Incidental Mutation 'R8519:Tpp2'
| ID |
658500 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tpp2
|
| Ensembl Gene |
ENSMUSG00000041763 |
| Gene Name |
tripeptidyl peptidase II |
| Synonyms |
TppII |
| MMRRC Submission |
067946-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.589)
|
| Stock # |
R8519 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
43973130-44042160 bp(+) (GRCm39) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
A to T
at 44016365 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139918
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087933]
[ENSMUST00000087933]
[ENSMUST00000087933]
[ENSMUST00000188302]
[ENSMUST00000188313]
[ENSMUST00000188313]
[ENSMUST00000188313]
[ENSMUST00000189388]
|
| AlphaFold |
Q64514 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000087933
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000087933
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000087933
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000186441
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000186441
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000186441
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188302
|
| SMART Domains |
Protein: ENSMUSP00000140474
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
4.3e-84 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000188313
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000188313
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000188313
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189388
|
| SMART Domains |
Protein: ENSMUSP00000140562
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
2.3e-81 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
880 |
7.8e-49 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (67/67) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
PHENOTYPE: Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts14 |
T |
C |
10: 61,038,619 (GRCm39) |
T964A |
possibly damaging |
Het |
| Adamts7 |
G |
A |
9: 90,075,610 (GRCm39) |
W1156* |
probably null |
Het |
| Adcy9 |
T |
C |
16: 4,105,992 (GRCm39) |
I1041V |
possibly damaging |
Het |
| Armh4 |
T |
C |
14: 50,010,693 (GRCm39) |
D338G |
probably damaging |
Het |
| Art4 |
C |
A |
6: 136,831,349 (GRCm39) |
|
probably null |
Het |
| Bcl9 |
A |
G |
3: 97,116,334 (GRCm39) |
S787P |
probably benign |
Het |
| Bptf |
T |
C |
11: 106,952,590 (GRCm39) |
T2088A |
probably damaging |
Het |
| Cdc45 |
T |
C |
16: 18,627,597 (GRCm39) |
N76S |
probably damaging |
Het |
| Cdon |
A |
G |
9: 35,389,950 (GRCm39) |
D868G |
probably damaging |
Het |
| Cldn10 |
T |
G |
14: 119,092,439 (GRCm39) |
V13G |
probably benign |
Het |
| Cnot6 |
G |
T |
11: 49,575,941 (GRCm39) |
Q178K |
probably benign |
Het |
| Crot |
T |
C |
5: 9,023,629 (GRCm39) |
I420V |
probably benign |
Het |
| Csgalnact1 |
T |
A |
8: 68,854,105 (GRCm39) |
H232L |
possibly damaging |
Het |
| Cuzd1 |
T |
C |
7: 130,910,626 (GRCm39) |
I556M |
possibly damaging |
Het |
| Cyp2c54 |
G |
A |
19: 40,026,857 (GRCm39) |
R433W |
probably damaging |
Het |
| Cyp2j11 |
A |
G |
4: 96,207,539 (GRCm39) |
F259L |
probably benign |
Het |
| Dhx9 |
C |
T |
1: 153,348,922 (GRCm39) |
G264R |
probably damaging |
Het |
| Dnah5 |
G |
A |
15: 28,299,245 (GRCm39) |
V1536M |
probably benign |
Het |
| Erlin1 |
T |
A |
19: 44,058,041 (GRCm39) |
|
probably benign |
Het |
| Foxb2 |
C |
A |
19: 16,850,347 (GRCm39) |
V220L |
possibly damaging |
Het |
| Gigyf2 |
A |
T |
1: 87,338,431 (GRCm39) |
T388S |
probably benign |
Het |
| Gimap5 |
T |
C |
6: 48,730,068 (GRCm39) |
C213R |
probably benign |
Het |
| Gkap1 |
T |
G |
13: 58,386,506 (GRCm39) |
K57N |
probably damaging |
Het |
| H60b |
T |
G |
10: 22,159,421 (GRCm39) |
|
probably benign |
Het |
| Hectd4 |
C |
T |
5: 121,442,489 (GRCm39) |
R670* |
probably null |
Het |
| Hoxc9 |
A |
G |
15: 102,892,341 (GRCm39) |
N185D |
probably damaging |
Het |
| Igkv1-117 |
A |
G |
6: 68,098,766 (GRCm39) |
E105G |
possibly damaging |
Het |
| Klk10 |
T |
A |
7: 43,432,239 (GRCm39) |
Y57* |
probably null |
Het |
| Lrrc63 |
A |
T |
14: 75,363,312 (GRCm39) |
I273K |
possibly damaging |
Het |
| M6pr |
T |
C |
6: 122,292,025 (GRCm39) |
I119T |
probably damaging |
Het |
| Mael |
T |
C |
1: 166,063,127 (GRCm39) |
|
probably null |
Het |
| Magi1 |
A |
G |
6: 93,681,330 (GRCm39) |
S574P |
possibly damaging |
Het |
| Man2c1 |
A |
G |
9: 57,044,061 (GRCm39) |
D291G |
probably benign |
Het |
| Mapk1ip1l |
A |
T |
14: 47,547,920 (GRCm39) |
|
probably benign |
Het |
| Mrc2 |
A |
G |
11: 105,238,132 (GRCm39) |
T1135A |
possibly damaging |
Het |
| Mrpl39 |
A |
G |
16: 84,527,736 (GRCm39) |
V164A |
probably benign |
Het |
| Mynn |
C |
A |
3: 30,661,290 (GRCm39) |
P124H |
probably damaging |
Het |
| Or11l3 |
T |
G |
11: 58,516,800 (GRCm39) |
Q23P |
probably damaging |
