Incidental Mutation 'R0233:Vmn2r11'
| ID |
65926 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r11
|
| Ensembl Gene |
ENSMUSG00000091450 |
| Gene Name |
vomeronasal 2, receptor 11 |
| Synonyms |
EG384219 |
| MMRRC Submission |
038474-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R0233 (G1)
|
| Quality Score |
199 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109194739-109207318 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 109201968 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 179
(S179T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133218
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164875]
|
| AlphaFold |
E9Q4X4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164875
AA Change: S179T
PolyPhen 2
Score 0.157 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: S179T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
167 |
475 |
1.6e-29 |
PFAM |
|
Pfam:NCD3G
|
520 |
574 |
9.1e-19 |
PFAM |
|
Pfam:7tm_3
|
607 |
842 |
4.6e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.6%
- 10x: 93.8%
- 20x: 81.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
A |
G |
14: 32,385,330 (GRCm39) |
S212P |
probably benign |
Het |
| A730018C14Rik |
A |
C |
12: 112,381,864 (GRCm39) |
|
noncoding transcript |
Het |
| Acsf3 |
A |
G |
8: 123,507,031 (GRCm39) |
Y108C |
probably damaging |
Het |
| Adad1 |
T |
A |
3: 37,139,097 (GRCm39) |
I389N |
possibly damaging |
Het |
| Ankrd27 |
T |
C |
7: 35,300,985 (GRCm39) |
L95P |
probably damaging |
Het |
| Ano5 |
T |
C |
7: 51,185,218 (GRCm39) |
F46S |
possibly damaging |
Het |
| Ap2a1 |
T |
C |
7: 44,565,397 (GRCm39) |
N114S |
probably damaging |
Het |
| Arap1 |
C |
T |
7: 101,049,448 (GRCm39) |
S970L |
possibly damaging |
Het |
| Atad3a |
A |
T |
4: 155,830,524 (GRCm39) |
S525T |
probably damaging |
Het |
| Bltp1 |
T |
A |
3: 37,002,712 (GRCm39) |
C1552* |
probably null |
Het |
| Cacna2d2 |
A |
T |
9: 107,391,869 (GRCm39) |
I463F |
probably damaging |
Het |
| Casp6 |
T |
A |
3: 129,699,624 (GRCm39) |
N34K |
probably damaging |
Het |
| Ccdc175 |
A |
T |
12: 72,152,650 (GRCm39) |
F752I |
probably benign |
Het |
| Cdhr4 |
A |
G |
9: 107,874,133 (GRCm39) |
I76V |
probably benign |
Het |
| Cox11 |
C |
T |
11: 90,535,326 (GRCm39) |
T259I |
probably damaging |
Het |
| Cuzd1 |
C |
A |
7: 130,913,545 (GRCm39) |
K357N |
possibly damaging |
Het |
| Dnase2b |
T |
A |
3: 146,288,305 (GRCm39) |
K263N |
probably benign |
Het |
| Dync1h1 |
T |
A |
12: 110,607,414 (GRCm39) |
D2668E |
probably benign |
Het |
| Fam124b |
T |
C |
1: 80,190,703 (GRCm39) |
S227G |
probably damaging |
Het |
| Fgf21 |
T |
A |
7: 45,264,721 (GRCm39) |
M4L |
probably benign |
Het |
| Flg2 |
T |
A |
3: 93,109,104 (GRCm39) |
C377* |
probably null |
Het |
| Gli2 |
A |
T |
1: 118,763,655 (GRCm39) |
S1499T |
probably damaging |
Het |
| Gm43638 |
T |
C |
5: 87,622,860 (GRCm39) |
N36S |
probably damaging |
Het |
| Gpx5 |
T |
A |
13: 21,471,573 (GRCm39) |
D210V |
probably damaging |
Het |
| H2-T5 |
A |
G |
17: 36,478,361 (GRCm39) |
Y224H |
probably benign |
Het |
| Hoxb5 |
T |
A |
11: 96,195,853 (GRCm39) |
S234T |
probably benign |
Het |
| Irf9 |
C |
A |
14: 55,843,551 (GRCm39) |
N140K |
probably benign |
Het |
| Isg20 |
C |
A |
7: 78,566,334 (GRCm39) |
D94E |
probably damaging |
Het |
| Isg20 |
C |
T |
7: 78,564,243 (GRCm39) |
T50M |
probably damaging |
Het |
| Izumo1 |
T |
C |
7: 45,273,592 (GRCm39) |
L115P |
probably damaging |
Het |
| Krt73 |
A |
T |
15: 101,710,451 (GRCm39) |
N94K |
probably benign |
Het |
| Lgmn |
G |
T |
12: 102,366,248 (GRCm39) |
D247E |
probably damaging |
Het |
| Lilra6 |
C |
T |
7: 3,917,935 (GRCm39) |
V70I |
possibly damaging |
Het |
| Lrig3 |
G |
A |
10: 125,849,395 (GRCm39) |
|
probably null |
Het |
| Lrrc4 |
T |
C |
6: 28,829,734 (GRCm39) |
H627R |
probably benign |
Het |
| Nat9 |
C |
A |
11: 115,074,234 (GRCm39) |
|
probably null |
Het |
| Nutm2 |
A |
G |
13: 50,621,441 (GRCm39) |
D2G |
probably benign |
Het |
| Or10j3b |
A |
T |
1: 173,043,868 (GRCm39) |
I217F |
probably benign |
Het |
| Or5h23 |
A |
T |
16: 58,906,038 (GRCm39) |
D269E |
probably benign |
Het |
