Incidental Mutation 'R8543:Cdk14'
ID 659463
Institutional Source Beutler Lab
Gene Symbol Cdk14
Ensembl Gene ENSMUSG00000028926
Gene Name cyclin dependent kinase 14
Synonyms Pftk1
MMRRC Submission 068508-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8543 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 4853384-5430251 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 5430079 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 16 (M16K)
Ref Sequence ENSEMBL: ENSMUSP00000030763 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030763] [ENSMUST00000167567]
AlphaFold O35495
Predicted Effect probably benign
Transcript: ENSMUST00000030763
AA Change: M16K

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000030763
Gene: ENSMUSG00000028926
AA Change: M16K

DomainStartEndE-ValueType
low complexity region 119 127 N/A INTRINSIC
S_TKc 135 419 3.63e-85 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167567
SMART Domains Protein: ENSMUSP00000130895
Gene: ENSMUSG00000028926

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 149 157 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 96% (47/49)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf1 T A 17: 43,624,097 (GRCm39) L839Q probably null Het
Ampd1 T A 3: 102,986,486 (GRCm39) F55Y possibly damaging Het
Ank3 A G 10: 69,838,266 (GRCm39) E891G probably damaging Het
Ankrd13c A G 3: 157,709,712 (GRCm39) probably null Het
Ankrd63 A G 2: 118,533,604 (GRCm39) probably benign Het
Arhgap30 T C 1: 171,232,530 (GRCm39) S392P probably damaging Het
Arhgef11 A T 3: 87,589,181 (GRCm39) K16M probably damaging Het
Birc6 T C 17: 74,872,860 (GRCm39) V373A probably damaging Het
Blm A G 7: 80,143,964 (GRCm39) M822T probably damaging Het
Car15 T C 16: 17,654,713 (GRCm39) N102D probably benign Het
Cep350 A G 1: 155,738,122 (GRCm39) Y2574H probably damaging Het
Coro1a C A 7: 126,301,188 (GRCm39) C104F probably damaging Het
D130043K22Rik T A 13: 25,073,852 (GRCm39) L977Q probably benign Het
Dcaf1 T G 9: 106,735,277 (GRCm39) S742A probably benign Het
Dnajb11 A T 16: 22,681,335 (GRCm39) I38L probably benign Het
Eppk1 C T 15: 75,994,319 (GRCm39) R854Q probably benign Het
Fat4 A C 3: 39,031,643 (GRCm39) H2476P probably damaging Het
Fmn2 CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC 1: 174,436,769 (GRCm39) probably benign Het
Gm14326 G A 2: 177,587,452 (GRCm39) R515W probably damaging Het
Gm49368 T C 7: 127,679,433 (GRCm39) Y192H probably damaging Het
Gm7579 GGCTGTGGCTCCTGTGGGGGCTGCAAGGGAAGCTGTGGCTCCTGTGGGGGCTGCAAGGGAAGCTGTGGCTCCTGTGGGGGATGCAAGGGAGGCTGTGGCTCCTGTGGGGG GGCTGTGGCTCCTGTGGGGGCTGCAAGGGAAGCTGTGGCTCCTGTGGGGGATGCAAGGGAGGCTGTGGCTCCTGTGGGGG 7: 141,765,782 (GRCm39) probably benign Het
Gpr182 T C 10: 127,586,861 (GRCm39) H30R probably benign Het
Gprc5c T A 11: 114,755,094 (GRCm39) V257E probably damaging Het
Iars2 T C 1: 185,019,341 (GRCm39) T982A probably benign Het
Ighg2b C A 12: 113,270,552 (GRCm39) A193S probably damaging Het
Izumo1 T A 7: 45,275,678 (GRCm39) V329E possibly damaging Het
Kcnj6 A T 16: 94,563,250 (GRCm39) V398E possibly damaging Het
Lef1 T A 3: 130,909,138 (GRCm39) N117K possibly damaging Het
Ltbp4 T C 7: 27,024,666 (GRCm39) S655G possibly damaging Het
Magi3 A T 3: 104,126,984 (GRCm39) I100N probably damaging Het
Mettl17 G A 14: 52,126,257 (GRCm39) A222T probably benign Het
Notch4 A G 17: 34,787,394 (GRCm39) E318G probably damaging Het
Nqo2 A T 13: 34,169,297 (GRCm39) probably null Het
Or8k31-ps1 A T 2: 86,356,386 (GRCm39) M45K probably damaging Het
Ptpn18 T C 1: 34,511,229 (GRCm39) S324P probably benign Het
Repin1 G T 6: 48,574,279 (GRCm39) E403* probably null Het
Rin1 A G 19: 5,102,100 (GRCm39) D203G probably damaging Het
Serpinb9c T A 13: 33,340,417 (GRCm39) E128V probably damaging Het
Slc3a1 C A 17: 85,335,925 (GRCm39) N22K probably benign Het
Sorbs1 G C 19: 40,365,244 (GRCm39) R180G probably benign Het
