Incidental Mutation 'R8535:Anks1b'
| ID |
659209 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Anks1b
|
| Ensembl Gene |
ENSMUSG00000058589 |
| Gene Name |
ankyrin repeat and sterile alpha motif domain containing 1B |
| Synonyms |
C030032C09Rik, AIDA-1b, LOC380650, Gm10937, E530015N03Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8535 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
89873509-90973300 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 90948631 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 1154
(S1154T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138539
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099364]
[ENSMUST00000099366]
[ENSMUST00000179337]
[ENSMUST00000179694]
[ENSMUST00000182053]
[ENSMUST00000182113]
[ENSMUST00000182284]
[ENSMUST00000182356]
[ENSMUST00000182430]
[ENSMUST00000182550]
[ENSMUST00000182595]
[ENSMUST00000182600]
[ENSMUST00000182786]
[ENSMUST00000182907]
[ENSMUST00000183156]
[ENSMUST00000182960]
[ENSMUST00000182966]
[ENSMUST00000183136]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099364
AA Change: S381T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000096965
Gene: ENSMUSG00000058589
AA Change: S381T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
PTB
|
131 |
269 |
1.5e-40 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099366
AA Change: S161T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000096967
Gene: ENSMUSG00000058589
AA Change: S161T
| Domain | Start | End | E-Value | Type |
|---|
|
PTB
|
63 |
201 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000179337
AA Change: S161T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000136410
Gene: ENSMUSG00000058589
AA Change: S161T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
PTB
|
156 |
294 |
1.6e-40 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000179694
AA Change: S161T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000136146
Gene: ENSMUSG00000058589
AA Change: S161T
| Domain | Start | End | E-Value | Type |
|---|
|
PTB
|
96 |
234 |
1.5e-40 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182053
AA Change: S290T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000138644
Gene: ENSMUSG00000058589
AA Change: S290T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
2 |
71 |
1.19e-19 |
SMART |
|
SAM
|
76 |
144 |
5.66e-17 |
SMART |
|
PTB
|
192 |
330 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182113
AA Change: S405T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000138655
Gene: ENSMUSG00000058589
AA Change: S405T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
low complexity region
|
195 |
210 |
N/A |
INTRINSIC |
|
PTB
|
307 |
445 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182284
AA Change: S346T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000138794
Gene: ENSMUSG00000058589
AA Change: S346T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
PTB
|
248 |
386 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182356
AA Change: S324T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000138234
Gene: ENSMUSG00000058589
AA Change: S324T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
1 |
45 |
4.05e1 |
SMART |
|
SAM
|
50 |
118 |
5.66e-17 |
SMART |
|
low complexity region
|
138 |
153 |
N/A |
INTRINSIC |
|
PTB
|
226 |
364 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182430
AA Change: S321T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000138660
Gene: ENSMUSG00000058589
AA Change: S321T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
PTB
|
223 |
361 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182550
AA Change: S406T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000138643
Gene: ENSMUSG00000058589
AA Change: S406T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
low complexity region
|
195 |
210 |
N/A |
INTRINSIC |
|
PTB
|
308 |
446 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182595