Het |
| Or14n1-ps1 |
A |
T |
7: 86,093,062 (GRCm39) |
N291I |
probably damaging |
Het |
| Or2k2 |
A |
G |
4: 58,785,203 (GRCm39) |
I173T |
probably damaging |
Het |
| Or2t48 |
A |
G |
11: 58,420,329 (GRCm39) |
F161S |
possibly damaging |
Het |
| Or6k2 |
A |
G |
1: 173,986,614 (GRCm39) |
I92V |
probably damaging |
Het |
| Pcif1 |
A |
G |
2: 164,726,303 (GRCm39) |
N68S |
probably damaging |
Het |
| Pcm1 |
T |
A |
8: 41,728,976 (GRCm39) |
N649K |
probably damaging |
Het |
| Pira1 |
T |
C |
7: 3,740,432 (GRCm39) |
Q263R |
probably benign |
Het |
| Plxna2 |
T |
A |
1: 194,476,266 (GRCm39) |
I1162N |
probably damaging |
Het |
| Pnp2 |
T |
A |
14: 51,201,842 (GRCm39) |
L276Q |
probably damaging |
Het |
| Sirpb1c |
T |
A |
3: 15,902,526 (GRCm39) |
I18F |
possibly damaging |
Het |
| Slc2a12 |
A |
T |
10: 22,540,678 (GRCm39) |
M178L |
probably damaging |
Het |
| Slc35c1 |
G |
T |
2: 92,285,052 (GRCm39) |
F187L |
probably benign |
Het |
| Smg1 |
T |
C |
7: 117,770,982 (GRCm39) |
|
probably benign |
Het |
| Spmip6 |
A |
G |
4: 41,505,071 (GRCm39) |
S214P |
possibly damaging |
Het |
| Spopfm2 |
T |
C |
3: 94,083,497 (GRCm39) |
M105V |
probably benign |
Het |
| Stn1 |
T |
C |
19: 47,490,111 (GRCm39) |
H342R |
probably benign |
Het |
| Sult1c2 |
A |
T |
17: 54,276,709 (GRCm39) |
H117Q |
probably damaging |
Het |
| Thap1 |
G |
A |
8: 26,650,925 (GRCm39) |
R42K |
probably damaging |
Het |
| Trib2 |
G |
T |
12: 15,865,347 (GRCm39) |
P76Q |
probably damaging |
Het |
| Ttc24 |
G |
T |
3: 87,980,369 (GRCm39) |
Q111K |
probably damaging |
Het |
| Ubr4 |
T |
C |
4: 139,143,958 (GRCm39) |
S1401P |
probably damaging |
Het |
| Uggt1 |
A |
C |
1: 36,215,724 (GRCm39) |
|
probably null |
Het |
| Ugt2b1 |
A |
G |
5: 87,074,326 (GRCm39) |
L11S |
probably damaging |
Het |
| Uso1 |
T |
G |
5: 92,343,222 (GRCm39) |
S769A |
probably benign |
Het |
| Vmn2r117 |
T |
C |
17: 23,698,442 (GRCm39) |
T44A |
probably benign |
Het |
| Vmn2r28 |
T |
A |
7: 5,489,347 (GRCm39) |
L497F |
probably benign |
Het |
| Vsig10l |
G |
A |
7: 43,114,326 (GRCm39) |
S318N |
probably benign |
Het |
| Wbp4 |
A |
G |
14: 79,714,263 (GRCm39) |
L83P |
probably damaging |
Het |
| Wnk1 |
G |
A |
6: 119,927,044 (GRCm39) |
R1510W |
probably damaging |
Het |
| Zc3hav1l |
C |
T |
6: 38,272,176 (GRCm39) |
V198M |
probably damaging |
Het |
| Zfp1004 |
A |
G |
2: 150,034,700 (GRCm39) |
I340M |
probably benign |
Het |
|
| Other mutations in Tpp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00977:Tpp2
|
APN |
1 |
44,022,451 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01021:Tpp2
|
APN |
1 |
43,973,347 (GRCm39) |
nonsense |
probably null |
|
|
IGL01096:Tpp2
|
APN |
1 |
44,000,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01344:Tpp2
|
APN |
1 |
44,022,422 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01642:Tpp2
|
APN |
1 |
43,993,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02719:Tpp2
|
APN |
1 |
43,979,391 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02890:Tpp2
|
APN |
1 |
44,038,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Tpp2
|
APN |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03175:Tpp2
|
APN |
1 |
44,012,671 (GRCm39) |
missense |
probably benign |
0.35 |
|
beaver
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
billingsly
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
cleaver
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
dow
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
Eddie
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
jerry
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
June
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
landers
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
mathers
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
recurrentis
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
state
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
wally
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
Ward
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
wilson
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
BB010:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB020:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0001:Tpp2
|
UTSW |
1 |
44,010,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0003:Tpp2
|
UTSW |
1 |
43,999,299 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Tpp2
|
UTSW |
1 |
44,020,908 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0110:Tpp2
|
UTSW |
1 |
44,017,664 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0110:Tpp2
|
UTSW |
1 |
44,038,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0167:Tpp2
|
UTSW |
1 |
44,009,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0441:Tpp2
|
UTSW |
1 |
44,029,722 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0520:Tpp2
|
UTSW |
1 |
