Incidental Mutation 'R8546:Or7e169'
ID 659637
Institutional Source Beutler Lab
Gene Symbol Or7e169
Ensembl Gene ENSMUSG00000066905
Gene Name olfactory receptor family 7 subfamily E member 169
Synonyms GA_x6K02T2PVTD-13586614-13585661, Olfr860, MOR146-2
MMRRC Submission 068511-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R8546 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 19756919-19761043 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19757685 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 77 (T77S)
Ref Sequence ENSEMBL: ENSMUSP00000148568 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086482] [ENSMUST00000211924] [ENSMUST00000212353]
AlphaFold Q8VFF7
Predicted Effect probably damaging
Transcript: ENSMUST00000086482
AA Change: T77S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000130735
Gene: ENSMUSG00000066905
AA Change: T77S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.5e-56 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.1e-8 PFAM
Pfam:7tm_1 41 290 9.3e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000211924
AA Change: T77S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000212353
AA Change: T77S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot1 T C 12: 84,064,139 (GRCm39) S416P probably benign Het
Adcy9 G T 16: 4,236,769 (GRCm39) A214E probably benign Het
Atp11a T A 8: 12,901,083 (GRCm39) W971R probably damaging Het
Axl C T 7: 25,473,588 (GRCm39) R346H probably benign Het
Bltp3b A G 10: 89,630,397 (GRCm39) N399S probably damaging Het
Bsn G A 9: 107,988,651 (GRCm39) A2367V probably benign Het
Cabin1 T C 10: 75,578,101 (GRCm39) D532G probably damaging Het
Cdh20 A G 1: 104,861,769 (GRCm39) probably benign Het
Cfap97d1 A G 11: 101,881,687 (GRCm39) R77G probably damaging Het
Clca3b T A 3: 144,533,158 (GRCm39) S625C probably damaging Het
Col3a1 G A 1: 45,380,099 (GRCm39) probably benign Het
Ctu2 T C 8: 123,206,102 (GRCm39) L281P probably damaging Het
Cyb5a G A 18: 84,889,759 (GRCm39) probably null Het
Cyb5rl T A 4: 106,925,923 (GRCm39) V35D probably damaging Het
Dnah17 A G 11: 118,015,101 (GRCm39) F381S probably benign Het
Eif3a A T 19: 60,755,208 (GRCm39) N991K unknown Het
Eif6 A G 2: 155,668,420 (GRCm39) probably benign Het
Fahd1 T C 17: 25,069,057 (GRCm39) M7V possibly damaging Het
Fam171b A G 2: 83,685,795 (GRCm39) T160A probably damaging Het
Fnip1 A G 11: 54,400,826 (GRCm39) E1075G probably benign Het
Fras1 G A 5: 96,857,825 (GRCm39) V2040I probably benign Het
Gjc2 G T 11: 59,067,182 (GRCm39) D433E unknown Het
H2bc13 G A 13: 21,900,042 (GRCm39) T91M probably damaging Het
Igsf9b T C 9: 27,244,426 (GRCm39) S794P possibly damaging Het
Irx6 A T 8: 93,405,264 (GRCm39) R377S probably benign Het
Khnyn A G 14: 56,123,275 (GRCm39) T10A probably benign Het
Kmt2e A T 5: 23,686,242 (GRCm39) H389L probably damaging Het
Lin7c A G 2: 109,726,716 (GRCm39) I122V probably null Het
Lonp1 G A 17: 56,933,702 (GRCm39) P58S probably benign Het
Loxl4 T C 19: 42,596,027 (GRCm39) H142R probably benign Het
Mcm6 C T 1: 128,273,685 (GRCm39) E382K possibly damaging Het
Mettl2 T A 11: 105,022,399 (GRCm39) N196K probably benign Het
Myo7b T C 18: 32,123,201 (GRCm39) E712G probably benign Het
Ncam2 C T 16: 81,314,419 (GRCm39) T465I probably benign Het