| Or5w8 |
A |
G |
2: 87,688,096 (GRCm39) |
I192M |
probably benign |
Het |
| Pdzd8 |
A |
T |
19: 59,288,811 (GRCm39) |
M863K |
probably damaging |
Het |
| Phlda3 |
T |
C |
1: 135,694,559 (GRCm39) |
S125P |
probably damaging |
Het |
| Pkd1l3 |
A |
T |
8: 110,377,412 (GRCm39) |
R217* |
probably null |
Het |
| Plekhg5 |
T |
C |
4: 152,196,676 (GRCm39) |
C695R |
probably damaging |
Het |
| Pramel24 |
A |
T |
4: 143,452,633 (GRCm39) |
E21D |
possibly damaging |
Het |
| Pyroxd1 |
A |
G |
6: 142,300,356 (GRCm39) |
E162G |
possibly damaging |
Het |
| R3hcc1l |
G |
A |
19: 42,571,360 (GRCm39) |
|
probably null |
Het |
| Rgs12 |
T |
A |
5: 35,187,842 (GRCm39) |
S500T |
probably damaging |
Het |
| Ripor3 |
T |
C |
2: 167,834,518 (GRCm39) |
D299G |
probably damaging |
Het |
| Robo4 |
T |
C |
9: 37,313,977 (GRCm39) |
L76P |
probably damaging |
Het |
| Sbno1 |
T |
C |
5: 124,514,289 (GRCm39) |
Y1302C |
probably damaging |
Het |
| Sec63 |
A |
G |
10: 42,699,904 (GRCm39) |
I655V |
possibly damaging |
Het |
| Serpina11 |
T |
A |
12: 103,946,729 (GRCm39) |
M389L |
probably benign |
Het |
| Sfswap |
C |
A |
5: 129,631,607 (GRCm39) |
P745Q |
possibly damaging |
Het |
| Slitrk3 |
C |
T |
3: 72,955,910 (GRCm39) |
S954N |
probably benign |
Het |
| Sorbs2 |
A |
G |
8: 46,222,866 (GRCm39) |
T190A |
probably damaging |
Het |
| Sos2 |
A |
T |
12: 69,664,104 (GRCm39) |
I460N |
probably benign |
Het |
| Spink7 |
T |
A |
18: 62,727,423 (GRCm39) |
I34L |
probably benign |
Het |
| Srbd1 |
A |
G |
17: 86,365,173 (GRCm39) |
S628P |
probably damaging |
Het |
| Srm |
G |
A |
4: 148,677,829 (GRCm39) |
G156S |
probably damaging |
Het |
| Tmc4 |
T |
A |
7: 3,669,866 (GRCm39) |
Y6F |
probably benign |
Het |
| Tmcc2 |
A |
G |
1: 132,288,389 (GRCm39) |
F433L |
probably damaging |
Het |
| Tnxb |
T |
C |
17: 34,918,007 (GRCm39) |
F2307L |
probably benign |
Het |
| Tsr3 |
A |
G |
17: 25,461,484 (GRCm39) |
E274G |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,725,488 (GRCm39) |
|
probably benign |
Het |
| Tub |
T |
C |
7: 108,628,548 (GRCm39) |
V352A |
possibly damaging |
Het |
| Tubb2a |
A |
G |
13: 34,259,325 (GRCm39) |
I155T |
possibly damaging |
Het |
| Usp13 |
T |
A |
3: 32,969,813 (GRCm39) |
|
probably null |
Het |
| Vmn1r52 |
T |
G |
6: 90,156,593 (GRCm39) |
L120R |
possibly damaging |
Het |
| Vwf |
A |
T |
6: 125,663,473 (GRCm39) |
R2805W |
possibly damaging |
Het |
| Zfp286 |
T |
C |
11: 62,671,219 (GRCm39) |
T285A |
possibly damaging |
Het |
|
| Other mutations in Vmn2r11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00925:Vmn2r11
|
APN |
5 |
109,194,885 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01677:Vmn2r11
|
APN |
5 |
109,201,823 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02048:Vmn2r11
|
APN |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Vmn2r11
|
APN |
5 |
109,200,046 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02879:Vmn2r11
|
APN |
5 |
109,201,704 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03084:Vmn2r11
|
APN |
5 |
109,207,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03163:Vmn2r11
|
APN |
5 |
109,201,692 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL03289:Vmn2r11
|
APN |
5 |
109,196,788 (GRCm39) |
splice site |
probably benign |
|
|
IGL03294:Vmn2r11
|
APN |
5 |
109,201,935 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0421:Vmn2r11
|
UTSW |
5 |
109,207,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0549:Vmn2r11
|
UTSW |
5 |
109,199,963 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0628:Vmn2r11
|
UTSW |
5 |
109,195,597 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1523:Vmn2r11
|
UTSW |
5 |
109,201,707 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1660:Vmn2r11
|
UTSW |
5 |
109,201,724 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1827:Vmn2r11
|
UTSW |
5 |
109,199,938 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1913:Vmn2r11
|
UTSW |
5 |
109,202,654 (GRCm39) |
missense |
probably benign |
|
|
R2260:Vmn2r11
|
UTSW |
5 |
109,201,657 (GRCm39) |
nonsense |
probably null |
|
|
R2400:Vmn2r11
|
UTSW |
5 |
109,199,928 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3933:Vmn2r11
