Incidental Mutation 'R8548:Or8g37'
ID 659745
Institutional Source Beutler Lab
Gene Symbol Or8g37
Ensembl Gene ENSMUSG00000095774
Gene Name olfactory receptor family 8 subfamily G member 37
Synonyms Olfr970, GA_x6K02T2PVTD-33517322-33518257, MOR171-16
MMRRC Submission 068513-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.318) question?
Stock # R8548 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 39730937-39731872 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39731537 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 201 (C201S)
Ref Sequence ENSEMBL: ENSMUSP00000150325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071132] [ENSMUST00000213975] [ENSMUST00000215922]
AlphaFold Q8VFN3
Predicted Effect probably benign
Transcript: ENSMUST00000071132
AA Change: C201S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000071132
Gene: ENSMUSG00000095774
AA Change: C201S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.2e-53 PFAM
Pfam:7tm_1 41 290 1.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213975
AA Change: C201S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000215922
AA Change: C201S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam1a A T 5: 121,658,165 (GRCm39) L376Q probably damaging Het
Akirin1 A G 4: 123,631,831 (GRCm39) M179T possibly damaging Het
Ap5b1 G T 19: 5,621,123 (GRCm39) V848L possibly damaging Het
Apoa2 T A 1: 171,053,798 (GRCm39) M91K probably benign Het
Bsn G A 9: 107,988,651 (GRCm39) A2367V probably benign Het
Cdc20 A C 4: 118,293,535 (GRCm39) S160A possibly damaging Het
Cftr G T 6: 18,273,698 (GRCm39) V839L possibly damaging Het
Ctf1 A T 7: 127,316,564 (GRCm39) H171L probably benign Het
Dmac2 T A 7: 25,324,217 (GRCm39) M225K probably damaging Het
Dmbx1 A T 4: 115,777,512 (GRCm39) V112E probably damaging Het
Eloa T C 4: 135,732,988 (GRCm39) K754R probably damaging Het
Ern2 G A 7: 121,777,062 (GRCm39) T286I probably damaging Het
Fam135b T C 15: 71,334,659 (GRCm39) D845G probably damaging Het
Fbxl6 T A 15: 76,421,542 (GRCm39) M232L possibly damaging Het
Gpr171 A T 3: 59,005,400 (GRCm39) I125K probably damaging Het
Hoxa2 G A 6: 52,140,098 (GRCm39) T296I probably damaging Het
Hspa8 A G 9: 40,713,767 (GRCm39) M87V probably benign Het
Ilkap G T 1: 91,318,882 (GRCm39) D31E possibly damaging Het
Ints9 T C 14: 65,269,770 (GRCm39) S487P probably benign Het
Macc1 T A 12: 119,414,091 (GRCm39) S756T probably benign Het
Map2 A G 1: 66,452,499 (GRCm39) D545G probably damaging Het
Mapkbp1 A G 2: 119,854,572 (GRCm39) N1390D probably benign Het
Mgat5 G A 1: 127,248,409 (GRCm39) V104M possibly damaging Het
Myoz2 T A 3: 122,827,916 (GRCm39) M1L possibly damaging Het
Nmt1 A G 11: 102,934,052 (GRCm39) K64E possibly damaging Het
Nr6a1 C A 2: 38,619,550 (GRCm39) Q448H probably damaging Het
Nr6a1 T G 2: 38,619,551 (GRCm39) Q448P probably damaging Het
Odf2 T C 2: 29,783,526 (GRCm39) probably null Het
Osbpl6 A G 2: 76,409,566 (GRCm39) N476S possibly damaging Het
Pclo A G 5: 14,732,268 (GRCm39) probably null Het
Plxnd1 C T 6: 115,934,558 (GRCm39) D1792N probably damaging Het
Prdm11 C T 2: 92,843,103 (GRCm39) V119M probably damaging Het
Prss23 A G 7: 89,159,416 (GRCm39) F218L probably benign Het
Rflnb A G 11: 75,913,047 (GRCm39) Y114H probably damaging Het
Skor2 T A 18: 76,946,581 (GRCm39) I101N unknown Het
Sp8 A C 12: 118,812,910 (GRCm39) Y255S possibly damaging Het
Srfbp1 G A 18: 52,621,463 (GRCm39) V175I probably benign Het
Stxbp5 C T 10: 9,693,050 (GRCm39) D359N probably null Het
Thnsl1 A G 2: 21,217,733 (GRCm39) I496V possibly damaging Het
Usp32 G A 11: 84,908,653 (GRCm39) P1018S possibly damaging Het
Usp7 A T 16: 8,529,939 (GRCm39) V142E possibly damaging Het
Other mutations in Or8g37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01388:Or8g37 APN 9 39,731,298 (GRCm39) missense probably damaging 1.00
IGL02674:Or8g37 APN 9 39,730,934 (GRCm39) splice site probably null
R0659:Or8g37 UTSW 9 39,731,112 (GRCm39) missense possibly damaging 0.78
R0686:Or8g37 UTSW 9 39,730,964 (GRCm39) missense probably damaging 0.98
R1952:Or8g37 UTSW 9 39,731,363 (GRCm39) missense probably benign 0.09
R2068:Or8g37 UTSW 9 39,731,846 (GRCm39) missense probably benign 0.00
R4472:Or8g37 UTSW 9 39,731,870 (GRCm39) makesense probably null
R4798:Or8g37 UTSW 9 39,731,193 (GRCm39) missense probably benign 0.13
R5035:Or8g37 UTSW 9 39,731,390 (GRCm39) missense possibly damaging 0.82
R5339:Or8g37 UTSW 9 39,731,229 (GRCm39) missense probably damaging 0.97
R6751:Or8g37 UTSW 9 39,731,193 (GRCm39) missense probably benign 0.13
R7211:Or8g37 UTSW 9 39,731,154 (GRCm39) missense possibly damaging 0.76
R7471:Or8g37 UTSW 9 39,731,423 (GRCm39) missense probably benign 0.00
R7609:Or8g37 UTSW 9 39,731,583 (GRCm39) missense probably benign
R7638:Or8g37 UTSW 9 39,731,189 (GRCm39) missense probably damaging 1.00
R7890:Or8g37 UTSW 9 39,731,310 (GRCm39) missense probably damaging 0.99
R7918:Or8g37 UTSW 9 39,731,406 (GRCm39) missense probably damaging 0.98
R8817:Or8g37 UTSW 9 39,730,939 (GRCm39) start codon destroyed probably null 0.40
R8868:Or8g37 UTSW 9 39,731,252 (GRCm39) missense probably benign
R9689:Or8g37 UTSW 9 39,731,801 (GRCm39) missense possibly damaging 0.95
Z1176:Or8g37 UTSW 9 39,731,651 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACCCCTTGCTTTACAATGCTG -3'
(R):5'- CTGCAAGTACATGAATGCAAGG -3'

Sequencing Primer
(F):5'- CAATGCTGTAATGTCCTTTCAAGTC -3'
(R):5'- GGAACCGAAGAAGATAGCAACAGC -3'
Posted On 2021-01-18