Incidental Mutation 'R8524:Ly86'
ID 658728
Institutional Source Beutler Lab
Gene Symbol Ly86
Ensembl Gene ENSMUSG00000021423
Gene Name lymphocyte antigen 86
Synonyms MD-1, MD1
MMRRC Submission 067949-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R8524 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 37529276-37603012 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 37560869 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 77 (D77N)
Ref Sequence ENSEMBL: ENSMUSP00000021860 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021860]
AlphaFold O88188
PDB Structure Crystal structure of mouse MD-1 in complex with phosphatidylcholine [X-RAY DIFFRACTION]
Crystal structure of mouse RP105/MD-1 complex [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000021860
AA Change: D77N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000021860
Gene: ENSMUSG00000021423
AA Change: D77N

DomainStartEndE-ValueType
ML 42 159 4.29e-26 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (41/41)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele display impaired LPS-induced B-cell proliferation and antibody production. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc65 A T 15: 98,606,990 (GRCm39) T66S probably benign Het
Cers1 G A 8: 70,783,898 (GRCm39) G282D probably damaging Het
Cfap57 C T 4: 118,472,128 (GRCm39) V84I probably benign Het
Col25a1 C A 3: 130,342,873 (GRCm39) P350H probably damaging Het
Coq5 T C 5: 115,422,612 (GRCm39) I172T probably damaging Het
Dand5 A T 8: 85,549,056 (GRCm39) L85* probably null Het
Dnah8 T A 17: 30,934,472 (GRCm39) W1486R possibly damaging Het
Dpp8 T C 9: 64,950,989 (GRCm39) Y142H probably damaging Het
G530012D18Rik C G 1: 85,504,935 (GRCm39) D113E unknown Het
Gng7 T A 10: 80,787,537 (GRCm39) H42L possibly damaging Het
Gps2 T C 11: 69,805,832 (GRCm39) V93A probably damaging Het
Hspa9 T C 18: 35,087,297 (GRCm39) S3G unknown Het
Impg2 A G 16: 56,038,757 (GRCm39) N132D probably benign Het
Jak2 A T 19: 29,273,105 (GRCm39) N643I probably damaging Het
Kcng2 T C 18: 80,338,896 (GRCm39) D464G probably benign Het
Kdm4b T A 17: 56,706,384 (GRCm39) C833S probably damaging Het
Map7 G A 10: 20,142,569 (GRCm39) A330T probably benign Het
Mettl1 T C 10: 126,877,908 (GRCm39) S21P probably damaging Het
Mga A G 2: 119,771,997 (GRCm39) Y1540C probably damaging Het
Mpp4 A G 1: 59,183,840 (GRCm39) L300P probably damaging Het
Mycbp2 A G 14: 103,392,895 (GRCm39) M3222T probably benign Het
Nat8f6 A G 6: 85,785,541 (GRCm39) Y203H probably benign Het
Nod1 C T 6: 54,925,060 (GRCm39) E84K probably damaging Het
Or10v9 A G 19: 11,832,445 (GRCm39) Y291H probably damaging Het
Or2b28 T C 13: 21,531,248 (GRCm39) V50A probably benign Het
Or8k28 T C 2: 86,285,961 (GRCm39) Y218C probably damaging Het
Padi2 A G 4: 140,677,006 (GRCm39) N598S possibly damaging Het
Pclo C T 5: 14,729,521 (GRCm39) probably benign Het
Pdik1l T G 4: 134,013,921 (GRCm39) E12D probably benign Het
Plcg1 G A 2: 160,603,387 (GRCm39) probably null Het
Rasgrf1 A G 9: 89,797,638 (GRCm39) H172R possibly damaging Het
Rnf41 C G 10: 128,271,299 (GRCm39) R70G possibly damaging Het
Rsbn1 A T 3: 103,835,687 (GRCm39) K203* probably null Het
Setbp1 T C 18: 78,901,969 (GRCm39) D566G probably damaging Het
Slc7a14 A C 3: 31,278,282 (GRCm39) V441G possibly damaging Het
Sorl1 T A 9: 41,885,370 (GRCm39) N2077I probably damaging Het
Spryd3 G A 15: 102,026,583 (GRCm39) R363* probably null Het
St6galnac1 G T 11: 116,658,547 (GRCm39) R306S possibly damaging Het
Tmem245 T C 4: 56,906,261 (GRCm39) Q548R probably benign Het
Trim35 C T 14: 66,544,493 (GRCm39) R276C probably damaging Het
Trim55 A T 3: 19,725,113 (GRCm39) D210V probably benign Het
Tsg101 A T 7: 46,542,115 (GRCm39) D279E probably benign Het
Other mutations in Ly86
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02693:Ly86 APN 13 37,559,005 (GRCm39) missense probably damaging 1.00
R0082:Ly86 UTSW 13 37,602,513 (GRCm39) critical splice acceptor site probably null
R4605:Ly86 UTSW 13 37,558,987 (GRCm39) missense possibly damaging 0.81
R4642:Ly86 UTSW 13 37,560,877 (GRCm39) missense possibly damaging 0.53
R4665:Ly86 UTSW 13 37,559,010 (GRCm39) missense probably damaging 0.98
R4904:Ly86 UTSW 13 37,599,496 (GRCm39) missense possibly damaging 0.94
R5112:Ly86 UTSW 13 37,559,013 (GRCm39) missense probably damaging 1.00
R5300:Ly86 UTSW 13 37,602,588 (GRCm39) missense probably benign 0.00
R7145:Ly86 UTSW 13 37,560,986 (GRCm39) missense probably damaging 1.00
R7258:Ly86 UTSW 13 37,529,473 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GCATTGATAGGGCAGAGTGCTG -3'
(R):5'- AGTCAGGACTTTGACCCCTG -3'

Sequencing Primer
(F):5'- AAGATAGCCAGTGAGCTGCCTC -3'
(R):5'- ACTTTGACCCCTGGGACC -3'
Posted On 2021-01-18