44,029,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Tpp2
|
UTSW |
1 |
44,014,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1118:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1119:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1593:Tpp2
|
UTSW |
1 |
44,014,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1702:Tpp2
|
UTSW |
1 |
44,029,708 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1756:Tpp2
|
UTSW |
1 |
44,017,885 (GRCm39) |
splice site |
probably null |
|
|
R2066:Tpp2
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2171:Tpp2
|
UTSW |
1 |
43,996,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Tpp2
|
UTSW |
1 |
44,038,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2394:Tpp2
|
UTSW |
1 |
44,022,346 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2507:Tpp2
|
UTSW |
1 |
44,040,609 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2879:Tpp2
|
UTSW |
1 |
44,010,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3436:Tpp2
|
UTSW |
1 |
43,979,304 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4106:Tpp2
|
UTSW |
1 |
44,040,617 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4658:Tpp2
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4760:Tpp2
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4963:Tpp2
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Tpp2
|
UTSW |
1 |
44,040,633 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5073:Tpp2
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6010:Tpp2
|
UTSW |
1 |
43,990,373 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6118:Tpp2
|
UTSW |
1 |
43,979,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6155:Tpp2
|
UTSW |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Tpp2
|
UTSW |
1 |
44,022,739 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6236:Tpp2
|
UTSW |
1 |
44,016,477 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6695:Tpp2
|
UTSW |
1 |
44,022,436 (GRCm39) |
missense |
probably benign |
|
|
R6845:Tpp2
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Tpp2
|
UTSW |
1 |
44,022,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7094:Tpp2
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7223:Tpp2
|
UTSW |
1 |
44,008,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7316:Tpp2
|
UTSW |
1 |
44,009,591 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7324:Tpp2
|
UTSW |
1 |
44,017,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7363:Tpp2
|
UTSW |
1 |
44,024,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7454:Tpp2
|
UTSW |
1 |
43,993,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7496:Tpp2
|
UTSW |
1 |
44,022,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7699:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7700:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7804:Tpp2
|
UTSW |
1 |
44,022,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7933:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7979:Tpp2
|
UTSW |
1 |
43,979,297 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8032:Tpp2
|
UTSW |
1 |
44,014,628 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8101:Tpp2
|
UTSW |
1 |
44,009,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tpp2
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Tpp2
|
UTSW |
1 |
43,973,387 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8518:Tpp2
|
UTSW |
1 |
44,019,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8529:Tpp2
|
UTSW |
1 |
44,022,300 (GRCm39) |
missense |
probably benign |
|
|
R8756:Tpp2
|
UTSW |
1 |
43,999,295 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Tpp2
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8773:Tpp2
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
R8915:Tpp2
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9049:Tpp2
|
UTSW |
1 |
43,992,502 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9090:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Tpp2
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
R9214:Tpp2
|
UTSW |
1 |
44,031,514 (GRCm39) |
missense |
probably benign |
|
|
R9271:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9316:Tpp2
|
UTSW |
1 |
44,017,604 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9371:Tpp2
|
UTSW |
1 |
43,999,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Tpp2
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9488:Tpp2
|
UTSW |
1 |
44,041,272 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9513:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9514:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9516:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTTACAGCTTTACTTTGAAGATCC -3'
(R):5'- AAATGTCTTGGGAGTGCTCTC -3'
Sequencing Primer
(F):5'- GAGACCTGGATTTGATTCTCAGCAC -3'
(R):5'- GCTCTCGATTTTCTTGTTACATAAAC -3'
|
| Posted On |
2021-01-18 |
Incidental Mutation