Incidental Mutation 'R8524:Dand5'
ID 658717
Institutional Source Beutler Lab
Gene Symbol Dand5
Ensembl Gene ENSMUSG00000053226
Gene Name DAN domain family member 5, BMP antagonist
Synonyms Dte, Cerl2, Cerl-2, Cerr2, GREM3, coco
MMRRC Submission 067949-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R8524 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 85542034-85558894 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 85549056 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 85 (L85*)
Ref Sequence ENSEMBL: ENSMUSP00000070057 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065539]
AlphaFold Q76LW6
Predicted Effect probably null
Transcript: ENSMUST00000065539
AA Change: L85*
SMART Domains Protein: ENSMUSP00000070057
Gene: ENSMUSG00000053226
AA Change: L85*

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 66 77 N/A INTRINSIC
CT 99 185 4.41e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (41/41)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display partial neonatal lethality with left pulmonary isomerism, abnormal heart looping, atrial and ventricular septal defects and thoracic situs inversus and surviving pups display partial premature death with abdominal organ position abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc65 A T 15: 98,606,990 (GRCm39) T66S probably benign Het
Cers1 G A 8: 70,783,898 (GRCm39) G282D probably damaging Het
Cfap57 C T 4: 118,472,128 (GRCm39) V84I probably benign Het
Col25a1 C A 3: 130,342,873 (GRCm39) P350H probably damaging Het
Coq5 T C 5: 115,422,612 (GRCm39) I172T probably damaging Het
Dnah8 T A 17: 30,934,472 (GRCm39) W1486R possibly damaging Het
Dpp8 T C 9: 64,950,989 (GRCm39) Y142H probably damaging Het
G530012D18Rik C G 1: 85,504,935 (GRCm39) D113E unknown Het
Gng7 T A 10: 80,787,537 (GRCm39) H42L possibly damaging Het
Gps2 T C 11: 69,805,832 (GRCm39) V93A probably damaging Het
Hspa9 T C 18: 35,087,297 (GRCm39) S3G unknown Het
Impg2 A G 16: 56,038,757 (GRCm39) N132D probably benign Het
Jak2 A T 19: 29,273,105 (GRCm39) N643I probably damaging Het
Kcng2 T C 18: 80,338,896 (GRCm39) D464G probably benign Het
Kdm4b T A 17: 56,706,384 (GRCm39) C833S probably damaging Het
Ly86 G A 13: 37,560,869 (GRCm39) D77N probably damaging Het
Map7 G A 10: 20,142,569 (GRCm39) A330T probably benign Het
Mettl1 T C 10: 126,877,908 (GRCm39) S21P probably damaging Het
Mga A G 2: 119,771,997 (GRCm39) Y1540C probably damaging Het
Mpp4 A G 1: 59,183,840 (GRCm39) L300P probably damaging Het
Mycbp2 A G 14: 103,392,895 (GRCm39) M3222T probably benign Het
Nat8f6 A G 6: 85,785,541 (GRCm39) Y203H probably benign Het
Nod1 C T 6: 54,925,060 (GRCm39) E84K probably damaging Het
Or10v9 A G 19: 11,832,445 (GRCm39) Y291H probably damaging Het
Or2b28 T C 13: 21,531,248 (GRCm39) V50A probably benign Het
Or8k28 T C 2: 86,285,961 (GRCm39) Y218C probably damaging Het
Padi2 A G 4: 140,677,006 (GRCm39) N598S possibly damaging Het
Pclo C T 5: 14,729,521 (GRCm39) probably benign Het
Pdik1l T G 4: 134,013,921 (GRCm39) E12D probably benign Het
Plcg1 G A 2: 160,603,387 (GRCm39) probably null Het
Rasgrf1 A G 9: 89,797,638 (GRCm39) H172R possibly damaging Het
Rnf41 C G 10: 128,271,299 (GRCm39) R70G possibly damaging Het
Rsbn1 A T 3: 103,835,687 (GRCm39) K203* probably null Het
Setbp1 T C 18: 78,901,969 (GRCm39) D566G probably damaging Het
Slc7a14 A C 3: 31,278,282 (GRCm39) V441G possibly damaging Het
Sorl1 T A 9: 41,885,370 (GRCm39) N2077I probably damaging Het
Spryd3 G A 15: 102,026,583 (GRCm39) R363* probably null Het
St6galnac1 G T 11: 116,658,547 (GRCm39) R306S possibly damaging Het
Tmem245 T C 4: 56,906,261 (GRCm39) Q548R probably benign Het
Trim35 C T 14: 66,544,493 (GRCm39) R276C probably damaging Het
Trim55 A T 3: 19,725,113 (GRCm39) D210V probably benign Het
Tsg101 A T 7: 46,542,115 (GRCm39) D279E probably benign Het
Other mutations in Dand5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0600:Dand5 UTSW 8 85,542,921 (GRCm39) missense probably damaging 0.98
R4921:Dand5 UTSW 8 85,543,113 (GRCm39) missense probably damaging 1.00
R8162:Dand5 UTSW 8 85,543,147 (GRCm39) missense probably damaging 1.00
R9463:Dand5 UTSW 8 85,542,938 (GRCm39) nonsense probably null
Z1177:Dand5 UTSW 8 85,543,152 (GRCm39) missense probably damaging 1.00
Z1177:Dand5 UTSW 8 85,542,966 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTGAACACTGCTGAGAGTGC -3'
(R):5'- ATGTTCCGTAGCCAGTTCAC -3'

Sequencing Primer
(F):5'- acacaaccaccaccacta -3'
(R):5'- TAGCCAGTTCACCACGCTG -3'
Posted On 2021-01-18