Incidental Mutation 'IGL00331:Klf17'
ID 6595
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klf17
Ensembl Gene ENSMUSG00000048626
Gene Name Kruppel-like factor 17
Synonyms D4Ertd561e, 7420700M05Rik, Zfp393
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00331
Quality Score
Status
Chromosome 4
Chromosomal Location 117757836-117765648 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 117761038 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 41 (T41A)
Ref Sequence ENSEMBL: ENSMUSP00000052316 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062747]
AlphaFold Q8CFA7
Predicted Effect probably benign
Transcript: ENSMUST00000062747
AA Change: T41A

PolyPhen 2 Score 0.056 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000052316
Gene: ENSMUSG00000048626
AA Change: T41A

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 142 157 N/A INTRINSIC
low complexity region 202 213 N/A INTRINSIC
ZnF_C2H2 256 280 4.47e-3 SMART
ZnF_C2H2 286 310 1.92e-2 SMART
ZnF_C2H2 316 338 1.1e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aamp C A 1: 74,281,436 probably benign Het
Adamts19 T A 18: 59,007,325 probably benign Het
Afg3l1 T A 8: 123,487,389 F190I probably benign Het
Alms1 T A 6: 85,641,371 S2800T possibly damaging Het
Alox5 A T 6: 116,415,517 W348R probably damaging Het
Atp13a5 G A 16: 29,267,014 Q823* probably null Het
Atp6v1b2 T C 8: 69,088,934 probably null Het
Chuk T C 19: 44,088,023 I416M possibly damaging Het
Dmbt1 A T 7: 131,099,290 Q1066L possibly damaging Het
Dnah5 A G 15: 28,421,620 T3873A probably damaging Het
Endog C T 2: 30,172,900 T184M probably damaging Het
Fam166b G A 4: 43,428,158 R100W possibly damaging Het
Fcgbp T C 7: 28,101,541 probably benign Het
Flii A G 11: 60,715,833 I1061T probably benign Het
Hdac2 T A 10: 36,997,071 N308K probably damaging Het
Hoxa2 T G 6: 52,163,517 Y163S probably damaging Het
Hsd3b7 T C 7: 127,802,972 L263P probably damaging Het
Lrrfip1 T C 1: 91,068,621 M42T probably damaging Het
Mapk8ip1 C T 2: 92,385,188 V614I probably benign Het
Mocs1 T G 17: 49,435,264 probably null Het
Moxd1 T C 10: 24,282,555 probably benign Het
Mterf1a T C 5: 3,891,610 E86G probably damaging Het
Muc4 A G 16: 32,753,185 D1021G probably benign Het
Nomo1 T C 7: 46,045,336 S212P possibly damaging Het
Olfr1471 A G 19: 13,445,624 D204G probably benign Het
Olfr893 T A 9: 38,209,238 Y60N probably damaging Het
Phf21a A C 2: 92,348,029 T385P probably damaging Het
Piwil4 A T 9: 14,715,031 probably benign Het
Pknox1 T C 17: 31,599,645 probably null Het
Prr14l T C 5: 32,831,066 I362V probably benign Het
Sergef C T 7: 46,635,420 probably null Het
Sez6l T C 5: 112,424,645 D948G probably damaging Het
Skor1 A T 9: 63,146,441 L54Q probably damaging Het
Sntn C T 14: 13,679,086 Q87* probably null Het
Syde2 A G 3: 146,014,341 K772E possibly damaging Het
Taf2 T A 15: 55,071,449 probably null Het
Tbc1d13 T A 2: 30,140,511 Y113N probably damaging Het
Tmem154 T C 3: 84,684,415 F91L probably benign Het
Tmem63a A G 1: 180,966,497 D533G possibly damaging Het
Tmprss15 A T 16: 78,985,994 N712K possibly damaging Het
Trip12 A T 1: 84,730,541 D603E probably damaging Het
Trmt11 T C 10: 30,566,449 D246G probably damaging Het
Vmn1r174 T A 7: 23,754,533 M208K possibly damaging Het
Wdr54 T C 6: 83,155,773 H33R probably benign Het
Zfp207 A G 11: 80,389,002 D111G probably benign Het
Other mutations in Klf17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01399:Klf17 APN 4 117759159 missense probably damaging 1.00
R0047:Klf17 UTSW 4 117761032 missense probably benign 0.00
R0051:Klf17 UTSW 4 117760392 missense probably damaging 1.00
R0051:Klf17 UTSW 4 117760392 missense probably damaging 1.00
R1513:Klf17 UTSW 4 117760935 missense probably damaging 0.96
R3103:Klf17 UTSW 4 117760608 missense possibly damaging 0.72
R4112:Klf17 UTSW 4 117760701 missense possibly damaging 0.85
R4180:Klf17 UTSW 4 117759186 missense probably benign 0.14
R4669:Klf17 UTSW 4 117760371 missense probably damaging 1.00
R4715:Klf17 UTSW 4 117760536 missense probably benign 0.44
R5063:Klf17 UTSW 4 117760659 missense possibly damaging 0.85
R7578:Klf17 UTSW 4 117760719 missense possibly damaging 0.85
R7765:Klf17 UTSW 4 117760615 missense probably benign 0.08
R9041:Klf17 UTSW 4 117760359 missense probably damaging 1.00
Z1176:Klf17 UTSW 4 117760351 missense probably benign 0.06
Posted On 2012-04-20