Incidental Mutation 'R8543:Gpr182'
ID 659479
Institutional Source Beutler Lab
Gene Symbol Gpr182
Ensembl Gene ENSMUSG00000058396
Gene Name G protein-coupled receptor 182
Synonyms Gpcr17, NOW, G10-D, Admr, AM-R, Gpcr22
MMRRC Submission 068508-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8543 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 127585471-127587667 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 127586861 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 30 (H30R)
Ref Sequence ENSEMBL: ENSMUSP00000100882 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054287] [ENSMUST00000079692]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000054287
SMART Domains Protein: ENSMUSP00000052717
Gene: ENSMUSG00000044617

DomainStartEndE-ValueType
BTB 30 126 9.15e-24 SMART
low complexity region 197 206 N/A INTRINSIC
low complexity region 213 229 N/A INTRINSIC
ZnF_C2H2 372 394 6.4e0 SMART
ZnF_C2H2 400 420 3.21e1 SMART
ZnF_C2H2 451 474 9.31e1 SMART
ZnF_C2H2 480 502 6.92e0 SMART
ZnF_C2H2 508 530 1.79e-2 SMART
ZnF_C2H2 538 560 1.18e-2 SMART
ZnF_C2H2 605 627 2.57e-3 SMART
ZnF_C2H2 633 655 3.78e-1 SMART
ZnF_C2H2 661 683 2.49e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000079692
AA Change: H30R

PolyPhen 2 Score 0.425 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000100882
Gene: ENSMUSG00000058396
AA Change: H30R