|
UTSW |
5 |
109,201,260 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4091:Vmn2r11
|
UTSW |
5 |
109,202,616 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4624:Vmn2r11
|
UTSW |
5 |
109,200,101 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4762:Vmn2r11
|
UTSW |
5 |
109,195,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Vmn2r11
|
UTSW |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5370:Vmn2r11
|
UTSW |
5 |
109,195,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5419:Vmn2r11
|
UTSW |
5 |
109,207,224 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R5516:Vmn2r11
|
UTSW |
5 |
109,195,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5643:Vmn2r11
|
UTSW |
5 |
109,194,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5671:Vmn2r11
|
UTSW |
5 |
109,202,772 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5679:Vmn2r11
|
UTSW |
5 |
109,202,708 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r11
|
UTSW |
5 |
109,207,114 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5746:Vmn2r11
|
UTSW |
5 |
109,201,560 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5995:Vmn2r11
|
UTSW |
5 |
109,194,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6147:Vmn2r11
|
UTSW |
5 |
109,202,700 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6220:Vmn2r11
|
UTSW |
5 |
109,201,434 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6374:Vmn2r11
|
UTSW |
5 |
109,201,679 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6491:Vmn2r11
|
UTSW |
5 |
109,196,800 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6804:Vmn2r11
|
UTSW |
5 |
109,201,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6814:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6872:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7014:Vmn2r11
|
UTSW |
5 |
109,201,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7041:Vmn2r11
|
UTSW |
5 |
109,202,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7043:Vmn2r11
|
UTSW |
5 |
109,200,098 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7050:Vmn2r11
|
UTSW |
5 |
109,202,657 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7184:Vmn2r11
|
UTSW |
5 |
109,201,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7388:Vmn2r11
|
UTSW |
5 |
109,202,742 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7477:Vmn2r11
|
UTSW |
5 |
109,207,214 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7524:Vmn2r11
|
UTSW |
5 |
109,201,848 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7682:Vmn2r11
|
UTSW |
5 |
109,195,481 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7715:Vmn2r11
|
UTSW |
5 |
109,195,307 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7869:Vmn2r11
|
UTSW |
5 |
109,199,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8094:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8277:Vmn2r11
|
UTSW |
5 |
109,202,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8506:Vmn2r11
|
UTSW |
5 |
109,207,270 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8676:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8701:Vmn2r11
|
UTSW |
5 |
109,195,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8749:Vmn2r11
|
UTSW |
5 |
109,195,319 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9046:Vmn2r11
|
UTSW |
5 |
109,202,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9138:Vmn2r11
|
UTSW |
5 |
109,201,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9267:Vmn2r11
|
UTSW |
5 |
109,199,929 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9306:Vmn2r11
|
UTSW |
5 |
109,196,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9384:Vmn2r11
|
UTSW |
5 |
109,201,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9443:Vmn2r11
|
UTSW |
5 |
109,195,159 (GRCm39) |
nonsense |
probably null |
|
|
R9520:Vmn2r11
|
UTSW |
5 |
109,201,455 (GRCm39) |
missense |
probably benign |
0.35 |
|
R9596:Vmn2r11
|
UTSW |
5 |
109,201,563 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9677:Vmn2r11
|
UTSW |
5 |
109,201,332 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
|
| Posted On |
2013-08-19 |
Incidental Mutation