AA Change: S381T
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000138314
Gene: ENSMUSG00000058589
AA Change: S381T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
low complexity region
|
195 |
210 |
N/A |
INTRINSIC |
|
PTB
|
283 |
421 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182600
AA Change: S314T
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000138650
Gene: ENSMUSG00000058589
AA Change: S314T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
1 |
45 |
4.05e1 |
SMART |
|
SAM
|
50 |
118 |
5.66e-17 |
SMART |
|
PTB
|
216 |
354 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182786
AA Change: S253T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000138720
Gene: ENSMUSG00000058589
AA Change: S253T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SAM_2
|
1 |
42 |
8.4e-8 |
PFAM |
|
Pfam:SAM_1
|
2 |
43 |
5.4e-7 |
PFAM |
|
Pfam:SAM_1
|
51 |
97 |
4.4e-10 |
PFAM |
|
Pfam:SAM_2
|
52 |
95 |
6.1e-7 |
PFAM |
|
PTB
|
155 |
293 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182907
|
| SMART Domains |
Protein: ENSMUSP00000138614
Gene: ENSMUSG00000058589
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
45 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183156
AA Change: S1154T
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000138539
Gene: ENSMUSG00000058589
AA Change: S1154T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
4.75e-2 |
SMART |
|
low complexity region
|
498 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
670 |
N/A |
INTRINSIC |
|
SAM
|
806 |
875 |
2.06e-19 |
SMART |
|
SAM
|
880 |
948 |
5.66e-17 |
SMART |
|
low complexity region
|
968 |
983 |
N/A |
INTRINSIC |
|
PTB
|
1056 |
1194 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182960
AA Change: S345T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000138222
Gene: ENSMUSG00000058589
AA Change: S345T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
PTB
|
247 |
385 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182966
AA Change: S186T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000138610
Gene: ENSMUSG00000058589
AA Change: S186T
| Domain | Start | End | E-Value | Type |
|---|
|
PTB
|
88 |
226 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183024
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183136
AA Change: S405T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000138738
Gene: ENSMUSG00000058589
AA Change: S405T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
low complexity region
|
195 |
210 |
N/A |
INTRINSIC |
|
PTB
|
307 |
445 |
2.94e-38 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
100% (34/34) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a conditional allele activated in neurons alters hippocampal synaptic transmission. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsl6 |
A |
T |
11: 54,338,502 |
I362F |
probably damaging |
Het |
| Bsn |
G |
A |
9: 108,111,452 |
A2367V |
probably benign |
Het |
| Cd163l1 |
G |
A |
7: 140,224,721 |
V546M |
probably benign |
Het |
| Chd7 |
T |
A |
4: 8,859,211 |
S2434T |
possibly damaging |
Het |
| Crybg2 |
T |
C |
4: 134,081,203 |
S1372P |
probably damaging |
Het |
| Dock5 |
A |
G |
14: 67,793,976 |
Y1002H |
probably benign |
Het |
| Dst |
T |
C |
1: 34,186,001 |
S1163P |
probably damaging |
Het |
| Dusp27 |
T |
C |
1: 166,101,161 |
D294G |
probably benign |
Het |
| Fah |
A |
T |
7: 84,601,097 |
S14T |
probably benign |
Het |
| Gcnt7 |
T |
C |
2: 172,454,546 |
I119M |
possibly damaging |
Het |
| Gja10 |
G |
A |
4: 32,602,274 |
L37F |
probably damaging |
Het |
| Gm10750 |
A |
G |
2: 149,015,968 |
V121A |
unknown |
Het |
| Klhl25 |
G |
A |
7: 75,866,095 |
V250I |
probably benign |
Het |
| Kmt2a |
A |
C |
9: 44,819,515 |
S200R |
possibly damaging |
Het |
| Map1b |
T |
A |
13: 99,435,154 |
D353V |
probably damaging |
Het |
| Myh8 |
G |
A |
11: 67,278,915 |
R20Q |
probably damaging |
Het |
| Olfr1262 |
G |
