Incidental Mutation 'R8537:Olfr1111'
ID 659272
Institutional Source Beutler Lab
Gene Symbol Olfr1111
Ensembl Gene ENSMUSG00000075158
Gene Name olfactory receptor 1111
Synonyms MOR181-2, GA_x6K02T2Q125-48635468-48634530
MMRRC Submission 067891-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.215) question?
Stock # R8537 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 87149181-87152624 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87150038 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 208 (T208S)
Ref Sequence ENSEMBL: ENSMUSP00000150760 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099860] [ENSMUST00000214492] [ENSMUST00000216378]
AlphaFold Q7TR55
Predicted Effect probably benign
Transcript: ENSMUST00000099860
AA Change: T208S

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000097446
Gene: ENSMUSG00000075158
AA Change: T208S

Pfam:7tm_4 31 307 2.2e-54 PFAM
Pfam:7tm_1 41 290 7e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214492
AA Change: T208S

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000216378
AA Change: T208S

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010111I01Rik A T 13: 63,190,550 (GRCm38) E579V probably damaging Het
Adgrv1 T A 13: 81,536,372 (GRCm38) D1790V probably damaging Het
Avl9 T A 6: 56,728,659 (GRCm38) Y175* probably null Het
Bmp2 A T 2: 133,561,282 (GRCm38) D251V probably damaging Het
Camsap2 T A 1: 136,277,205 (GRCm38) K1191N probably damaging Het
Ccdc102a A C 8: 94,906,056 (GRCm38) F431C probably benign Het
Ccdc186 T C 19: 56,810,245 (GRCm38) I270M probably damaging Het
Copb2 A G 9: 98,587,619 (GRCm38) Q851R probably null Het
Cyp11b2 C T 15: 74,856,167 (GRCm38) R22K probably benign Het
Ddx50 A G 10: 62,642,849 (GRCm38) F186S probably damaging Het
Dhx38 T C 8: 109,553,380 (GRCm38) Y926C probably damaging Het
Dmrt2 T C 19: 25,673,936 (GRCm38) M162T possibly damaging Het
Dnah10 G T 5: 124,816,100 (GRCm38) G3309V probably damaging Het
Dnajb2 T C 1: 75,239,598 (GRCm38) F107S probably damaging Het
Dock8 T A 19: 25,130,506 (GRCm38) S867T probably benign Het
Eif2ak1 C A 5: 143,899,069 (GRCm38) T526K probably damaging Het
Gm30302 A G 13: 49,786,632 (GRCm38) V534A possibly damaging Het
Gnas T C 2: 174,298,601 (GRCm38) S188P possibly damaging Het
Gpam T C 19: 55,096,239 (GRCm38) D36G probably benign Het
Gucy2e C A 11: 69,236,353 (GRCm38) R98L probably benign Het
Hmcn2 C A 2: 31,391,076 (GRCm38) L1867I probably benign Het
Hnrnpu T C 1: 178,333,634 (GRCm38) probably benign Het
Icos A G 1: 60,993,942 (GRCm38) D100G probably damaging Het
Ifi203 A T 1: 173,928,906 (GRCm38) probably benign Het
Ift46 T A 9: 44,783,983 (GRCm38) L92Q probably damaging Het
Kcnip2 C T 19: 45,815,730 (GRCm38) probably null Het
Lgr5 T C 10: 115,452,402 (GRCm38) Y779C probably damaging Het
Ltk G T 2: 119,758,107 (GRCm38) P287Q probably benign Het
Mapk8ip3 A T 17: 24,901,678 (GRCm38) C852* probably null Het
Mmp27 A G 9: 7,579,775 (GRCm38) M443V probably benign Het
Muc6 T C 7: 141,647,917 (GRCm38) D769G probably benign Het
Myo7b T C 18: 31,977,089 (GRCm38) I1107V probably benign Het
Nebl T A 2: 17,350,709 (GRCm38) H211L probably benign Het
Oaz3 T A 3: 94,436,435 (GRCm38) K40N probably damaging Het
Olfr860 T A 9: 19,846,552 (GRCm38) E22D probably damaging Het
Osbpl10 G T 9: 115,229,909 (GRCm38) A718S probably benign Het
Ppp3ca T A 3: 136,797,858 (GRCm38) I64K possibly damaging Het
Prlr T C 15: 10,314,180 (GRCm38) probably benign Het
Rab3ip A G 10: 116,910,154 (GRCm38) I424T probably damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,579,914 (GRCm38) probably benign Het
Sec62 G T 3: 30,818,812 (GRCm38) R348L unknown Het
Sema5b C T 16: 35,651,609 (GRCm38) A479V possibly damaging Het
Shank3 T C 15: 89,532,215 (GRCm38) I222T probably damaging Het
Sp1 C T 15: 102,408,529 (GRCm38) T154I possibly damaging Het
Srek1 A G 13: 103,752,449 (GRCm38) probably benign Het
Tmem129 A G 5: 33,655,576 (GRCm38) S143P possibly damaging Het
Tmem202 A T 9: 59,519,646 (GRCm38) C194S probably benign Het
Tmprss15 A T 16: 79,087,515 (GRCm38) I93K probably damaging Het
Ttn A G 2: 76,776,309 (GRCm38) Y16340H probably damaging Het
Uck1 C A 2: 32,260,141 (GRCm38) probably benign Het
Other mutations in Olfr1111
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01023:Olfr1111 APN 2 87,149,825 (GRCm38) missense possibly damaging 0.53
IGL02217:Olfr1111 APN 2 87,149,887 (GRCm38) missense probably benign 0.00
R0789:Olfr1111 UTSW 2 87,149,827 (GRCm38) missense probably damaging 1.00
R1437:Olfr1111 UTSW 2 87,149,771 (GRCm38) missense possibly damaging 0.94
R1696:Olfr1111 UTSW 2 87,150,380 (GRCm38) missense probably benign 0.00
R1700:Olfr1111 UTSW 2 87,149,779 (GRCm38) missense probably damaging 1.00
R1717:Olfr1111 UTSW 2 87,149,806 (GRCm38) nonsense probably null
R4965:Olfr1111 UTSW 2 87,150,659 (GRCm38) start codon destroyed possibly damaging 0.89
R5221:Olfr1111 UTSW 2 87,150,481 (GRCm38) missense probably damaging 1.00
R5297:Olfr1111 UTSW 2 87,150,449 (GRCm38) missense probably benign 0.01
R5837:Olfr1111 UTSW 2 87,150,355 (GRCm38) missense probably benign 0.02
R6544:Olfr1111 UTSW 2 87,149,863 (GRCm38) missense probably damaging 1.00
R6911:Olfr1111 UTSW 2 87,149,767 (GRCm38) missense probably damaging 1.00
R8969:Olfr1111 UTSW 2 87,150,584 (GRCm38) missense probably benign
R9747:Olfr1111 UTSW 2 87,150,554 (GRCm38) missense probably benign 0.21
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2021-01-18