Padi4 T C 4: 140,484,841 (GRCm39) E340G probably damaging Het
Patj T A 4: 98,325,634 (GRCm39) S490R probably benign Het
Pkd1l3 G A 8: 110,393,615 (GRCm39) S1981N possibly damaging Het
Poll T A 19: 45,546,416 (GRCm39) D208V probably damaging Het
Polr3f A G 2: 144,374,284 (GRCm39) D64G probably damaging Het
Prkdc A G 16: 15,480,899 (GRCm39) Y340C probably damaging Het
Prmt6 C T 3: 110,158,034 (GRCm39) R85Q possibly damaging Het
Rgl3 T C 9: 21,899,156 (GRCm39) K140R probably benign Het
Rhoj A G 12: 75,422,124 (GRCm39) T61A probably benign Het
Skor1 T C 9: 63,049,570 (GRCm39) D795G probably damaging Het
Slc28a2b A T 2: 122,353,235 (GRCm39) M472L probably benign Het
Tekt5 A G 16: 10,175,877 (GRCm39) V556A probably benign Het
Tlr1 T A 5: 65,084,374 (GRCm39) I68F probably damaging Het
Tnni3k G T 3: 154,498,444 (GRCm39) N798K probably benign Het
Tuft1 T A 3: 94,529,420 (GRCm39) E227D probably benign Het
Tulp1 T C 17: 28,582,710 (GRCm39) K146R probably benign Het
Usp24 G A 4: 106,259,326 (GRCm39) A1616T probably benign Het
Ythdc1 A T 5: 86,974,607 (GRCm39) K452N possibly damaging Het
Zscan4-ps3 T A 7: 11,346,697 (GRCm39) H244Q possibly damaging Het
Other mutations in Or7e169
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00942:Or7e169 APN 9 19,757,555 (GRCm39) missense probably damaging 1.00
IGL02216:Or7e169 APN 9 19,757,861 (GRCm39) missense probably damaging 0.99
IGL02269:Or7e169 APN 9 19,757,024 (GRCm39) missense possibly damaging 0.85
IGL02964:Or7e169 APN 9 19,757,550 (GRCm39) nonsense probably null
R0042:Or7e169 UTSW 9 19,757,075 (GRCm39) missense probably benign
R1505:Or7e169 UTSW 9 19,757,084 (GRCm39) missense probably benign 0.39
R1941:Or7e169 UTSW 9 19,757,246 (GRCm39) missense probably damaging 0.99
R2030:Or7e169 UTSW 9 19,757,709 (GRCm39) missense probably benign 0.30
R3150:Or7e169 UTSW 9 19,757,510 (GRCm39) missense possibly damaging 0.80
R4597:Or7e169 UTSW 9 19,756,987 (GRCm39) missense probably benign 0.01
R5004:Or7e169 UTSW 9 19,757,398 (GRCm39) missense probably benign 0.00
R5006:Or7e169 UTSW 9 19,757,567 (GRCm39) missense probably benign 0.33
R5350:Or7e169 UTSW 9 19,757,912 (GRCm39) start codon destroyed probably null 0.97
R6163:Or7e169 UTSW 9 19,757,024 (GRCm39) missense probably benign 0.45
R6368:Or7e169 UTSW 9 19,757,705 (GRCm39) missense probably damaging 1.00
R7206:Or7e169 UTSW 9 19,757,856 (GRCm39) missense probably damaging 0.99
R7315:Or7e169 UTSW 9 19,757,131 (GRCm39) missense probably damaging 0.99
R8195:Or7e169 UTSW 9 19,757,780 (GRCm39) missense probably damaging 0.99
R8537:Or7e169 UTSW 9 19,757,848 (GRCm39) missense probably damaging 0.96
R8803:Or7e169 UTSW 9 19,757,462 (GRCm39) missense possibly damaging 0.95
R9049:Or7e169 UTSW 9 19,757,045 (GRCm39) missense probably damaging 1.00
R9164:Or7e169 UTSW 9 19,757,504 (GRCm39) missense possibly damaging 0.73
R9254:Or7e169 UTSW 9 19,757,212 (GRCm39) missense possibly damaging 0.83
R9379:Or7e169 UTSW 9 19,757,212 (GRCm39) missense possibly damaging 0.83
R9513:Or7e169 UTSW 9 19,757,816 (GRCm39) missense possibly damaging 0.73
R9515:Or7e169 UTSW 9 19,757,816 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- CAGTGCACCTGTGAATCAATG -3'
(R):5'- GGACCCTGAACTACAACCTGTC -3'

Sequencing Primer
(F):5'- TGCACCTGTGAATCAATGAGACTG -3'
(R):5'- GAACTACAACCTGTCTTATTTGCAC -3'
Posted On 2021-01-18