Incidental Mutation 'R8532:Or9m2'
ID 659091
Institutional Source Beutler Lab
Gene Symbol Or9m2
Ensembl Gene ENSMUSG00000062793
Gene Name olfactory receptor family 9 subfamily M member 2
Synonyms GA_x6K02T2Q125-49480812-49481753, Olfr1158, MOR173-3
MMRRC Submission 068502-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R8532 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 87820457-87821398 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87820913 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 153 (T153A)
Ref Sequence ENSEMBL: ENSMUSP00000099682 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102622]
AlphaFold A2BHP7
Predicted Effect probably damaging
Transcript: ENSMUST00000102622
AA Change: T153A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000099682
Gene: ENSMUSG00000062793
AA Change: T153A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.5e-45 PFAM
Pfam:7tm_1 41 289 4.5e-15 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 C A 2: 69,090,035 (GRCm39) V950L possibly damaging Het
Acsl6 T A 11: 54,218,001 (GRCm39) V238E probably damaging Het
Adam2 C A 14: 66,293,970 (GRCm39) A286S probably damaging Het
Ankrd17 A T 5: 90,412,679 (GRCm39) I1215N probably damaging Het
Anxa2 T C 9: 69,374,594 (GRCm39) Y24H probably benign Het
Brms1l T C 12: 55,891,264 (GRCm39) L106P probably damaging Het
Cacna1e A T 1: 154,341,510 (GRCm39) L1166Q probably damaging Het
Ccdc110 T C 8: 46,396,032 (GRCm39) L641P probably damaging Het
Cep78 T A 19: 15,936,948 (GRCm39) D586V possibly damaging Het
Chek1 T C 9: 36,630,988 (GRCm39) D142G probably benign Het
Dennd1b A G 1: 139,097,912 (GRCm39) probably benign Het
Eif2b5 T C 16: 20,323,956 (GRCm39) V433A probably damaging Het
Enpep A T 3: 129,070,302 (GRCm39) Y868* probably null Het
Fam149a T A 8: 45,801,991 (GRCm39) T414S possibly damaging Het
Ggnbp2 C T 11: 84,728,815 (GRCm39) probably null Het
Gm3604 A T 13: 62,516,769 (GRCm39) C530S possibly damaging Het
Gtf2e2 T C 8: 34,248,633 (GRCm39) F140S probably damaging Het
Ighv1-63 T C 12: 115,459,270 (GRCm39) D109G probably damaging Het
Igkv3-9 G C 6: 70,565,706 (GRCm39) V102L possibly damaging Het
Kif12 G A 4: 63,087,656 (GRCm39) Q276* probably null Het
Lrba C T 3: 86,664,790 (GRCm39) R557C probably damaging Het
Matn2 C A 15: 34,316,699 (GRCm39) Q14K probably benign Het
Mical2 C A 7: 111,917,751 (GRCm39) F369L probably damaging Het
Or13a17 T C 7: 140,271,712 (GRCm39) V298A probably damaging Het
Or52e8b T C 7: 104,673,773 (GRCm39) Y138C probably damaging Het
Pramel1 A G 4: 143,125,125 (GRCm39) T350A probably benign Het
Rcbtb1 T A 14: 59,447,973 (GRCm39) C72* probably null Het
Ros1 T G 10: 51,974,852 (GRCm39) T1578P possibly damaging Het
Rps6kb2 A T 19: 4,209,243 (GRCm39) I200N probably damaging Het
Slc17a4 C A 13: 24,088,718 (GRCm39) W223L probably damaging Het
Slitrk5 A T 14: 111,916,909 (GRCm39) M178L probably benign Het
Snrpa A G 7: 26,891,027 (GRCm39) probably null Het
Syt10 C T 15: 89,676,889 (GRCm39) E366K probably damaging Het
Tbc1d16 A G 11: 119,045,993 (GRCm39) F484L probably benign Het
Tbc1d30 A T 10: 121,103,335 (GRCm39) W566R probably damaging Het
Tcaf1 A T 6: 42,655,065 (GRCm39) I551K probably damaging Het
Tdrd7 A G 4: 46,016,920 (GRCm39) T654A probably damaging Het
Timm44 A T 8: 4,310,549 (GRCm39) I401N possibly damaging Het
Xcl1 T A 1: 164,759,515 (GRCm39) T62S probably damaging Het
Zbtb11 A T 16: 55,811,252 (GRCm39) H470L probably benign Het
Zfp57 A G 17: 37,320,793 (GRCm39) T213A possibly damaging Het
Zfp715 A C 7: 42,948,829 (GRCm39) I377S possibly damaging Het
Zfp715 A T 7: 42,949,134 (GRCm39) D275E probably benign Het
Other mutations in Or9m2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00272:Or9m2 APN 2 87,820,782 (GRCm39) missense probably damaging 1.00
IGL01287:Or9m2 APN 2 87,821,288 (GRCm39) missense probably benign 0.01
IGL01374:Or9m2 APN 2 87,820,892 (GRCm39) missense probably benign
IGL01821:Or9m2 APN 2 87,820,933 (GRCm39) missense probably benign 0.12
IGL01832:Or9m2 APN 2 87,820,513 (GRCm39) missense probably benign 0.02
IGL02327:Or9m2 APN 2 87,820,601 (GRCm39) missense probably damaging 1.00
IGL02580:Or9m2 APN 2 87,820,857 (GRCm39) missense probably benign 0.09
IGL03001:Or9m2 APN 2 87,820,493 (GRCm39) missense probably benign 0.43
IGL03196:Or9m2 APN 2 87,820,826 (GRCm39) missense possibly damaging 0.67
R0546:Or9m2 UTSW 2 87,820,816 (GRCm39) nonsense probably null
R1474:Or9m2 UTSW 2 87,821,334 (GRCm39) missense probably damaging 1.00
R1650:Or9m2 UTSW 2 87,821,145 (GRCm39) missense probably benign 0.01
R1757:Or9m2 UTSW 2 87,820,926 (GRCm39) missense probably damaging 0.99
R2992:Or9m2 UTSW 2 87,821,121 (GRCm39) missense probably benign 0.00
R4038:Or9m2 UTSW 2 87,821,262 (GRCm39) missense possibly damaging 0.88
R5190:Or9m2 UTSW 2 87,821,107 (GRCm39) nonsense probably null
R5871:Or9m2 UTSW 2 87,821,355 (GRCm39) missense possibly damaging 0.82
R8220:Or9m2 UTSW 2 87,820,496 (GRCm39) missense probably damaging 1.00
R8475:Or9m2 UTSW 2 87,820,536 (GRCm39) missense probably damaging 1.00
R9026:Or9m2 UTSW 2 87,820,568 (GRCm39) missense probably damaging 0.99
R9522:Or9m2 UTSW 2 87,821,175 (GRCm39) missense probably damaging 1.00
R9657:Or9m2 UTSW 2 87,821,310 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTTACAATGGCTGTGCTACAC -3'
(R):5'- TACTGCCAGGTGAGAAGCAC -3'

Sequencing Primer
(F):5'- GTGCTACACAGTTTTATTTTTGCTGC -3'
(R):5'- GCAGAACCTGTTTTAAGAATGGCC -3'
Posted On 2021-01-18