GRCm39) missense probably benign 0.16
R7521:Or5t16 UTSW 2 86,818,954 (GRCm39) missense probably damaging 1.00
R7672:Or5t16 UTSW 2 86,818,663 (GRCm39) missense possibly damaging 0.93
R7725:Or5t16 UTSW 2 86,819,323 (GRCm39) missense probably benign 0.00
R7863:Or5t16 UTSW 2 86,819,424 (GRCm39) missense probably damaging 1.00
R7965:Or5t16 UTSW 2 86,818,707 (GRCm39) missense probably benign 0.12
R8447:Or5t16 UTSW 2 86,818,885 (GRCm39) missense probably benign 0.01
R8899:Or5t16 UTSW 2 86,818,710 (GRCm39) missense probably benign 0.03
R9776:Or5t16 UTSW 2 86,819,055 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TCCTGAGACTGTAGATGATGGG -3'
(R):5'- TATCCATACAGCAGCCACTG -3'

Sequencing Primer
(F):5'- ACTGTAGATGATGGGATTCAGC -3'
(R):5'- GCCACTGCTAGCTTGTCG -3'
Posted On 2021-01-18