Incidental Mutation 'R8536:Zmat4'
ID 659241
Institutional Source Beutler Lab
Gene Symbol Zmat4
Ensembl Gene ENSMUSG00000037492
Gene Name zinc finger, matrin type 4
Synonyms 9630048M01Rik
MMRRC Submission 067890-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.134) question?
Stock # R8536 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 24137347-24553133 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 24238523 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000146734 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042352] [ENSMUST00000123412] [ENSMUST00000131410] [ENSMUST00000135747] [ENSMUST00000207301]
AlphaFold Q8BZ94
Predicted Effect probably null
Transcript: ENSMUST00000042352
SMART Domains Protein: ENSMUSP00000049430
Gene: ENSMUSG00000037492

DomainStartEndE-ValueType
ZnF_U1 11 45 8.34e-6 SMART
ZnF_C2H2 14 38 4.99e1 SMART
ZnF_U1 72 106 8.6e-8 SMART
ZnF_C2H2 75 99 1.33e1 SMART
ZnF_U1 142 176 4.37e-9 SMART
ZnF_C2H2 145 169 4.38e1 SMART
ZnF_U1 195 229 3.08e-2 SMART
ZnF_C2H2 198 222 1.62e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000123412
SMART Domains Protein: ENSMUSP00000121626
Gene: ENSMUSG00000037492

DomainStartEndE-ValueType
ZnF_U1 11 45 8.34e-6 SMART
ZnF_C2H2 14 38 4.99e1 SMART
ZnF_U1 72 106 8.6e-8 SMART
ZnF_C2H2 75 99 1.33e1 SMART
ZnF_U1 142 176 4.37e-9 SMART
ZnF_C2H2 145 169 4.38e1 SMART
ZnF_U1 195 225 5.76e0 SMART
ZnF_C2H2 198 222 1.62e0 SMART
Predicted Effect probably null
Transcript: ENSMUST00000131410
SMART Domains Protein: ENSMUSP00000115719
Gene: ENSMUSG00000037492

DomainStartEndE-ValueType
ZnF_U1 11 45 8.34e-6 SMART
ZnF_U1 72 96 1.09e1 SMART
Predicted Effect probably null
Transcript: ENSMUST00000135747
SMART Domains Protein: ENSMUSP00000121337
Gene: ENSMUSG00000037492