A |
2: 90,003,167 |
V254M |
probably benign |
Het |
| Olfr764-ps1 |
T |
C |
10: 129,034,023 |
Y273C |
probably damaging |
Het |
| Pcnt |
G |
A |
10: 76,420,205 |
R734W |
probably damaging |
Het |
| Pkn3 |
A |
T |
2: 30,079,924 |
|
probably null |
Het |
| Ptpn21 |
T |
A |
12: 98,680,026 |
T1058S |
probably damaging |
Het |
| Ryr3 |
A |
G |
2: 112,949,088 |
|
probably null |
Het |
| Sardh |
T |
A |
2: 27,239,645 |
I263F |
probably damaging |
Het |
| Sh3bp5 |
A |
G |
14: 31,417,418 |
V66A |
probably benign |
Het |
| Taf4b |
T |
A |
18: 14,822,138 |
S583T |
probably damaging |
Het |
| Tbcb |
G |
A |
7: 30,226,996 |
P132L |
probably benign |
Het |
| Tcirg1 |
A |
G |
19: 3,896,324 |
I791T |
probably damaging |
Het |
| Tmeff2 |
T |
A |
1: 51,181,826 |
V320D |
probably damaging |
Het |
| Tnfrsf19 |
T |
C |
14: 60,970,968 |
E368G |
probably benign |
Het |
| Trdv2-1 |
T |
A |
14: 53,946,515 |
I67N |
probably damaging |
Het |
| Unc13c |
G |
A |
9: 73,540,371 |
T1849I |
probably benign |
Het |
| Vav2 |
G |
A |
2: 27,271,829 |
T655I |
probably damaging |
Het |
| Vps50 |
T |
C |
6: 3,565,612 |
Y517H |
possibly damaging |
Het |
| Wdr27 |
G |
A |
17: 14,903,537 |
T558I |
possibly damaging |
Het |
| Yeats2 |
C |
T |
16: 20,159,176 |
R137W |
probably damaging |
Het |
|
| Other mutations in Anks1b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01669:Anks1b
|
APN |
10 |
90897238 |
splice site |
probably benign |
|
|
IGL01890:Anks1b
|
APN |
10 |
90644527 |
missense |
probably benign |
0.15 |
|
IGL01966:Anks1b
|
APN |
10 |
90895132 |
missense |
probably damaging |
1.00 |
|
IGL02176:Anks1b
|
APN |
10 |
90042668 |
missense |
probably damaging |
0.99 |
|
IGL02205:Anks1b
|
APN |
10 |
90071094 |
missense |
probably benign |
0.00 |
|
IGL02465:Anks1b
|
APN |
10 |
90163265 |
nonsense |
probably null |
|
|
IGL02534:Anks1b
|
APN |
10 |
90895117 |
missense |
probably benign |
0.45 |
|
IGL02554:Anks1b
|
APN |
10 |
90921378 |
missense |
probably damaging |
1.00 |
|
IGL02820:Anks1b
|
APN |
10 |
90077059 |
missense |
possibly damaging |
0.93 |
|
IGL03164:Anks1b
|
APN |
10 |
90042692 |
missense |
probably damaging |
1.00 |
|
R0096:Anks1b
|
UTSW |
10 |
90074062 |
missense |
possibly damaging |
0.90 |
|
R0482:Anks1b
|
UTSW |
10 |
90359195 |
missense |
probably benign |
0.00 |
|
R0542:Anks1b
|
UTSW |
10 |
90073967 |
splice site |
probably benign |
|
|
R0848:Anks1b
|
UTSW |
10 |
90071125 |
missense |
probably damaging |
0.99 |
|
R1056:Anks1b
|
UTSW |
10 |
90921429 |
splice site |
probably null |
|
|
R1398:Anks1b
|
UTSW |
10 |
90050029 |
missense |
probably damaging |
1.00 |
|
R1446:Anks1b
|
UTSW |
10 |
90511073 |
missense |
probably benign |
0.00 |
|
R1548:Anks1b
|
UTSW |
10 |
90049985 |
missense |
possibly damaging |
0.79 |
|
R1551:Anks1b
|
UTSW |
10 |
90076981 |
missense |
probably benign |
0.00 |
|
R1607:Anks1b
|
UTSW |
10 |
90042548 |
missense |
probably damaging |
1.00 |
|
R1667:Anks1b
|
UTSW |
10 |
90511184 |
critical splice donor site |
probably null |
|
|
R1701:Anks1b
|
UTSW |
10 |
90049954 |
missense |
probably damaging |
1.00 |
|
R1843:Anks1b
|
UTSW |
10 |
90512889 |
critical splice donor site |
probably null |
|
|
R1899:Anks1b
|
UTSW |
10 |
90260756 |
missense |
probably damaging |
1.00 |
|
R1957:Anks1b
|
UTSW |
10 |
90049930 |
missense |
probably damaging |
1.00 |
|
R2036:Anks1b
|
UTSW |
10 |
90969853 |
missense |
probably damaging |
0.99 |
|
R2279:Anks1b
|
UTSW |
10 |
90050096 |
missense |
probably damaging |
1.00 |
|
R2280:Anks1b
|
UTSW |
10 |
90966302 |
missense |
probably damaging |
1.00 |
|
R2937:Anks1b
|
UTSW |
10 |
90077066 |
missense |
probably damaging |
1.00 |
|
R3739:Anks1b
|
UTSW |
10 |
90033216 |
missense |
probably damaging |
1.00 |
|
R4061:Anks1b
|
UTSW |
10 |
90307622 |
missense |
probably damaging |
0.98 |
|
R4459:Anks1b
|
UTSW |
10 |
90510844 |
missense |
probably damaging |
1.00 |
|
R4479:Anks1b
|
UTSW |
10 |
90049892 |
missense |