Tmco4 G T 4: 138,781,251 (GRCm39) V472L probably benign Het
Tmem132d T C 5: 128,345,799 (GRCm39) E241G probably benign Het
Trim17 T A 11: 58,862,281 (GRCm39) S438T probably damaging Het
Trmt44 T C 5: 35,732,374 (GRCm39) R6G probably benign Het
Vcl G T 14: 21,045,127 (GRCm39) L277F probably benign Het
Vmn2r68 C T 7: 84,883,648 (GRCm39) M152I probably benign Het
Vmn2r94 C T 17: 18,463,984 (GRCm39) V769I possibly damaging Het
Vps13d G T 4: 144,743,353 (GRCm39) S3027* probably null Het
Zfp282 A G 6: 47,881,561 (GRCm39) Q416R probably benign Het
Zfp668 A G 7: 127,466,392 (GRCm39) L264P probably damaging Het
Zfp747 A G 7: 126,973,655 (GRCm39) Y172H probably damaging Het
Other mutations in Cdk14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00678:Cdk14 APN 5 5,299,237 (GRCm39) splice site probably benign
IGL01376:Cdk14 APN 5 5,060,839 (GRCm39) missense probably damaging 1.00
IGL02102:Cdk14 APN 5 5,430,083 (GRCm39) missense probably benign 0.01
IGL02179:Cdk14 APN 5 5,153,845 (GRCm39) missense probably damaging 1.00
IGL02423:Cdk14 APN 5 4,938,905 (GRCm39) missense probably benign 0.00
IGL03081:Cdk14 APN 5 4,999,527 (GRCm39) splice site probably benign
IGL02988:Cdk14 UTSW 5 5,086,484 (GRCm39) missense probably damaging 1.00
R0465:Cdk14 UTSW 5 5,143,019 (GRCm39) missense probably damaging 1.00
R0630:Cdk14 UTSW 5 5,185,422 (GRCm39) splice site probably benign
R1452:Cdk14 UTSW 5 4,938,927 (GRCm39) missense possibly damaging 0.85
R1601:Cdk14 UTSW 5 5,185,378 (GRCm39) missense probably damaging 1.00
R1629:Cdk14 UTSW 5 5,153,807 (GRCm39) missense probably benign 0.18
R1659:Cdk14 UTSW 5 4,999,571 (GRCm39) missense probably benign 0.08
R1809:Cdk14 UTSW 5 5,060,901 (GRCm39) missense probably damaging 0.98
R2013:Cdk14 UTSW 5 5,143,047 (GRCm39) missense probably damaging 1.00
R2015:Cdk14 UTSW 5 5,430,082 (GRCm39) missense probably benign
R2256:Cdk14 UTSW 5 4,938,924 (GRCm39) missense probably benign
R2257:Cdk14 UTSW 5 4,938,924 (GRCm39) missense probably benign
R2908:Cdk14 UTSW 5 5,299,051 (GRCm39) missense probably benign 0.33
R4324:Cdk14 UTSW 5 5,086,532 (GRCm39) nonsense probably null
R4432:Cdk14 UTSW 5 5,086,427 (GRCm39) missense probably damaging 1.00
R4907:Cdk14 UTSW 5 5,299,140 (GRCm39) missense probably damaging 0.96
R5426:Cdk14 UTSW 5 4,938,975 (GRCm39) missense possibly damaging 0.93
R5708:Cdk14 UTSW 5 5,316,036 (GRCm39) intron probably benign
R6006:Cdk14 UTSW 5 5,299,211 (GRCm39) start codon destroyed probably null 0.33
R6120:Cdk14 UTSW 5 4,944,029 (GRCm39) missense probably damaging 0.96
R7048:Cdk14 UTSW 5 5,143,005 (GRCm39) missense probably damaging 1.00
R7104:Cdk14 UTSW 5 5,245,325 (GRCm39) missense possibly damaging 0.92
R7712:Cdk14 UTSW 5 5,430,061 (GRCm39) missense possibly damaging 0.86
R8046:Cdk14 UTSW 5 5,299,159 (GRCm39) missense possibly damaging 0.86
R8121:Cdk14 UTSW 5 5,277,195 (GRCm39) missense possibly damaging 0.92
R8195:Cdk14 UTSW 5 5,277,159 (GRCm39) splice site probably null
R8279:Cdk14 UTSW 5 5,316,125 (GRCm39) intron probably benign
R8312:Cdk14 UTSW 5 4,944,141 (GRCm39) missense probably benign 0.03
R8728:Cdk14 UTSW 5 5,470,117 (GRCm39) synonymous silent
R8862:Cdk14 UTSW 5 5,060,862 (GRCm39) missense probably benign 0.01
R8914:Cdk14 UTSW 5 5,086,515 (GRCm39) missense possibly damaging 0.93
R8956:Cdk14 UTSW 5 5,277,182 (GRCm39) missense probably damaging 1.00
R9111:Cdk14 UTSW 5 5,315,985 (GRCm39) missense possibly damaging 0.93
R9649:Cdk14 UTSW 5 5,423,477 (GRCm39) missense probably benign 0.07
R9796:Cdk14 UTSW 5 5,316,012 (GRCm39) missense probably benign 0.10
Z1176:Cdk14 UTSW 5 5,185,322 (GRCm39) nonsense probably null
Z1177:Cdk14 UTSW 5 4,938,894 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- AGGCTTAAGACAGTCCACGAAC -3'
(R):5'- GCTCTTGCTTACAAAGGAGGG -3'

Sequencing Primer
(F):5'- AACGAAGCCCAGGTCCTG -3'
(R):5'- CTCTTGCTTACAAAGGAGGGAAAATG -3'
Posted On 2021-01-18