DomainStartEndE-ValueType
ZnF_U1 25 59 8.34e-6 SMART
Predicted Effect probably null
Transcript: ENSMUST00000207301
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik C T 11: 30,376,217 (GRCm39) V217M probably benign Het
Abca4 A G 3: 121,973,394 (GRCm39) Q1074R probably benign Het
Ablim1 T C 19: 57,170,718 (GRCm39) probably benign Het
Acox2 A T 14: 8,256,081 (GRCm38) D79E probably benign Het
Bpifb9b A G 2: 154,158,197 (GRCm39) I440V probably benign Het
Ccdc7a T A 8: 129,516,601 (GRCm39) T118S possibly damaging Het
Cntln T C 4: 84,875,286 (GRCm39) I240T probably damaging Het
Col15a1 T C 4: 47,208,536 (GRCm39) probably null Het
Cox18 A G 5: 90,362,877 (GRCm39) F326S probably damaging Het
Dnm1l C A 16: 16,176,639 (GRCm39) V31L probably benign Het
Dst C A 1: 34,236,327 (GRCm39) L3578M possibly damaging Het
Fbxw24 G A 9: 109,452,599 (GRCm39) T132I probably damaging Het
Fchsd1 A G 18: 38,100,823 (GRCm39) V120A probably benign Het
Fibcd1 T C 2: 31,706,643 (GRCm39) E396G probably damaging Het
Fryl G T 5: 73,257,696 (GRCm39) T702K probably damaging Het
Gatb A T 3: 85,511,868 (GRCm39) I208F probably damaging Het
Gzmd T C 14: 56,367,158 (GRCm39) I245V probably damaging Het
Lats2 G A 14: 57,940,495 (GRCm39) A119V probably damaging Het
Lztfl1 A T 9: 123,540,119 (GRCm39) F129L probably benign Het
Meak7 T C 8: 120,490,787 (GRCm39) N320S probably benign Het
Mmp2 A T 8: 93,557,253 (GRCm39) Y53F probably damaging Het
Mttp G A 3: 137,810,704 (GRCm39) R637C probably damaging Het
Ndufa8 A C 2: 35,939,312 (GRCm39) probably benign Het
Nek11 A T 9: 105,175,538 (GRCm39) M302K probably benign Het
Nek6 A G 2: 38,404,797 (GRCm39) probably null Het
Numa1 C T 7: 101,650,787 (GRCm39) A1506V probably damaging Het
Plxdc1 A T 11: 97,869,522 (GRCm39) probably null Het
Poteg C A 8: 27,938,048 (GRCm39) T6K probably benign Het
Rbm26 A T 14: 105,380,274 (GRCm39) N514K possibly damaging Het
Rnf145 T C 11: 44,450,942 (GRCm39) L422P probably damaging Het
Scn5a G T 9: 119,368,811 (GRCm39) T238K probably damaging Het
Shd G A 17: 56,283,315 (GRCm39) A315T probably damaging Het
Sirpd A G 3: 15,361,614 (GRCm39) *179R probably null Het
Slco5a1 T G 1: 12,951,525 (GRCm39) T593P possibly damaging Het
Stard9 G A 2: 120,545,140 (GRCm39) R4560H possibly damaging Het
Traf3ip3 C T 1: 192,876,823 (GRCm39) probably null Het
Trpm1 G C 7: 63,897,155 (GRCm39) K252N probably damaging Het
Ttc7b A T 12: 100,339,803 (GRCm39) I584K possibly damaging Het
Vmn1r218 T C 13: 23,321,535 (GRCm39) V214A probably benign Het
Wdfy3 G T 5: 102,033,064 (GRCm39) H2215Q probably benign Het
Wls G A 3: 159,578,748 (GRCm39) M103I probably damaging Het
Zmynd15 G T 11: 70,353,387 (GRCm39) C334F probably damaging Het
Other mutations in Zmat4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01317:Zmat4 APN 8 24,392,185 (GRCm39) missense probably benign 0.00
IGL01678:Zmat4 APN 8 24,392,064 (GRCm39) missense probably damaging 1.00
IGL02528:Zmat4 APN 8 24,505,212 (GRCm39) missense probably damaging 0.99
IGL02638:Zmat4 APN 8 24,287,389 (GRCm39) missense probably damaging 1.00
IGL03203:Zmat4 APN 8 24,505,200 (GRCm39) missense probably damaging 0.99
R0208:Zmat4 UTSW 8 24,392,083 (GRCm39) missense probably damaging 1.00
R0884:Zmat4 UTSW 8 24,505,143 (GRCm39) missense probably benign 0.00
R1856:Zmat4 UTSW 8 24,419,151 (GRCm39) missense probably benign 0.41
R1888:Zmat4 UTSW 8 24,505,177 (GRCm39) missense probably damaging 0.99
R1888:Zmat4 UTSW 8 24,505,177 (GRCm39) missense probably damaging 0.99
R2166:Zmat4 UTSW 8 24,392,152 (GRCm39) missense probably damaging 1.00
R3704:Zmat4 UTSW 8 24,287,430 (GRCm39) missense probably benign 0.18
R4966:Zmat4 UTSW 8 24,392,085 (GRCm39) missense probably damaging 1.00
R5063:Zmat4 UTSW 8 24,238,457 (GRCm39) missense probably damaging 0.97
R5536:Zmat4 UTSW 8 24,238,508 (GRCm39) missense probably damaging 1.00
R5990:Zmat4 UTSW 8 24,419,279 (GRCm39) missense probably damaging 1.00
R6191:Zmat4 UTSW 8 24,392,083 (GRCm39) missense probably damaging 1.00
R6645:Zmat4 UTSW 8 24,287,417 (GRCm39) splice site probably null
R6962:Zmat4 UTSW 8 24,392,181 (GRCm39) missense probably benign 0.00
R7944:Zmat4 UTSW 8 24,238,436 (GRCm39) missense possibly damaging 0.95
R7945:Zmat4 UTSW 8 24,238,436 (GRCm39) missense possibly damaging 0.95
R9182:Zmat4 UTSW 8 24,419,226 (GRCm39) missense probably damaging 1.00
R9718:Zmat4 UTSW 8 24,238,507 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGGGACCCTGGCTTTTCAC -3'
(R):5'- TTTATTTACCCAGGGCTGCAG -3'

Sequencing Primer
(F):5'- GTTCCTCATTATCATCAGAGTAACCG -3'
(R):5'- TTACCCAGGGCTGCAGAATAAATTC -3'
Posted On 2021-01-18