Incidental Mutation 'R8540:Or5ac16'
ID 659385
Institutional Source Beutler Lab
Gene Symbol Or5ac16
Ensembl Gene ENSMUSG00000052537
Gene Name olfactory receptor family 5 subfamily AC member 16
Synonyms MOR182-8, GA_x54KRFPKG5P-55416332-55415412, Olfr198
MMRRC Submission 068506-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R8540 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 59021867-59022787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 59022323 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 155 (H155Q)
Ref Sequence ENSEMBL: ENSMUSP00000146813 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064452] [ENSMUST00000208244]
AlphaFold Q7TS40
Predicted Effect possibly damaging
Transcript: ENSMUST00000064452
AA Change: H155Q

PolyPhen 2 Score 0.564 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000065535
Gene: ENSMUSG00000052537
AA Change: H155Q

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 4.9e-45 PFAM
Pfam:7tm_1 41 290 4.2e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000208244
AA Change: H155Q

PolyPhen 2 Score 0.564 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aebp2 A T 6: 140,579,437 (GRCm39) I225L probably benign Het
Aebp2 A G 6: 140,579,439 (GRCm39) I225M probably benign Het
Ap2a1 C A 7: 44,553,750 (GRCm39) G566C probably damaging Het
Cdk15 T C 1: 59,349,992 (GRCm39) V328A possibly damaging Het
Cyld G A 8: 89,473,568 (GRCm39) G929D probably damaging Het
Ddx50 G A 10: 62,476,569 (GRCm39) L235F possibly damaging Het
Dlg5 T C 14: 24,208,767 (GRCm39) D813G probably damaging Het
Epb41l3 C T 17: 69,593,757 (GRCm39) T797M probably damaging Het
Foxred2 G A 15: 77,836,212 (GRCm39) R382W probably damaging Het
Gm5798 T A 14: 41,070,674 (GRCm39) I28N possibly damaging Het
Grb14 C T 2: 64,851,478 (GRCm39) V91M probably benign Het
Ints6 T C 14: 62,934,353 (GRCm39) D718G probably benign Het
Man2a1 C A 17: 64,965,982 (GRCm39) H307N probably benign Het
Mylk T C 16: 34,750,257 (GRCm39) Y1199H possibly damaging Het
Nim1k T C 13: 120,175,718 (GRCm39) S163G probably benign Het
Or1r1 A G 11: 73,875,153 (GRCm39) F94L probably damaging Het
Or51f5 G C 7: 102,424,339 (GRCm39) A203P possibly damaging Het
Or8h6 C A 2: 86,703,776 (GRCm39) C97F probably damaging Het
Phyhip A G 14: 70,704,594 (GRCm39) D271G probably benign Het
Pramel27 T A 4: 143,579,496 (GRCm39) S360R probably benign Het
Pycr2 G A 1: 180,734,178 (GRCm39) A187T possibly damaging Het
Ryr3 T A 2: 112,630,367 (GRCm39) E2148V probably damaging Het
Septin12 T C 16: 4,805,481 (GRCm39) H304R probably damaging Het
Sorbs1 G C 19: 40,365,244 (GRCm39) R180G probably benign Het
Ssx2ip T C 3: 146,124,114 (GRCm39) V43A probably benign Het
Syne2 A T 12: 76,141,148 (GRCm39) N6087Y probably damaging Het
Tbc1d4 A T 14: 101,845,712 (GRCm39) I62N probably damaging Het
Ttn C T 2: 76,573,337 (GRCm39) G24106D probably damaging Het
Uhrf1 T A 17: 56,612,105 (GRCm39) I3N probably damaging Het
Urgcp A C 11: 5,667,915 (GRCm39) L141R probably damaging Het
Ush2a G A 1: 188,274,858 (GRCm39) R1777H probably benign Het
Vamp3 A G 4: 151,135,507 (GRCm39) V37A possibly damaging Het
Vmn1r172 C T 7: 23,359,498 (GRCm39) L128F possibly damaging Het
Vmn1r76 A G 7: 11,664,897 (GRCm39) Y71H probably damaging Het
Vmn2r111 C T 17: 22,778,023 (GRCm39) probably null Het
Vmn2r111 T A 17: 22,778,024 (GRCm39) N552Y probably damaging Het
Vmn2r81 A T 10: 79,129,065 (GRCm39) N652I probably damaging Het
Vmn2r87 T C 10: 130,314,762 (GRCm39) N275D possibly damaging Het
Wrn T A 8: 33,842,154 (GRCm39) I47F probably damaging Het
Other mutations in Or5ac16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01395:Or5ac16 APN 16 59,022,460 (GRCm39) missense possibly damaging 0.94
IGL03053:Or5ac16 APN 16 59,022,610 (GRCm39) missense probably damaging 1.00
IGL03168:Or5ac16 APN 16 59,022,610 (GRCm39) missense probably damaging 1.00
R1355:Or5ac16 UTSW 16 59,022,043 (GRCm39) missense probably damaging 1.00
R1370:Or5ac16 UTSW 16 59,022,043 (GRCm39) missense probably damaging 1.00
R1510:Or5ac16 UTSW 16 59,022,546 (GRCm39) missense probably damaging 0.99
R1777:Or5ac16 UTSW 16 59,022,379 (GRCm39) missense probably benign 0.35
R1962:Or5ac16 UTSW 16 59,022,271 (GRCm39) missense possibly damaging 0.88
R1964:Or5ac16 UTSW 16 59,022,271 (GRCm39) missense possibly damaging 0.88
R5409:Or5ac16 UTSW 16 59,021,920 (GRCm39) missense probably damaging 1.00
R5642:Or5ac16 UTSW 16 59,022,369 (GRCm39) missense probably damaging 1.00
R5704:Or5ac16 UTSW 16 59,022,369 (GRCm39) missense probably damaging 1.00
R6323:Or5ac16 UTSW 16 59,022,645 (GRCm39) missense probably damaging 1.00
R6829:Or5ac16 UTSW 16 59,021,898 (GRCm39) missense probably damaging 1.00
R7315:Or5ac16 UTSW 16 59,022,496 (GRCm39) missense probably benign 0.00
R7738:Or5ac16 UTSW 16 59,022,318 (GRCm39) missense probably benign 0.00
R8815:Or5ac16 UTSW 16 59,022,264 (GRCm39) missense possibly damaging 0.78
R8844:Or5ac16 UTSW 16 59,021,929 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTTCAGGATGGCAAGAAGGAC -3'
(R):5'- ATTCTTGGTTGAGTGCTTCACC -3'

Sequencing Primer
(F):5'- ACGATAATAGTCATAAAAGTCAAGCC -3'
(R):5'- GAGTGCTTCACCCAGTTTTATTTC -3'
Posted On 2021-01-18