DomainStartEndE-ValueType
Pfam:7tm_1 66 316 1.2e-40 PFAM
low complexity region 340 352 N/A INTRINSIC
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 96% (47/49)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf1 T A 17: 43,624,097 (GRCm39) L839Q probably null Het
Ampd1 T A 3: 102,986,486 (GRCm39) F55Y possibly damaging Het
Ank3 A G 10: 69,838,266 (GRCm39) E891G probably damaging Het
Ankrd13c A G 3: 157,709,712 (GRCm39) probably null Het
Ankrd63 A G 2: 118,533,604 (GRCm39) probably benign Het
Arhgap30 T C 1: 171,232,530 (GRCm39) S392P probably damaging Het
Arhgef11 A T 3: 87,589,181 (GRCm39) K16M probably damaging Het
Birc6 T C 17: 74,872,860 (GRCm39) V373A probably damaging Het
Blm A G 7: 80,143,964 (GRCm39) M822T probably damaging Het
Car15 T C 16: 17,654,713 (GRCm39) N102D probably benign Het
Cdk14 A T 5: 5,430,079 (GRCm39) M16K probably benign Het
Cep350 A G 1: 155,738,122 (GRCm39) Y2574H probably damaging Het
Coro1a C A 7: 126,301,188 (GRCm39) C104F probably damaging Het
D130043K22Rik T A 13: 25,073,852 (GRCm39) L977Q probably benign Het
Dcaf1 T G 9: 106,735,277 (GRCm39) S742A probably benign Het
Dnajb11 A T 16: 22,681,335 (GRCm39) I38L probably benign Het
Eppk1 C T 15: 75,994,319 (GRCm39) R854Q probably benign Het
Fat4 A C 3: 39,031,643 (GRCm39) H2476P probably damaging Het
Fmn2 CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC 1: 174,436,769 (GRCm39) probably benign Het
Gm14326 G A 2: 177,587,452 (GRCm39) R515W probably damaging Het
Gm49368 T C 7: 127,679,433 (GRCm39) Y192H probably damaging Het
Gm7579 GGCTGTGGCTCCTGTGGGGGCTGCAAGGGAAGCTGTGGCTCCTGTGGGGGCTGCAAGGGAAGCTGTGGCTCCTGTGGGGGATGCAAGGGAGGCTGTGGCTCCTGTGGGGG GGCTGTGGCTCCTGTGGGGGCTGCAAGGGAAGCTGTGGCTCCTGTGGGGGATGCAAGGGAGGCTGTGGCTCCTGTGGGGG 7: 141,765,782 (GRCm39) probably benign Het
Gprc5c T A 11: 114,755,094 (GRCm39) V257E probably damaging Het
Iars2 T C 1: 185,019,341 (GRCm39) T982A probably benign Het
Ighg2b C A 12: 113,270,552 (GRCm39) A193S probably damaging Het
Izumo1 T A 7: 45,275,678 (GRCm39) V329E possibly damaging Het
Kcnj6 A T 16: 94,563,250 (GRCm39) V398E possibly damaging Het
Lef1 T A 3: 130,909,138 (GRCm39) N117K possibly damaging Het
Ltbp4 T C 7: 27,024,666 (GRCm39) S655G possibly damaging Het
Magi3 A T 3: 104,126,984 (GRCm39) I100N probably damaging Het
Mettl17 G A 14: 52,126,257 (GRCm39) A222T probably benign Het
Notch4 A G 17: 34,787,394 (GRCm39) E318G probably damaging Het
Nqo2 A T 13: 34,169,297 (GRCm39) probably null Het
Or8k31-ps1 A T 2: 86,356,386 (GRCm39) M45K probably damaging Het
Ptpn18 T C 1: 34,511,229 (GRCm39) S324P probably benign Het
Repin1 G T 6: 48,574,279 (GRCm39) E403* probably null Het
Rin1 A G 19: 5,102,100 (GRCm39) D203G probably damaging Het
Serpinb9c T A 13: 33,340,417 (GRCm39) E128V probably damaging Het
Slc3a1 C A 17: 85,335,925 (GRCm39) N22K probably benign Het
Sorbs1 G C 19: 40,365,244 (GRCm39) R180G probably benign Het
Tmco4 G T 4: 138,781,251 (GRCm39) V472L probably benign Het
Tmem132d T C 5: 128,345,799 (GRCm39) E241G probably benign Het
Trim17 T A 11: 58,862,281 (GRCm39) S438T probably damaging Het
Trmt44 T C 5: 35,732,374 (GRCm39) R6G probably benign Het
Vcl G T 14: 21,045,127 (GRCm39) L277F probably benign Het
Vmn2r68 C T 7: 84,883,648 (GRCm39) M152I probably benign Het
Vmn2r94 C T 17: 18,463,984 (GRCm39) V769I possibly damaging Het
Vps13d G T 4: 144,743,353 (GRCm39) S3027* probably null Het
Zfp282 A G 6: 47,881,561 (GRCm39) Q416R probably benign Het
Zfp668 A G 7: 127,466,392 (GRCm39) L264P probably damaging Het
Zfp747 A G 7: 126,973,655 (GRCm39) Y172H probably damaging Het
Other mutations in Gpr182
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00961:Gpr182 APN 10 127,586,559 (GRCm39) missense probably benign 0.09
IGL00983:Gpr182 APN 10 127,586,657 (GRCm39) missense possibly damaging 0.89
IGL01337:Gpr182 APN 10 127,586,655 (GRCm39) missense possibly damaging 0.95
IGL01810:Gpr182 APN 10 127,586,733 (GRCm39) missense probably damaging 1.00
R0449:Gpr182 UTSW 10 127,586,565 (GRCm39) missense probably damaging 1.00
R0554:Gpr182 UTSW 10 127,586,940 (GRCm39) missense probably benign 0.00
R2229:Gpr182 UTSW 10 127,586,010 (GRCm39) missense possibly damaging 0.91
R2292:Gpr182 UTSW 10 127,586,051 (GRCm39) missense possibly damaging 0.89
R2349:Gpr182 UTSW 10 127,586,806 (GRCm39) missense probably damaging 1.00
R2445:Gpr182 UTSW 10 127,586,496 (GRCm39) missense probably benign 0.01
R5977:Gpr182 UTSW 10 127,586,748 (GRCm39) missense possibly damaging 0.79
R6290:Gpr182 UTSW 10 127,586,893 (GRCm39) missense probably benign 0.00
R6415:Gpr182 UTSW 10 127,586,375 (GRCm39) missense possibly damaging 0.88
R8014:Gpr182 UTSW 10 127,586,874 (GRCm39) missense possibly damaging 0.59
R8093:Gpr182 UTSW 10 127,586,783 (GRCm39) missense probably damaging 1.00
R8333:Gpr182 UTSW 10 127,585,790 (GRCm39) missense probably benign 0.08
R8788:Gpr182 UTSW 10 127,586,529 (GRCm39) missense probably benign 0.00
R9047:Gpr182 UTSW 10 127,586,517 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCTGCGATGGCCATGTTGAG -3'
(R):5'- CCCCTGAGGCCTTTTAGTTG -3'

Sequencing Primer
(F):5'- AGGATGTACAGGTTCAGCATCCC -3'
(R):5'- TTGGAGGTATGGGGGCAGAC -3'
Posted On 2021-01-18