probably damaging |
1.00 |
|
R4510:Anks1b
|
UTSW |
10 |
90510790 |
missense |
probably benign |
0.01 |
|
R4511:Anks1b
|
UTSW |
10 |
90510790 |
missense |
probably benign |
0.01 |
|
R4780:Anks1b
|
UTSW |
10 |
89873732 |
missense |
probably damaging |
1.00 |
|
R4785:Anks1b
|
UTSW |
10 |
90914750 |
missense |
probably null |
0.88 |
|
R4790:Anks1b
|
UTSW |
10 |
90163275 |
missense |
probably damaging |
0.99 |
|
R5012:Anks1b
|
UTSW |
10 |
90359137 |
missense |
probably benign |
0.06 |
|
R5400:Anks1b
|
UTSW |
10 |
90512824 |
missense |
probably damaging |
1.00 |
|
R5586:Anks1b
|
UTSW |
10 |
90077064 |
missense |
probably damaging |
0.98 |
|
R5687:Anks1b
|
UTSW |
10 |
90914711 |
missense |
probably benign |
0.03 |
|
R5899:Anks1b
|
UTSW |
10 |
90923517 |
splice site |
probably null |
|
|
R5917:Anks1b
|
UTSW |
10 |
90576941 |
intron |
probably benign |
|
|
R5999:Anks1b
|
UTSW |
10 |
90359048 |
missense |
probably damaging |
1.00 |
|
R6080:Anks1b
|
UTSW |
10 |
90966349 |
nonsense |
probably null |
|
|
R6216:Anks1b
|
UTSW |
10 |
90260756 |
missense |
probably damaging |
1.00 |
|
R6265:Anks1b
|
UTSW |
10 |
90941500 |
missense |
probably damaging |
1.00 |
|
R6298:Anks1b
|
UTSW |
10 |
90680837 |
missense |
probably damaging |
1.00 |
|
R6337:Anks1b
|
UTSW |
10 |
90921296 |
missense |
probably benign |
0.27 |
|
R6522:Anks1b
|
UTSW |
10 |
90897327 |
intron |
probably benign |
|
|
R6843:Anks1b
|
UTSW |
10 |
90948598 |
missense |
probably damaging |
1.00 |
|
R6852:Anks1b
|
UTSW |
10 |
90260654 |
missense |
probably damaging |
1.00 |
|
R6933:Anks1b
|
UTSW |
10 |
90069490 |
missense |
probably damaging |
1.00 |
|
R7114:Anks1b
|
UTSW |
10 |
90307698 |
missense |
probably damaging |
1.00 |
|
R7211:Anks1b
|
UTSW |
10 |
90511070 |
missense |
possibly damaging |
0.94 |
|
R7241:Anks1b
|
UTSW |
10 |
90512837 |
missense |
probably damaging |
1.00 |
|
R7264:Anks1b
|
UTSW |
10 |
90512870 |
missense |
probably benign |
0.08 |
|
R7325:Anks1b
|
UTSW |
10 |
90941432 |
missense |
probably damaging |
1.00 |
|
R7392:Anks1b
|
UTSW |
10 |
90680786 |
missense |
possibly damaging |
0.47 |
|
R7578:Anks1b
|
UTSW |
10 |
90049927 |
missense |
probably damaging |
1.00 |
|
R7604:Anks1b
|
UTSW |
10 |
90260846 |
splice site |
probably null |
|
|
R7633:Anks1b
|
UTSW |
10 |
90948584 |
missense |
probably damaging |
1.00 |
|
R7881:Anks1b
|
UTSW |
10 |
90967018 |
missense |
probably benign |
0.07 |
|
R7910:Anks1b
|
UTSW |
10 |
90680792 |
missense |
probably damaging |
1.00 |
|
R7941:Anks1b
|
UTSW |
10 |
90577155 |
missense |
probably damaging |
0.98 |
|
R8045:Anks1b
|
UTSW |
10 |
90680860 |
missense |
probably benign |
|
|
R8146:Anks1b
|
UTSW |
10 |
90307698 |
missense |
probably damaging |
1.00 |
|
R8176:Anks1b
|
UTSW |
10 |
90069491 |
missense |
probably damaging |
1.00 |
|
R8681:Anks1b
|
UTSW |
10 |
90050006 |
missense |
probably damaging |
0.99 |
|
R9300:Anks1b
|
UTSW |
10 |
90577104 |
missense |
possibly damaging |
0.93 |
|
R9469:Anks1b
|
UTSW |
10 |
90897343 |
missense |
possibly damaging |
0.58 |
|
R9541:Anks1b
|
UTSW |
10 |
90577085 |
missense |
probably benign |
0.02 |
|
R9550:Anks1b
|
UTSW |
10 |
90576498 |
start codon destroyed |
probably null |
|
|
R9653:Anks1b
|
UTSW |
10 |
90510662 |
missense |
probably damaging |
1.00 |
|
RF004:Anks1b
|
UTSW |
10 |
90033225 |
missense |
probably damaging |
1.00 |
|
RF008:Anks1b
|
UTSW |
10 |
90033225 |
missense |
probably damaging |
1.00 |
|
RF017:Anks1b
|
UTSW |
10 |
90033225 |
missense |
probably damaging |
1.00 |
|
RF018:Anks1b
|
UTSW |
10 |
90033225 |
missense |
probably damaging |
1.00 |
|
RF023:Anks1b
|
UTSW |
10 |
90033225 |
missense |
probably damaging |
1.00 |
|
X0064:Anks1b
|
UTSW |
10 |
90512845 |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTCATTGAGTCACTTTGGAC -3'
(R):5'- GCAGTGTTTCATCATGGCAG -3'
Sequencing Primer
(F):5'- GAGTCACTTTGGACTAGAACCTTC -3'
(R):5'- TTCATCATGGCAGACTGAGC -3'
|
| Posted On |
2021-01-18 |
Incidental Mutation